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Volumn 6, Issue 17, 2014, Pages 1967-1984

MiRNA-based therapies: Strategies and delivery platforms for oligonucleotide and non-oligonucleotide agents

Author keywords

[No Author keywords available]

Indexed keywords

LIPOSOME; MICRORNA; OLIGONUCLEOTIDE; POLYMER; SMALL INTERFERING RNA; DOUBLE STRANDED RNA; DRUG CARRIER; LOCKED NUCLEIC ACID;

EID: 84919792381     PISSN: 17568919     EISSN: 17568927     Source Type: Journal    
DOI: 10.4155/fmc.14.116     Document Type: Review
Times cited : (233)

References (175)
  • 2
    • 84870409612 scopus 로고    scopus 로고
    • Mipomersen: Evidence-based review of its potential in the treatment of homozygous and severe heterozygous familial hypercholesterolemia
    • Parhofer KG. Mipomersen: evidence-based review of its potential in the treatment of homozygous and severe heterozygous familial hypercholesterolemia. Core Evid. 7, 29-38 (2012
    • (2012) Core Evid , vol.7 , pp. 29-38
    • Parhofer, K.G.1
  • 4
    • 84877908608 scopus 로고    scopus 로고
    • Influence of diverse chemical modifications on the ADME characteristics and toxicology of antisense oligonucleotides
    • Dirin M, Winkler J. Influence of diverse chemical modifications on the ADME characteristics and toxicology of antisense oligonucleotides. Expert Opin. Biol. Ther. 13(6), 875-888 (2013
    • (2013) Expert Opin. Biol. Ther , vol.13 , Issue.6 , pp. 875-888
    • Dirin, M.1    Winkler, J.2
  • 5
    • 84896705346 scopus 로고    scopus 로고
    • Review of Phase II and Phase III clinical trials for Duchenne muscular dystrophy
    • Scully MA, Pandya S, Moxley RT. Review of Phase II and Phase III clinical trials for Duchenne muscular dystrophy. Expert Opin. Orphan Drugs 1(1), 33-46 (2013
    • (2013) Expert Opin. Orphan Drugs , vol.1 , Issue.1 , pp. 33-46
    • Scully, M.A.1    Pandya, S.2    Moxley, R.T.3
  • 6
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by doublestranded RNA in Caenorhabditis elegans
    • Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by doublestranded RNA in Caenorhabditis elegans. Nature 391(6669), 806-811 (1998
    • (1998) Nature , vol.391 , Issue.6669 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 7
    • 79961203099 scopus 로고    scopus 로고
    • Nanomedicines based on recombinant fusion proteins for targeting therapeutic siRNA oligonucleotides
    • Winkler J. Nanomedicines based on recombinant fusion proteins for targeting therapeutic siRNA oligonucleotides. Ther. Deliv. 2(7), 891-905 (2011
    • (2011) Ther. Deliv , vol.2 , Issue.7 , pp. 891-905
    • Winkler, J.1
  • 9
    • 76349111051 scopus 로고    scopus 로고
    • Rational design of cationic lipids for siRNA delivery
    • Semple SC, Akinc A, Chen J et al. Rational design of cationic lipids for siRNA delivery. Nat. Biotechnol. 28(2), 172-176 (2010
    • (2010) Nat. Biotechnol , vol.28 , Issue.2 , pp. 172-176
    • Semple, S.C.1    Akinc, A.2    Chen, J.3
  • 10
    • 84880915038 scopus 로고    scopus 로고
    • Oligonucleotide conjugates for therapeutic applications
    • Winkler J. Oligonucleotide conjugates for therapeutic applications. Ther. Deliv. 4(7), 791-809 (2013
    • (2013) Ther. Deliv , vol.4 , Issue.7 , pp. 791-809
    • Winkler, J.1
  • 12
    • 77954243341 scopus 로고    scopus 로고
    • Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms
    • Akinc A, Querbes W, De S et al. Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms. Mol. Ther. 18(7), 1357-1364 (2010
    • (2010) Mol. Ther , vol.18 , Issue.7 , pp. 1357-1364
    • Akinc, A.1    Querbes, W.2    De, S.3
  • 13
    • 83455206025 scopus 로고    scopus 로고
    • MicroRNAs and cancer therapeutics
    • Yeung ML, Jeang KT. MicroRNAs and cancer therapeutics. Pharm. Res. 28(12), 3043-3049 (2011
    • (2011) Pharm. Res , vol.28 , Issue.12 , pp. 3043-3049
    • Yeung, M.L.1    Jeang, K.T.2
  • 14
    • 84859464569 scopus 로고    scopus 로고
    • Blood cell origin of circulating micrornas a cautionary note for cancer biomarker studies
    • Pritchard CC, Kroh E, Wood B et al. Blood cell origin of circulating micrornas. a cautionary note for cancer biomarker studies. Cancer Prev. Res. (Phila.) 5(3), 492-497 (2012
    • (2012) Cancer Prev. Res. (Phila , vol.5 , Issue.3 , pp. 492-497
    • Pritchard, C.C.1    Kroh, E.2    Wood, B.3
  • 15
    • 84877258007 scopus 로고    scopus 로고
    • Treatment of HCV infection by targeting microRNA
    • Janssen HLA, Reesink HW, Lawitz EJ et al. Treatment of HCV infection by targeting microRNA. N. Engl. J. Med. 368(18), 1685-1694 (2013
    • (2013) N. Engl. J. Med , vol.368 , Issue.18 , pp. 1685-1694
    • Janssen, H.L.A.1    Reesink, H.W.2    Lawitz, E.J.3
  • 17
    • 79751473114 scopus 로고    scopus 로고
    • The microRNA miR?34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
    • Liu C, Kelnar K, Liu B et al. The microRNA miR?34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat. Med. 17(2), 211-215 (2011
    • (2011) Nat. Med , vol.17 , Issue.2 , pp. 211-215
    • Liu, C.1    Kelnar, K.2    Liu, B.3
  • 18
    • 0027751663 scopus 로고
    • The C elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75, 843-854 (1993
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 19
    • 0035955361 scopus 로고    scopus 로고
    • An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
    • Lau NC, Lim LP, Weinstein EG, Bartel DP. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 294, 858-862 (2001
    • (2001) Science , vol.294 , pp. 858-862
    • Lau, N.C.1    Lim, L.P.2    Weinstein, E.G.3    Bartel, D.P.4
  • 20
    • 0035955406 scopus 로고    scopus 로고
    • Glimpses of a tiny RNA world
    • Ruvkun G. Glimpses of a tiny RNA world. Science 797-799 (2001
    • (2001) Science , pp. 797-799
    • Ruvkun, G.1
  • 22
    • 8144225486 scopus 로고    scopus 로고
    • MicroRNA genes are transcribed by RNA polymerase II
    • Lee Y, Kim M, Han J et al MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 23, 4051-4060 (2004
    • (2004) EMBO J. , vol.23 , pp. 4051-4060
    • Lee, Y.1    Kim, M.2    Han, J.3
  • 24
    • 0037772254 scopus 로고    scopus 로고
    • The time of appearance of the C elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter
    • Johnson SM, Lin S-Y, Slack FJ. The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter. Dev. Biol. 259, 364-379 (2003
    • (2003) Dev. Biol , vol.259 , pp. 364-379
    • Johnson, S.M.1    Lin, S.-Y.2    Slack, F.J.3
  • 25
    • 84873525693 scopus 로고    scopus 로고
    • Identification and analysis of the proximal promoters of microRNA genes in Arabidopsis
    • Zhao X, Zhang H, Li L. Identification and analysis of the proximal promoters of microRNA genes in Arabidopsis. Genomics 101, 187-194 (2013
    • (2013) Genomics , vol.101 , pp. 187-194
    • Zhao, X.1    Zhang, H.2    Li, L.3
  • 26
    • 0037009364 scopus 로고    scopus 로고
    • MicroRNA maturation: Stepwise processing and subcellular localization
    • Lee Y, Jeon K, Lee JT, Kim S, Kim VN. MicroRNA maturation: stepwise processing and subcellular localization. EMBO J. 21, 4663-4670 (2002
    • (2002) EMBO J. , vol.21 , pp. 4663-4670
    • Lee, Y.1    Jeon, K.2    Lee, J.T.3    Kim, S.4    Kim, V.N.5
  • 27
    • 33744520104 scopus 로고    scopus 로고
    • Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex
    • Han J, Lee Y, Yeom K-H et al. Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. Cell 125, 887-901 (2006
    • (2006) Cell , vol.125 , pp. 887-901
    • Han, J.1    Lee, Y.2    Yeom, K.-H.3
  • 28
    • 0347361541 scopus 로고    scopus 로고
    • Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
    • Yi R, Qin Y, Macara IG, Cullen BR. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 17, 3011-3016 (2003
    • (2003) Genes Dev , vol.17 , pp. 3011-3016
    • Yi, R.1    Qin, Y.2    MacAra, I.G.3    Cullen, B.R.4
  • 30
    • 0035887005 scopus 로고    scopus 로고
    • Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C elegans
    • Ketting RF, Fischer SEJ, Bernstein E, Sijen T, Hannon GJ, Plasterk RHA. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev. 15(20), 2654-2659 (2001
    • (2001) Genes Dev , vol.15 , Issue.20 , pp. 2654-2659
    • Ketting, R.F.1    Fischer, S.E.J.2    Bernstein, E.3    Sijen, T.4    Hannon, G.J.5    Plasterk, R.H.A.6
  • 31
    • 0036845374 scopus 로고    scopus 로고
    • Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP
    • Zhang H, Kolb FA, Brondani V, Billy E, Filipowicz W. Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP. EMBO J. 21, 5875-5885 (2002
    • (2002) EMBO J. , vol.21 , pp. 5875-5885
    • Zhang, H.1    Kolb, F.A.2    Brondani, V.3    Billy, E.4    Filipowicz, W.5
  • 32
    • 0038076109 scopus 로고    scopus 로고
    • Negative feedback regulation of dicer-like1 in Arabidopsis by microRNA-guided mRNA degradation
    • Xie Z, Kasschau K, Carrington J. Negative feedback regulation of dicer-like1 in Arabidopsis by microRNA-guided mRNA degradation. Curr. Biol. 13, 784-789 (2003
    • (2003) Curr. Biol , vol.13 , pp. 784-789
    • Xie, Z.1    Kasschau, K.2    Carrington, J.3
  • 33
    • 23644433363 scopus 로고    scopus 로고
    • TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
    • Chendrimada TP, Gregory RI, Kumaraswamy E et al. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 436(7051), 740-744 (2005
    • (2005) Nature , vol.436 , Issue.7051 , pp. 740-744
    • Chendrimada, T.P.1    Gregory, R.I.2    Kumaraswamy, E.3
  • 34
    • 26944431852 scopus 로고    scopus 로고
    • Small RNA asymmetry in RNAi: Function in RISC assembly and gene regulation
    • Hutvagner G. Small RNA asymmetry in RNAi: function in RISC assembly and gene regulation. FEBS Lett. 579, 5850-5857 (2005
    • (2005) FEBS Lett , vol.579 , pp. 5850-5857
    • Hutvagner, G.1
  • 35
    • 5144225452 scopus 로고    scopus 로고
    • Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity
    • Rand TA, Ginalski K, Grishin NV, Wang X. Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity. Proc. Natl Acad. Sci. USA 101, 14385-14389 (2004
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 14385-14389
    • Rand, T.A.1    Ginalski, K.2    Grishin, N.V.3    Wang, X.4
  • 36
    • 33644768174 scopus 로고    scopus 로고
    • Control of translation and mRNA degradation by miRNAs and siRNAs
    • Valencia-Sanchez MA, Liu J, Hannon GJ, Parker R. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev. 20, 515-524 (2006
    • (2006) Genes Dev , vol.20 , pp. 515-524
    • Valencia-Sanchez, M.A.1    Liu, J.2    Hannon, G.J.3    Parker, R.4
  • 37
    • 0142173075 scopus 로고    scopus 로고
    • Small RNAs with imperfect match to endogenous mRNA repress translation Implications for off-target activity of small inhibitory RNA in mammalian cells
    • Saxena S, Jónsson ZO, Dutta A. Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells. J. Biol. Chem. 278, 44312-44319 (2003
    • (2003) J. Biol. Chem , vol.278 , pp. 44312-44319
    • Saxena, S.1    Jónsson, Z.O.2    Dutta, A.3
  • 38
    • 20944450160 scopus 로고    scopus 로고
    • Combinatorial microRNA target predictions
    • Krek A, Grün D, Poy MN et al. Combinatorial microRNA target predictions. Nat. Genet. 37, 495-500 (2005
    • (2005) Nat. Genet , vol.37 , pp. 495-500
    • Krek, A.1    Grün, D.2    Poy, M.N.3
  • 39
    • 32444436121 scopus 로고    scopus 로고
    • Short RNAs repress translation after initiation in mammalian cells
    • Petersen CP, Bordeleau M-E, Pelletier J, Sharp PA. Short RNAs repress translation after initiation in mammalian cells. Mol. Cell 21, 533-542 (2006
    • (2006) Mol. Cell , vol.21 , pp. 533-542
    • Petersen, C.P.1    Bordeleau, M.-E.2    Pelletier, J.3    Sharp, P.A.4
  • 40
    • 79956227111 scopus 로고    scopus 로고
    • Shielding the messenger (RNA): MicroRNA-based anticancer therapies
    • Sotillo E, Thomas-Tikhonenko A. Shielding the messenger (RNA): microRNA-based anticancer therapies. Pharmacol. Ther. 131, 18-32 (2011
    • (2011) Pharmacol. Ther , vol.131 , pp. 18-32
    • Sotillo, E.1    Thomas-Tikhonenko, A.2
  • 41
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120, 15-20 (2005
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 42
    • 84896396537 scopus 로고    scopus 로고
    • MicroRNA-targeting therapeutics for hepatitis C
    • Baek J, Kang S, Min H. MicroRNA-targeting therapeutics for hepatitis C. Arch. Pharm. Res. 37(3), 299-305 (2014
    • (2014) Arch. Pharm. Res , vol.37 , Issue.3 , pp. 299-305
    • Baek, J.1    Kang, S.2    Min, H.3
  • 43
    • 84878108145 scopus 로고    scopus 로고
    • EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2
    • Shen J, Xia W, Khotskaya YB et al. EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2. Nature 497, 383-387 (2013
    • (2013) Nature , vol.497 , pp. 383-387
    • Shen, J.1    Xia, W.2    Khotskaya, Y.B.3
  • 44
    • 82755189644 scopus 로고    scopus 로고
    • MicroRNA history: Discovery, recent applications, and next frontiers
    • Almeida MI, Reis RM, Calin GA. MicroRNA history: discovery, recent applications, and next frontiers. Mutat. Res. 717, 1-8 (2011
    • (2011) Mutat. Res , vol.717 , pp. 1-8
    • Almeida, M.I.1    Reis, R.M.2    Calin, G.A.3
  • 45
    • 81855224576 scopus 로고    scopus 로고
    • Epigenetics and genetics MicroRNAs en route to the clinic: Progress in validating and targeting microRNAs for cancer therapy
    • Kasinski AL, Slack FJ. Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy. Nat. Rev. Cancer 11, 849-864 (2011
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 849-864
    • Kasinski, A.L.1    Slack, F.J.2
  • 47
    • 84878112868 scopus 로고    scopus 로고
    • MiRNAs and cancer: An epigenetics view
    • Malumbres M. miRNAs and cancer: an epigenetics view. Mol. Aspects Med. 34, 863-874 (2013
    • (2013) Mol. Aspects Med , vol.34 , pp. 863-874
    • Malumbres, M.1
  • 48
    • 84877317891 scopus 로고    scopus 로고
    • Cross-platform microarray meta-analysis for the mouse jejunum selects novel reference genes with highly uniform levels of expression
    • Meyer FRL, Grausgruber H, Binter C et al. Cross-platform microarray meta-analysis for the mouse jejunum selects novel reference genes with highly uniform levels of expression. PLoS ONE 8, e63125 (2013
    • (2013) PLoS ONE , vol.8 , pp. e63125
    • Meyer, F.R.L.1    Grausgruber, H.2    Binter, C.3
  • 49
    • 33645241407 scopus 로고    scopus 로고
    • The RIN: An RNA integrity number for assigning integrity values to RNA measurements
    • Schroeder A, Mueller O, Stocker S et al. The RIN: an RNA integrity number for assigning integrity values to RNA measurements. BMC Mol. Biol. 7, 3 (2006
    • (2006) BMC Mol. Biol , vol.7 , pp. 3
    • Schroeder, A.1    Mueller, O.2    Stocker, S.3
  • 50
    • 42449098100 scopus 로고    scopus 로고
    • Normalization of microRNA expression levels in quantitative RT-PCR assays: Identification of suitable reference RNA targets in normal and cancerous human solid
    • Peltier H, Latham G. Normalization of microRNA expression levels in quantitative RT-PCR assays: identification of suitable reference RNA targets in normal and cancerous human solid. RNA 14(5), 844-852 (2008
    • (2008) RNA , vol.14 , Issue.5 , pp. 844-852
    • Peltier, H.1    Latham, G.2
  • 51
    • 0035161457 scopus 로고    scopus 로고
    • Unsuitability of using ribosomal RNA as loading control for Northern blot analyses related to the imbalance between messenger and ribosomal RNA content in rat mammary tumors
    • Solanas M, Moral R, Escrich E. Unsuitability of using ribosomal RNA as loading control for Northern blot analyses related to the imbalance between messenger and ribosomal RNA content in rat mammary tumors. Anal. Biochem. 288, 99-102 (2001
    • (2001) Anal. Biochem , vol.288 , pp. 99-102
    • Solanas, M.1    Moral, R.2    Escrich, E.3
  • 52
    • 84864967988 scopus 로고    scopus 로고
    • Selective depletion of rRNA enables whole transcriptome profiling of archival fixed tissue
    • Morlan JD, Qu K, Sinicropi DV. Selective depletion of rRNA enables whole transcriptome profiling of archival fixed tissue. PLoS ONE 7, e42882 (2012
    • (2012) PLoS ONE , vol.7 , pp. e42882
    • Morlan, J.D.1    Qu, K.2    Sinicropi, D.V.3
  • 53
    • 84879692466 scopus 로고    scopus 로고
    • Comparative analysis of RNA sequencing methods for degraded or lowinput samples
    • Adiconis X, Borges-Rivera D, Satija R et al. Comparative analysis of RNA sequencing methods for degraded or lowinput samples. Nat. Methods 10, 623-629 (2013
    • (2013) Nat. Methods , vol.10 , pp. 623-629
    • Adiconis, X.1    Borges-Rivera, D.2    Satija, R.3
  • 54
    • 79953207276 scopus 로고    scopus 로고
    • The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis
    • Gee HE, Buffa FM, Camps C et al. The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis. Br. J. Cancer 104, 1168-1177 (2011
    • (2011) Br. J. Cancer , vol.104 , pp. 1168-1177
    • Gee, H.E.1    Buffa, F.M.2    Camps, C.3
  • 55
    • 29144470346 scopus 로고    scopus 로고
    • Real-time quantification of microRNAs by stem-loop RT-PCR
    • Chen C, Ridzon Da, Broomer AJ et al. Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res. 33, e179 (2005
    • (2005) Nucleic Acids Res , vol.33 , pp. e179
    • Chen, C.1    Ridzon Da Broomer, A.J.2
  • 56
    • 38849140922 scopus 로고    scopus 로고
    • Protocol: A highly sensitive RT-PCR method for detection and quantification of microRNAs
    • Varkonyi-Gasic E, Wu R, Wood M, Walton EF, Hellens RP. Protocol: a highly sensitive RT-PCR method for detection and quantification of microRNAs. Plant Methods 3, 12 (2007
    • (2007) Plant Methods , vol.3 , pp. 12
    • Varkonyi-Gasic, E.1    Wu, R.2    Wood, M.3    Walton, E.F.4    Hellens, R.P.5
  • 57
    • 84869008360 scopus 로고    scopus 로고
    • A Novel Real-Time PCR Assay of microRNAs Using S-Poly(T), a Specific Oligo(dT) Reverse Transcription Primer with Excellent Sensitivity and Specificity
    • Kang K, Xiaoying Z, Hongtao L et al. A Novel Real-Time PCR Assay of microRNAs Using S-Poly(T), a Specific Oligo(dT) Reverse Transcription Primer with Excellent Sensitivity and Specificity. PLoS ONE 7(11), e48536 (2012
    • (2012) PLoS ONE , vol.7 , Issue.11 , pp. e48536
    • Kang, K.1    Xiaoying, Z.2    Hongtao, L.3
  • 58
    • 64149097786 scopus 로고    scopus 로고
    • The MIQE guidelines minimum information for publication of quantitative realtime PCR experiments
    • Bustin SA, Benes V, Garson JA et al. The MIQE guidelines. minimum information for publication of quantitative realtime PCR experiments. Clin. Chem. 55, 611-622 (2009
    • (2009) Clin. Chem , vol.55 , pp. 611-622
    • Bustin, S.A.1    Benes, V.2    Garson, J.A.3
  • 59
    • 18744396337 scopus 로고    scopus 로고
    • Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    • Calin GA, Dumitru CD, Shimizu M et al. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc. Natl Acad. Sci. USA 99, 15524-15529 (2002
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 15524-15529
    • Calin, G.A.1    Dumitru, C.D.2    Shimizu, M.3
  • 61
    • 84865062501 scopus 로고    scopus 로고
    • Molecular Pathways: MicroRNAs as cancer therapeutics
    • Melo SA, Kalluri R. Molecular Pathways: microRNAs as cancer therapeutics. Clin. Cancer Res. 18(16), 4234-4239 (2012
    • (2012) Clin. Cancer Res , vol.18 , Issue.16 , pp. 4234-4239
    • Melo, S.A.1    Kalluri, R.2
  • 62
    • 20444460289 scopus 로고    scopus 로고
    • MicroRNA expression profiles classify human cancers
    • Lu J, Getz G, Miska E, Alvarez-Saavedra E. MicroRNA expression profiles classify human cancers. Nature 435, (2005
    • (2005) Nature , vol.435
    • Lu, J.1    Getz, G.2    Miska, E.3    Alvarez-Saavedra, E.4
  • 63
    • 53349177819 scopus 로고    scopus 로고
    • Characterization of microRNAs in serum: A novel class of biomarkers for diagnosis of cancer and other diseases
    • Chen X, Ba Y, Ma L et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 18, 997-1006 (2008
    • (2008) Cell Res , vol.18 , pp. 997-1006
    • Chen, X.1    Ba, Y.2    Ma, L.3
  • 64
    • 77953192081 scopus 로고    scopus 로고
    • Plasma microRNAs are promising novel biomarkers for early detection of colorectal cancer
    • Huang Z, Huang D, Ni S, Peng Z, Sheng W, Du X. Plasma microRNAs are promising novel biomarkers for early detection of colorectal cancer. Int. J. Cancer 127, 118-126 (2010
    • (2010) Int. J. Cancer , vol.127 , pp. 118-126
    • Huang, Z.1    Huang, D.2    Ni, S.3    Peng, Z.4    Sheng, W.5    Du, X.6
  • 65
    • 82755187564 scopus 로고    scopus 로고
    • Extracellular microRNA: A new source of biomarkers
    • Etheridge A, Lee I, Hood L, Galas D, Wang K. Extracellular microRNA: a new source of biomarkers. Mutat. Res. 717, 85-90 (2011
    • (2011) Mutat. Res , vol.717 , pp. 85-90
    • Etheridge, A.1    Lee, I.2    Hood, L.3    Galas, D.4    Wang, K.5
  • 66
  • 67
    • 84857672136 scopus 로고    scopus 로고
    • Metastami Rs non-coding microRNAs driving cancer invasion and metastasis
    • Lopez-Camarillo C, Marchat LA, Arechaga-Ocampo E et al. MetastamiRs. non-coding microRNAs driving cancer invasion and metastasis. Int. J. Mol. Sci. 13, 1347-1379 (2012
    • (2012) Int. J. Mol. Sci , vol.13 , pp. 1347-1379
    • Lopez-Camarillo, C.1    Marchat, L.A.2    Arechaga-Ocampo, E.3
  • 69
    • 84893649514 scopus 로고    scopus 로고
    • The role of microRNAs in the regulation of cancer stem cells
    • Takahashi R-U, Miyazaki H, Ochiya T. The role of microRNAs in the regulation of cancer stem cells. Front. Genet. 4, 295 (2014
    • (2014) Front. Genet , vol.4 , Issue.295
    • Takahashi, R.-U.1    Miyazaki, H.2    Ochiya, T.3
  • 70
    • 84867740278 scopus 로고    scopus 로고
    • MicroRNAs involved in regulating epithelial-mesenchymal transition and cancer stem cells as molecular targets for cancer therapeutics
    • Xia H, Hui KM. MicroRNAs involved in regulating epithelial-mesenchymal transition and cancer stem cells as molecular targets for cancer therapeutics. Cancer Gene Ther. 19, 723-730 (2012
    • (2012) Cancer Gene Ther , vol.19 , pp. 723-730
    • Xia, H.1    Hui, K.M.2
  • 72
    • 22244467087 scopus 로고    scopus 로고
    • MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells
    • Chan Ja, Krichevsky AM, Kosik KS. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res. 65, 6029-6033 (2005
    • (2005) Cancer Res , vol.65 , pp. 6029-6033
    • Chan, J.A.1    Krichevsky, A.M.2    Kosik, K.S.3
  • 73
    • 25444520537 scopus 로고    scopus 로고
    • MiR?15 and miR?16 induce apoptosis by targeting BCL2
    • Cimmino A, Calin G. miR?15 and miR?16 induce apoptosis by targeting BCL2. Proc. Natl Acad. Sci. USA 103, (2005
    • (2005) Proc. Natl Acad. Sci. USA , vol.103
    • Cimmino, A.1    Calin, G.2
  • 74
    • 20044395613 scopus 로고    scopus 로고
    • RAS is regulated by the let-7 microRNA family
    • Johnson SM, Grosshans H, Shingara J et al. RAS is regulated by the let-7 microRNA family. Cell 120, 635-647 (2005
    • (2005) Cell , vol.120 , pp. 635-647
    • Johnson, S.M.1    Grosshans, H.2    Shingara, J.3
  • 75
    • 12144290519 scopus 로고    scopus 로고
    • Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
    • Calin GA, Sevignani C, Dumitru CD et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc. Natl Acad. Sci. USA 101, 2999-3004 (2004
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 2999-3004
    • Calin, G.A.1    Sevignani, C.2    Dumitru, C.D.3
  • 76
    • 84878529330 scopus 로고    scopus 로고
    • CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia
    • Chen Y, Jacamo R, Konopleva M, Garzon R, Croce C, Andreeff M. CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia. J. Clin. Invest. 123(6), 2395-2407 (2013
    • (2013) J. Clin. Invest , vol.123 , Issue.6 , pp. 2395-2407
    • Chen, Y.1    Jacamo, R.2    Konopleva, M.3    Garzon, R.4    Croce, C.5    Andreeff, M.6
  • 77
    • 78650385772 scopus 로고    scopus 로고
    • MicroRNA-21: A novel therapeutic target in human cancer
    • Pan X, Wang Z-X, Wang R. MicroRNA-21: a novel therapeutic target in human cancer. Cancer Biol. Ther. 10(12), 1224-1232 (2010
    • (2010) Cancer Biol. Ther , vol.10 , Issue.12 , pp. 1224-1232
    • Pan, X.1    Wang, Z.-X.2    Wang, R.3
  • 78
    • 84869219338 scopus 로고    scopus 로고
    • MiR?34 - A microRNA replacement therapy is headed to the clinic
    • Bader AG. miR?34 - a microRNA replacement therapy is headed to the clinic. Front. Genet. 3, 120 (2012
    • (2012) Front. Genet , vol.3 , Issue.120
    • Bader, A.G.1
  • 79
    • 84888013022 scopus 로고    scopus 로고
    • MiR?137 suppresses cell growth in ovarian cancer by targeting AEG-1
    • Guo J, Xia B, Meng F, Lou G. miR?137 suppresses cell growth in ovarian cancer by targeting AEG-1. Biochem. Biophys. Res. Commun. 441, 357-363 (2013
    • (2013) Biochem. Biophys. Res. Commun , vol.441 , pp. 357-363
    • Guo, J.1    Xia, B.2    Meng, F.3    Lou, G.4
  • 80
    • 84871716820 scopus 로고    scopus 로고
    • MiR?137 inhibits the proliferation of lung cancer cells by targeting Cdc42 and Cdk6
    • Zhu X, Li Y, Shen H et al. miR?137 inhibits the proliferation of lung cancer cells by targeting Cdc42 and Cdk6. FEBS Lett. 587, 73-81 (2013
    • (2013) FEBS Lett , vol.587 , pp. 73-81
    • Zhu, X.1    Li, Y.2    Shen, H.3
  • 81
    • 84864183740 scopus 로고    scopus 로고
    • MiR-145 modulates multiple components of the insulin-like growth factor pathway in hepatocellular carcinoma
    • Law PTY, Ching AKK, Chan AWH et al. MiR-145 modulates multiple components of the insulin-like growth factor pathway in hepatocellular carcinoma. Carcinogenesis 33, 1134-1141 (2012
    • (2012) Carcinogenesis , vol.33 , pp. 1134-1141
    • Law, P.T.Y.1    Ching, A.K.K.2    Chan, A.W.H.3
  • 82
    • 84899490560 scopus 로고    scopus 로고
    • MicroRNA-145 suppresses hepatocellular carcinoma by targeting IRS1 and its downstream Akt signaling
    • Wang Y, Hu C, Cheng J et al. MicroRNA-145 suppresses hepatocellular carcinoma by targeting IRS1 and its downstream Akt signaling. Biochem. Biophys. Res. Commun. 446, 1255-1260 (2014
    • (2014) Biochem. Biophys. Res. Commun , vol.446 , pp. 1255-1260
    • Wang, Y.1    Hu, C.2    Cheng, J.3
  • 83
    • 84874444612 scopus 로고    scopus 로고
    • MiRNA-145 targets v-ets erythroblastosis virus E26 oncogene homolog 1 to suppress the invasion, metastasis, and angiogenesis of gastric cancer cells
    • Zheng L, Pu J, Qi T et al. miRNA-145 targets v-ets erythroblastosis virus E26 oncogene homolog 1 to suppress the invasion, metastasis, and angiogenesis of gastric cancer cells. Mol. Cancer Res. 11, 182-193 (2013
    • (2013) Mol. Cancer Res , vol.11 , pp. 182-193
    • Zheng, L.1    Pu, J.2    Qi, T.3
  • 84
    • 84895417104 scopus 로고    scopus 로고
    • MicroRNA-149 targets GIT1 to suppress integrin signaling and breast cancer metastasis
    • Chan SH, Huang WC, Chang JW et al. MicroRNA-149 targets GIT1 to suppress integrin signaling and breast cancer metastasis. Oncogene 33(36), 4496-4507 (2014
    • (2014) Oncogene , vol.33 , Issue.36 , pp. 4496-4507
    • Chan, S.H.1    Huang, W.C.2    Chang, J.W.3
  • 85
    • 80053139025 scopus 로고    scopus 로고
    • MicroRNA-149, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma
    • Jin L, Hu WL, Jiang CC et al. MicroRNA-149. a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma. Proc. Natl Acad. Sci. USA 108(38), 15840-15845 (2011
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , Issue.38 , pp. 15840-15845
    • Jin, L.1    Hu, W.L.2    Jiang, C.C.3
  • 86
    • 84888204275 scopus 로고    scopus 로고
    • MicroRNA-181a enhances the chemoresistance of human cervical squamous cell carcinoma to cisplatin by targeting PRKCD
    • Chen Y, Ke G, Han D, Liang S, Yang G, Wu X. MicroRNA-181a enhances the chemoresistance of human cervical squamous cell carcinoma to cisplatin by targeting PRKCD. Exp. Cell Res. 320, 12-20 (2014
    • (2014) Exp. Cell Res , vol.320 , pp. 12-20
    • Chen, Y.1    Ke, G.2    Han, D.3    Liang, S.4    Yang, G.5    Wu, X.6
  • 87
    • 84888008102 scopus 로고    scopus 로고
    • MiR?181a-Twist1 pathway in the chemoresistance of tongue squamous cell carcinoma
    • Liu M, Wang J, Huang H, Hou J, Zhang B, Wang A. miR?181a-Twist1 pathway in the chemoresistance of tongue squamous cell carcinoma. Biochem. Biophys. Res. Commun. 441, 364-370 (2013
    • (2013) Biochem. Biophys. Res. Commun , vol.441 , pp. 364-370
    • Liu, M.1    Wang, J.2    Huang, H.3    Hou, J.4    Zhang, B.5    Wang, A.6
  • 88
    • 81855206547 scopus 로고    scopus 로고
    • Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR?210 expression caused by stabilizing HIF-1?.
    • Wang H, Bian S, Yang CS. Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR?210 expression caused by stabilizing HIF-1?. Carcinogenesis 32, 1881-1889 (2011
    • (2011) Carcinogenesis , vol.32 , pp. 1881-1889
    • Wang, H.1    Bian, S.2    Yang, C.S.3
  • 89
    • 79952751773 scopus 로고    scopus 로고
    • MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway
    • Alajez NM, Lenarduzzi M, Ito E et al. MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway. Cancer Res. 71, 2381-2391 (2011
    • (2011) Cancer Res , vol.71 , pp. 2381-2391
    • Alajez, N.M.1    Lenarduzzi, M.2    Ito, E.3
  • 90
    • 84899674559 scopus 로고    scopus 로고
    • MiR-330-mediated regulation of SH3GL2 expression enhances malignant behaviors of glioblastoma stem cells by activating ERK and PI3K/AKT signaling pathways
    • Yao Y, Xue Y, Ma J et al. MiR-330-mediated regulation of SH3GL2 expression enhances malignant behaviors of glioblastoma stem cells by activating ERK and PI3K/AKT signaling pathways. PLoS ONE 9, e95060 (2014
    • (2014) PLoS ONE , vol.9 , pp. e95060
    • Yao, Y.1    Xue, Y.2    Ma, J.3
  • 91
    • 84873745294 scopus 로고    scopus 로고
    • Yan J. MiR?330 regulates the proliferation of colorectal cancer cells by targeting Cdc42
    • Li Y, Zhu X, Xu W, Wang D, Yan J. miR?330 regulates the proliferation of colorectal cancer cells by targeting Cdc42. Biochem. Biophys. Res. Commun. 431, 560-565 (2013
    • (2013) Biochem. Biophys. Res. Commun , vol.431 , pp. 560-565
    • Li, Y.1    Zhu, X.2    Xu, W.3    Wang, D.4
  • 92
    • 84899723953 scopus 로고    scopus 로고
    • MicroRNA-338 inhibits growth, invasion and metastasis of gastric cancer by targeting NRP1 expression
    • Peng Y, Liu YM, Li LC, Wang LL, Wu XL. MicroRNA-338 inhibits growth, invasion and metastasis of gastric cancer by targeting NRP1 expression. PLoS ONE 9, e94422 (2014
    • (2014) PLoS ONE , vol.9 , pp. e94422
    • Peng, Y.1    Liu, Y.M.2    Li, L.C.3    Wang, L.L.4    Wu, X.L.5
  • 93
    • 84896442949 scopus 로고    scopus 로고
    • MicroRNA-363-mediated downregulation of S1PR1 suppresses the proliferation of hepatocellular carcinoma cells
    • Zhou P, Huang G, Zhao Y et al. MicroRNA-363-mediated downregulation of S1PR1 suppresses the proliferation of hepatocellular carcinoma cells. Cell Signal 26, 1347-1354 (2014
    • (2014) Cell Signal , vol.26 , pp. 1347-1354
    • Zhou, P.1    Huang, G.2    Zhao, Y.3
  • 94
    • 84899624549 scopus 로고    scopus 로고
    • A novel berbamine derivative inhibits cell viability and induces apoptosis in cancer stem-like cells of human glioblastoma, via upregulation of miRNA-4284 and JNK/AP-1 signaling
    • Yang F, Nam S, Brown CE et al. A novel berbamine derivative inhibits cell viability and induces apoptosis in cancer stem-like cells of human glioblastoma, via upregulation of miRNA-4284 and JNK/AP-1 signaling. PLoS ONE 9, e94443 (2014
    • (2014) PLoS ONE , vol.9 , pp. e94443
    • Yang, F.1    Nam, S.2    Brown, C.E.3
  • 95
    • 34248217444 scopus 로고    scopus 로고
    • Methylation of human microRNA genes in normal and neoplastic cells
    • Weber B, Stresemann C, Brueckner B, Lyko F. Methylation of human microRNA genes in normal and neoplastic cells. Cell Cycle 6(9), 1001-1005 (2007
    • (2007) Cell Cycle , vol.6 , Issue.9 , pp. 1001-1005
    • Weber, B.1    Stresemann, C.2    Brueckner, B.3    Lyko, F.4
  • 96
    • 0343621494 scopus 로고    scopus 로고
    • Aberrant CpG-island methylation has non
    • random and tumour-typespecific patterns
    • Costello JF, Frühwald MC, Smiraglia DJ et al. Aberrant CpG-island methylation has non-random and tumour-typespecific patterns. Nat. Genet. 24, 132-138 (2000
    • (2000) Nat. Genet , vol.24 , pp. 132-138
    • Costello, J.F.1    Frühwald, M.C.2    Smiraglia, D.J.3
  • 97
    • 31744433660 scopus 로고    scopus 로고
    • Evidence for an instructive mechanism of de novo methylation in cancer cells
    • Keshet I, Schlesinger Y, Farkash S et al. Evidence for an instructive mechanism of de novo methylation in cancer cells. Nat. Genet. 38, 149-153 (2006
    • (2006) Nat. Genet , vol.38 , pp. 149-153
    • Keshet, I.1    Schlesinger, Y.2    Farkash, S.3
  • 98
    • 82755161786 scopus 로고    scopus 로고
    • Epigenetic regulation of microRNAs in cancer: An integrated review of literature
    • Kunej T, Godnic I, Ferdin J, Horvat S, Dovc P, Calin GA. Epigenetic regulation of microRNAs in cancer: an integrated review of literature. Mutat. Res. 717, 77-84 (2011
    • (2011) Mutat. Res , vol.717 , pp. 77-84
    • Kunej, T.1    Godnic, I.2    Ferdin, J.3    Horvat, S.4    Dovc, P.5    Calin, G.A.6
  • 99
    • 33744805399 scopus 로고    scopus 로고
    • Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells
    • Saito Y, Liang G, Egger G et al. Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 9, 435-443 (2006
    • (2006) Cancer Cell , vol.9 , pp. 435-443
    • Saito, Y.1    Liang, G.2    Egger, G.3
  • 100
    • 44349124725 scopus 로고    scopus 로고
    • Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer
    • Zhang L, Volinia S, Bonome T et al. Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer. Proc. Natl Acad. Sci. USA 105, 7004-7009 (2008
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 7004-7009
    • Zhang, L.1    Volinia, S.2    Bonome, T.3
  • 101
    • 32944462300 scopus 로고    scopus 로고
    • Rapid alteration of microRNA levels by histone deacetylase inhibition
    • Scott GK, Mattie MD, Berger CE, Benz SC, Benz CC. Rapid alteration of microRNA levels by histone deacetylase inhibition. Cancer Res. 66, 1277-1281 (2006
    • (2006) Cancer Res , vol.66 , pp. 1277-1281
    • Scott, G.K.1    Mattie, M.D.2    Berger, C.E.3    Benz, S.C.4    Benz, C.C.5
  • 102
    • 51049119231 scopus 로고    scopus 로고
    • Diagnostic and prognostic microRNAs in stage II colon cancer
    • Schepeler T, Reinert JT, Ostenfeld MS et al. Diagnostic and prognostic microRNAs in stage II colon cancer. Cancer Res. 68, 6416-6424 (2008
    • (2008) Cancer Res , vol.68 , pp. 6416-6424
    • Schepeler, T.1    Reinert, J.T.2    Ostenfeld, M.S.3
  • 103
    • 42249089850 scopus 로고    scopus 로고
    • MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma
    • Varnholt H, Drebber U, Schulze F et al. MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma. Hepatology 47, 1223-1232 (2008
    • (2008) Hepatology , vol.47 , pp. 1223-1232
    • Varnholt, H.1    Drebber, U.2    Schulze, F.3
  • 104
    • 84875372911 scopus 로고    scopus 로고
    • Natural RNA circles function as efficient microRNA sponges
    • Hansen TB, Jensen TI, Clausen BH et al. Natural RNA circles function as efficient microRNA sponges. Nature 495, 384-388 (2013
    • (2013) Nature , vol.495 , pp. 384-388
    • Hansen, T.B.1    Jensen, T.I.2    Clausen, B.H.3
  • 105
    • 77953957633 scopus 로고    scopus 로고
    • A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
    • Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ, Pandolfi PP. A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature 465, 1033-1038 (2010
    • (2010) Nature , vol.465 , pp. 1033-1038
    • Poliseno, L.1    Salmena, L.2    Zhang, J.3    Carver, B.4    Haveman, W.J.5    Pandolfi, P.P.6
  • 106
    • 84881503516 scopus 로고    scopus 로고
    • Pseudogene OCT4-pg4 functions as a natural micro RNA sponge to regulate OCT4 expression by competing for miR?145 in hepatocellular carcinoma
    • Wang L, Guo Z-Y, Zhang R et al. Pseudogene OCT4-pg4 functions as a natural micro RNA sponge to regulate OCT4 expression by competing for miR?145 in hepatocellular carcinoma. Carcinogenesis 34, 1773-1781 (2013
    • (2013) Carcinogenesis , vol.34 , pp. 1773-1781
    • Wang, L.1    Guo, Z.-Y.2    Zhang, R.3
  • 107
    • 84868106545 scopus 로고    scopus 로고
    • MicroRNA-149 inhibits proliferation and cell cycle progression through the targeting of ZBTB2 in human gastric cancer
    • Wang Y, Zheng X, Zhang Z et al. MicroRNA-149 inhibits proliferation and cell cycle progression through the targeting of ZBTB2 in human gastric cancer. PLoS ONE 7(10), e41693 (2012
    • (2012) PLoS ONE , vol.7 , Issue.10 , pp. e41693
    • Wang, Y.1    Zheng, X.2    Zhang, Z.3
  • 108
    • 84878650763 scopus 로고    scopus 로고
    • MiR?149 inhibits non-smallcell lung cancer cells EMT by targeting FOXM1
    • Ke Y, Zhao W, Xiong J, Cao R. miR?149 inhibits non-smallcell lung cancer cells EMT by targeting FOXM1. Biochem. Res. Int. 2013, 506731 (2013
    • (2013) Biochem. Res. Int , vol.2013 , pp. 506731
    • Ke, Y.1    Zhao, W.2    Xiong, J.3    Cao, R.4
  • 109
    • 79952783987 scopus 로고    scopus 로고
    • MicroRNAs as therapeutic targets in cancer
    • Nana-Sinkam SP, Croce CM. MicroRNAs as therapeutic targets in cancer. Transl. Res. 157, 216-225 (2011
    • (2011) Transl. Res , vol.157 , pp. 216-225
    • Nana-Sinkam, S.P.1    Croce, C.M.2
  • 110
    • 84869866890 scopus 로고    scopus 로고
    • MicroRNA and cancer
    • Jansson MD, Lund AH. MicroRNA and cancer. Mol. Oncol. 6(6), 590-610 (2012
    • (2012) Mol. Oncol , vol.6 , Issue.6 , pp. 590-610
    • Jansson, M.D.1    Lund, A.H.2
  • 111
    • 84887101163 scopus 로고    scopus 로고
    • MicroRNAs and other noncoding RNAs as targets for anticancer drug development
    • Ling H, Fabbri M, Calin GA. MicroRNAs and other noncoding RNAs as targets for anticancer drug development. Nat. Rev. Drug Discov. 12(11), 847-865 (2013
    • (2013) Nat. Rev. Drug Discov , vol.12 , Issue.11 , pp. 847-865
    • Ling, H.1    Fabbri, M.2    Calin, G.A.3
  • 112
    • 80052102044 scopus 로고    scopus 로고
    • Diabetes complications: The microRNA perspective
    • Kantharidis P, Wang B, Carew RM, Lan HY. Diabetes complications: The microRNA perspective. Diabetes 60(7), 1832-1837 (2011
    • (2011) Diabetes , vol.60 , Issue.7 , pp. 1832-1837
    • Kantharidis, P.1    Wang, B.2    Carew, R.M.3    Lan, H.Y.4
  • 113
    • 84900797916 scopus 로고    scopus 로고
    • MicroRNA-7a regulates pancreatic cell function
    • Latreille M, Hausser J, Stützer I et al. MicroRNA-7a regulates pancreatic ? cell function. J. Clin. Invest. 124(6), 2722-2735 (2014
    • (2014) J. Clin. Invest , vol.124 , Issue.6 , pp. 2722-2735
    • Latreille, M.1    Hausser, J.2    Stützer, I.3
  • 114
    • 84868475728 scopus 로고    scopus 로고
    • MicroRNA therapeutics for cardiovascular disease: Opportunities and obstacles
    • van Rooij E, Olson EN. MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles. Nat. Rev. Drug Discov. 11(11), 860-872 (2012
    • (2012) Nat. Rev. Drug Discov , vol.11 , Issue.11 , pp. 860-872
    • Van Rooij, E.1    Olson, E.N.2
  • 115
    • 84859500144 scopus 로고    scopus 로고
    • MicroRNA dysregulation in schizophrenia
    • Beveridge NJ, Cairns MJ. MicroRNA dysregulation in schizophrenia. Neurobiol. Dis. 46(2), 263-271 (2012
    • (2012) Neurobiol. Dis , vol.46 , Issue.2 , pp. 263-271
    • Beveridge, N.J.1    Cairns, M.J.2
  • 116
    • 84880956260 scopus 로고    scopus 로고
    • A blood based 12-miRNA signature of Alzheimer disease patients
    • Leidinger P, Backes C, Deutscher S et al. A blood based 12-miRNA signature of Alzheimer disease patients. Genome Biol. 14(7), R78 (2013
    • (2013) Genome Biol , vol.14 , Issue.7 , pp. R78
    • Leidinger, P.1    Backes, C.2    Deutscher, S.3
  • 117
    • 79956032718 scopus 로고    scopus 로고
    • Hsa-miR?34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease
    • Gaughwin PM, Ciesla M, Lahiri N, Tabrizi SJ, Brundin P, Björkqvist M. Hsa-miR?34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease. Hum. Mol. Genet. 20(11), 2225-2237 (2011
    • (2011) Hum. Mol. Genet , vol.20 , Issue.11 , pp. 2225-2237
    • Gaughwin, P.M.1    Ciesla, M.2    Lahiri, N.3    Tabrizi, S.J.4    Brundin, P.5    Björkqvist, M.6
  • 118
    • 84881245624 scopus 로고    scopus 로고
    • Circulating MicroRNAs as biomarkers for disease staging in multiple sclerosis
    • Gandhi R, Healy B, Gholipour T et al. Circulating MicroRNAs as biomarkers for disease staging in multiple sclerosis. Ann. Neurol. 73(6), 729-740 (2013
    • (2013) Ann. Neurol , vol.73 , Issue.6 , pp. 729-740
    • Gandhi, R.1    Healy, B.2    Gholipour, T.3
  • 120
    • 83255194160 scopus 로고    scopus 로고
    • Chemical modification and design of anti-miRNA oligonucleotides
    • Lennox KA, Behlke MA. Chemical modification and design of anti-miRNA oligonucleotides. Gene Ther. 18(12), 1111-1120 (2011
    • (2011) Gene Ther , vol.18 , Issue.12 , pp. 1111-1120
    • Lennox, K.A.1    Behlke, M.A.2
  • 121
    • 84892919070 scopus 로고    scopus 로고
    • Methods to enable the design of bioactive small molecules targeting RNA
    • Disney MD, Yildirim I, Childs-Disney JL. Methods to enable the design of bioactive small molecules targeting RNA. Org. Biomol. Chem. 12(7), 1029-1039 (2014
    • (2014) Org. Biomol. Chem , vol.12 , Issue.7 , pp. 1029-1039
    • Disney, M.D.1    Yildirim, I.2    Childs-Disney, J.L.3
  • 122
    • 66349108231 scopus 로고    scopus 로고
    • A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity
    • Bramsen JB, Laursen MB, Nielsen AF et al. A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity. Nucleic Acids Res. 37(9), 2867-2881 (2009
    • (2009) Nucleic Acids Res , vol.37 , Issue.9 , pp. 2867-2881
    • Bramsen, J.B.1    Laursen, M.B.2    Nielsen, A.F.3
  • 124
    • 0036294527 scopus 로고    scopus 로고
    • Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells
    • Zeng Y, Wagner E, Cullen B. Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells. Mol. Cell 9, 1327-1333 (2002
    • (2002) Mol. Cell , vol.9 , pp. 1327-1333
    • Zeng, Y.1    Wagner, E.2    Cullen, B.3
  • 125
    • 12844285548 scopus 로고    scopus 로고
    • Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs
    • Yi R, Doehle B, Qin Y. Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs. RNA 11( 2), 220-226 (2005
    • (2005) RNA , vol.11 , Issue.2 , pp. 220-226
    • Yi, R.1    Doehle, B.2    Qin, Y.3
  • 126
    • 84868361171 scopus 로고    scopus 로고
    • Arresting the culprit: Targeted antagomir delivery to sequester oncogenic miR?221 in HCC
    • Kasinski AL, Slack FJ. Arresting the culprit: Targeted antagomir delivery to sequester oncogenic miR?221 in HCC. Mol. Ther. Nucleic Acids 1, e12 (2012
    • (2012) Mol. Ther. Nucleic Acids , vol.1 , pp. e12
    • Kasinski, A.L.1    Slack, F.J.2
  • 127
    • 0035962892 scopus 로고    scopus 로고
    • A critical survey of the structure-function of the antisense oligo/RNA heteroduplex as substrate for RNase H
    • Zamaratski E, Pradeepkumar PI, Chattopadhyaya J. A critical survey of the structure-function of the antisense oligo/RNA heteroduplex as substrate for RNase H. J. Biochem. Biophys. Methods 48(3), 189-208 (2001
    • (2001) J. Biochem. Biophys. Methods , vol.48 , Issue.3 , pp. 189-208
    • Zamaratski, E.1    Pradeepkumar, P.I.2    Chattopadhyaya, J.3
  • 128
    • 79953202455 scopus 로고    scopus 로고
    • Silencing of microRNA families by seed-targeting tiny LNAs
    • Obad S, dos Santos CO, Petri A et al. Silencing of microRNA families by seed-targeting tiny LNAs. Nat. Genet. 43(4), 371-378 (2011
    • (2011) Nat. Genet , vol.43 , Issue.4 , pp. 371-378
    • Obad, S.1    Dos Santos, C.O.2    Petri, A.3
  • 129
    • 0035113736 scopus 로고    scopus 로고
    • Locked nucleic acid (LNA): Finetuning the recognition of DNA and RNA
    • Braasch DA, Corey DR. Locked nucleic acid (LNA): finetuning the recognition of DNA and RNA. Chem. Biol. 8(1), 1-7 (2001
    • (2001) Chem. Biol , vol.8 , Issue.1 , pp. 1-7
    • Braasch, D.A.1    Corey, D.R.2
  • 130
    • 74049124186 scopus 로고    scopus 로고
    • Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application
    • Jackson AL, Linsley PS. Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat. Rev. Drug Discov. 9(1), 57-67 (2010
    • (2010) Nat. Rev. Drug Discov , vol.9 , Issue.1 , pp. 57-67
    • Jackson, A.L.1    Linsley, P.S.2
  • 131
    • 0034015113 scopus 로고    scopus 로고
    • Phosphorothioate oligodeoxynucleotides: What is their origin and what is unique about them?
    • Eckstein F. Phosphorothioate oligodeoxynucleotides: what is their origin and what is unique about them?. Antisense Nucleic Acid Drug Dev. 10(2), 117-121 (2000
    • (2000) Antisense Nucleic Acid Drug Dev , vol.10 , Issue.2 , pp. 117-121
    • Eckstein, F.1
  • 132
    • 28444469246 scopus 로고    scopus 로고
    • Silencing of microRNAs in vivo with 'antagomirs'
    • Krutzfeldt J, Rajewsky N, Braich R et al. Silencing of microRNAs in vivo with 'antagomirs'. Nature 438(7068), 685-689 (2005
    • (2005) Nature , vol.438 , Issue.7068 , pp. 685-689
    • Krutzfeldt, J.1    Rajewsky, N.2    Braich, R.3
  • 133
    • 38649105459 scopus 로고    scopus 로고
    • Gait MJ. MiR?122 targeting with LNA/2'-Omethyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNA-peptide conjugates
    • Fabani MM, Gait MJ. miR?122 targeting with LNA/2'-Omethyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNA-peptide conjugates. RNA 14(2), 336-346 (2008
    • (2008) RNA , vol.14 , Issue.2 , pp. 336-346
    • Fabani, M.M.1
  • 134
    • 79251581020 scopus 로고    scopus 로고
    • The art of microRNA research
    • van Rooij E. The art of microRNA research. Circ. Res. 108(2), 219-234 (2011
    • (2011) Circ. Res , vol.108 , Issue.2 , pp. 219-234
    • Van Rooij, E.1
  • 135
    • 84891498808 scopus 로고    scopus 로고
    • Antagomirs and microRNA in status epilepticus
    • Henshall DC. Antagomirs and microRNA in status epilepticus. Epilepsia 54, 17-19 (2013
    • (2013) Epilepsia , vol.54 , pp. 17-19
    • Henshall, D.C.1
  • 136
    • 79960595150 scopus 로고    scopus 로고
    • MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis
    • Kurowska-Stolarska M, Alivernini S, Ballantine LE et al. MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proc. Natl Acad. Sci. USA 108(27), 11193-11198 (2011
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , Issue.27 , pp. 11193-11198
    • Kurowska-Stolarska, M.1    Alivernini, S.2    Ballantine, L.E.3
  • 137
    • 80053897836 scopus 로고    scopus 로고
    • Silencing of microRNA?21 in vivo ameliorates autoimmune splenomegaly in lupus mice
    • Garchow BG, Bartulos Encinas O, Leung YT et al. Silencing of microRNA?21 in vivo ameliorates autoimmune splenomegaly in lupus mice. EMBO Mol. Med. 3(10), 605-615 (2011
    • (2011) EMBO Mol. Med , vol.3 , Issue.10 , pp. 605-615
    • Garchow, B.G.1    Bartulos Encinas, O.2    Leung, Y.T.3
  • 138
    • 79960015327 scopus 로고    scopus 로고
    • Antagonism of miR?33 in mice promotes reverse cholesterol transport and regression of atherosclerosis
    • Rayner KJ, Sheedy FJ, Esau CC et al. Antagonism of miR?33 in mice promotes reverse cholesterol transport and regression of atherosclerosis. J. Clin. Invest. 121(7), 2921-2931 (2011
    • (2011) J. Clin. Invest , vol.121 , Issue.7 , pp. 2921-2931
    • Rayner, K.J.1    Sheedy, F.J.2    Esau, C.C.3
  • 139
    • 84857683479 scopus 로고    scopus 로고
    • An antagomir to microRNA Let7f promotes neuroprotection in an ischemic stroke model
    • Selvamani A, Sathyan P, Miranda RC, Sohrabji F. An antagomir to microRNA Let7f promotes neuroprotection in an ischemic stroke model. PLoS ONE 7(2), e32662 (2012
    • (2012) PLoS ONE , vol.7 , Issue.2 , pp. e32662
    • Selvamani, A.1    Sathyan, P.2    Miranda, R.C.3    Sohrabji, F.4
  • 140
    • 78149303249 scopus 로고    scopus 로고
    • MicroRNA sponges: Progress and possibilities
    • Ebert MS, Sharp PA. MicroRNA sponges: progress and possibilities. RNA 16(11), 2043-2050 (2010
    • (2010) RNA , vol.16 , Issue.11 , pp. 2043-2050
    • Ebert, M.S.1    Sharp, P.A.2
  • 142
    • 77449141681 scopus 로고    scopus 로고
    • Small molecule modifiers of the microRNA and RNA interference pathway
    • Deiters A. Small molecule modifiers of the microRNA and RNA interference pathway. AAPS J. 12(1), 51-60 (2010
    • (2010) AAPS J. , vol.12 , Issue.1 , pp. 51-60
    • Deiters, A.1
  • 143
    • 84897024057 scopus 로고    scopus 로고
    • Sequence-based design of bioactive small molecules that target precursor microRNAs
    • Velagapudi SP, Gallo SM, Disney MD. Sequence-based design of bioactive small molecules that target precursor microRNAs. Nat. Chem. Biol. 10(4), 291-297 (2014
    • (2014) Nat. Chem. Biol , vol.10 , Issue.4 , pp. 291-297
    • Velagapudi, S.P.1    Gallo, S.M.2    Disney, M.D.3
  • 144
    • 77953312157 scopus 로고    scopus 로고
    • Small molecule modifiers of microRNA miR?122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma
    • Young DD, Connelly CM, Grohmann C, Deiters A. Small molecule modifiers of microRNA miR?122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma. J. Am. Chem. Soc. 132(23), 7976-7981 (2010
    • (2010) J. Am. Chem. Soc , vol.132 , Issue.23 , pp. 7976-7981
    • Young, D.D.1    Connelly, C.M.2    Grohmann, C.3    Deiters, A.4
  • 145
    • 84894488215 scopus 로고    scopus 로고
    • Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor
    • Velagapudi SP, Disney MD. Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor. Chem. Commun. (Camb) 50(23), 3027-3029 (2014
    • (2014) Chem. Commun. (Camb , vol.50 , Issue.23 , pp. 3027-3029
    • Velagapudi, S.P.1    Disney, M.D.2
  • 146
    • 53349168896 scopus 로고    scopus 로고
    • Enhancement of RNAi by a small molecule antibiotic enoxacin
    • Zhang Q, Zhang C, Xi Z. Enhancement of RNAi by a small molecule antibiotic enoxacin. Cell Res. 18(10), 1077-1079 (2008
    • (2008) Cell Res , vol.18 , Issue.10 , pp. 1077-1079
    • Zhang, Q.1    Zhang, C.2    Xi, Z.3
  • 147
    • 79952717616 scopus 로고    scopus 로고
    • Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing
    • Melo S, Villanueva A, Moutinho C et al. Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing. Proc. Natl Acad. Sci. USA, 108(11), 4394-4399 (2011
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , Issue.11 , pp. 4394-4399
    • Melo, S.1    Villanueva, A.2    Moutinho, C.3
  • 148
    • 84895522921 scopus 로고    scopus 로고
    • Enoxacin elevates microRNA levels in rat frontal cortex and prevents learned helplessness
    • Smalheiser NR, Zhang H, Dwivedi Y. Enoxacin elevates microRNA levels in rat frontal cortex and prevents learned helplessness. Front. Psychiatry 5, 6 (2014
    • (2014) Front. Psychiatry , vol.5 , Issue.6
    • Smalheiser, N.R.1    Zhang, H.2    Dwivedi, Y.3
  • 149
    • 66449136951 scopus 로고    scopus 로고
    • Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model
    • Kota J, Chivukula RR, O'Donnell KA et al. Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 137(6), 1005-1017 (2009
    • (2009) Cell , vol.137 , Issue.6 , pp. 1005-1017
    • Kota, J.1    Chivukula, R.R.2    O'donnell, K.A.3
  • 150
    • 84861902017 scopus 로고    scopus 로고
    • Lipid-based nanoparticle delivery of Pre-miR?107 inhibits the tumorigenicity of head and neck squamous cell carcinoma
    • Piao L, Zhang M, Datta J et al. Lipid-based nanoparticle delivery of Pre-miR?107 inhibits the tumorigenicity of head and neck squamous cell carcinoma. Mol. Ther. 20(6), 1261-1269 (2012
    • (2012) Mol. Ther , vol.20 , Issue.6 , pp. 1261-1269
    • Piao, L.1    Zhang, M.2    Datta, J.3
  • 151
    • 84886415287 scopus 로고    scopus 로고
    • Cationic lipid nanoparticles for therapeutic delivery of siRNA and miRNA to murine liver tumor
    • Hsu S-H, Yu B, Wang X et al. Cationic lipid nanoparticles for therapeutic delivery of siRNA and miRNA to murine liver tumor. Nanomed. Nanotechnol. 9(8), 1169-1180 (2013
    • (2013) Nanomed. Nanotechnol , vol.9 , Issue.8 , pp. 1169-1180
    • Hsu, S.-H.1    Yu, B.2    Wang, X.3
  • 152
    • 43049176170 scopus 로고    scopus 로고
    • A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
    • Akinc A, Zumbuehl A, Goldberg M et al. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat. Biotechnol. 26(5), 561-569 (2008
    • (2008) Nat. Biotechnol , vol.26 , Issue.5 , pp. 561-569
    • Akinc, A.1    Zumbuehl, A.2    Goldberg, M.3
  • 154
    • 79961043075 scopus 로고    scopus 로고
    • MicroRNA delivery by cationic lipoplexes for lung cancer therapy
    • Wu Y, Crawford M, Yu B, Mao Y, Nana-Sinkam SP, Lee LJ. MicroRNA delivery by cationic lipoplexes for lung cancer therapy. Mol. Pharm. 8(4), 1381-1389 (2011
    • (2011) Mol. Pharm , vol.8 , Issue.4 , pp. 1381-1389
    • Wu, Y.1    Crawford, M.2    Yu, B.3    Mao, Y.4    Nana-Sinkam, S.P.5    Lee, L.J.6
  • 155
    • 84878858306 scopus 로고    scopus 로고
    • Therapeutic delivery of microRNA-29b by cationic lipoplexes for lung cancer
    • Wu Y, Crawford M, Mao Y et al. Therapeutic delivery of microRNA-29b by cationic lipoplexes for lung cancer. Mol. Ther. Nucleic Acids 2, e84 (2013
    • (2013) Mol. Ther. Nucleic Acids , vol.2 , pp. e84
    • Wu, Y.1    Crawford, M.2    Mao, Y.3
  • 156
    • 84875740719 scopus 로고    scopus 로고
    • Systemic delivery of microRNA-34a for cancer stem cell therapy
    • Shi S, Han L, Gong T, Zhang Z, Sun X. Systemic delivery of microRNA-34a for cancer stem cell therapy. Angew. Chem. Int. Ed. Engl. 52(14), 3901-3905 (2013
    • (2013) Angew. Chem. Int. Ed. Engl , vol.52 , Issue.14 , pp. 3901-3905
    • Shi, S.1    Han, L.2    Gong, T.3    Zhang, Z.4    Sun, X.5
  • 157
    • 77956269093 scopus 로고    scopus 로고
    • Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy
    • Chen Y, Zhu X, Zhang X, Liu B, Huang L. Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy. Mol. Ther. 18(9), 1650-1656 (2010
    • (2010) Mol. Ther , vol.18 , Issue.9 , pp. 1650-1656
    • Chen, Y.1    Zhu, X.2    Zhang, X.3    Liu, B.4    Huang, L.5
  • 158
    • 79957900919 scopus 로고    scopus 로고
    • Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice
    • Trang P, Wiggins JF, Daige CL et al. Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice. Mol. Ther. 19(6), 1116-1122 (2011
    • (2011) Mol. Ther , vol.19 , Issue.6 , pp. 1116-1122
    • Trang, P.1    Wiggins, J.F.2    Daige, C.L.3
  • 160
    • 84863229706 scopus 로고    scopus 로고
    • Efficient delivery of sticky siRNA and potent gene silencing in a prostate cancer model using a generation 5 triethanolamine-core PAMAM dendrimer
    • Liu X, Liu C, Laurini E et al. Efficient delivery of sticky siRNA and potent gene silencing in a prostate cancer model using a generation 5 triethanolamine-core PAMAM dendrimer. Mol. Pharm. 9(3), 470-481 (2011
    • (2011) Mol. Pharm , vol.9 , Issue.3 , pp. 470-481
    • Liu, X.1    Liu, C.2    Laurini, E.3
  • 161
    • 84862808036 scopus 로고    scopus 로고
    • Cationic polyurethanes-short branch PEI-mediated delivery of Mir145 inhibited epithelial-mesenchymal transdifferentiation and cancer stem-like properties and in lung adenocarcinoma
    • Chiou GY, Cherng JY, Hsu HS et al. Cationic polyurethanes-short branch PEI-mediated delivery of Mir145 inhibited epithelial-mesenchymal transdifferentiation and cancer stem-like properties and in lung adenocarcinoma. J. Control. Release 159(2), 240-250 (2012
    • (2012) J. Control. Release , vol.159 , Issue.2 , pp. 240-250
    • Chiou, G.Y.1    Cherng, J.Y.2    Hsu, H.S.3
  • 162
    • 83355166283 scopus 로고    scopus 로고
    • Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethane-short branch PEI
    • Yang YP, Chien Y, Chiou GY et al. Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethane-short branch PEI. Biomaterials 33(5), 1462-1476 (2012
    • (2012) Biomaterials , vol.33 , Issue.5 , pp. 1462-1476
    • Yang, Y.P.1    Chien, Y.2    Chiou, G.Y.3
  • 163
    • 79955774513 scopus 로고    scopus 로고
    • A brain-targeted rabies virus glycoprotein-disulfide linked PEI nanocarrier for delivery of neurogenic microRNA
    • Hwang do W, Son S, Jang J et al. A brain-targeted rabies virus glycoprotein-disulfide linked PEI nanocarrier for delivery of neurogenic microRNA. Biomaterials 32(21), 4968-4975 (2011
    • (2011) Biomaterials , vol.32 , Issue.21 , pp. 4968-4975
  • 164
    • 68549104191 scopus 로고    scopus 로고
    • Nanotechnologies and controlled release systems for the delivery of antisense oligonucleotides and small interfering RNA
    • Fattal E, Barratt G. Nanotechnologies and controlled release systems for the delivery of antisense oligonucleotides and small interfering RNA. Br. J. Pharmacol. 157(2), 179-194 (2009
    • (2009) Br. J. Pharmacol , vol.157 , Issue.2 , pp. 179-194
    • Fattal, E.1    Barratt, G.2
  • 165
    • 84862993281 scopus 로고    scopus 로고
    • Nanoparticle-based therapy in an in vivo microRNA-155 (miR?155)-dependent mouse model of lymphoma
    • Babar IA, Cheng CJ, Booth CJ et al. Nanoparticle-based therapy in an in vivo microRNA-155 (miR?155)-dependent mouse model of lymphoma. Proc. Natl Acad. Sci. USA 109(26), e1695-e1704 (2012
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , Issue.26 , pp. e1695-e1704
    • Babar, I.A.1    Cheng, C.J.2    Booth, C.J.3
  • 166
    • 84860720576 scopus 로고    scopus 로고
    • Polymer nanoparticle-mediated delivery of microRNA inhibition and alternative splicing
    • Cheng CJ, Saltzman WM. Polymer nanoparticle-mediated delivery of microRNA inhibition and alternative splicing. Mol. Pharm. 9(5), 1481-1488 (2012
    • (2012) Mol. Pharm , vol.9 , Issue.5 , pp. 1481-1488
    • Cheng, C.J.1    Saltzman, W.M.2
  • 167
    • 84861473531 scopus 로고    scopus 로고
    • Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticles
    • Tivnan A, Orr WS, Gubala V et al. Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticles. PLoS ONE 7(5), e38129 (2012
    • (2012) PLoS ONE , vol.7 , Issue.5 , pp. e38129
    • Tivnan, A.1    Orr, W.S.2    Gubala, V.3
  • 168
    • 9144247189 scopus 로고    scopus 로고
    • Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
    • Soutschek J, Akinc A, Bramlage B et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432(7014), 173-178 (2004
    • (2004) Nature , vol.432 , Issue.7014 , pp. 173-178
    • Soutschek, J.1    Akinc, A.2    Bramlage, B.3
  • 170
    • 84862908547 scopus 로고    scopus 로고
    • Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes
    • Montecalvo A, Larregina AT, Shufesky WJ et al. Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood 119(3), 756-766 (2012
    • (2012) Blood , vol.119 , Issue.3 , pp. 756-766
    • Montecalvo, A.1    Larregina, A.T.2    Shufesky, W.J.3
  • 171
    • 84893577906 scopus 로고    scopus 로고
    • A paradigm shift for extracellular vesicles as small RNA carriers: From cellular waste elimination to therapeutic applications
    • Hagiwara K, Ochiya T, Kosaka N. A paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications. Drug Deliv. Transl. Res. 4, 31-37 (2014
    • (2014) Drug Deliv. Transl. Res , vol.4 , pp. 31-37
    • Hagiwara, K.1    Ochiya, T.2    Kosaka, N.3
  • 172
    • 79953858598 scopus 로고    scopus 로고
    • Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
    • Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat. Biotechnol. 29(4), 341-345 (2011
    • (2011) Nat. Biotechnol , vol.29 , Issue.4 , pp. 341-345
    • Alvarez-Erviti, L.1    Seow, Y.2    Yin, H.3    Betts, C.4    Lakhal, S.5    Wood, M.J.6
  • 173
    • 84871923602 scopus 로고    scopus 로고
    • Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells
    • Ohno SI, Takanashi M, Sudo K et al. Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells. Mol. Ther. 21(1), 185-191 (2013
    • (2013) Mol. Ther , vol.21 , Issue.1 , pp. 185-191
    • Ohno, S.I.1    Takanashi, M.2    Sudo, K.3
  • 174
    • 84862785747 scopus 로고    scopus 로고
    • Development of a microRNA delivery system based on bacteriophage MS2 virus-like particles
    • Pan Y, Zhang Y, Jia T, Zhang K, Li J, Wang L. Development of a microRNA delivery system based on bacteriophage MS2 virus-like particles. FEBS J. 279(7), 1198-1208 (2012
    • (2012) FEBS J. , vol.279 , Issue.7 , pp. 1198-1208
    • Pan, Y.1    Zhang, Y.2    Jia, T.3    Zhang, K.4    Li, J.5    Wang, L.6
  • 175
    • 79958858482 scopus 로고    scopus 로고
    • Targeted delivery of mutant tolerant anti-coxsackievirus artificial microRNAs using folate conjugated bacteriophage Phi29 pRNA
    • Ye X, Liu Z, Hemida MG, Yang D. Targeted delivery of mutant tolerant anti-coxsackievirus artificial microRNAs using folate conjugated bacteriophage Phi29 pRNA. PLoS ONE 6(6), e21215 (2011
    • (2011) PLoS ONE , vol.6 , Issue.6 , pp. e21215
    • Ye, X.1    Liu, Z.2    Hemida, M.G.3    Yang, D.4


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