The Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase δ

Journal of Biological Chemistry

Volumn 287, Issue 15, 2012, Pages 12480-12490

  Kamath Loeb, Ashwini S ^a   Shen, Jiang Cheng ^a   Schmitt, Michael W ^a   Loeb, Lawrence A ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COOPERATIVITY; DNA DEGRADATION; DNA POLYMERASE; DNA POLYMERIZATION; DNA REPAIR; DNA STRUCTURE; DNA SYNTHESISS; EXONUCLEASE; EXONUCLEASE ACTIVITY; GENOME STABILITY; GENOMIC DNA; GENOMIC STABILITY; HIGH FIDELITY; HUMAN DNA POLYMERASE; IN-VITRO; IN-VIVO; LAGGING STRAND; MUTATION FREQUENCY; PREMATURE AGING; PRIMER EXTENSION; RECQ HELICASES; SECONDARY STRUCTURES; STALLED REPLICATION; WERNER SYNDROME; WERNER SYNDROME PROTEIN; WILD-TYPE CELLS;

GENES;

DNA;

DNA DIRECTED DNA POLYMERASE DELTA; EXONUCLEASE; WERNER SYNDROME PROTEIN;

3' UNTRANSLATED REGION; ARTICLE; BASE MISPAIRING; BIOACCUMULATION; CELL TYPE; CONTROLLED STUDY; DNA DEGRADATION; DNA EXTRACTION; DNA POLYMERIZATION; DNA REPLICATION; DNA STRUCTURE; DNA SYNTHESIS; ENZYME ACTIVITY; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN POLYMERIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; WERNER SYNDROME; WILD TYPE;

BASE PAIR MISMATCH; BASE PAIRING; CELLS, CULTURED; DNA; DNA CLEAVAGE; DNA POLYMERASE III; DNA REPLICATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EXODEOXYRIBONUCLEASES; HUMANS; HYDROLYSIS; MULTIPROTEIN COMPLEXES; MUTAGENESIS; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; RECQ HELICASES;

EID: 84859492258     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.332577     Document Type: Article

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