Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes

Structure

Volumn 22, Issue 1, 2014, Pages 125-135

  Li, Yi ^a   Lu, Stephen Hsueh Jeng ^a   Tsai, Ching Ju ^a,h   Bohm, Christopher ^b   Qamar, Seema ^a   Dodd, Roger B ^a   Meadows, William ^a   Jeon, Amy ^b   McLeod, Adam ^b   Chen, Fusheng ^b   Arimon, Muriel ^c   Berezovska, Oksana ^c   Hyman, Bradley T ^c   Tomita, Taisuke ^d,e   Iwatsubo, Takeshi ^d,e   Johnson, Christopher M ^f   Farrer, Lindsay A ^g   Schmitt Ulms, Gerold ^b   Fraser, Paul E ^b   St George Hyslop, Peter H ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF TORONTO   (Canada)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF TOKYO   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^f MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^g BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h PAUL SCHERRER INSTITUTE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DETERGENT; GAMMA SECRETASE INHIBITOR; NICASTRIN; PEPTIDOMIMETIC AGENT; PRESENILIN 1; PROPIONAMIDE DERIVATIVE;

ALLOSTERISM; ARTICLE; BINDING SITE; BIOPHYSICS; CATALYSIS; CONTROLLED STUDY; DISSOCIATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; MICROSOME MEMBRANE; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN STRUCTURE; STAINING;

ALLOSTERIC REGULATION; AMYLOID PRECURSOR PROTEIN SECRETASES; BENZODIAZEPINONES; CATALYTIC DOMAIN; ENZYME INHIBITORS; HEK293 CELLS; HUMANS; LIGANDS; MEMBRANE GLYCOPROTEINS; MOLECULAR DOCKING SIMULATION; PEPTIDOMIMETICS; PRESENILIN-1; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84891889942     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2013.09.018     Document Type: Article

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