The Fanconi anemia pathway is required for the DNA replication stress respone and for the regulation of common fragile site stability

Human Molecular Genetics

Volumn 14, Issue 5, 2005, Pages 693-701

  Howlett, Niall G ^a   Taniguchi, Toshiyasu ^b,c   Durkin, Sandra G ^a   D'Andrea, Alan D ^b   Glover, Thomas W ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APHIDICOLIN; CYCLINE; FANCONI ANEMIA CD2 PROTEIN; FANCONI ANEMIA PROTEIN; GENE PRODUCT; HYDROXYUREA; REPLICATION PROTEIN A; SMALL INTERFERING RNA; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CHROMOSOME BREAKAGE; CHROMOSOME FRAGILE SITE; CONTROLLED STUDY; DNA REPLICATION; FANCONI ANEMIA; GENE ACTIVATION; GENE CONTROL; GENE TARGETING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRESS; UBIQUITINATION;

APHIDICOLIN; CHROMOSOMAL INSTABILITY; CHROMOSOME FRAGILE SITES; DNA REPLICATION; FANCONI ANEMIA; FANCONI ANEMIA COMPLEMENTATION GROUP D2 PROTEIN; HUMANS; HYDROXYUREA; NUCLEAR PROTEINS; NUCLEIC ACID SYNTHESIS INHIBITORS; PROLIFERATING CELL NUCLEAR ANTIGEN; RNA, SMALL INTERFERING; TIME FACTORS; UBIQUITIN;

EID: 14644391577     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/ddi065     Document Type: Article

References (32)

1. Grompe, M. and D'Andrea, A. (2001) Fanconi anemia and DNA repair. Hum. Mol. Genet., 10, 2253-2259.
2. Joenje, H. and Patel, K.J. (2001) The emerging genetic and molecular basis of Fanconi anaemia. Nat. Rev. Genet., 2, 446-459.
3. Alter, B.P. (1996) Fanconi's anemia and malignancies. Am. J. Hematol., 53, 99-110.
4. Meetei, A.R., de Winter, J.P., Medhurst, A.L., Wallisch, M., Waisfisz, Q., van de Vrugt, H.J., Oostra, A.B., Yan, Z., Ling, C., Bishop, C.E. et al. (2003) A novel ubiquitin ligase is deficient in Fanconi anemia. Nat. Genet., 35, 165-170.
5. Howlett, N.G., Taniguchi, T., Olson, S., Cox, B., Waisfisz, Q., De Die-Smulders, C., Persky, N., Grompe, M., Joenje, H., Pals, G. et al. (2002) Biallelic inactivation of BRCA2 in Fanconi anemia. Science, 297, 606-609.
6. Meetei, A.R., Levitus, M., Xue, Y., Medhurst, A.L., Zwaari, M., Ling, C., Rooimans, M.A., Bier, P., Hoatlin, M., Pals, G. et al. (2004) X-linked inheritance of Fanconi anemia complementation group B. Nat. Genet., 36, 1219-1224.
7. Medhurst, A.L., Huber, P.A., Waisfisz, Q., de Winter, J.P. and Mathew, C.G. (2001) Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway. Hum. Mol. Genet. 10, 423-429.
8. Meetei, A.R., Sechi, S., Wallisch, M., Yang, D., Young, M.K., Joenje, H., Hoatlin, M.E. and Wang, W. (2003) A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome. Mol. Cell. Biol. 23, 3417-3426.
9. Garcia-Higuera, I., Kuang, Y., Naf, D., Wasik, J. and D'Andrea, A.D. (1999) Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex. Mol. Cell. Biol. 19, 4866-4873.
10. Taniguchi, T., Garcia-Higuera, I., Andreassen, P.R., Gregory, R.C., Grompe, M. and D'Andrea, A.D. (2002) S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood, 100, 2414-2420.
11. Garcia-Higuera, I., Taniguchi, T., Ganesan, S., Meyn, M.S., Timmers, C., Hejna, J., Grompe, M. and D'Andrea, A.D. (2001) Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol. Cell, 7, 249-262.
12. Wang, X., Andreassen, P.R. and D'Andrea, A.D. (2004) Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin. Mol. Cell. Biol., 24, 5850-5862.
13. Hussain, S., Wilson, J.B., Medhurst, A.L., Hejna, J., Witt, E., Ananth, S., Davies, A., Masson, J.Y., Moses, R., West, S.C. et al. (2004) Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways. Hum. Mol. Genet., 13, 1241-1248.
14. Marians, K.J. (2004) Mechanisms of replication fork restart in Escherichia coli. Philos. Trans. R. Soc. Lond. B. Biol. Sci., 359, 71-77.
15. Haber, J.E. (1999) DNA recombination: the replication connection. Trends Biochem. Sci., 24, 271-275.
16. Glover, T.W., Berger, C., Coyle, J. and Echo, B. (1984) DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes. Hum. Genet., 67, 136-142.
17. Arlt, M.F., Casper, A.M. and Glover, T.W. (2003) Common fragile sites. Cytogenet. Genome Res., 100, 92-100.
18. Masramon, L., Ribas, M., Cifuentes, P., Arribas, R., Garcia, F., Egozcue, J., Peinado, M.A. and Miro, R. (2000) Cytogenetic characterization of two colon cell lines by using conventional G-banding, comparative genomic hybridization, and whole chromosome painting. Cancer Genet. Cytogenet., 121, 17-21.
19. Casper, A.M., Nghiem, P., Arlt, M.F. and Glover, T.W. (2002) ATR regulates fragile site stability. Cell, 111, 779-789.
20. Arlt, M.F., Xu, B., Durkin, S.G., Casper, A.M., Kastan, M.B. and Glover, T.W. (2004) BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function. Mol. Cell. Biol., 24 6701-6709.
21. Kannouche, P.L., Wing, J. and Lehmann, A.R. (2004) Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage. Mol. Cell, 14, 491-500.
22. Vassin, V.M., Wold, M.S. and Borowiec, J.A. (2004) Replication protein A (RPA) phosphorylation prevents RPA association with replication centers. Mol. Cell. Biol., 24, 1930-1943.
23. Hoege, C., Pfander, B., Moldovan, G.L., Pyrowolakis, G. and Jentsch, S. (2002) RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature, 419, 135-141.
24. Barbie, D.A., Kudlow, B.A., Frock, R., Zhao, J., Johnson, B.R., Dyson, N., Harlow, E. and Kennedy, B.K. (2004) Nuclear reorganization of mammalian DNA synthesis prior to cell cycle exit. Mol. Cell. Biol., 24, 595-607.
25. Andreassen, P.R., D'Andrea, A.D. and Taniguchi, T. (2004) ATR couples FANCD2 monoubiquitination to the DNA-damage response. Genes Dev., 18, 1958-1963.
26. Saintigny, Y., Delacote, F., Vares, G., Petitot, F., Lambert, S., Averbeck, D. and Lopez, B.S. (2001) Characterization of homologous recombination induced by replication inhibition in mammalian cells. EMBO J., 20, 3861-3870.
27. Casper, A.M., Durkin, S.G., Arlt, M.F. and Glover, T.W. (2004) Chromosomal instability at common fragile sites in Seckel syndrome. Am. J. Hum. Genet., 75, 654-660.
28. Zou, L. and Elledge, S.J. (2003) Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science, 300, 1542-1548.
29. Lomonosov, M., Anand, S., Sangrithi, M., Davies, R. and Venkitaraman, A.R. (2003) Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein. Genes Dev., 17, 3017-3022.
30. Stelter, P. and Ulrich, H.D. (2003) Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation. Nature, 425, 188-191.
31. Ory, D.S., Neugeboren, B.A. and Mulligan, R.C. (1996) A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes. Proc. Natl Acad. Sci. USA, 93, 11400-11406.
32. Scully, R., Chen, J., Ochs, R.L., Keegan, K., Hoekstra, M., Feunteun, J. and Livingston, D.M. (1997) Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell, 90, 425-435.