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Volumn 44, Issue 6, 2011, Pages 966-977

Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN B1; DNA TOPOISOMERASE; FRAGILE HISTIDINE TRIAD PROTEIN; MSH4 PROTEIN; PROTEIN; PROTEIN P21; RIBONUCLEASE H; RIBONUCLEASE H2; UNCLASSIFIED DRUG;

EID: 84255198334     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2011.10.013     Document Type: Article
Times cited : (433)

References (60)
  • 1
    • 39449096135 scopus 로고    scopus 로고
    • Genome instability: a mechanistic view of its causes and consequences
    • Aguilera A., Gómez-González B. Genome instability: a mechanistic view of its causes and consequences. Nat. Rev. Genet. 2008, 9:204-217.
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 204-217
    • Aguilera, A.1    Gómez-González, B.2
  • 2
    • 67449113551 scopus 로고    scopus 로고
    • Highly transcribed RNA polymerase II genes are impediments to replication fork progression in Saccharomyces cerevisiae
    • Azvolinsky A., Giresi P.G., Lieb J.D., Zakian V.A. Highly transcribed RNA polymerase II genes are impediments to replication fork progression in Saccharomyces cerevisiae. Mol. Cell 2009, 34:722-734.
    • (2009) Mol. Cell , vol.34 , pp. 722-734
    • Azvolinsky, A.1    Giresi, P.G.2    Lieb, J.D.3    Zakian, V.A.4
  • 3
    • 0037069944 scopus 로고    scopus 로고
    • Evidence that instability within the FRA3B region extends four megabases
    • Becker N.A., Thorland E.C., Denison S.R., Phillips L.A., Smith D.I. Evidence that instability within the FRA3B region extends four megabases. Oncogene 2002, 21:8713-8722.
    • (2002) Oncogene , vol.21 , pp. 8713-8722
    • Becker, N.A.1    Thorland, E.C.2    Denison, S.R.3    Phillips, L.A.4    Smith, D.I.5
  • 6
    • 0024276903 scopus 로고
    • When polymerases collide: replication and the transcriptional organization of the E. coli chromosome
    • Brewer B.J. When polymerases collide: replication and the transcriptional organization of the E. coli chromosome. Cell 1988, 53:679-686.
    • (1988) Cell , vol.53 , pp. 679-686
    • Brewer, B.J.1
  • 8
    • 0037178723 scopus 로고    scopus 로고
    • ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones
    • Cha R.S., Kleckner N. ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones. Science 2002, 297:602-606.
    • (2002) Science , vol.297 , pp. 602-606
    • Cha, R.S.1    Kleckner, N.2
  • 9
    • 0036849512 scopus 로고    scopus 로고
    • Initiation of the breakage-fusion-bridge mechanism through common fragile site activation in human breast cancer cells: the model of PIP gene duplication from a break at FRA7I
    • Ciullo M., Debily M.A., Rozier L., Autiero M., Billault A., Mayau V., El Marhomy S., Guardiola J., Bernheim A., Coullin P., et al. Initiation of the breakage-fusion-bridge mechanism through common fragile site activation in human breast cancer cells: the model of PIP gene duplication from a break at FRA7I. Hum. Mol. Genet. 2002, 11:2887-2894.
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 2887-2894
    • Ciullo, M.1    Debily, M.A.2    Rozier, L.3    Autiero, M.4    Billault, A.5    Mayau, V.6    El Marhomy, S.7    Guardiola, J.8    Bernheim, A.9    Coullin, P.10
  • 12
    • 0029740114 scopus 로고    scopus 로고
    • DNA replication fork pause sites dependent on transcription
    • Deshpande A.M., Newlon C.S. DNA replication fork pause sites dependent on transcription. Science 1996, 272:1030-1033.
    • (1996) Science , vol.272 , pp. 1030-1033
    • Deshpande, A.M.1    Newlon, C.S.2
  • 14
    • 33746495515 scopus 로고    scopus 로고
    • Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites
    • Durkin S.G., Arlt M.F., Howlett N.G., Glover T.W. Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites. Oncogene 2006, 25:4381-4388.
    • (2006) Oncogene , vol.25 , pp. 4381-4388
    • Durkin, S.G.1    Arlt, M.F.2    Howlett, N.G.3    Glover, T.W.4
  • 15
    • 80052008241 scopus 로고    scopus 로고
    • Linking RNA polymerase backtracking to genome instability in E. coli
    • Dutta D., Shatalin K., Epshtein V., Gottesman M.E., Nudler E. Linking RNA polymerase backtracking to genome instability in E. coli. Cell 2011, 146:533-543.
    • (2011) Cell , vol.146 , pp. 533-543
    • Dutta, D.1    Shatalin, K.2    Epshtein, V.3    Gottesman, M.E.4    Nudler, E.5
  • 16
    • 77954841539 scopus 로고    scopus 로고
    • Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis
    • El Hage A., French S.L., Beyer A.L., Tollervey D. Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis. Genes Dev. 2010, 24:1546-1558.
    • (2010) Genes Dev. , vol.24 , pp. 1546-1558
    • El Hage, A.1    French, S.L.2    Beyer, A.L.3    Tollervey, D.4
  • 17
    • 0026733965 scopus 로고
    • Consequences of replication fork movement through transcription units in vivo
    • French S. Consequences of replication fork movement through transcription units in vivo. Science 1992, 258:1362-1365.
    • (1992) Science , vol.258 , pp. 1362-1365
    • French, S.1
  • 18
    • 70349335582 scopus 로고    scopus 로고
    • The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants
    • Gómez-González B., Felipe-Abrio I., Aguilera A. The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants. Mol. Cell. Biol. 2009, 29:5203-5213.
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 5203-5213
    • Gómez-González, B.1    Felipe-Abrio, I.2    Aguilera, A.3
  • 20
    • 37549026516 scopus 로고    scopus 로고
    • Transcription-associated recombination is dependent on replication in Mammalian cells
    • Gottipati P., Cassel T.N., Savolainen L., Helleday T. Transcription-associated recombination is dependent on replication in Mammalian cells. Mol. Cell. Biol. 2008, 28:154-164.
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 154-164
    • Gottipati, P.1    Cassel, T.N.2    Savolainen, L.3    Helleday, T.4
  • 22
    • 33749384368 scopus 로고    scopus 로고
    • Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes
    • Helmrich A., Stout-Weider K., Hermann K., Schrock E., Heiden T. Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes. Genome Res. 2006, 16:1222-1230.
    • (2006) Genome Res. , vol.16 , pp. 1222-1230
    • Helmrich, A.1    Stout-Weider, K.2    Hermann, K.3    Schrock, E.4    Heiden, T.5
  • 23
    • 33845424480 scopus 로고    scopus 로고
    • Identification of the human/mouse syntenic common fragile site FRA7K/Fra12C1-relation of FRA7K and other human common fragile sites on chromosome 7 to evolutionary breakpoints
    • Helmrich A., Stout-Weider K., Matthaei A., Hermann K., Heiden T., Schrock E. Identification of the human/mouse syntenic common fragile site FRA7K/Fra12C1-relation of FRA7K and other human common fragile sites on chromosome 7 to evolutionary breakpoints. Int. J. Cancer 2007, 120:48-54.
    • (2007) Int. J. Cancer , vol.120 , pp. 48-54
    • Helmrich, A.1    Stout-Weider, K.2    Matthaei, A.3    Hermann, K.4    Heiden, T.5    Schrock, E.6
  • 24
    • 0025914050 scopus 로고
    • Sister chromatid exchanges are preferentially induced at expressed and nonexpressed common fragile sites
    • Hirsch B. Sister chromatid exchanges are preferentially induced at expressed and nonexpressed common fragile sites. Hum. Genet. 1991, 87:302-306.
    • (1991) Hum. Genet. , vol.87 , pp. 302-306
    • Hirsch, B.1
  • 25
    • 78650849800 scopus 로고    scopus 로고
    • DNA-RNA hybrids contribute to the replication dependent genomic instability induced by Omcg1 deficiency
    • Houlard M., Artus J., Léguillier T., Vandormael-Pournin S., Cohen-Tannoudji M. DNA-RNA hybrids contribute to the replication dependent genomic instability induced by Omcg1 deficiency. Cell Cycle 2011, 10:108-117.
    • (2011) Cell Cycle , vol.10 , pp. 108-117
    • Houlard, M.1    Artus, J.2    Léguillier, T.3    Vandormael-Pournin, S.4    Cohen-Tannoudji, M.5
  • 26
    • 0141819093 scopus 로고    scopus 로고
    • Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination
    • Huertas P., Aguilera A. Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination. Mol. Cell 2003, 12:711-721.
    • (2003) Mol. Cell , vol.12 , pp. 711-721
    • Huertas, P.1    Aguilera, A.2
  • 27
    • 0029895337 scopus 로고    scopus 로고
    • Intracellular localization of cyclin B1 during the cell cycle in glioma cells
    • Kakino S., Sasaki K., Kurose A., Ito H. Intracellular localization of cyclin B1 during the cell cycle in glioma cells. Cytometry 1996, 24:49-54.
    • (1996) Cytometry , vol.24 , pp. 49-54
    • Kakino, S.1    Sasaki, K.2    Kurose, A.3    Ito, H.4
  • 29
    • 0034306548 scopus 로고    scopus 로고
    • The characterization of the common fragile site FRA16D and its involvement in multiple myeloma translocations
    • Krummel K.A., Roberts L.R., Kawakami M., Glover T.W., Smith D.I. The characterization of the common fragile site FRA16D and its involvement in multiple myeloma translocations. Genomics 2000, 69:37-46.
    • (2000) Genomics , vol.69 , pp. 37-46
    • Krummel, K.A.1    Roberts, L.R.2    Kawakami, M.3    Glover, T.W.4    Smith, D.I.5
  • 31
    • 23744455164 scopus 로고    scopus 로고
    • Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability
    • Li X., Manley J.L. Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability. Cell 2005, 122:365-378.
    • (2005) Cell , vol.122 , pp. 365-378
    • Li, X.1    Manley, J.L.2
  • 33
    • 79952126098 scopus 로고    scopus 로고
    • Co-directional replication-transcription conflicts lead to replication restart
    • Merrikh H., Machón C., Grainger W.H., Grossman A.D., Soultanas P. Co-directional replication-transcription conflicts lead to replication restart. Nature 2011, 470:554-557.
    • (2011) Nature , vol.470 , pp. 554-557
    • Merrikh, H.1    Machón, C.2    Grainger, W.H.3    Grossman, A.D.4    Soultanas, P.5
  • 34
    • 12844265439 scopus 로고    scopus 로고
    • Mechanisms of transcription-replication collisions in bacteria
    • Mirkin E.V., Mirkin S.M. Mechanisms of transcription-replication collisions in bacteria. Mol. Cell. Biol. 2005, 25:888-895.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 888-895
    • Mirkin, E.V.1    Mirkin, S.M.2
  • 35
    • 33947432388 scopus 로고    scopus 로고
    • Replication fork stalling at natural impediments
    • Mirkin E.V., Mirkin S.M. Replication fork stalling at natural impediments. Microbiol. Mol. Biol. Rev. 2007, 71:13-35.
    • (2007) Microbiol. Mol. Biol. Rev. , vol.71 , pp. 13-35
    • Mirkin, E.V.1    Mirkin, S.M.2
  • 36
    • 33947499627 scopus 로고    scopus 로고
    • Perturbation of the activity of replication origin by meiosis-specific transcription
    • Mori S., Shirahige K. Perturbation of the activity of replication origin by meiosis-specific transcription. J. Biol. Chem. 2007, 282:4447-4452.
    • (2007) J. Biol. Chem. , vol.282 , pp. 4447-4452
    • Mori, S.1    Shirahige, K.2
  • 39
    • 79959885574 scopus 로고    scopus 로고
    • Failure of origin activation in response to fork stalling leads to chromosomal instability at fragile sites
    • Ozeri-Galai E., Lebofsky R., Rahat A., Bester A.C., Bensimon A., Kerem B. Failure of origin activation in response to fork stalling leads to chromosomal instability at fragile sites. Mol. Cell 2011, 43:122-131.
    • (2011) Mol. Cell , vol.43 , pp. 122-131
    • Ozeri-Galai, E.1    Lebofsky, R.2    Rahat, A.3    Bester, A.C.4    Bensimon, A.5    Kerem, B.6
  • 40
    • 0345283196 scopus 로고    scopus 로고
    • The role of late/slow replication of the FRA16D in common fragile site induction
    • Palakodeti A., Han Y., Jiang Y., Le Beau M.M. The role of late/slow replication of the FRA16D in common fragile site induction. Genes Chromosomes Cancer 2004, 39:71-76.
    • (2004) Genes Chromosomes Cancer , vol.39 , pp. 71-76
    • Palakodeti, A.1    Han, Y.2    Jiang, Y.3    Le Beau, M.M.4
  • 41
    • 34247238676 scopus 로고    scopus 로고
    • Genomics and gene transcription kinetics in yeast
    • Pérez-Ortín J.E., Alepuz P.M., Moreno J. Genomics and gene transcription kinetics in yeast. Trends Genet. 2007, 23:250-257.
    • (2007) Trends Genet. , vol.23 , pp. 250-257
    • Pérez-Ortín, J.E.1    Alepuz, P.M.2    Moreno, J.3
  • 42
    • 57649129186 scopus 로고    scopus 로고
    • The replisome uses mRNA as a primer after colliding with RNA polymerase
    • Pomerantz R.T., O'Donnell M. The replisome uses mRNA as a primer after colliding with RNA polymerase. Nature 2008, 456:762-766.
    • (2008) Nature , vol.456 , pp. 762-766
    • Pomerantz, R.T.1    O'Donnell, M.2
  • 43
    • 79952253141 scopus 로고    scopus 로고
    • Polymerase trafficking: A role for transcription factors in preventing replication fork arrest
    • Pomerantz R.T., O'Donnell M. Polymerase trafficking: A role for transcription factors in preventing replication fork arrest. Transcr 2010, 1:136-139.
    • (2010) Transcr , vol.1 , pp. 136-139
    • Pomerantz, R.T.1    O'Donnell, M.2
  • 44
    • 17144426028 scopus 로고    scopus 로고
    • Impairment of replication fork progression mediates RNA polII transcription-associated recombination
    • Prado F., Aguilera A. Impairment of replication fork progression mediates RNA polII transcription-associated recombination. EMBO J. 2005, 24:1267-1276.
    • (2005) EMBO J. , vol.24 , pp. 1267-1276
    • Prado, F.1    Aguilera, A.2
  • 45
    • 0028106344 scopus 로고
    • Transcription induces the formation of a stable RNA.DNA hybrid in the immunoglobulin alpha switch region
    • Reaban M.E., Lebowitz J., Griffin J.A. Transcription induces the formation of a stable RNA.DNA hybrid in the immunoglobulin alpha switch region. J. Biol. Chem. 1994, 269:21850-21857.
    • (1994) J. Biol. Chem. , vol.269 , pp. 21850-21857
    • Reaban, M.E.1    Lebowitz, J.2    Griffin, J.A.3
  • 46
    • 0037168516 scopus 로고    scopus 로고
    • Excision of misincorporated ribonucleotides in DNA by RNase H (type 2) and FEN-1 in cell-free extracts
    • Rydberg B., Game J. Excision of misincorporated ribonucleotides in DNA by RNase H (type 2) and FEN-1 in cell-free extracts. Proc. Natl. Acad. Sci. USA 2002, 99:16654-16659.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 16654-16659
    • Rydberg, B.1    Game, J.2
  • 47
    • 70350754211 scopus 로고    scopus 로고
    • Rates of in situ transcription and splicing in large human genes
    • Singh J., Padgett R.A. Rates of in situ transcription and splicing in large human genes. Nat. Struct. Mol. Biol. 2009, 16:1128-1133.
    • (2009) Nat. Struct. Mol. Biol. , vol.16 , pp. 1128-1133
    • Singh, J.1    Padgett, R.A.2
  • 48
    • 79959345878 scopus 로고    scopus 로고
    • Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination
    • Skourti-Stathaki K., Proudfoot N.J., Gromak N. Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination. Mol. Cell 2011, 42:794-805.
    • (2011) Mol. Cell , vol.42 , pp. 794-805
    • Skourti-Stathaki, K.1    Proudfoot, N.J.2    Gromak, N.3
  • 50
    • 0028837312 scopus 로고
    • The human dystrophin gene requires 16 hours to be transcribed and is cotranscriptionally spliced
    • Tennyson C.N., Klamut H.J., Worton R.G. The human dystrophin gene requires 16 hours to be transcribed and is cotranscriptionally spliced. Nat. Genet. 1995, 9:184-190.
    • (1995) Nat. Genet. , vol.9 , pp. 184-190
    • Tennyson, C.N.1    Klamut, H.J.2    Worton, R.G.3
  • 51
    • 1642309305 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae Rrm3p DNA helicase promotes genome integrity by preventing replication fork stalling: viability of rrm3 cells requires the intra-S-phase checkpoint and fork restart activities
    • Torres J.Z., Schnakenberg S.L., Zakian V.A. Saccharomyces cerevisiae Rrm3p DNA helicase promotes genome integrity by preventing replication fork stalling: viability of rrm3 cells requires the intra-S-phase checkpoint and fork restart activities. Mol. Cell. Biol. 2004, 24:3198-3212.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 3198-3212
    • Torres, J.Z.1    Schnakenberg, S.L.2    Zakian, V.A.3
  • 55
    • 0033051760 scopus 로고    scopus 로고
    • Allele-specific late replication and fragility of the most active common fragile site, FRA3B
    • Wang L., Darling J., Zhang J.S., Huang H., Liu W., Smith D.I. Allele-specific late replication and fragility of the most active common fragile site, FRA3B. Hum. Mol. Genet. 1999, 8:431-437.
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 431-437
    • Wang, L.1    Darling, J.2    Zhang, J.S.3    Huang, H.4    Liu, W.5    Smith, D.I.6
  • 56
    • 62249199182 scopus 로고    scopus 로고
    • ReplicationDomain: a visualization tool and comparative database for genome-wide replication timing data
    • Weddington N., Stuy A., Hiratani I., Ryba T., Yokochi T., Gilbert D.M. ReplicationDomain: a visualization tool and comparative database for genome-wide replication timing data. BMC Bioinformatics 2008, 9:530.
    • (2008) BMC Bioinformatics , vol.9 , pp. 530
    • Weddington, N.1    Stuy, A.2    Hiratani, I.3    Ryba, T.4    Yokochi, T.5    Gilbert, D.M.6
  • 57
    • 0032483372 scopus 로고    scopus 로고
    • Segregation of transcription and replication sites into higher order domains
    • Wei X., Samarabandu J., Devdhar R.S., Siegel A.J., Acharya R., Berezney R. Segregation of transcription and replication sites into higher order domains. Science 1998, 281:1502-1506.
    • (1998) Science , vol.281 , pp. 1502-1506
    • Wei, X.1    Samarabandu, J.2    Devdhar, R.S.3    Siegel, A.J.4    Acharya, R.5    Berezney, R.6
  • 60
    • 0037650190 scopus 로고    scopus 로고
    • R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
    • Yu K., Chedin F., Hsieh C.-L., Wilson T.E., Lieber M.R. R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat. Immunol. 2003, 4:442-451.
    • (2003) Nat. Immunol. , vol.4 , pp. 442-451
    • Yu, K.1    Chedin, F.2    Hsieh, C.-L.3    Wilson, T.E.4    Lieber, M.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.