Functional analysis of the transmembrane domains of presenilin 1: Participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of γ-secretase

Journal of Biological Chemistry

Volumn 285, Issue 26, 2010, Pages 19738-19746

  Watanabe, Naoto ^a   Takagi, Shizuka ^a   Tominaga, Aya ^a   Tomita, Taisuke ^a,c   Iwatsubo, Takeshi ^a,b,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HELICAL PEPTIDE; INTRAMEMBRANE PROTEOLYSIS; MEMBRANE PROTEIN COMPLEX; MULTIMERIC; N-TERMINALS; NICASTRIN; PRESENILINS; PROTEOLYTIC ACTIVITIES; PROTEOLYTIC MECHANISMS; SECRETASE COMPLEX; SECRETASES; STRUCTURE-FUNCTION ANALYSIS; SUBSTRATE BINDING; SUBSTRATE-BINDING SITES; TRANS-MEMBRANE DOMAINS; TRANS-MEMBRANE PROTEINS;

ACTIVATION ANALYSIS; BINDING ENERGY; BIOLOGICAL MEMBRANES; ENZYME ACTIVITY; PROTEINS;

SUBSTRATES;

GAMMA SECRETASE; PRESENILIN 1;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; BINDING SITES; CELL LINE; GENETIC COMPLEMENTATION TEST; GENETIC VECTORS; HUMANS; IMMUNOBLOTTING; MOLECULAR SEQUENCE DATA; MUTATION; PHOTOAFFINITY LABELS; PRESENILIN-1; RETROVIRIDAE; SUBSTRATE SPECIFICITY; TRANSDUCTION, GENETIC;

EID: 77953782609     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.101287     Document Type: Article

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