Shielding the messenger (RNA): MicroRNA-based anticancer therapies

Pharmacology and Therapeutics

Volumn 131, Issue 1, 2011, Pages 18-32

  Sotillo, Elena ^a   Thomas Tikhonenko, Andrei ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b 4056 Colket Translational Research Building ^*  (United States)

Author keywords

Adjuvant; Cancer; Chemosensitivity; miRNA; Target prediction; Therapy

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ANTAGOMIR; ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; BORTEZOMIB; CAMPTOTHECIN; CISPLATIN; CURCUMIN; CYTARABINE; DOCETAXEL; DOXORUBICIN; DOXYCYCLINE; ETEPLIRSEN; ETOPOSIDE; FLUOROURACIL; GELDANAMYCIN; GEMCITABINE; IMATINIB; LIPOPLEX; LOCKED NUCLEIC ACID; MELPHALAN; MICRORNA; MORPHOLINO; NSC 236613; NSC 265450; NSC 621888; NSC 622700; NSC 670550; ONCOMIR; PACLITAXEL; RIBONUCLEOTIDE; SMALL INTERFERING RNA; TAMOXIFEN; TRANSFER RNA; UNCLASSIFIED DRUG; VINBLASTINE; VINCRISTINE;

ADENOVIRUS; ARTICLE; BIOGENESIS; BREAST CANCER; BURKITT LYMPHOMA; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CANCER THERAPY; CLINICAL TRIAL (TOPIC); DATA BASE; DRUG MECHANISM; DRUG TARGETING; DUCHENNE MUSCULAR DYSTROPHY; EPIGENETICS; GENE EXPRESSION; GENE LOCUS; GENE MAPPING; GENE TARGETING; GLIOBLASTOMA; HEPATITIS C; HUMAN; IMMUNE RESPONSE; IN VIVO STUDY; INVERTEBRATE; LENTIVIRINAE; LEUKEMIA; LIVER CELL CARCINOMA; LUNG CANCER; LUNG SMALL CELL CANCER; MEDICAL RESEARCH; MEDULLOBLASTOMA; METASTASIS; MULTIPLE MYELOMA; NEOPLASM; NEUROBLASTOMA; NONHUMAN; ONCOGENE; OVARY CANCER; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; PROTO ONCOGENE; RETINOBLASTOMA; RNA STABILITY; RNA TRANSLATION; STOMACH CANCER; TRANSCRIPTION REGULATION; TUMOR; TUMOR SUPPRESSOR GENE; VALIDATION STUDY; VERTEBRATE; VIRAL GENE THERAPY;

EID: 79956227111     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2011.04.006     Document Type: Review

References (279)

1. A. Aartsma-Rus, W.E. Kaman, M. Bremmer-Bout, A.A. Janson, J.T. den Dunnen, and G.J. van Ommen Comparative analysis of antisense oligonucleotide analogs for targeted DMD exon 46 skipping in muscle cells Gene Ther 11 2004 1391 1398 (Pubitemid 39263892)
2. Y. Akao, S. Noguchi, A. Iio, K. Kojima, T. Takagi, and T. Naoe Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cells Cancer Lett 300 2011 197 204
3. P. Alexiou, T. Vergoulis, M. Gleditzsch, G. Prekas, T. Dalamagas, and M. Megraw miRGen 2.0: a database of microRNA genomic information and regulation Nucleic Acids Res 38 2010 137 141
4. J. Alter, F. Lou, A. Rabinowitz, H. Yin, J. Rosenfeld, and S.D. Wilton Systemic delivery of morpholino oligonucleotide restores dystrophin expression bodywide and improves dystrophic pathology Nat Med 12 2006 175 177 (Pubitemid 43214742)
5. N. Azoitei, G.V. Pusapati, A. Kleger, P. Moller, R. Kufer, and F. Genze Protein kinase D2 is a crucial regulator of tumour cell-endothelial cell communication in gastrointestinal tumours Gut 59 2010 1316 1330
6. D. Baek, J. Villen, C. Shin, F.D. Camargo, S.P. Gygi, and D.P. Bartel The impact of microRNAs on protein output Nature 455 2008 64 71
7. A. Bagchi, and A.A. Mills The quest for the 1p36 tumor suppressor Cancer Res 68 2008 2551 2556 (Pubitemid 351556249)
8. F. Balaguer, A. Link, J.J. Lozano, M. Cuatrecasas, T. Nagasaka, and C.R. Boland Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis Cancer Res 70 2010 6609 6618
9. E. Batlle, E. Sancho, C. Franci, D. Dominguez, M. Monfar, and J. Baulida The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells Nat Cell Biol 2 2000 84 89
10. R. Benetti, S. Gonzalo, I. Jaco, P. Munoz, S. Gonzalez, and S. Schoeftner A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases Nat Struct Mol Biol 15 2008 268 279 (Pubitemid 351654050)
11. I. Bentwich, A. Avniel, Y. Karov, R. Aharonov, S. Gilad, and O. Barad Identification of hundreds of conserved and nonconserved human microRNAs Nat Genet 37 2005 766 770 (Pubitemid 41754896)
12. E. Berezikov, W.J. Chung, J. Willis, E. Cuppen, and E.C. Lai Mammalian mirtron genes Mol Cell 28 2007 328 336 (Pubitemid 47600007)
13. E. Bernstein, A.A. Caudy, S.M. Hammond, and G.J. Hannon Role for a bidentate ribonuclease in the initiation step of RNA interference Nature 409 2001 363 366 (Pubitemid 32151243)
14. D. Betel, M. Wilson, A. Gabow, D.S. Marks, and C. Sander The microRNA.org resource: targets and expression Nucleic Acids Res 36 2008 149 153
15. P.E. Blower, J.H. Chung, J.S. Verducci, S. Lin, J.K. Park, and Z. Dai MicroRNAs modulate the chemosensitivity of tumor cells Mol Cancer Ther 7 2008 1 9
16. M.T. Bohnsack, K. Czaplinski, and D. Gorlich Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs RNA 10 2004 185 191 (Pubitemid 38129823)
17. G.T. Bommer, I. Gerin, Y. Feng, A.J. Kaczorowski, R. Kuick, and R.E. Love p53-mediated activation of miRNA34 candidate tumor-suppressor genes Curr Biol 17 2007 1298 1307 (Pubitemid 47176893)
18. C.P. Bracken, P.A. Gregory, N. Kolesnikoff, A.G. Bert, J. Wang, and M.F. Shannon A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition Cancer Res 68 2008 7846 7854
19. J. Braun, C. Hoang-Vu, H. Dralle, and S. Huttelmaier Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas Oncogene 29 2010 4237 4244
20. A.G. Brown, F.M. Ross, E.M. Dunne, C.M. Steel, and E.M. Weir-Thompson Evidence for a new tumour suppressor locus (DBM) in human B-cell neoplasia telomeric to the retinoblastoma gene Nat Genet 3 1993 67 72 (Pubitemid 23063291)
21. M.J. Bueno, d.C.I. Perez, C.M. Gomez de, J. Santos, G.A. Calin, and J.C. Cigudosa Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression Cancer Cell 13 2008 496 506 (Pubitemid 351763902)
22. U. Burk, J. Schubert, U. Wellner, O. Schmalhofer, E. Vincan, and S. Spaderna A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells EMBO Rep 9 2008 582 589 (Pubitemid 351772923)
23. G.A. Calin, C.D. Dumitru, M. Shimizu, R. Bichi, S. Zupo, and E. Noch Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia Proc Natl Acad Sci U S A 99 2002 15524 15529 (Pubitemid 35403967)
24. A. Cano, M.A. Perez-Moreno, I. Rodrigo, A. Locascio, M.J. Blanco, and M.G. del Barrio The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression Nat Cell Biol 2 2000 76 83
25. M. Carrillo, S. Kim, S.K. Rajpurohit, V. Kulkarni, and P. Jagadeeswaran Zebrafish von Willebrand factor Blood Cells Mol Dis 9 45 2010 326 333
26. M.A. Castilla, G. Moreno-Bueno, L. Romero-Perez, D.V. Van, M. Biscuola, and M.A. Lopez-Garcia Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma J Pathol 223 2011 72 80
27. C. Cattoglio, G. Facchini, D. Sartori, A. Antonelli, A. Miccio, and B. Cassani Hot spots of retroviral integration in human CD34+ hematopoietic cells Blood 110 2007 1770 1778 (Pubitemid 47443887)
28. T.C. Chang, E.A. Wentzel, O.A. Kent, K. Ramachandran, M. Mullendore, and K.H. Lee Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis Mol Cell 26 2007 745 752 (Pubitemid 46856245)
29. T.C. Chang, D. Yu, Y.S. Lee, E.A. Wentzel, D.E. Arking, and K.M. West Widespread microRNA repression by Myc contributes to tumorigenesis Nat Genet 40 2008 43 50
30. T.C. Chang, L.R. Zeitels, H.W. Hwang, R.R. Chivukula, E.A. Wentzel, and M. Dews Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation Proc Natl Acad Sci U S A 106 2009 3384 3389
31. C.Z. Chen, L. Li, H.F. Lodish, and D.P. Bartel MicroRNAs modulate hematopoietic lineage differentiation Science 303 2004 83 86 (Pubitemid 38055775)
32. Z. Chen, H. Zeng, Y. Guo, P. Liu, H. Pan, and A. Deng miRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-Myc J Exp Clin Cancer Res 29 2010 151
33. Y. Chen, J. Zuo, Y. Liu, H. Gao, and W. Liu Inhibitory effects of miRNA-200c on chemotherapy-resistance and cell proliferation of gastric cancer SGC7901/DDP cells Chin J Cancer 29 2010 1006 1011
34. T.P. Chendrimada, K.J. Finn, X. Ji, D. Baillat, R.I. Gregory, and S.A. Liebhaber MicroRNA silencing through RISC recruitment of eIF6 Nature 447 2007 823 828 (Pubitemid 46920131)
35. T.P. Chendrimada, R.I. Gregory, E. Kumaraswamy, J. Norman, N. Cooch, and K. Nishikura TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing Nature 436 2005 740 744 (Pubitemid 41117280)
36. J. Cheng, P. Scully, J.Y. Shew, W.H. Lee, V. Vila, and M. Haas Homozygous deletion of the retinoblastoma gene in an acute lymphoblastic leukemia (T) cell line Blood 75 1990 730 735
37. S.W. Chi, J.B. Zang, A. Mele, and R.B. Darnell Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps Nature 460 2009 479 486
38. L.J. Chin, E. Ratner, S. Leng, R. Zhai, S. Nallur, and I. Babar A SNP in a let-7 microRNA complementary site in the KRAS 3′ untranslated region increases non-small cell lung cancer risk Cancer Res 68 2008 8535 8540
39. W.Y. Choi, A.J. Giraldez, and A.F. Schier Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430 Science 318 2007 271 274 (Pubitemid 47574854)
40. N.R. Christoffersen, R. Shalgi, L.B. Frankel, E. Leucci, M. Lees, and M. Klausen p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC Cell Death Differ 17 2010 236 245
41. E.Y. Chung, M. Dews, D. Cozma, D. Yu, E.A. Wentzel, and T.C. Chang c-Myb oncoprotein is an essential target of the dleu2 tumor suppressor microRNA cluster Cancer Biol Ther 7 2008 1758 1764
42. A. Cimmino, G.A. Calin, M. Fabbri, M.V. Iorio, M. Ferracin, and M. Shimizu miR-15 and miR-16 induce apoptosis by targeting BCL2 Proc Natl Acad Sci U S A 102 2005 13944 13949 (Pubitemid 41377683)
43. J. Comijn, G. Berx, P. Vermassen, K. Verschueren, G.L. van, and E. Bruyneel The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion Mol Cell 7 2001 1267 1278 (Pubitemid 32607360)
44. D.C. Corney, A. Flesken-Nikitin, A.K. Godwin, W. Wang, and A.Y. Nikitin MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth Cancer Res 67 2007 8433 8438 (Pubitemid 47437414)
45. J. Datta, H. Kutay, M.W. Nasser, G.J. Nuovo, B. Wang, and S. Majumder Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis Cancer Res 68 2008 5049 5058
46. E. Davis, F. Caiment, X. Tordoir, J. Cavaille, A. Ferguson-Smith, and N. Cockett RNAi-mediated allelic trans-interaction at the imprinted Rtl1/Peg11 locus Curr Biol 15 2005 743 749 (Pubitemid 40599929)
47. A.M. Denli, B.B. Tops, R.H. Plasterk, R.F. Ketting, and G.J. Hannon Processing of primary microRNAs by the Microprocessor complex Nature 432 2004 231 235 (Pubitemid 39545854)
48. M. Dews, J.L. Fox, S. Hultine, P. Sundaram, W. Wang, and Y.Y. Liu The myc-miR-17 92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors Cancer Res 70 2010 8233 8246
49. M. Dews, A. Homayouni, D. Yu, D. Murphy, C. Sevignani, and E. Wentzel Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster Nat Genet 38 2006 1060 1065 (Pubitemid 44325933)
50. J.G. Doench, C.P. Petersen, and P.A. Sharp siRNAs can function as miRNAs Genes Dev 17 2003 438 442 (Pubitemid 36258757)
51. J.G. Doench, and P.A. Sharp Specificity of microRNA target selection in translational repression Genes Dev 18 2004 504 511 (Pubitemid 38372808)
52. M.S. Ebert, J.R. Neilson, and P.A. Sharp MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells Nat Methods 4 2007 721 726 (Pubitemid 47338166)
53. M.S. Ebert, and P.A. Sharp MicroRNA sponges: progress and possibilities RNA 16 2010 2043 2050
54. S.M. Elbashir, W. Lendeckel, and T. Tuschl RNA interference is mediated by 21- and 22-nucleotide RNAs Genes Dev 15 2001 188 200 (Pubitemid 32107664)
55. A. Ernst, B. Campos, J. Meier, F. Devens, F. Liesenberg, and M. Wolter De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures Oncogene 29 2010 3411 3422
56. A. Esquela-Kerscher, P. Trang, J.F. Wiggins, L. Patrawala, A. Cheng, and L. Ford The let-7 microRNA reduces tumor growth in mouse models of lung cancer Cell Cycle 7 2008 759 764 (Pubitemid 351520040)
57. M. Fabbri, A. Bottoni, M. Shimizu, R. Spizzo, M.S. Nicoloso, and S. Rossi Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia JAMA 305 2011 59 67
58. M. Fabbri, R. Garzon, A. Cimmino, Z. Liu, N. Zanesi, and E. Callegari MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B Proc Natl Acad Sci U S A 104 2007 15805 15810 (Pubitemid 350035380)
59. Feng, D. D.; Zhang, H.; Zhang, P.; Zheng, Y. S.; Zhang, X. J.; Han, B. W.; et al. (in press). Down-regulated miR-331-5p and miR-27a are associated with chemotherapy resistance and relapse in leukemia. J Cell Mol Med. doi:10.1111/j.1582-4934.2010.01213.
60. A. Fire, S. Xu, M.K. Montgomery, S.A. Kostas, S.E. Driver, and C.C. Mello Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature 391 1998 806 811 (Pubitemid 28099681)
61. M. Folini, P. Gandellini, N. Longoni, V. Profumo, M. Callari, and M. Pennati miR-21: an oncomir on strike in prostate cancer Mol Cancer 9 2010 12
62. L. Fontana, M.E. Fiori, S. Albini, L. Cifaldi, S. Giovinazzi, and M. Forloni Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM PLoS One 3 2008 e2236
63. F. Fornari, L. Gramantieri, C. Giovannini, A. Veronese, M. Ferracin, and S. Sabbioni MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells Cancer Res 69 2009 5761 5767
64. F. Fornari, M. Milazzo, P. Chieco, M. Negrini, G.A. Calin, and G.L. Grazi MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells Cancer Res 70 2010 5184 5193
65. L.B. Frankel, N.R. Christoffersen, A. Jacobsen, M. Lindow, A. Krogh, and A.H. Lund Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells J Biol Chem 283 2008 1026 1033
66. T.Y. Fu, C.C. Chang, C.T. Lin, C.H. Lai, S.Y. Peng, and Y.J. Ko Let-7b-mediated suppression of basigin expression and metastasis in mouse melanoma cells Exp Cell Res 317 2010 445 451
67. Y. Fujita, K. Kojima, N. Hamada, R. Ohhashi, Y. Akao, and Y. Nozawa Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cells Biochem Biophys Res Commun 377 2008 114 119
68. G. Gabriely, T. Wurdinger, S. Kesari, C.C. Esau, J. Burchard, and P.S. Linsley MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators Mol Cell Biol 28 2008 5369 5380
69. H. Gal, G. Pandi, A.A. Kanner, Z. Ram, G. Lithwick-Yanai, and N. Amariglio MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells Biochem Biophys Res Commun 376 2008 86 90
70. L. Garzia, I. Andolfo, E. Cusanelli, N. Marino, G. Petrosino, and M.D. De MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma PLoS One 4 2009 e4998
71. M.E. Gatt, J.J. Zhao, M.S. Ebert, Y. Zhang, Z. Chu, and M. Mani MicroRNAs 15a/16-1 function as tumor suppressor genes in multiple myeloma Blood 2010 10.1182/blood-2009-11-253294 blood-2009-11-253294 [pii]
72. C.A. Gebeshuber, K. Zatloukal, and J. Martinez miR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis EMBO Rep 10 2009 400 405
73. A.J. Giraldez, Y. Mishima, J. Rihel, R.J. Grocock, D.S. van, and K. Inoue Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs Science 312 2006 75 79
74. P.A. Gregory, A.G. Bert, E.L. Paterson, S.C. Barry, A. Tsykin, and G. Farshid The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 Nat Cell Biol 10 2008 593 601 (Pubitemid 351627379)
75. R.I. Gregory, K.P. Yan, G. Amuthan, T. Chendrimada, B. Doratotaj, and N. Cooch The microprocessor complex mediates the genesis of microRNAs Nature 432 2004 235 240 (Pubitemid 39545855)
76. S. Griffiths-Jones, H.K. Saini, D.S. van, and A.J. Enright miRBase: tools for microRNA genomics Nucleic Acids Res 36 2008 154 158
77. D. Grimm, K.L. Streetz, C.L. Jopling, T.A. Storm, K. Pandey, and C.R. Davis Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways Nature 441 2006 537 541 (Pubitemid 44050158)
78. A. Grishok, A.E. Pasquinelli, D. Conte, N. Li, S. Parrish, and I. Ha Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing Cell 106 2001 23 34 (Pubitemid 32709955)
79. L. Guo, Y. Liu, Y. Bai, Y. Sun, F. Xiao, and Y. Guo Gene expression profiling of drug-resistant small cell lung cancer cells by combining microRNA and cDNA expression analysis Eur J Cancer 46 2010 1692 1702
80. Y. Guo, L. Ma, M. Cristofanilli, R.P. Hart, A. Hao, and M. Schachner Transcription factor Sox11b is involved in spinal cord regeneration in adult zebrafish Neuroscience 172 2010 329 341
81. S. Hacein-Bey-Abina, A. Garrigue, G.P. Wang, J. Soulier, A. Lim, and E. Morillon Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1 J Clin Invest 118 2008 3132 3142
82. S. Hacein-Bey-Abina, K.C. von, M. Schmidt, M.P. McCormack, N. Wulffraat, and P. Leboulch LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1 Science 302 2003 415 419 (Pubitemid 37296260)
83. L. He, X. He, L.P. Lim, S.E. de, Z. Xuan, and Y. Liang A microRNA component of the p53 tumour suppressor network Nature 447 2007 1130 1134 (Pubitemid 47014436)
84. L. He, J.M. Thomson, M.T. Hemann, E. Hernando-Monge, D. Mu, and S. Goodson A microRNA polycistron as a potential human oncogene Nature 435 2005 828 833 (Pubitemid 40839734)
85. C. Hebert, K. Norris, M.A. Scheper, N. Nikitakis, and J.J. Sauk High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma Mol Cancer 6 2007 5
86. H. Hermeking The miR-34 family in cancer and apoptosis Cell Death Differ 17 2010 193 199
87. S.J. Howe, M.R. Mansour, K. Schwarzwaelder, C. Bartholomae, M. Hubank, and H. Kempski Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients J Clin Invest 118 2008 3143 3150
88. P.W. Hsu, H.D. Huang, S.D. Hsu, L.Z. Lin, A.P. Tsou, and C.P. Tseng miRNAMap: genomic maps of microRNA genes and their target genes in mammalian genomes Nucleic Acids Res 34 2006 135 139
89. R.J. Hsu, H.J. Yang, and H.J. Tsai Labeled microRNA pull-down assay system: an experimental approach for high-throughput identification of microRNA-target mRNAs Nucleic Acids Res 37 2009 e77
90. W. Hu, C.S. Chan, R. Wu, C. Zhang, Y. Sun, and J.S. Song Negative regulation of tumor suppressor p53 by microRNA miR-504 Mol Cell 38 2010 689 699
91. D.T. Humphreys, B.J. Westman, D.I. Martin, and T. Preiss MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function Proc Natl Acad Sci U S A 102 2005 16961 16966 (Pubitemid 41692666)
92. D.R. Hurst, M.D. Edmonds, and D.R. Welch Metastamir: the field of metastasis-regulatory microRNA is spreading Cancer Res 69 2009 7495 7498
93. G. Hutvagner, J. McLachlan, A.E. Pasquinelli, E. Balint, T. Tuschl, and P.D. Zamore A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA Science 293 2001 834 838 (Pubitemid 32743968)
94. G. Hutvagner, and P.D. Zamore A microRNA in a multiple-turnover RNAi enzyme complex Science 297 2002 2056 2066
95. J.H. Hwang, J. Voortman, E. Giovannetti, S.M. Steinberg, L.G. Leon, and Y.T. Kim Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer PLoS One 5 2010 e10630
96. H.W. Hwang, E.A. Wentzel, and J.T. Mendell A hexanucleotide element directs microRNA nuclear import Science 315 2007 97 100 (Pubitemid 46196987)
97. M. Inomata, H. Tagawa, Y.M. Guo, Y. Kameoka, N. Takahashi, and K. Sawada MicroRNA-17-92 down-regulates expression of distinct targets in different B-cell lymphoma subtypes Blood 113 2009 396 402
98. I. Ivanovska, A.S. Ball, R.L. Diaz, J.F. Magnus, M. Kibukawa, and J.M. Schelter MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression Mol Cell Biol 28 2008 2167 2174 (Pubitemid 351429964)
99. Q. Ji, X. Hao, Y. Meng, M. Zhang, J. Desano, and D. Fan Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres BMC Cancer 8 2008 266
100. C.D. Johnson, A. Esquela-Kerscher, G. Stefani, M. Byrom, K. Kelnar, and D. Ovcharenko The let-7 microRNA represses cell proliferation pathways in human cells Cancer Res 67 2007 7713 7722 (Pubitemid 47281364)
101. J.K. Kang, A. Malerba, L. Popplewell, K. Foster, and G. Dickson Antisense-induced myostatin exon skipping leads to muscle hypertrophy in mice following octa guanidine morpholino oligomer treatment Mol Ther 19 2010 159 164
102. H. Kaur, A. Arora, J. Wengel, and S. Maiti Thermodynamic, counterion, and hydration effects for the incorporation of locked nucleic acid nucleotides into DNA duplexes Biochemistry 45 2006 7347 7355 (Pubitemid 43877421)
103. M. Kertesz, N. Iovino, U. Unnerstall, U. Gaul, and E. Segal The role of site accessibility in microRNA target recognition Nat Genet 39 2007 1278 1284 (Pubitemid 47482690)
104. R.F. Ketting, S.E. Fischer, E. Bernstein, T. Sijen, G.J. Hannon, and R.H. Plasterk Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans Genes Dev 15 2001 2654 2659 (Pubitemid 32988876)
105. A. Khvorova, A. Reynolds, and S.D. Jayasena Functional siRNAs and miRNAs exhibit strand bias Cell 115 2003 209 216 (Pubitemid 37329584)
106. D.H. Kim, P. Saetrom, O. Snove Jr.; and J.J. Rossi MicroRNA-directed transcriptional gene silencing in mammalian cells Proc Natl Acad Sci U S A 105 2008 16230 16235
107. M. Kinali, V. Arechavala-Gomeza, L. Feng, S. Cirak, D. Hunt, and C. Adkin Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study Lancet Neurol 8 2009 918 928
108. M. Kiriakidou, G.S. Tan, S. Lamprinaki, M. De Planell-Saguer, P.T. Nelson, and Z. Mourelatos An mRNA m7G cap binding-like motif within human Ago2 represses translation Cell 129 2007 1141 1151 (Pubitemid 46891041)
109. U. Klein, M. Lia, M. Crespo, R. Siegel, Q. Shen, and T. Mo The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia Cancer Cell 17 2010 28 40
110. Y.W. Kong, I.G. Cannell, C.H. de Moor, K. Hill, P.G. Garside, and T.L. Hamilton The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene Proc Natl Acad Sci U S A 105 2008 8866 8871
111. W. Kong, H. Yang, L. He, J.J. Zhao, D. Coppola, and W.S. Dalton MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA Mol Cell Biol 28 2008 6773 6784
112. S.B. Koralov, S.A. Muljo, G.R. Galler, A. Krek, T. Chakraborty, and C. Kanellopoulou Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage Cell 132 2008 860 874 (Pubitemid 351312808)
113. M. Korpal, E.S. Lee, G. Hu, and Y. Kang The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2 J Biol Chem 283 2008 14910 14914
114. J. Kota, R.R. Chivukula, K.A. O'Donnell, E.A. Wentzel, C.L. Montgomery, and H.W. Hwang Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model Cell 137 2009 1005 1017
115. O. Kovalchuk, J. Filkowski, J. Meservy, Y. Ilnytskyy, V.P. Tryndyak, and V.F. Chekhun Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin Mol Cancer Ther 7 2008 2152 2159
116. A. Krek, D. Grun, M.N. Poy, R. Wolf, L. Rosenberg, and E.J. Epstein Combinatorial microRNA target predictions Nat Genet 37 2005 495 500 (Pubitemid 40617277)
117. A.J. Kriegel, Y. Fang, Y. Liu, Z. Tian, D. Mladinov, and I.R. Matus MicroRNA-target pairs in human renal epithelial cells treated with transforming growth factor beta 1: a novel role of miR-382 Nucleic Acids Res 38 2010 8338 8347
118. J. Krutzfeldt, N. Rajewsky, R. Braich, K.G. Rajeev, T. Tuschl, and M. Manoharan Silencing of microRNAs in vivo with 'antagomirs' Nature 438 2005 685 689
119. M.S. Kumar, J. Lu, K.L. Mercer, T.R. Golub, and T. Jacks Impaired microRNA processing enhances cellular transformation and tumorigenesis Nat Genet 39 2007 673 677 (Pubitemid 46676103)
120. M. Kumar, Z. Lu, A.A. Takwi, W. Chen, N.S. Callander, and K.S. Ramos Negative regulation of the tumor suppressor p53 gene by microRNAs Oncogene 30 2010 843 853
121. M. Lagos-Quintana, R. Rauhut, W. Lendeckel, and T. Tuschl Identification of novel genes coding for small expressed RNAs Science 294 2001 853 858 (Pubitemid 33032103)
122. A. Lal, F. Navarro, C.A. Maher, L.E. Maliszewski, N. Yan, and E. O'Day miR-24 inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3′UTR microRNA recognition elements Mol Cell 35 2009 610 625
123. F.F. Lan, H. Wang, Y.C. Chen, C.Y. Chan, S.S. Ng, and K. Li Hsa-let-7 g inhibits proliferation of hepatocellular carcinoma cells by downregulation of c-Myc and upregulation of p16(INK4A) Int J Cancer 128 2011 319 331
124. R.E. Lanford, E.S. Hildebrandt-Eriksen, A. Petri, R. Persson, M. Lindow, and M.E. Munk Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection Science 327 2010 198 201
125. N.C. Lau, L.P. Lim, E.G. Weinstein, and D.P. Bartel An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans Science 294 2001 858 862 (Pubitemid 33032104)
126. C. le Sage, R. Nagel, D.A. Egan, M. Schrier, E. Mesman, and A. Mangiola Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation EMBO J 26 2007 3699 3708 (Pubitemid 47236875)
127. M.T. Le, C. Teh, N. Shyh-Chang, H. Xie, B. Zhou, and V. Korzh MicroRNA-125b is a novel negative regulator of p53 Genes Dev 23 2009 862 876
128. Y. Lee, C. Ahn, J. Han, H. Choi, J. Kim, and J. Yim The nuclear RNase III Drosha initiates microRNA processing Nature 425 2003 415 419 (Pubitemid 37187272)
129. R.C. Lee, and V. Ambros An extensive class of small RNAs in Caenorhabditis elegans Science 294 2001 862 864 (Pubitemid 33032105)
130. Y.S. Lee, and A. Dutta The tumor suppressor microRNA let-7 represses the HMGA2 oncogene Genes Dev 21 2007 1025 1030 (Pubitemid 46686471)
131. R.C. Lee, R.L. Feinbaum, and V. Ambros The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 Cell 75 1993 843 854 (Pubitemid 24014542)
132. Y. Lee, I. Hur, S.Y. Park, Y.K. Kim, M.R. Suh, and V.N. Kim The role of PACT in the RNA silencing pathway EMBO J 25 2006 522 535
133. Y. Lee, K. Jeon, J.T. Lee, S. Kim, and V.N. Kim MicroRNA maturation: stepwise processing and subcellular localization EMBO J 21 2002 4663 4670 (Pubitemid 34984353)
134. Y. Lee, M. Kim, J. Han, K.H. Yeom, S. Lee, and S.H. Baek MicroRNA genes are transcribed by RNA polymerase II EMBO J 23 2004 4051 4060 (Pubitemid 39472426)
135. K.H. Lee, C. Lotterman, C. Karikari, N. Omura, G. Feldmann, and N. Habbe Epigenetic silencing of MicroRNA miR-107 regulates cyclin-dependent kinase 6 expression in pancreatic cancer Pancreatology 9 2009 293 301
136. C. Leucht, C. Stigloher, A. Wizenmann, R. Klafke, A. Folchert, and L. Bally-Cuif MicroRNA-9 directs late organizer activity of the midbrain-hindbrain boundary Nat Neurosci 11 2008 641 648 (Pubitemid 351748112)
137. C. Levy, M. Khaled, D. Iliopoulos, M.M. Janas, S. Schubert, and S. Pinner Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma Mol Cell 40 2010 841 849
138. B.P. Lewis, C.B. Burge, and D.P. Bartel Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets Cell 120 1 2005, Jan.14 15.-20. 120, 15-20
139. B.P. Lewis, I.H. Shih, M.W. Jones-Rhoades, D.P. Bartel, and C.B. Burge Prediction of mammalian microRNA targets Cell 115 2003 787 798 (Pubitemid 38058492)
140. N. Li, A.S. Flynt, H.R. Kim, L. Solnica-Krezel, and J.G. Patton Dispatched Homolog 2 is targeted by miR-214 through a combination of three weak microRNA recognition sites Nucleic Acids Res 36 2008 4277 4285
141. Y. Li, F. Guessous, Y. Zhang, C. Dipierro, B. Kefas, and E. Johnson MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes Cancer Res 69 2009 7569 7576
142. Y. Li, X. Zhu, J. Gu, H. Hu, D. Dong, and J. Yao Anti-miR-21 oligonucleotide enhances chemosensitivity of leukemic HL60 cells to arabinosylcytosine by inducing apoptosis Hematology 14 2010 215 221
143. Z. Liang, H. Wu, J. Xia, Y. Li, Y. Zhang, and K. Huang Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1 Biochem Pharmacol 79 2010 817 824
144. J.Y. Liao, L.M. Ma, Y.H. Guo, Y.C. Zhang, H. Zhou, and P. Shao Deep sequencing of human nuclear and cytoplasmic small RNAs reveals an unexpectedly complex subcellular distribution of miRNAs and tRNA 3′ trailers PLoS One 5 2010 e10563
145. J. Liu, M.A. Carmell, F.V. Rivas, C.G. Marsden, J.M. Thomson, and J.J. Song Argonaute2 is the catalytic engine of mammalian RNAi Science 305 2004 1437 1441 (Pubitemid 39167657)
146. C. Liu, K. Kelnar, B. Liu, X. Chen, T. Calhoun-Davis, and H. Li The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44 Nat Med 17 2011 211 215
147. Q. Liu, and Z. Paroo Biochemical principles of small RNA pathways Annu Rev Biochem 79 2010 295 319
148. J. Liu, F.V. Rivas, J. Wohlschlegel, J.R.I. Yates, R. Parker, and G.J. Hannon A role for the P-body component GW182 in microRNA function Nat Cell Biol 7 2005 1261 1266
149. J. Liu, M.A. Valencia-Sanchez, G.J. Hannon, and R. Parker MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies Nat Cell Biol 7 2005 719 723 (Pubitemid 40975754)
150. J. Lu, G. Getz, E.A. Miska, E. Alvarez-Saavedra, J. Lamb, and D. Peck MicroRNA expression profiles classify human cancers Nature 435 2005 834 838 (Pubitemid 40839735)
151. A. Lujambio, S. Ropero, E. Ballestar, M.F. Fraga, C. Cerrato, and F. Setien Genetic unmasking of an epigenetically silenced microRNA in human cancer cells Cancer Res 67 2007 1424 1429 (Pubitemid 46383366)
152. E. Lund, S. Guttinger, A. Calado, J.E. Dahlberg, and U. Kutay Nuclear export of microRNA precursors Science 303 2004 95 98 (Pubitemid 38055779)
153. L. Ma, F. Reinhardt, E. Pan, J. Soutschek, B. Bhat, and E.G. Marcusson Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model Nat Biotechnol 28 2010 341 347
154. L. Ma, J. Teruya-Feldstein, and R.A. Weinberg Tumour invasion and metastasis initiated by microRNA-10b in breast cancer Nature 449 2007 682 688 (Pubitemid 47552092)
155. L. Ma, J. Young, H. Prabhala, E. Pan, P. Mestdagh, and D. Muth miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis Nat Cell Biol 12 2010 247 256
156. Y.L. Ma, P. Zhang, F. Wang, M.P. Moyer, J.J. Yang, and Z.H. Liu Human embryonic stem cells and metastatic colorectal cancer cells shared the common endogenous human microRNA-26b J Cell Mol Med 2010 10.1111/j.1582-4934.2010.01170
157. I.J. Macrae, E. Ma, M. Zhou, C.V. Robinson, and J.A. Doudna In vitro reconstitution of the human RISC-loading complex Proc Natl Acad Sci U S A 105 2008 512 517 (Pubitemid 351171739)
158. N. Maki, R. Suetsugu-Maki, S. Sano, K. Nakamura, O. Nishimura, and H. Tarui Oocyte-type linker histone B4 is required for transdifferentiation of somatic cells in vivo FASEB J 24 2010 3462 3467
159. M. Maragkakis, P. Alexiou, G.L. Papadopoulos, M. Reczko, T. Dalamagas, and G. Giannopoulos Accurate microRNA target prediction correlates with protein repression levels BMC Bioinformatics 10 2009 295
160. V. Maselli, B.D. Di, and S. Banfi CoGemiR: a comparative genomics microRNA database BMC Genomics 9 2008 457
161. H. Matsuda, and Y.B. Shi An essential and evolutionarily conserved role of protein arginine methyltransferase 1 for adult intestinal stem cells during postembryonic development Stem Cells 28 2010 2073 2083
162. C. Mayr, M.T. Hemann, and D.P. Bartel Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation Science 315 2007 1576 1579 (Pubitemid 46449474)
163. G. McClorey, H.M. Moulton, P.L. Iversen, S. Fletcher, and S.D. Wilton Antisense oligonucleotide-induced exon skipping restores dystrophin expression in vitro in a canine model of DMD Gene Ther 13 2006 1373 1381 (Pubitemid 44420632)
164. G. Meister, M. Landthaler, A. Patkaniowska, Y. Dorsett, G. Teng, and T. Tuschl Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs Mol Cell 15 2004 185 197 (Pubitemid 38950966)
165. F. Meng, R. Henson, M. Lang, H. Wehbe, S. Maheshwari, and J.T. Mendell Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines Gastroenterology 130 2006 2113 2129 (Pubitemid 43816961)
166. L.M. Merlo, J.W. Pepper, B.J. Reid, and C.C. Maley Cancer as an evolutionary and ecological process Nat Rev Cancer 6 2006 924 935 (Pubitemid 44862677)
167. P. Mestdagh, A.K. Bostrom, F. Impens, E. Fredlund, P.G. Van, and A.P. De The miR-17-92 microRNA cluster regulates multiple components of the TGF-beta pathway in neuroblastoma Mol Cell 40 2010 762 773
168. A. Migliazza, F. Bosch, H. Komatsu, E. Cayanis, S. Martinotti, and E. Toniato Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia Blood 97 2001 2098 2104 (Pubitemid 32239092)
169. T.E. Miller, K. Ghoshal, B. Ramaswamy, S. Roy, J. Datta, and C.L. Shapiro MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1 J Biol Chem 283 2008 29897 29903
170. K.C. Miranda, T. Huynh, Y. Tay, Y.S. Ang, W.L. Tam, and A.M. Thomson A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes Cell 126 2006 1203 1217 (Pubitemid 44380294)
171. P.S. Mongroo, and A.K. Rustgi The role of the miR-200 family in epithelial-mesenchymal transition Cancer Biol Ther 10 2010 219 222
172. E. Montini, D. Cesana, M. Schmidt, F. Sanvito, C.C. Bartholomae, and M. Ranzani The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy J Clin Invest 119 2009 964 975
173. E. Montini, D. Cesana, M. Schmidt, F. Sanvito, M. Ponzoni, and C. Bartholomae Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration Nat Biotechnol 24 2006 687 696 (Pubitemid 43882120)
174. P.A. Morcos, Y. Li, and S. Jiang Vivo-morpholinos: a non-peptide transporter delivers Morpholinos into a wide array of mouse tissues Biotechniques 45 2008 613 618
175. E.E. Morrisey The magic and mystery of miR-21 J Clin Invest 120 2010 3817 3819
176. J.L. Mott, S. Kobayashi, S.F. Bronk, and G.J. Gores mir-29 regulates Mcl-1 protein expression and apoptosis Oncogene 26 2007 6133 6140 (Pubitemid 47414372)
177. H.M. Moulton, and J.D. Moulton Morpholinos and their peptide conjugates: therapeutic promise and challenge for Duchenne muscular dystrophy Biochim Biophys Acta 1798 2010 2296 2303
178. Z. Mourelatos, J. Dostie, S. Paushkin, A. Sharma, B. Charroux, and L. Abel miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs Genes Dev 16 2002 720 728 (Pubitemid 34274041)
179. P. Mu, Y.C. Han, D. Betel, E. Yao, M. Squatrito, and P. Ogrodowski Genetic dissection of the miR-17 92 cluster of microRNAs in Myc-induced B-cell lymphomas Genes Dev 23 2009 2806 2811
180. M.W. Nasser, J. Datta, G. Nuovo, H. Kutay, T. Motiwala, and S. Majumder Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1 J Biol Chem 283 2008 33394 33405
181. S. Nayak, and R.W. Herzog Progress and prospects: immune responses to viral vectors Gene Ther 17 2010 295 304
182. P. Neveu, M.J. Kye, S. Qi, D.E. Buchholz, D.O. Clegg, and M. Sahin MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states Cell Stem Cell 7 2010 671 681
183. E.J. Noonan, R.F. Place, D. Pookot, S. Basak, J.M. Whitson, and H. Hirata miR-449a targets HDAC-1 and induces growth arrest in prostate cancer Oncogene 28 2009 1714 1724
184. R.M. O'Connell, A.A. Chaudhuri, D.S. Rao, W.S. Gibson, A.B. Balazs, and D. Baltimore MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output Proc Natl Acad Sci U S A 107 2010 14235 14240
185. E. O'Day, and A. Lal MicroRNAs and their target gene networks in breast cancer Breast Cancer Res 12 2010 201
186. K.A. O'Donnell, E.A. Wentzel, K.I. Zeller, C.V. Dang, and J.T. Mendell c-Myc-regulated microRNAs modulate E2F1 expression Nature 435 2005 839 843 (Pubitemid 40839736)
187. K. Okamura, J.W. Hagen, H. Duan, D.M. Tyler, and E.C. Lai The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila Cell 130 2007 89 100 (Pubitemid 47031325)
188. V. Olive, M.J. Bennett, J.C. Walker, C. Ma, I. Jiang, and C. Cordon-Cardo miR-19 is a key oncogenic component of mir-17-92 Genes Dev 23 2009 2839 2849
189. A. Ota, H. Tagawa, S. Karnan, S. Tsuzuki, A. Karpas, and S. Kira Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma Cancer Res 64 2004 3087 3095 (Pubitemid 38581408)
190. T. Papagiannakopoulos, A. Shapiro, and K.S. Kosik MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells Cancer Res 68 2008 8164 8172
191. S.M. Park, A.B. Gaur, E. Lengyel, and M.E. Peter The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2 Genes Dev 22 2008 894 907 (Pubitemid 351482843)
192. Z. Paroo, Q. Liu, and X. Wang Biochemical mechanisms of the RNA-induced silencing complex Cell Res 17 2007 187 194 (Pubitemid 46438721)
193. M.K. Parra, S. Gee, N. Mohandas, and J.G. Conboy Efficient in vivo manipulation of alternative pre-mRNA splicing events using antisense morpholinos in mice J Biol Chem 2010 10.1074/jbc.M110.158154
194. D.M. Patrick, R.L. Montgomery, X. Qi, S. Obad, S. Kauppinen, and J.A. Hill Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice J Clin Invest 120 2010 3912 3916
195. Y. Pekarsky, U. Santanam, A. Cimmino, A. Palamarchuk, A. Efanov, and V. Maximov Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181 Cancer Res 66 2006 11590 11593 (Pubitemid 46094168)
196. F. Petrocca, R. Visone, M.R. Onelli, M.H. Shah, M.S. Nicoloso, and M.I. de E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer Cancer Cell 13 2008 272 286 (Pubitemid 351318375)
197. F. Pichiorri, S.S. Suh, A. Rocci, L.L. De, C. Taccioli, and R. Santhanam Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development Cancer Cell 18 2010 367 381
198. R.S. Pillai, S.N. Bhattacharyya, C.G. Artus, T. Zoller, N. Cougot, and E. Basyuk Inhibition of translational initiation by Let-7 microRNA in human cells Science 309 2005 1573 1576 (Pubitemid 41266485)
199. R.F. Place, L.C. Li, D. Pookot, E.J. Noonan, and R. Dahiya MicroRNA-373 induces expression of genes with complementary promoter sequences Proc Natl Acad Sci U S A 105 2008 1608 1613 (Pubitemid 351346562)
200. T.M. Rana Illuminating the silence: understanding the structure and function of small RNAs Nat Rev Mol Cell Biol 8 2007 23 36 (Pubitemid 46012012)
201. E. Ratner, L. Lu, M. Boeke, R. Barnett, S. Nallur, and L.J. Chin A KRAS-variant in ovarian cancer acts as a genetic marker of cancer risk Cancer Res 70 2010 6509 6515
202. H.E. Rauhala, S.E. Jalava, J. Isotalo, H. Bracken, S. Lehmusvaara, and T.L. Tammela miR-193b is an epigenetically regulated putative tumor suppressor in prostate cancer Int J Cancer 127 2010 1363 1372
203. N. Raver-Shapira, E. Marciano, E. Meiri, Y. Spector, N. Rosenfeld, and N. Moskovits Transcriptional activation of miR-34a contributes to p53-mediated apoptosis Mol Cell 26 2007 731 743 (Pubitemid 46856247)
204. B.J. Reinhart, F.J. Slack, M. Basson, A.E. Pasquinelli, J.C. Bettinger, and A.E. Rougvie The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans Nature 403 2000 901 906 (Pubitemid 30130993)
205. A.M. Roccaro, A. Sacco, B. Thompson, X. Leleu, A.K. Azab, and F. Azab MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma Blood 113 2009 6669 6680
206. J.G. Ruby, C.H. Jan, and D.P. Bartel Intronic microRNA precursors that bypass Drosha processing Nature 448 2007 83 86 (Pubitemid 47037009)
207. M. Sachdeva, S. Zhu, F. Wu, H. Wu, V. Walia, and S. Kumar p53 represses c-Myc through induction of the tumor suppressor miR-145 Proc Natl Acad Sci U S A 106 2009 3207 3212
208. Y. Saito, G. Liang, G. Egger, J.M. Friedman, J.C. Chuang, and G.A. Coetzee Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells Cancer Cell 9 2006 435 443 (Pubitemid 43832188)
209. D. Sayed, S. Rane, J. Lypowy, M. He, I.Y. Chen, and H. Vashistha MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths Mol Biol Cell 19 2008 3272 3282
210. D.S. Schwarz, G. Hutvagner, T. Du, Z. Xu, N. Aronin, and P.D. Zamore Asymmetry in the assembly of the RNAi enzyme complex Cell 115 2003 199 208 (Pubitemid 37329583)
211. G.K. Scott, M.D. Mattie, C.E. Berger, S.C. Benz, and C.C. Benz Rapid alteration of microRNA levels by histone deacetylase inhibition Cancer Res 66 2006 1277 1281 (Pubitemid 43259904)
212. M. Selbach, B. Schwanhausser, N. Thierfelder, Z. Fang, R. Khanin, and N. Rajewsky Widespread changes in protein synthesis induced by microRNAs Nature 455 2008 58 63
213. S.D. Selcuklu, M.T. Donoghue, and C. Spillane miR-21 as a key regulator of oncogenic processes Biochem Soc Trans 37 2009 918 925
214. P. Sethupathy, B. Corda, and A.G. Hatzigeorgiou TarBase: a comprehensive database of experimentally supported animal microRNA targets RNA 12 2006 192 197 (Pubitemid 43121923)
215. X.B. Shi, L. Xue, A.H. Ma, C.G. Tepper, H.J. Kung, and R.W. White miR-125b promotes growth of prostate cancer xenograft tumor through targeting pro-apoptotic genes Prostate 71 2011 538 549
216. K.H. Shin, S.D. Bae, H.S. Hong, R.H. Kim, M.K. Kang, and N.H. Park miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras Biochem Biophys Res Commun 2010 10.1016/j.bbrc.2010.12.055
217. C. Shin, J.W. Nam, K.K. Farh, H.R. Chiang, A. Shkumatava, and D.P. Bartel Expanding the microRNA targeting code: functional sites with centered pairing Mol Cell 38 2010 789 802
218. S.I. Shpyleva, V.P. Tryndyak, O. Kovalchuk, A. Starlard-Davenport, V.F. Chekhun, and F.A. Beland Role of ferritin alterations in human breast cancer cells Breast Cancer Res Treat 2010 10.1007/s10549-010-0849-4
219. L. Sinkkonen, T. Hugenschmidt, P. Berninger, D. Gaidatzis, F. Mohn, and C.G. Artus-Revel MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells Nat Struct Mol Biol 15 2008 259 267 (Pubitemid 351654045)
220. F.J. Slack, M. Basson, Z. Liu, V. Ambros, H.R. Horvitz, and G. Ruvkun The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor Mol Cell 5 2000 659 669
221. E. Sotillo, T. Laver, H. Mellert, J.M. Schelter, M.A. Cleary, and S. McMahon Myc overexpression brings out unexpected antiapoptotic effects of miR-34a Oncogene 2011 10.1038/onc.2010.634 onc2010634 [pii]
222. D.T. Starczynowski, F. Kuchenbauer, J. Wegrzyn, A. Rouhi, O. Petriv, and C.L. Hansen MicroRNA-146a disrupts hematopoietic differentiation and survival Exp Hematol 2010 10.1016/j.exphem.2010.09.011
223. A. Stark, J. Brennecke, R.B. Russell, and S.M. Cohen Identification of Drosophila microRNA targets PLoS Biol 1 2003 E60
224. H. Su, J.R. Yang, T. Xu, J. Huang, L. Xu, and Y. Yuan MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity Cancer Res 69 2009 1135 1142
225. J. Summerton Morpholino antisense oligomers: the case for an RNase H-independent structural type Biochim Biophys Acta 1489 1999 141 158
226. F. Sun, H. Fu, Q. Liu, Y. Tie, J. Zhu, and R. Xing Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest FEBS Lett 582 2008 1564 1568
227. H. Suzuki, E. Yamamoto, M. Nojima, M. Kai, H.O. Yamano, and K. Yoshikawa Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect Carcinogenesis 31 2010 2066 2073
228. Y. Sylvestre, G.V. De, E. Querido, U.K. Mukhopadhyay, V. Bourdeau, and F. Major An E2F/miR-20a autoregulatory feedback loop J Biol Chem 282 2007 2135 2143 (Pubitemid 47076740)
229. V. Tarasov, P. Jung, B. Verdoodt, D. Lodygin, A. Epanchintsev, and A. Menssen Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest Cell Cycle 6 2007 1586 1593 (Pubitemid 47327945)
230. S.F. Tavazoie, C. Alarcon, T. Oskarsson, D. Padua, Q. Wang, and P.D. Bos Endogenous human microRNAs that suppress breast cancer metastasis Nature 451 2008 147 152
231. Y. Tay, J. Zhang, A.M. Thomson, B. Lim, and I. Rigoutsos MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation Nature 455 2008 1124 1128
232. M.F. Taylor, J.D. Paulauskis, D.D. Weller, and L. Kobzik In vitro efficacy of morpholino-modified antisense oligomers directed against tumor necrosis factor-alpha mRNA J Biol Chem 271 1996 17445 17452 (Pubitemid 26244310)
233. J.P. Thiery Epithelial-mesenchymal transitions in development and pathologies Curr Opin Cell Biol 15 6 2003, Dec 740 746 740.-6. 15 (Pubitemid 37487967)
234. T. Thum, C. Gross, J. Fiedler, T. Fischer, S. Kissler, and M. Bussen MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts Nature 456 2008 980 984
235. P. Trang, P.P. Medina, J.F. Wiggins, L. Ruffino, K. Kelnar, and M. Omotola Regression of murine lung tumors by the let-7 microRNA Oncogene 29 2010 1580 1587
236. W.P. Tsang, and T.T. Kwok Let-7a microRNA suppresses therapeutics-induced cancer cell death by targeting caspase-3 Apoptosis 13 2008 1215 1222
237. L. Tuddenham, G. Wheeler, S. Ntounia-Fousara, J. Waters, M.K. Hajihosseini, and I. Clark The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells FEBS Lett 580 2006 4214 4217 (Pubitemid 44037596)
238. S. Valastyan, F. Reinhardt, N. Benaich, D. Calogrias, A.M. Szasz, and Z.C. Wang A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis Cell 12 2009 1032 1046
239. N. Valeri, P. Gasparini, C. Braconi, A. Paone, F. Lovat, and M. Fabbri MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2) Proc Natl Acad Sci U S A 107 2010 21098 21103
240. I.M. Verma, and M.D. Weitzman Gene therapy: twenty-first century medicine Annu Rev Biochem 74 2005 711 738 (Pubitemid 40995522)
241. F. Vogel Genetics of retinoblastoma Hum Genet 52 1979 1 54 (Pubitemid 10194798)
242. S. Volinia, G.A. Calin, C.G. Liu, S. Ambs, A. Cimmino, and F. Petrocca A microRNA expression signature of human solid tumors defines cancer gene targets Proc Natl Acad Sci U S A 103 2006 2257 2261 (Pubitemid 43271657)
243. L. Vrba, T.J. Jensen, J.C. Garbe, R.L. Heimark, A.E. Cress, and S. Dickinson Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells PLoS One 5 2010 e8697
244. B. Wang, M. Herman-Edelstein, P. Koh, W. Burns, K. Jandeleit-Dahm, and A. Watson E-cadherin expression is regulated by miR-192/215 by a mechanism that is independent of the profibrotic effects of transforming growth factor-beta Diabetes 59 2010 1794 1802
245. B. Wang, S.H. Hsu, S. Majumder, H. Kutay, W. Huang, and S.T. Jacob TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3 Oncogene 29 2009 1787 1797
246. Z. Wang, Y. Li, A. Ahmad, A.S. Azmi, D. Kong, and S. Banerjee Targeting miRNAs involved in cancer stem cell and EMT regulation: an emerging concept in overcoming drug resistance Drug Resist Updat 13 2010 109 118
247. C. Welch, Y. Chen, and R.L. Stallings MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells Oncogene 26 2007 5017 5022 (Pubitemid 47172643)
248. E. Wienholds, M.J. Koudijs, F.J. van Eeden, E. Cuppen, and R.H. Plasterk The microRNA-producing enzyme Dicer1 is essential for zebrafish development Nat Genet 35 2003 217 218 (Pubitemid 37363173)
249. J.F. Wiggins, L. Ruffino, K. Kelnar, M. Omotola, L. Patrawala, and D. Brown Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34 Cancer Res 70 2010 5923 5930
250. B. Wightman, I. Ha, and G. Ruvkun Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans Cell 75 1993 855 862 (Pubitemid 24014543)
251. E.D. Wiklund, J.B. Bramsen, T. Hulf, L. Dyrskjot, R. Ramanathan, and T.B. Hansen Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer Int J Cancer 128 2010 1327 1334
252. S.M. Wilting, R.A. van Boerdonk, F.E. Henken, C.J. Meijer, B. Diosdado, and G.A. Meijer Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer Mol Cancer 9 2010 167
253. L. Wu, and J.G. Belasco Micro-RNA regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cells Mol Cell Biol 25 2005 9198 9208 (Pubitemid 41507823)
254. H. Wu, S. Zhu, and Y.Y. Mo Suppression of cell growth and invasion by miR-205 in breast cancer Cell Res 19 2009 439 448
255. L. Xia, D. Zhang, R. Du, Y. Pan, L. Zhao, and S. Sun miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells Int J Cancer 123 2008 372 379 (Pubitemid 351842022)
256. C. Xiao, L. Srinivasan, D.P. Calado, H.C. Patterson, B. Zhang, and J. Wang Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes Nat Immunol 9 2008 405 414 (Pubitemid 351405110)
257. F. Xiao, Z. Zuo, G. Cai, S. Kang, X. Gao, and T. Li miRecords: an integrated resource for microRNA-target interactions Nucleic Acids Res 37 2009 105 110
258. Y. Xiong, J.H. Fang, J.P. Yun, J. Yang, Y. Zhang, and W.H. Jia Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma Hepatology 51 2010 836 845
259. H. Xu, I.Y. Cheung, H.F. Guo, and N.K. Cheung MicroRNA miR-29 modulates expression of immunoinhibitory molecule B7-H3: potential implications for immune based therapy of human solid tumors Cancer Res 69 2009 6275 6281
260. M. Yamakuchi, M. Ferlito, and C.J. Lowenstein miR-34a repression of SIRT1 regulates apoptosis Proc Natl Acad Sci U S A 105 2008 13421 13426
261. L.X. Yan, X.F. Huang, Q. Shao, M.Y. Huang, L. Deng, and Q.L. Wu MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis RNA 14 2008 2348 2360
262. N. Yang, S. Kaur, S. Volinia, J. Greshock, H. Lassus, and K. Hasegawa MicroRNA microarray identifies Let-7i as a novel biomarker and therapeutic target in human epithelial ovarian cancer Cancer Res 68 2008 10307 10314
263. H. Yang, W. Kong, L. He, J.J. Zhao, J.D. O'Donnell, and J. Wang MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN Cancer Res 68 2006 425 433 (Pubitemid 351380068)
264. J.H. Yang, J.H. Li, P. Shao, H. Zhou, Y.Q. Chen, and L.H. Qu starBase: a database for exploring microRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data Nucleic Acids Res 39 2010 202 209
265. J. Yang, S.A. Mani, J.L. Donaher, S. Ramaswamy, R.A. Itzykson, and C. Come Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis Cell 117 2004 927 939 (Pubitemid 38798858)
266. J.H. Yang, P. Shao, H. Zhou, Y.Q. Chen, and L.H. Qu deepBase: a database for deeply annotating and mining deep sequencing data Nucleic Acids Res 38 2010 123 130
267. S. Yekta, I.H. Shih, and D.P. Bartel MicroRNA-directed cleavage of HOXB8 mRNA Science 304 2004 594 596 (Pubitemid 38541919)
268. R. Yi, Y. Qin, I.G. Macara, and B.R. Cullen Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs Genes Dev 17 2003 3011 3013
269. M. Yilmaz, and G. Christofori Mechanisms of motility in metastasizing cells Mol Cancer Res 8 2010 629 642
270. D. Yu, M. Carroll, and A. Thomas-Tikhonenko p53 status dictates responses of B lymphomas to monotherapy with proteasome inhibitors Blood 109 2007 4936 4943 (Pubitemid 46827792)
271. J. Zavadil, M. Narasimhan, M. Blumenberg, and R.J. Schneider Transforming growth factor-beta and microRNA:mRNA regulatory networks in epithelial plasticity Cells Tissues Organs 185 2007 157 161 (Pubitemid 46956856)
272. L. Zeng, A.D. Carter, and S.J. Childs miR-145 directs intestinal maturation in zebrafish Proc Natl Acad Sci U S A 106 2009 17993 17998
273. Y. Zeng, E.J. Wagner, and B.R. Cullen Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells Mol Cell 9 2002 1327 1333 (Pubitemid 34722311)
274. Y. Zhang, P. Cristofaro, R. Silbermann, O. Pusch, D. Boden, and T. Konkin Engineering mucosal RNA interference in vivo Mol Ther 14 2006 336 342 (Pubitemid 44184961)
275. J.J. Zhao, J. Lin, H. Yang, W. Kong, L. He, and X. Ma MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer J Biol Chem 283 2008 31079 31086
276. X. Zhao, L. Yang, J. Hu, and J. Ruan miR-138 might reverse multidrug resistance of leukemia cells Leuk Res 34 2010 1078 1082
277. B.P. Zhou, J. Deng, W. Xia, J. Xu, Y.M. Li, and M. Gunduz Dual regulation of snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition Nat Cell Biol 6 2004 931 940 (Pubitemid 39359846)
278. H. Zhu, H. Wu, X. Liu, B.R. Evans, D.J. Medina, and C.G. Liu Role of microRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells Biochem Pharmacol 76 2008 582 588
279. S. Zhu, H. Wu, F. Wu, D. Nie, S. Sheng, and Y.Y. Mo MicroRNA-21 targets tumor suppressor genes in invasion and metastasis Cell Res 18 2008 350 359 (Pubitemid 351333899)