Three-dimensional structure of the signal peptide peptidase

Journal of Biological Chemistry

Volumn 286, Issue 29, 2011, Pages 26188-26197

  Miyashita, Hiroyuki ^a   Maruyama, Yuusuke ^b   Isshiki, Hayato ^a   Osawa, Satoko ^a   Ogura, Toshihiko ^b   Mio, Kazuhiro ^b   Sato, Chikara ^b   Tomita, Taisuke ^a,c   Iwatsubo, Takeshi ^a,c,d  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC PROTEASE; FUNCTIONAL UNITS; HOMOTETRAMERS; N-TERMINALS; OVER-EXPRESSION; PATHOLOGICAL FUNCTIONS; PEPTIDE BONDS; PROTEOLYTIC ACTIVITIES; SIGNAL PEPTIDE; TETRAMERS; THREE-DIMENSIONAL STRUCTURE; TRANS-MEMBRANE DOMAINS;

ACTIVATION ANALYSIS; OLIGOMERS; THREE DIMENSIONAL;

PEPTIDES;

SIGNAL PEPTIDASE;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME DEGRADATION; ENZYME REGULATION; ENZYME STRUCTURE; GENE OVEREXPRESSION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; THREE DIMENSIONAL IMAGING;

ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; HEK293 CELLS; HUMANS; MICROSCOPY, ELECTRON; MODELS, MOLECULAR; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY;

EID: 79960417562     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.260273     Document Type: Article

References (54)

1. Wolfe, M. S. (2009) J. Biol. Chem. 284, 13969-13973
2. Fluhrer, R., Steiner, H., and Haass, C. (2009) J. Biol. Chem. 284, 13975-13979
3. Golde, T. E., Wolfe, M. S., and Greenbaum, D. C. (2009) Semin. Cell Dev. Biol. 20, 225-230
4. Weihofen, A., Binns, K., Lemberg, M. K., Ashman, K., and Martoglio, B. (2002) Science 296, 2215-2218
5. Kornilova, A. Y., Das, C., and Wolfe, M. S. (2003) J. Biol. Chem. 278, 16470-16473
6. Weihofen, A., Lemberg, M. K., Friedmann, E., Rueeger, H., Schmitz, A., Paganetti, P., Rovelli, G., and Martoglio, B. (2003) J. Biol. Chem. 278, 16528-16533
7. Nyborg, A. C., Ladd, T. B., Jansen, K., Kukar, T., and Golde, T. E. (2006) FASEB J. 20, 1671-1679
8. Sato, T., Ananda, K., Cheng, C. I., Suh, E. J., Narayanan, S., and Wolfe, M. S. (2008) J. Biol. Chem. 283, 33287-33295
9. Edbauer, D., Winkler, E., Regula, J. T., Pesold, B., Steiner, H., and Haass, C. (2003) Nat. Cell Biol. 5, 486-488
10. Kimberly, W. T., LaVoie, M. J., Ostaszewski, B. L., Ye, W., Wolfe, M. S., and Selkoe, D. J. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 6382-6387
11. Takasugi, N., Tomita, T., Hayashi, I., Tsuruoka, M., Niimura, M., Takahashi, Y., Thinakaran, G., and Iwatsubo, T. (2003) Nature 422, 438-441
12. Weihofen, A., Lemberg, M. K., Ploegh, H. L., Bogyo, M., and Martoglio, B. (2000) J. Biol. Chem. 275, 30951-30956
13. Crawshaw, S. G., Martoglio, B., Meacock, S. L., and High, S. (2004) Biochem. J. 384, 9-17
14. Loureiro, J., Lilley, B. N., Spooner, E., Noriega, V., Tortorella, D., and Ploegh, H. L. (2006) Nature 441, 894-897
15. Martoglio, B., Graf, R., and Dobberstein, B. (1997) EMBO J. 16, 6636-6645
16. Lemberg, M. K., Bland, F. A., Weihofen, A., Braud, V. M., and Martoglio, B. (2001) J. Immunol. 167, 6441-6446
17. Grigorenko, A. P., Moliaka, Y. K., Soto, M. C., Mello, C. C., and Rogaev, E. I. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 14955-14960
18. Casso, D. J., Tanda, S., Biehs, B., Martoglio, B., and Kornberg, T. B. (2005) Genetics 170, 139-148
19. Krawitz, P., Haffner, C., Fluhrer, R., Steiner, H., Schmid, B., and Haass, C. (2005) J. Biol. Chem. 280, 39515-39523
20. McLauchlan, J., Lemberg, M. K., Hope, G., and Martoglio, B. (2002)EMBO J. 21, 3980-3988
21. Takasugi, N., Takahashi, Y., Morohashi, Y., Tomita, T., and Iwatsubo, T. (2002) J. Biol. Chem. 277, 50198-50205
22. Nyborg, A. C., Jansen, K., Ladd, T. B., Fauq, A., and Golde, T. E. (2004) J. Biol. Chem. 279, 43148-43156
23. Li, Y. M., Xu, M., Lai, M. T., Huang, Q., Castro, J. L., DiMuzio-Mower, J., Harrison, T., Lellis, C., Nadin, A., Neduvelil, J. G., Register, R. B., Sardana, M. K., Shearman, M. S., Smith, A. L., Shi, X. P., Yin, K. C., Shafer, J. A., and Gardell, S. J. (2000) Nature 405, 689-694
24. Fuwa, H., Takahashi, Y., Konno, Y., Watanabe, N., Miyashita, H., Sasaki, M., Natsugari, H., Kan, T., Fukuyama, T., Tomita, T., and Iwatsubo, T. (2007) ACS Chem. Biol. 2, 408-418
25. Imamura, Y., Watanabe, N., Umezawa, N., Iwatsubo, T., Kato, N., Tomita, T., and Higuchi, T. (2009) J. Am Chem. Soc. 131, 7353-7359
26. Yoshida, H., Haze, K., Yanagi, H., Yura, T., and Mori, K. (1998) J. Biol. Chem. 273, 33741-33749
27. Hayashi, I., Urano, Y., Fukuda, R., Isoo, N., Kodama, T., Hamakubo, T., Tomita, T., and Iwatsubo, T. (2004) J. Biol. Chem. 279, 38040-38046
28. Ogura, T., Mio, K., Hayashi, I., Miyashita, H., Fukuda, R., Kopan, R., Kodama, T., Hamakubo, T., Iwatsubo, T., Iwastubo, T., Tomita, T., and Sato, C. (2006) Biochem. Biophys. Res. Commun. 343, 525-534
29. Morohashi, Y., Kan, T., Tominari, Y., Fuwa, H., Okamura, Y., Watanabe, N., Sato, C., Natsugari, H., Fukuyama, T., Iwatsubo, T., and Tomita, T. (2006) J. Biol. Chem. 281, 14670-14676
30. Tomita, T., Maruyama, K., Saido, T. C., Kume, H., Shinozaki, K., Tokuhiro, S., Capell, A., Walter, J., Grünberg, J., Haass, C., Iwatsubo, T., and Obata, K. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 2025-2030
31. Sato, T., Nyborg, A. C., Iwata, N., Diehl, T. S., Saido, T. C., Golde, T. E., and Wolfe, M. S. (2006) Biochemistry 45, 8649-8656
32. Frank, J. (2006) Three-Dimensional Electron Microscopy of Macromolecular Assemblies: Visualization of Biological Molecules in Their Native State, Oxford University Press, New York
33. van Heel, M., Harauz, G., Orlova, E. V., Schmidt, R., and Schatz, M. (1996) J. Struct. Biol. 116, 17-24
34. Ogura, T., and Sato, C. (2004) J. Struct. Biol. 146, 344-358
35. Ogura, T., and Sato, C. (2004) J. Struct. Biol. 145, 63-75
36. Ogura, T., and Sato, C. (2006) J. Struct. Biol. 156, 371-386
37. Ogura, T., Iwasaki, K., and Sato, C. (2003) J. Struct. Biol. 143, 185-200
38. Penczek, P., Radermacher, M., and Frank, J. (1992) Ultramicroscopy 40, 33-53
39. Penczek, P. A., Grassucci, R. A., and Frank, J. (1994) Ultramicroscopy 53, 251-270
40. Nyborg, A. C., Kornilova, A. Y., Jansen, K., Ladd, T. B., Wolfe, M. S., and Golde, T. E. (2004) J. Biol. Chem. 279, 15153-15160
41. Harauz, G., and van Heel, M. (1986) Optik 73, 146-156
42. Friedmann, E., Lemberg, M. K., Weihofen, A., Dev, K. K., Dengler, U., Rovelli, G., and Martoglio, B. (2004) J. Biol. Chem. 279, 50790-50798
43. Narayanan, S., Sato, T., and Wolfe, M. S. (2007) J. Biol. Chem. 282, 20172-20179
44. Das, C., Berezovska, O., Diehl, T. S., Genet, C., Buldyrev, I., Tsai, J. Y., Hyman, B. T., and Wolfe, M. S. (2003) J. Am Chem. Soc. 125, 11794-11795
45. Micchelli, C. A., Esler, W. P., Kimberly, W. T., Jack, C., Berezovska, O., Kornilova, A., Hyman, B. T., Perrimon, N., and Wolfe, M. S. (2003) FASEB J. 17, 79-81
46. Schrul, B., Kapp, K., Sinning, I., and Dobberstein, B. (2010) Biochem. J. 427, 523-534
47. Urban, S., and Shi, Y. (2008) Curr. Opin. Struct. Biol. 18, 432-441
48. Sato, C., Morohashi, Y., Tomita, T., and Iwatsubo, T. (2006) J. Neurosci. 26, 12081-12088
49. Tomita, T., Tokuhiro, S., Hashimoto, T., Aiba, K., Saido, T. C., Maruyama, K., and Iwatsubo, T. (1998) J. Biol. Chem. 273, 21153-21160
50. Shirotani, K., Takahashi, K., and Tabira, T. (1999) Neurosci. Lett. 262, 37-40
51. Laudon, H., Mathews, P. M., Karlström, H., Bergman, A., Farmery, M. R., Nixon, R. A., Winblad, B., Gandy, S. E., Lendahl, U., Lundkvist, J., and Näslund, J. (2004) J. Neurochem. 89, 44-53
52. Mathai, J. C., and Agre, P. (1999) Biochemistry 38, 923-928
53. King, L. S., Kozono, D., and Agre, P. (2004) Nat. Rev. Mol. Cell Biol. 5, 687-698
54. Buck, T. M., Wagner, J., Grund, S., and Skach, W. R. (2007) Nat. Struct. Mol. Biol. 14, 762-769