Pen-2 is dispensable for endoproteolysis of presenilin 1, and nicastrin-Aph subcomplex is important for both γ-secretase assembly and substrate recruitment

Journal of Neurochemistry

Volumn 123, Issue 5, 2012, Pages 837-844

  Mao, Guozhang ^a   Cui, Mei Zhen ^a   Li, Tong ^b   Jin, Yipeng ^c   Xu, Xuemin ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; APP; gamma secretase; pen 2; presenilin

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1ALPHA PROTEIN; CELL ENZYME; GAMMA SECRETASE; MEMBRANE PROTEIN; NICASTRIN; PRESENILIN 1; PRESENILIN ENHANCER 2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DEGRADATION KINETICS; EMBRYO; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; ENZYME SYNTHESIS; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BLOTTING, WESTERN; ENDOPEPTIDASES; GENE KNOCKDOWN TECHNIQUES; GENE KNOCKOUT TECHNIQUES; IMMUNOPRECIPITATION; MEMBRANE GLYCOPROTEINS; MICE; PRESENILIN-1; PROTEOLYSIS; RNA, SMALL INTERFERING;

EID: 84868633110     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12016     Document Type: Article

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