γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ43

Cell Reports

Volumn 3, Issue 1, 2013, Pages 42-51

  Okochi, Masayasu ^a   Tagami, Shinji ^a   Yanagida, Kanta ^a   Takami, Mako ^b,c   Kodama, Takashi S ^a   Mori, Kohji ^a   Nakayama, Taisuke ^a   Ihara, Yasuo ^b,c   Takeda, Masatoshi ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b DOSHISHA UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS AFFECTING PROTEIN METABOLISM; AMYLOID BETA PROTEIN[1-38]; AMYLOID BETA PROTEIN[1-42]; AMYLOID BETA PROTEIN[1-43]; GAMMA SECRETASE; GAMMA SECRETASE MODULATOR; GLYCOPROTEIN; PRESENILIN 1; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DISSOCIATION; DRUG EFFECT; DRUG MECHANISM; EMBRYO; HUMAN; HUMAN CELL; IN VITRO STUDY; MUTANT; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN FUNCTION;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; CELL SURVIVAL; HEK293 CELLS; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; PEPTIDES; PRESENILIN-1; PROTEIN BINDING; PROTEOLYSIS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY;

EID: 84873143698     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2012.11.028     Document Type: Article

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