Common fragile sites

Cancer Letters

Volumn 232, Issue 1, 2006, Pages 4-12

  Glover, Thomas W ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER; CELL CULTURE; CELL CYCLE; CHROMOSOME BREAKAGE; CHROMOSOME FRAGILE SITE; CHROMOSOME REARRANGEMENT; CONFERENCE PAPER; DNA REPLICATION; DNA SYNTHESIS; GENETIC ASSOCIATION; GENOMIC INSTABILITY; HUMAN; METAPHASE CHROMOSOME; PRIORITY JOURNAL; SOMATIC CELL;

ANIMALS; CELL CYCLE PROTEINS; CHROMOSOME FRAGILE SITES; CHROMOSOME FRAGILITY; CHROMOSOMES, HUMAN; DISEASE SUSCEPTIBILITY; HUMANS; PROTEIN-SERINE-THREONINE KINASES;

EID: 30144439370     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2005.08.032     Document Type: Conference Paper

References (87)

1. T.W. Glover, M.F. Arlt, A.M. Casper, S.G. Durkin, Mechanisms of common fragile site instability, Hum. Molec. Genet. 14 (in press).
2. D.M. Stone, K.E. Stephens, and J. Doles Folate-sensitive and aphidicolin-inducible fragile sites are expressed in the genome of the domestic cat Cancer Genet. Cytogenet. 65 1993 130 134
3. D.M. Stone, P.B. Jacky, D.D. Hancock, and D.J. Prieur Chromosomal fragile site expression in dogs Am. J. Med. Gen. 40 1991 214 222
4. F.F.B. Elder, and T.J. Robinson Rodent fragile sites: are they conserved? Evidence from mouse and rat Chromosoma 97 1989 459 464
5. D.F.C.M. Smeets, and F.A.J.M. van de Klundert Common fragile sites in man and three closely related primate species Cytogenet. Cell Genet. 53 1990 8 14
6. M.Y. Yang, and S.E. Long Folate sensitive common fragile sites in chromosomes of the domestic pig (Sus scrofa) Res. Vet. Sci. 55 1993 231 235
7. B.F. McAllister, and I.F. Greenbaum How common are common fragile sites: variation of aphidicolin-induced chromosomal fragile sites in a population of the deer mouse (Peromyscus maniculatus) Hum. Genet. 100 1997 182 188
8. A. Ruiz-Herrera, F. Garcia, L. Fronicke, M. Ponsa, J. Egozcue, M.G. Caldes, and R. Stanyon Conservation of aphidicolin-induced fragile sites in Papionini (Primates) species and humans Chromosome Res. 12 2004 683 690
9. J. Soulie, and J. De Grouchy A cytogenetic survey of 110 baboons (Papio cynocephalus) Am. J. Phys. Anthrop. 56 1981 107 113
10. T.W. Glover, A.W. Hoge, D.E. Miller, J.E. Ascara-Wilke, A.N. Adam, and S.L. Dagenais The murine Fhit gene is highly similar to its human orthologue and maps to a common fragile site region Cancer Res. 58 1998 3409 3414
11. T. Shiraishi, T. Druck, K. Mimori, J. Flomenberg, L. Berk, and H. Alder Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit Proc. Natl. Acad. Sci. USA 98 2001 5722 5727
12. A. Matsuyama, T. Shiraishi, F. Trapasso, T. Kuroki, H. Alder, and M. Mori Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic Proc. Natl. Acad. Sci. USA 100 2003 14988 14993
13. K.A. Krummel, S.R. Denison, E. Calhoun, L.A. Phillips, and D.I. Smith The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1 Genes. Chromosomes Cancer 34 2002 154 167
14. R.S. Cha, N. Kleckner, and A.T.R. homolog ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones Science 297 2002 602 606
15. F.J. Lemoine, N.P. Degtyareva, K. Lobcchev, and T.D. Petes Chromosomal translocations in yeast induced by low levels of DNA polymerase a model for chromosome fragile sites Cell 120 2005 587 598
16. T.W. Glover, C. Berger, J. Coyle, and B. Echo DNA polymerase α inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes Hum. Genet. 67 1984 136 142
17. J.J. Yunis, and A.L. Soreng Constitutive fragile sites and cancer Science 226 1984 1199 1204
18. T.W. Glover, and C.K. Stein Induction of sister chromatid exchanges at common fragile sites Am. J. Hum. Genet. 41 1987 882 890
19. T.W. Glover, and C.K. Stein Chromosome breakage and recombination at fragile sites Am. J. Hum. Genet. 43 1988 265 273
20. N.D. Wang, J.R. Testa, and D.I. Smith Determination of the specificity of aphidicolin-induced breakage of the human 3p14.2 fragile site Genomics 17 1993 341 347
21. F.V. Rassool, T.W. McKeithan, M.E. Neilly, E. van Melle, R. Espinosa III, and M.M. Le Beau Preferential integration of marker DNA into the chromosomal fragile site at 3p14: an approach to cloning fragile sites Proc. Natl. Acad. Sci. USA 88 1991 6657 6661
22. C.M. Wilke, B.K. Hall, A. Hoge, W. Paradee, D.I. Smith, and T.W. Glover FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites Hum. Mol. Genet. 5 1996 187 195
23. M. De Braekeleer, C. Sreekantaiah, and O. Haas Herpes simplex virus and human papillomavirus sites correlate with chromosomal breakpoints in human cervical carcinoma Cancer Genet. Cytogenet. 59 1992 135 137
24. N.C. Popescu, and J.A. DiPaolo Preferential sites for viral integration on mammalian genome Cancer Genet. Cytogenet. 42 1989 157 171
25. P.P. Smith, C. Friedman, E.M. Bryant, and J.K. McDougall Viral integration and fragile sites in human papillomavirus-immortalized human keratinocyte cell lines Genes. Chromosomes Cancer 5 1992 150 157
26. A. Coquelle, E. Pipiras, F. Toledo, G. Buttin, and M. Debatisse Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons Cell 89 1997 215 225
27. M.Z. Limongi, F. Pelliccia, and A. Rocchi Characterization of the human common fragile site FRA2G Genomics 81 2003 93 97
28. M. Ohta, H. Inoue, M.G. Cotticelli, K. Kastury, R. Baffa, and J. Palazzo The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers Cell 84 1996 587 597
29. L. Rozier, E. El-Achkar, F. Apiou, and M. Debatisse Characterization of a conserved aphidicolin-sensitive common fragile site at human 4q22 and mouse 6C1: possible association with an inherited disease and cancer Oncogene 23 2004 6872 6880
30. S.R. Denison, G. Callahan, N.A. Becker, L.A. Phillips, and D.I. Smith Characterization of FRA6E and its potential role in autosomal recessive juvenile parkinsonism and ovarian cancer Genes. Chromosomes Cancer 38 2003 40 52
31. C. Morelli, E. Karayianni, C. Magnanini, A.J. Mungall, E. Thorland, and M. Negrini Cloning and characterization of the common fragile site FRA6F harboring a replicative senescence gene and frequently deleted in human tumors Oncogene 21 2002 7266 7276
32. E. Zlotorynski, A. Rahat, J. Sakaug, N. Ben-Porat, E. Ozeri, and R. Herschberg Molecular basis for expression of common and rare fragile sites Mol. Cell. Biol. 23 2003 7143 7151
33. A.K. Bednarek, K.J. Laflin, R.L. Daniel, Q. Liao, K.A. Hawkins, and C.M Aldaz WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer Cancer Res. 60 2000 2140 2145
34. H. Huang, J. Qian, J. Proffit, K. Wilber, R. Jenkins, and D.I. Smith FRA7G extends over a broad region: coincidence of human endogenous retroviral sequences (HERV-H) and small polydispersed circular DNAs (spcDNA) and fragile sites Oncogene 16 1998 2311 2319
35. D. Mishmar, A. Rahat, S.W. Scherer, G. Nyakatura, B. Hinzmann, and Y. Kohwi Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site Proc. Natl. Acad. Sci. USA 95 1998 8141 8146
36. G. Callahan, S.R. Denison, L.A. Phillips, V. Shridhar, and D.I. Smith Characterization of the common fragile site FRA9E and its potential role in ovarian cancer Oncogene 22 2003 590 601
37. K. Ried, M. Finnis, L. Hobson, M. Mangelsdorf, S. Sayan, and J.K. Nancarrow Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells Hum. Molec. Genet. 9 2000 1651 1663
38. M.F. Arlt, D.E. Miller, D.G. Beer, and T.W. Glover Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells Genes. Chromosomes Cancer 33 2002 82 92
39. C.M. Wilke, S.W. Guo, B.K. Hall, F. Boldog, R.M. Gemmill, and S.C. Chandrasekharappa Multicolor FISH mapping of YAC clones in 3p14 and identification of a YAC spanning both FRA3B and the t(3;8) associated with hereditary renal cell carcinoma Genomics 22 1994 319 326
40. F.L. Boldog, B. Waggoner, T.W. Glover, I. Chumakov, D. Le Paslier, and D. Cohen Integrated YAC contig containing the 3p14.2 hereditary renal carcinoma 3;8 translocation breakpoint and the fragile site FRA3B Genes. Chromosomes Cancer 11 1994 216 221
41. E.C. Thorland, S.L. Myers, D.H. Persing, G. Sarkar, R.M. McGovern, B.S. Gostout, and D.I. Smith Human papillomavirus type 16 integrations in cervical tumors frequently occur in common fragile sites Cancer Res. 60 2000 5916 5921
42. T. Druck, P. Hadaczek, T.-B. Fu, M. Ohta, Z. Siprashvili, and R. Baffa Structure and expression of the human FHIT gene in normal and tumor cells Cancer Res. 57 1997 504 512
43. D. Michael, D.G. Beer, C.W. Wilke, D.E. Miller, and T.W. Glover Frequent deletions of FHIT and FRA3B in Barrett's metaplasia and esophageal adenocarcinomas Oncogene 15 1997 1653 1659
44. K. Mimori, T. Druck, H. Inoue, H. Alder, L. Berk, and M. Mori Cancer-specific chromosome alterations in the constitutive fragile region FRA3B Proc. Natl. Acad. Sci. USA 96 1999 7456 7461
45. S. Corbin, M.E. Neilly, R. Espinosa III, E.M. Davis, T.W. McKeithan, and M.M. Le Beau Identification of unstable sequences within the common fragile site at 3p14.2: implications for the mechanism of deletions within fragile histidine triad gene/common fragile site at 3p14.2 in tumors Cancer Res. 62 2002 3477 3484
46. J.M.W. Geurts, E.F.P.M. Schoenmakers, E. Roijer, G. Stenman, and W.J.M. Van de Ven Expression of reciprocal hybrid transcripts of HMGIC and FHIT in a pleomorphic adenoma of the parotid gland Cancer Res. 57 1997 13 17
47. R.M. Gemmill, J.D. West, F. Boldog, N. Tanaka, L.J. Robinson, and D.I. Smith The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8 Proc. Natl. Acad. Sci. USA 95 1998 9572 9577
48. J.M. Fang, S.L. Dagenais, R.P. Erickson, M.F. Arlt, M.W. Glynn, and J.L. Gorski Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome Am. J. Hum. Genet. 67 2000 1382 1387
49. N. Zanesi, V. Fidanza, L.Y. Fong, R. Mancini, T. Druck, and M. Valtieri The tumour spectrum in Fhit-deficient mice Proc. Natl. Acad. Sci. USA 98 2001 10250 10255
50. Z. Siprashvili, G. Sozzi, L.D. Barnes, P. McCue, A.K. Robinson, and V. Eryomin Replacement of Fhit in cancer cells suppresses tumorigenicity Proc. Natl. Acad. Sci. USA 94 1997 13771 13776
51. A.J.W. Paige, K.J. Taylor, C. Taylor, S.G. Hillier, S. Farrington, and D. Scott WWOX: a candidate tumor suppressor gene involved in multiple tumor types Proc. Natl. Acad. Sci. USA 98 2001 11417 11422
52. A. Bednarek, C.L. Keck-Waggoner, R.L. Daniel, K.J. Laflin, P.L. Bergsagel, and K. Kiguchi WWOX, the FRA16D gene, behaves as a suppressor of tumor growth Cancer Res. 61 2001 8068 8073
53. M. Mangelsdorf, K. Ried, E. Woollatt, S. Dayan, H. Eyre, and M. Finnis Chromosomal fragile site FRA16D and DNA instability in cancer Cancer Res. 60 2000 1683 1689
54. A.J.W. Paige, K.J. Taylor, A. Stewart, J.G. Sgouros, H. Gabra, and G.C. Sellar A 700-kb physical map of a region of 16q23.2 homozygously deleted in multiple cancers and spanning the common fragile site FRA16D Cancer Res. 60 2000 1690 1697
55. K. Huebner, and C.M. Croce FRA3B and other common fragile sites: the weakest links Nat. Rev. Cancer 1 2001 214 221
56. M. Finnis, S. Dayan, L. Hobson, G. Chenevix-Trench, K. Friend, and K. Ried Common chromosomal fragile site FRA16D mutation in cancer cells Hum. Mol. Genet. 14 2005 1341 1349
57. M. Debatisse, A. Coquelle, F. Toledo, and G. Buttin Gene amplification mechanisms: the role of fragile sites Recent Results Cancer Res. 154 1998 216 226
58. A. Hellman, E. Zlotorynski, S.W. Scherer, J. Cheung, J.B. Vincent, and D.I. Smith A role for common fragile site induction in amplification of human oncogenes Cancer Cell 1 2002 89 97
59. C.T. Miller, L. Lin, A.M. Casper, J. Lim, D.G. Thomas, M.B. Orringer, A.C. Chang, A.F. Chambers, T.J. Giordano, T.W. Glover, D.G. Beer, Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET signaling pathways in esophageal adenocarcinoma, (Submitted).
60. A.M. Casper, P. Nghiem, M.F. Arlt, and T.W. Glover ATR regulates fragile site stability Cell 111 2002 779 789
61. V.G. Gorgoulis, L.V. Vassiliou, P. Karakaidos, P. Zacharatos, A. Kotsinas, and T. Liloglou Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions Nature 434 2005 907 913
62. J. Bartkova, Z. Horejsi, K. Koed, A. Kramer, F. Tort, and K. Zieger DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis Nature 434 2005 864 870
63. F. Boldog, R. Gemmill, J. West, M. Robinson, and E. Li Chromosome 3p14 homozygous deletions and sequence analysis of FRA3B Hum. Mol. Genet. 6 1997 193 203
64. H. Ohashi, A. Kuwano, M. Tsukahara, T. Arinami, and T. Kajii Replication patterns of the fragile X in heterozygous carriers: analysis by a BrdUrd antibody method Am. J. Hum. Genet. 47 1990 988 993
65. W.D. Yu, S.L. Wenger, and M.W. Steele X chromosome imprinting in fragile X syndrome Hum. Genet. 85 1990 590 594
66. R.S. Hansen, T.K. Canfield, M.M. Lamb, S.M. Gartler, and C.D. Laird Association of fragile X syndrome with delayed replication of the FMR1 gene Cell 73 1993 1403 1409
67. R.S. Hansen, T.K. Canfield, A.D. Fjeld, S. Mumm, C.D. Laird, and S.M. Gartler A variable domain of delayed replication in FRAXA fragile X chromosomes: X inactivation-like spread of late replication Proc. Natl. Acad. Sci. USA 94 1997 4587 4592
68. P.S. Subramanian, D.L. Nelson, and A.C. Chinault Large domains of apparent delayed replication timing associated with triplet repeat expansion at FRAXA and FRAXE Am. J. Hum. Genet. 59 1996 407 416
69. O. Handt, E. Baker, S. Dayan, S.M. Gartler, E. Woollatt, R.I. Richards, and R.S. Hansen Analysis of replication timing at the FRA10B and FRA16B fragile site loci Chromosome Res. 8 2000 677 688
70. X. Chen, S.V. Mariappan, P. Catasti, R. Ratliff, R.K. Moyzis, and A. Laayoun Hairpins are formed by the single DNA strands of the fragile X triplet repeats: structure and biological implications Proc. Natl. Acad. Sci. USA 92 1995 5199 5203
71. D.R. Hewett, O. Handt, L. Hobson, M. Mangelsdorf, H.J. Eyre, and E. Baker FRA10B structure reveals common elements in repeat expansion and chromosomal fragile site genesis Mol. Cell 1 1998 773 781
72. M.M. Le Beau, F.V. Rassool, M.E. Neilly, R. Espinosa III, T.W. Glover, D.I. Smith, and T.W. McKeithan Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: implications for the mechanism of fragile site induction Hum. Mol. Genet. 7 1998 755 761
73. A. Palakodeti, Y. Han, Y. Jiang, and M.M. Le Beau The role of late/slow replication of the FRA16D in common fragile site induction Genes. Chromosomes Cancer 39 2004 71 76
74. A. Hellman, A. Rahat, S.W. Scherer, A. Darvasi, L.-C. Tsui, and S. Kerem Replication delay along FRA7H, a common fragile site on human chromosome 7, leads to chromosomal instability Mol. Cell. Biol. 20 2000 4420 4427
75. R.T. Abraham Cell cycle checkpoint signaling through the ATM, ATR kinases Genes Dev. 15 2001 2177 2196
76. D. Durocher, and S.P. Jackson DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? Curr. Opin. Cell Biol. 13 2001 225 231
77. A.M. Casper, S.G. Durkin, M.F. Arlt, and T.W. Glover Chromosomal instability at common fragile sites in Seckel syndrome Am. J. Hum. Genet. 75 2004 654 660
78. M.F. Arlt, B. Xu, S.G. Durkin, A.M. Casper, M.B. Kastan, and T.W. Glover BRCA1 is required for common fragile-site stability via its G2/M checkpoint function Mol. Cell. Biol. 24 2004 6701 6709
79. N.G. Howlett, T. Taniguchi, S.G. Durkin, A.D. D'Andrea, and T.W. Glover The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability Hum. Molec. Genet. 14 2005 693 701
80. A. Musio, C. Montagna, T. Mariani, M. Tilenni, M.L. Focarelli, and L. Brait SMC1 involvement in fragile site expression Hum. Molec. Genet. 14 2005 525 533
81. M.L.G. Dronkert, H.B. Beverloo, R.D. Johnson, J.H.J. Hoeijmakers, M. Jasin, and R. Kanaar Mouse RAD54 affects DNA double-strand break repair and sister chromatid exchange Mol. Cell. Biol. 20 2000 3147 3156
82. L.F. Fuller, and R.B. Painter A Chinese hamster ovary cell line hypersensitive to ionizing radiation and deficient in repair replication Mutat. Res. 193 1988 109 121
83. S. Lambert, and B.S. Lopez Role of RAD51 in sister-chromatid exchanges in mammalian cells Oncogene 20 2001 6627 6631
84. M.S. Sasaki, M. Takata, E. Sonoda, A. Tachibana, and S. Takeda Recombination repair pathway in the maintenance of chromosomal integrity against DNA interstrand crosslinks Cytogenet. Genome Res. 104 2004 28 34
85. J.M. Stark, P. Hu, A.J. Pierce, M.E. Moynahan, N. Ellis, and M. Jasin ATP hydrolysis by mammalian RAD51 had a key role during homology-directed DNA repair J. Biol. Chem. 277 2002 20185 20194
86. M. Takata, M.S. Sasaki, S. Tachiiri, T. Fukushima, E. Sonoda, and D. Schild Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs Mol. Cell. Biol. 21 2001 2858 2866
87. J.D. Tucker, N.J. Jones, N.A. Allen, J.L. Minkler, L.H. Thompson, and A.V. Carrano Cytogenetic characterization of the ionizing radiation-sensitive Chinese hamster mutant irs1 Mutat. Res. 254 1991 143 152