MicroRNA replacement therapy for cancer

Pharmaceutical Research

Volumn 28, Issue 12, 2011, Pages 3030-3042

  Henry, Jon C ^a   Azevedo Pouly, Ana Clara P ^a   Schmittgen, Thomas D ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

cancer treatment; microRNA mimetic; microRNA mimic; therapeutic microRNAs

Indexed keywords

ADENOVIRUS VECTOR; ANTISENSE OLIGONUCLEOTIDE; CISPLATIN; DOXORUBICIN; LENTIVIRUS VECTOR; LIPID EMULSION; MESSENGER RNA; MICRORNA; PACLITAXEL; UNTRANSLATED RNA;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; BLADDER CANCER; BREAST CANCER; CANCER CELL CULTURE; CHEMOSENSITIVITY; COLON CANCER; DRUG POTENTIATION; GENE EXPRESSION; GENE REPRESSION; GENE VECTOR; GENETIC TRANSFECTION; GLIOMA; HUMAN; LARYNX CANCER; LIVER CANCER; LIVER CELL CARCINOMA; LUNG CANCER; LUNG NON SMALL CELL CANCER; MALIGNANT NEOPLASTIC DISEASE; MEDICAL LITERATURE; MELANOMA; NONHUMAN; ONCOGENE; PANCREAS CANCER; PRIORITY JOURNAL; PROSTATE CANCER; RHABDOMYOSARCOMA; STOMACH CANCER; TUMOR GROWTH; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC VECTORS; HUMANS; MICRORNAS; NEOPLASMS; OLIGONUCLEOTIDES;

EID: 83555165954     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0548-9     Document Type: Article

References (126)

1. DP Bartel 2004 MicroRNAs: genomics, biogenesis, mechanism, and function Cell 116 2 281 297 14744438 1:CAS:528:DC%2BD2cXhtVals7o%3D 10.1016/S0092- 8674(04)00045-5 (Pubitemid 38167318)
2. R Garzon G Marcucci CM Croce 2010 Targeting microRNAs in cancer: rationale, strategies and challenges Nat Rev Drug Discov 9 10 775 789 20885409 1:CAS:528:DC%2BC3cXht1akur7L 10.1038/nrd3179
3. AH Williams N Liu E van Rooij EN Olson 2009 MicroRNA control of muscle development and disease Curr Opin Cell Biol 21 3 461 469 19278845 1:CAS:528:DC%2BD1MXmvFGns74%3D 10.1016/j.ceb.2009.01.029
4. BH Miller C Wahlestedt 2010 MicroRNA dysregulation in psychiatric disease Brain Res 1338 89 99 20303342 1:CAS:528:DC%2BC3cXmslShs74%3D 10.1016/j.brainres.2010.03.035
5. C Guay E Roggli V Nesca C Jacovetti R Regazzi 2011 Diabetes mellitus, a microRNA-related disease? Transl Res 157 4 253 264 21420036 1:CAS:528: DC%2BC3MXjsV2ntLs%3D 10.1016/j.trsl.2011.01.009
6. GA Calin CM Croce 2006 MicroRNA signatures in human cancers Nat Rev Cancer 6 11 857 866 17060945 1:CAS:528:DC%2BD28XhtFWhs7fM 10.1038/nrc1997 (Pubitemid 44629897)
7. J Krutzfeldt N Rajewsky R Braich KG Rajeev T Tuschl M Manoharan, et al. 2005 Silencing of microRNAs in vivo with 'antagomirs' Nature 438 7068 685 689 16258535 10.1038/nature04303 1:CAS:528:DC%2BD2MXht1Gqs7zP (Pubitemid 41740580)
8. N Bushati SM Cohen 2007 MicroRNA functions Annu Rev Cell Dev Biol 23 175 205 17506695 1:CAS:528:DC%2BD2sXhtlartr3M 10.1146/annurev.cellbio.23.090506. 123406
9. CL Bartels GJ Tsongalis 2009 MicroRNAs: novel biomarkers for human cancer Clin Chem 55 4 623 631 19246618 1:CAS:528:DC%2BD1MXktVWqs7k%3D 10.1373/clinchem.2008.112805
10. A Deiters 2010 Small molecule modifiers of the microRNA and RNA interference pathway AAPS J 12 1 51 60 19937410 1:CAS:528:DC%2BC3cXisVGrtrg%3D 10.1208/s12248-009-9159-3
11. VN Kim JW Nam 2006 Genomics of microRNA Trends Genet 22 3 165 173 16446010 1:CAS:528:DC%2BD28XhvVWitLw%3D 10.1016/j.tig.2006.01.003 (Pubitemid 43290020)
12. DS Schwarz G Hutvagner T Du Z Xu N Aronin PD Zamore 2003 Asymmetry in the assembly of the RNAi enzyme complex Cell 115 2 199 208 14567917 1:CAS:528:DC%2BD3sXosFCqsLo%3D 10.1016/S0092-8674(03)00759-1 (Pubitemid 37329583)
13. NH Tolia L Joshua-Tor 2007 Slicer and the argonautes Nat Chem Biol 3 1 36 43 17173028 1:CAS:528:DC%2BD28Xhtlakt7bL 10.1038/nchembio848 (Pubitemid 46005696)
14. I Lee SS Ajay JI Yook HS Kim SH Hong NH Kim, et al. 2009 New class of microRNA targets containing simultaneous 5′-UTR and 3′-UTR interaction sites Genome Res 19 7 1175 1183 19336450 1:CAS:528: DC%2BD1MXosVCktLo%3D 10.1101/gr.089367.108
15. JR Lytle TA Yario JA Steitz 2007 Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5′ UTR as in the 3′ UTR Proc Natl Acad Sci U S A 104 23 9667 9672 17535905 1:CAS:528: DC%2BD2sXmsFWjsbc%3D 10.1073/pnas.0703820104 (Pubitemid 47175324)
16. Y Tay J Zhang AM Thomson B Lim I Rigoutsos 2008 MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation Nature 455 7216 1124 1128 18806776 1:CAS:528:DC%2BD1cXht1yju7jO 10.1038/nature07299
17. GA Calin CG Liu M Ferracin T Hyslop R Spizzo C Sevignani, et al. 2007 Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas Cancer Cell 12 3 215 229 17785203 1:CAS:528:DC%2BD2sXhtVKqsb3L 10.1016/j.ccr.2007.07.027 (Pubitemid 47333418)
18. J Lu G Getz EA Miska E Alvarez-Saavedra J Lamb D Peck, et al. 2005 MicroRNA expression profiles classify human cancers Nature 435 7043 834 838 15944708 1:CAS:528:DC%2BD2MXkvVGgsLc%3D 10.1038/nature03702 (Pubitemid 40839735)
19. MV Iorio M Ferracin CG Liu A Veronese R Spizzo S Sabbioni, et al. 2005 MicroRNA gene expression deregulation in human breast cancer Cancer Res 65 16 7065 7070 16103053 1:CAS:528:DC%2BD2MXns1WrtL8%3D 10.1158/0008-5472.CAN-05-1783 (Pubitemid 41161233)
20. J Jiang Y Gusev I Aderca TA Mettler DM Nagorney DJ Brackett, et al. 2008 Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival Clin Cancer Res 14 2 419 427 18223217 1:CAS:528:DC%2BD1cXhtVKitLk%3D 10.1158/1078-0432.CCR-07-0523 (Pubitemid 351226109)
21. TD Schmittgen J Jiang Q Liu L Yang 2004 A high-throughput method to monitor the expression of microRNA precursors Nucleic Acids Res 32 4 E43 14985473 10.1093/nar/gnh040 1:CAS:528:DC%2BD2cXhvFSqtL0%3D
22. S Volinia GA Calin CG Liu S Ambs A Cimmino F Petrocca, et al. 2006 A microRNA expression signature of human solid tumors defines cancer gene targets Proc Natl Acad Sci U S A 103 7 2257 2261 16461460 1:CAS:528:DC%2BD28XhslGjsbg%3D 10.1073/pnas.0510565103 (Pubitemid 43271657)
23. MV Iorio M Ferracin CG Liu A Veronese R Spizzo S Sabbioni, et al. 2005 MicroRNA gene expression deregulation in human breast cancer Cancer Res 65 16 7065 7070 16103053 1:CAS:528:DC%2BD2MXns1WrtL8%3D 10.1158/0008-5472.CAN-05-1783 (Pubitemid 41161233)
24. EJ Lee Y Gusev J Jiang GJ Nuovo MR Lerner WL Frankel, et al. 2007 Expression profiling identifies microRNA signature in pancreatic cancer Int J Cancer 120 5 1046 1054 17149698 1:CAS:528:DC%2BD2sXhsVWhsrc%3D 10.1002/ijc.22394 (Pubitemid 46214304)
25. A Cimmino GA Calin M Fabbri MV Iorio M Ferracin M Shimizu, et al. 2005 MiR-15 and miR-16 induce apoptosis by targeting BCL2 Proc Natl Acad Sci U S A 102 39 13944 13949 16166262 1:CAS:528:DC%2BD2MXhtVOqsbjK 10.1073/pnas.0506654102 (Pubitemid 41377683)
26. F Meng R Henson M Lang H Wehbe S Maheshwari JT Mendell, et al. 2006 Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines Gastroenterology 130 7 2113 2129 16762633 1:CAS:528:DC%2BD28XntVWit7g%3D 10.1053/j.gastro.2006.02.057 (Pubitemid 43816961)
27. P Wong M Iwasaki TC Somervaille F Ficara C Carico C Arnold, et al. 2010 The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression Cancer Res 70 9 3833 3842 20406979 1:CAS:528:DC%2BC3cXltlensbw%3D 10.1158/0008-5472.CAN-09-3268
28. Fornari F, Gramantieri L, Ferracin M, Veronese A, Sabbioni S, Calin GA, et al. MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma. Oncogene 2008.
29. GA Calin C Sevignani CD Dumitru T Hyslop E Noch S Yendamuri, et al. 2004 Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers Proc Natl Acad Sci U S A 101 9 2999 3004 14973191 1:CAS:528:DC%2BD2cXitlWhtr8%3D 10.1073/pnas.0307323101 (Pubitemid 38327724)
30. Y Saito G Liang G Egger JM Friedman JC Chuang GA Coetzee, et al. 2006 Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells Cancer Cell 9 6 435 443 16766263 1:CAS:528:DC%2BD28Xmt1eksLY%3D 10.1016/j.ccr.2006.04.020 (Pubitemid 43832188)
31. SA Melo C Moutinho S Ropero GA Calin S Rossi R Spizzo, et al. 2010 A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells Cancer Cell 18 4 303 315 20951941 1:CAS:528:DC%2BC3cXhtlSnu77I 10.1016/j.ccr.2010.09.007
32. MS Kumar J Lu KL Mercer TR Golub T Jacks 2007 Impaired microRNA processing enhances cellular transformation and tumorigenesis Nat Genet 39 5 673 677 17401365 1:CAS:528:DC%2BD2sXksFersLo%3D 10.1038/ng2003 (Pubitemid 46676103)
33. L He JM Thomson MT Hemann E Hernando-Monge D Mu S Goodson, et al. 2005 A microRNA polycistron as a potential human oncogene Nature 435 7043 828 833 15944707 1:CAS:528:DC%2BD2MXkvVGgs70%3D 10.1038/nature03552 (Pubitemid 40839734)
34. PP Medina M Nolde FJ Slack 2010 OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma Nature 467 7311 86 90 20693987 1:CAS:528:DC%2BC3cXpvVWgsr8%3D 10.1038/nature09284
35. S Costinean N Zanesi Y Pekarsky E Tili S Volinia N Heerema, et al. 2006 Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice Proc Natl Acad Sci U S A 103 18 7024 7029 16641092 1:CAS:528:DC%2BD28XkslCktrg%3D 10.1073/pnas.0602266103
36. Pineau P, Volinia S, McJunkin K, Marchio A, Battiston C, Terris B, et al. MiR-221 over-expression contributes to liver tumorigenesis. Proc Natl Acad Sci U S A 2009.
37. Wang B, Hsu SH, Majumder S, Kutay H, Huang W, Jacob ST, et al. TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3. Oncogene 2009.
38. T Papagiannakopoulos A Shapiro KS Kosik 2008 MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells Cancer Res 68 19 8164 8172 18829576 1:CAS:528:DC%2BD1cXhtF2msLjO 10.1158/0008-5472.CAN-08-1305
39. E Wienholds WP Kloosterman E Miska E Alvarez-Saavedra E Berezikov E de Bruijn, et al. 2005 MicroRNA expression in zebrafish embryonic development Science 309 5732 310 311 15919954 1:CAS:528:DC%2BD2MXlsl2jtL0%3D 10.1126/science.1114519 (Pubitemid 40967869)
40. WC Tsai PW Hsu TC Lai GY Chau CW Lin CM Chen, et al. 2009 MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma Hepatology 49 5 1571 1582 19296470 1:CAS:528: DC%2BD1MXlslKmurY%3D 10.1002/hep.22806
41. J Silber DA Lim C Petritsch AI Persson AK Maunakea M Yu, et al. 2008 MiR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells BMC Med 6 14 18577219 10.1186/1741-7015-6-14 1:CAS:528:DC%2BD1cXpvF2lurg%3D (Pubitemid 352003733)
42. R Taulli F Bersani V Foglizzo A Linari E Vigna M Ladanyi, et al. 2009 The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation J Clin Invest 119 8 2366 2378 19620785 1:CAS:528:DC%2BD1MXpsFCksr4%3D
43. J Silber DA Lim C Petritsch AI Persson AK Maunakea M Yu, et al. 2008 MiR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells BMC Med 6 14 18577219 10.1186/1741-7015-6-14 1:CAS:528:DC%2BD1cXpvF2lurg%3D (Pubitemid 352003733)
44. MA Behlke 2008 Chemical modification of siRNAs for in vivo use Oligonucleotides 18 4 305 319 19025401 1:CAS:528:DC%2BD1cXhsVGhu77N 10.1089/oli.2008.0164 (Pubitemid 352791344)
45. M Amarzguioui T Holen E Babaie H Prydz 2003 Tolerance for mutations and chemical modifications in a siRNA Nucleic Acids Res 31 2 589 595 12527766 1:CAS:528:DC%2BD3sXitlCgurk%3D 10.1093/nar/gkg147 (Pubitemid 36175948)
46. YL Chiu TM Rana 2003 siRNA function in RNAi: a chemical modification analysis RNA 9 9 1034 1048 12923253 1:CAS:528:DC%2BD3sXntFaqur8%3D 10.1261/rna.5103703 (Pubitemid 37093614)
47. F Czauderna M Fechtner S Dames H Aygun A Klippel GJ Pronk, et al. 2003 Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells Nucleic Acids Res 31 11 2705 2716 12771196 1:CAS:528: DC%2BD3sXkt1Wqsbo%3D 10.1093/nar/gkg393 (Pubitemid 37442115)
48. J Harborth SM Elbashir K Vandenburgh H Manninga SA Scaringe K Weber, et al. 2003 Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing Antisense Nucleic Acid Drug Dev 13 2 83 105 12804036 1:CAS:528:DC%2BD3sXjsFejtLw%3D 10.1089/108729003321629638
49. S Choung YJ Kim S Kim HO Park YC Choi 2006 Chemical modification of siRNAs to improve serum stability without loss of efficacy Biochem Biophys Res Commun 342 3 919 927 16598842 1:CAS:528:DC%2BD28XitVKjtL4%3D 10.1016/j.bbrc.2006.02.049 (Pubitemid 43320485)
50. TP Prakash CR Allerson P Dande TA Vickers N Sioufi R Jarres, et al. 2005 Positional effect of chemical modifications on short interference RNA activity in mammalian cells J Med Chem 48 13 4247 4253 15974578 1:CAS:528: DC%2BD2MXks1Sgt7k%3D 10.1021/jm050044o (Pubitemid 40884928)
51. JM Layzer AP McCaffrey AK Tanner Z Huang MA Kay BA Sullenger 2004 In vivo activity of nuclease-resistant siRNAs RNA 10 5 766 771 15100431 1:CAS:528:DC%2BD2cXjs1Gnt74%3D 10.1261/rna.5239604 (Pubitemid 38529739)
52. DV Morrissey JA Lockridge L Shaw K Blanchard K Jensen W Breen, et al. 2005 Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs Nat Biotechnol 23 8 1002 1007 16041363 1:CAS:528:DC%2BD2MXntVSrtrc%3D 10.1038/nbt1122 (Pubitemid 41114035)
53. Y Kitade Y Akao 2010 MicroRNAs and their therapeutic potential for human diseases: microRNAs, miR-143 and -145, function as anti-oncomirs and the application of chemically modified miR-143 as an anti-cancer drug J Pharmacol Sci 114 3 276 280 20953119 1:CAS:528:DC%2BC3cXhsFaqs7%2FO 10.1254/jphs.10R12FM
54. S Hamm E Latz D Hangel T Muller P Yu D Golenbock, et al. 2010 Alternating 2′-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist Immunobiology 215 7 559 569 19854535 1:CAS:528:DC%2BC3cXhtVGltbbF 10.1016/j.imbio.2009.09.003
55. F Eberle K Giessler C Deck K Heeg M Peter C Richert, et al. 2008 Modifications in small interfering RNA that separate immunostimulation from RNA interference J Immunol 180 5 3229 3237 18292547 1:CAS:528:DC%2BD1cXit1OksLk%3D
56. M Sioud G Furset L Cekaite 2007 Suppression of immunostimulatory siRNA-driven innate immune activation by 2′-modified RNAs Biochem Biophys Res Commun 361 1 122 126 17658482 1:CAS:528:DC%2BD2sXotlWrtLw%3D 10.1016/j.bbrc.2007.06.177 (Pubitemid 47102276)
57. JC Henry JK Park J Jiang JH Kim DM Nagorney LR Roberts, et al. 2010 MiR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines Biochem Biophys Res Commun 403 1 120 125 21055388 1:CAS:528:DC%2BC3cXhsFantb%2FP 10.1016/j.bbrc.2010.10.130
58. SM Johnson H Grosshans J Shingara M Byrom R Jarvis A Cheng, et al. 2005 RAS is regulated by the let-7 microRNA family Cell 120 5 635 647 15766527 1:CAS:528:DC%2BD2MXis1yhsbs%3D 10.1016/j.cell.2005.01.014 (Pubitemid 40343076)
59. S Adhikary M Eilers 2005 Transcriptional regulation and transformation by Myc proteins Nat Rev Mol Cell Biol 6 8 635 645 16064138 1:CAS:528: DC%2BD2MXmvVGht78%3D 10.1038/nrm1703 (Pubitemid 41081267)
60. J Torrisani B Bournet MC du Rieu M Bouisson A Souque J Escourrou, et al. 2009 let-7 MicroRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression Hum Gene Ther 20 8 831 844 19323605 1:CAS:528:DC%2BD1MXpvV2gs74%3D 10.1089/hum.2008.134
61. XB Long GB Sun S Hu GT Liang N Wang XH Zhang, et al. 2009 Let-7a microRNA functions as a potential tumor suppressor in human laryngeal cancer Oncol Rep 22 5 1189 1195 19787239 1:CAS:528:DC%2BD1MXhtlCjtb3M
62. Y Akao Y Nakagawa T Naoe 2006 let-7 microRNA functions as a potential growth suppressor in human colon cancer cells Biol Pharm Bull 29 5 903 906 16651716 1:CAS:528:DC%2BD28Xmt1ehtrc%3D 10.1248/bpb.29.903
63. YS Lee A Dutta 2007 The tumor suppressor microRNA let-7 represses the HMGA2 oncogene Genes Dev 21 9 1025 1030 17437991 1:CAS:528:DC%2BD2sXltFCnsrs%3D 10.1101/gad.1540407 (Pubitemid 46686471)
64. VB Sampson NH Rong J Han Q Yang V Aris P Soteropoulos, et al. 2007 MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells Cancer Res 67 20 9762 9770 17942906 1:CAS:528: DC%2BD2sXhtFOnsb%2FF 10.1158/0008-5472.CAN-07-2462 (Pubitemid 47621223)
65. FF Lan H Wang YC Chen CY Chan SS Ng K Li, et al. 2011 Hsa-let-7g inhibits proliferation of hepatocellular carcinoma cells by downregulation of c-Myc and upregulation of p16(INK4A) Int J Cancer 128 2 319 331 20309945 1:CAS:528:DC%2BC3cXhsVGrur3P 10.1002/ijc.25336
66. Trang P, Wiggins JF, Daige CL, Cho C, Omotola M, Brown D, et al. Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice. Mol Ther 2011 Mar 22.
67. Y Xiong JH Fang JP Yun J Yang Y Zhang WH Jia, et al. 2010 Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma Hepatology 51 3 836 845 20041405 1:CAS:528:DC%2BC3cXks1Sqsro%3D
68. R Garzon CE Heaphy V Havelange M Fabbri S Volinia T Tsao, et al. 2009 MicroRNA 29b functions in acute myeloid leukemia Blood 114 26 5331 5341 19850741 1:CAS:528:DC%2BC3cXislWrtw%3D%3D 10.1182/blood-2009-03-211938
69. H Su JR Yang T Xu J Huang L Xu Y Yuan, et al. 2009 MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity Cancer Res 69 3 1135 1142 19155302 1:CAS:528:DC%2BD1MXhtFOluro%3D 10.1158/0008-5472.CAN-08-2886
70. Q Ji X Hao Y Meng M Zhang J Desano D Fan, et al. 2008 Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres BMC Cancer 8 266 18803879 10.1186/1471-2407-8-266 1:CAS:528:DC%2BD1cXhtlWju7zJ
71. Q Ji X Hao M Zhang W Tang M Yang L Li, et al. 2009 MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells PLoS One 4 8 e6816 19714243 10.1371/journal.pone.0006816 1:CAS:528:DC%2BD1MXhtVOqsLzE
72. K Kojima Y Fujita Y Nozawa T Deguchi M Ito 2010 MiR-34a attenuates paclitaxel-resistance of hormone-refractory prostate cancer PC3 cells through direct and indirect mechanisms Prostate 70 14 1501 1512 20687223 1:CAS:528:DC%2BC3cXht1yqtbjP 10.1002/pros.21185
73. C Liu K Kelnar B Liu X Chen T Calhoun-Davis H Li, et al. 2011 The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44 Nat Med 17 2 211 215 21240262 1:CAS:528:DC%2BC3MXmsFCmsw%3D%3D 10.1038/nm.2284
74. JF Wiggins L Ruffino K Kelnar M Omotola L Patrawala D Brown, et al. 2010 Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34 Cancer Res 70 14 5923 5930 20570894 1:CAS:528:DC%2BC3cXovVanu7s%3D 10.1158/0008-5472.CAN-10-0655
75. V Tarasov P Jung B Verdoodt D Lodygin A Epanchintsev A Menssen, et al. 2007 Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest Cell Cycle 6 13 1586 1593 17554199 1:CAS:528:DC%2BD2sXhtFWlsr3O 10.4161/cc.6.13.4436 (Pubitemid 47327945)
76. GT Bommer I Gerin Y Feng AJ Kaczorowski R Kuick RE Love, et al. 2007 p53-mediated activation of miRNA34 candidate tumor-suppressor genes Curr Biol 17 15 1298 1307 17656095 1:CAS:528:DC%2BD2sXosF2ju7o%3D 10.1016/j.cub.2007.06.068 (Pubitemid 47176893)
77. M Yamakuchi M Ferlito CJ Lowenstein 2008 MiR-34a repression of SIRT1 regulates apoptosis Proc Natl Acad Sci U S A 105 36 13421 13426 18755897 1:CAS:528:DC%2BD1cXhtFChs7rO 10.1073/pnas.0801613105
78. Q Ji X Hao Y Meng M Zhang J Desano D Fan, et al. 2008 Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres BMC Cancer 8 266 18803879 10.1186/1471-2407-8-266 1:CAS:528:DC%2BD1cXhtlWju7zJ
79. JF Wiggins L Ruffino K Kelnar M Omotola L Patrawala D Brown, et al. 2010 Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34 Cancer Res 70 14 5923 5930 20570894 1:CAS:528:DC%2BC3cXovVanu7s%3D 10.1158/0008-5472.CAN-10-0655
80. M Lagos-Quintana R Rauhut W Lendeckel T Tuschl 2001 Identification of novel genes coding for small expressed RNAs Science 294 5543 853 858 11679670 1:CAS:528:DC%2BD3MXotVChtb8%3D 10.1126/science.1064921 (Pubitemid 33032103)
81. J Chang JT Guo D Jiang H Guo JM Taylor TM Block 2008 Liver-specific microRNA miR-122 enhances the replication of hepatitis C virus in nonhepatic cells J Virol 82 16 8215 8223 18550664 1:CAS:528:DC%2BD1cXpsVyjsrg%3D 10.1128/JVI.02575-07
82. H Kutay S Bai J Datta T Motiwala I Pogribny W Frankel, et al. 2006 Downregulation of miR-122 in the rodent and human hepatocellular carcinomas J Cell Biochem 99 3 671 678 16924677 1:CAS:528:DC%2BD28XhtVClu77O 10.1002/jcb.20982 (Pubitemid 44521987)
83. J Hou L Lin W Zhou Z Wang G Ding Q Dong, et al. 2011 Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma Cancer Cell 19 2 232 243 21316602 1:CAS:528:DC%2BC3MXhvFeksbk%3D 10.1016/j.ccr.2011.01.001
84. S Bai MW Nasser B Wang SH Hsu J Datta H Kutay, et al. 2009 MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib J Biol Chem 284 46 32015 32027 19726678 1:CAS:528:DC%2BD1MXhtlyjsLfI 10.1074/jbc.M109.016774
85. S Bai MW Nasser B Wang SH Hsu J Datta H Kutay, et al. 2009 MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib J Biol Chem 284 46 32015 32027 19726678 1:CAS:528:DC%2BD1MXhtlyjsLfI 10.1074/jbc.M109.016774
86. Y Akao Y Nakagawa T Naoe 2006 MicroRNAs 143 and 145 are possible common onco-microRNAs in human cancers Oncol Rep 16 4 845 850 16969504 1:CAS:528:DC%2BD28XhtFSisrrN
87. Y Akao Y Nakagawa T Naoe 2007 MicroRNA-143 and -145 in colon cancer DNA Cell Biol 26 5 311 320 17504027 1:CAS:528:DC%2BD2sXltleit7c%3D 10.1089/dna.2006.0550 (Pubitemid 46799180)
88. J Zhang H Guo H Zhang H Wang G Qian X Fan, et al. 2011 Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1 gene Cancer 117 1 86 95 20737575 1:CAS:528:DC%2BC3MXmtl2jtw%3D%3D 10.1002/cncr.25522
89. LH Gregersen AB Jacobsen LB Frankel J Wen A Krogh AH Lund 2010 MicroRNA-145 targets YES and STAT1 in colon cancer cells PLoS One 5 1 e8836 20098684 10.1371/journal.pone.0008836 1:CAS:528:DC%2BC3cXht1emt7o%3D
90. C Esau X Kang E Peralta E Hanson EG Marcusson LV Ravichandran, et al. 2004 MicroRNA-143 regulates adipocyte differentiation J Biol Chem 279 50 52361 52365 15504739 1:CAS:528:DC%2BD2cXhtVCkur%2FI 10.1074/jbc.C400438200 (Pubitemid 39656612)
91. F Fornari M Milazzo P Chieco M Negrini GA Calin GL Grazi, et al. 2010 MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells Cancer Res 70 12 5184 5193 20501828 1:CAS:528:DC%2BC3cXntlKlurw%3D 10.1158/0008-5472.CAN-10-0145
92. L Gramantieri M Ferracin F Fornari A Veronese S Sabbioni CG Liu, et al. 2007 Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma Cancer Res 67 13 6092 6099 17616664 1:CAS:528:DC%2BD2sXnsVyqsbo%3D 10.1158/0008-5472.CAN-06-4607 (Pubitemid 47037488)
93. JC Henry JK Park J Jiang JH Kim DM Nagorney LR Roberts, et al. 2010 MiR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines Biochem Biophys Res Commun 403 1 120 125 21055388 1:CAS:528:DC%2BC3cXhsFantb%2FP 10.1016/j.bbrc.2010.10.130
94. S Kim UJ Lee MN Kim EJ Lee JY Kim MY Lee, et al. 2008 MicroRNA miR-199a*regulates the MET proto-oncogene and the downstream extracellular signal-regulated kinase 2 (ERK2) J Biol Chem 283 26 18158 18166 18456660 1:CAS:528:DC%2BD1cXnsVCgu7k%3D 10.1074/jbc.M800186200
95. Y Murakami HH Aly A Tajima I Inoue K Shimotohno 2009 Regulation of the hepatitis C virus genome replication by miR-199a J Hepatol 50 3 453 460 19144437 1:CAS:528:DC%2BD1MXhs1ektrw%3D 10.1016/j.jhep.2008.06.010
96. J Bo G Yang K Huo H Jiang L Zhang D Liu, et al. 2011 MicroRNA-203 suppresses bladder cancer development by repressing bcl-w expression FEBS J 278 5 786 792 21205209 1:CAS:528:DC%2BC3MXjtVahtro%3D 10.1111/j.1742-4658.2010. 07997.x
97. F Gottardo CG Liu M Ferracin GA Calin M Fassan P Bassi, et al. 2007 Micro-RNA profiling in kidney and bladder cancers Urol Oncol 25 5 387 392 17826655 1:CAS:528:DC%2BD2sXhtVWhtrzL 10.1016/j.urolonc.2007.01.019 (Pubitemid 47362758)
98. MA Castilla G Moreno-Bueno L Romero-Perez K Van De Vijver M Biscuola MA Lopez-Garcia, et al. 2011 Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma J Pathol 223 1 72 80 21125666 1:CAS:528:DC%2BC3MXht1GnsLc%3D 10.1002/path.2802
99. Y Chiang Y Song Z Wang Y Chen Z Yue H Xu, et al. 2011 Aberrant expression of miR-203 and its clinical significance in gastric and colorectal cancers J Gastrointest Surg 15 1 63 70 21063914 10.1007/s11605-010-1367-8
100. H Zhu H Wu X Liu BR Evans DJ Medina CG Liu, et al. 2008 Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells Biochem Pharmacol 76 5 582 588 18619946 1:CAS:528: DC%2BD1cXhtVSitbfN 10.1016/j.bcp.2008.06.007
101. Z Liang H Wu J Xia Y Li Y Zhang K Huang, et al. 2010 Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1 Biochem Pharmacol 79 6 817 824 19883630 1:CAS:528:DC%2BC3cXnvFCruw%3D%3D 10.1016/j.bcp.2009.10.017
102. O Kovalchuk J Filkowski J Meservy Y Ilnytskyy VP Tryndyak VF Chekhun, et al. 2008 Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin Mol Cancer Ther 7 7 2152 2159 18645025 1:CAS:528:DC%2BD1cXoslCnsr8%3D 10.1158/1535-7163.MCT-08-0021
103. EJ Noonan RF Place S Basak D Pookot LC Li 2010 MiR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cells Oncotarget 1 5 349 358 20948989
104. EJ Noonan RF Place D Pookot S Basak JM Whitson H Hirata, et al. 2009 MiR-449a targets HDAC-1 and induces growth arrest in prostate cancer Oncogene 28 14 1714 1724 19252524 1:CAS:528:DC%2BD1MXisVOrtrk%3D 10.1038/onc.2009.19
105. Y Nan L Han A Zhang G Wang Z Jia Y Yang, et al. 2010 miRNA-451 plays a role as tumor suppressor in human glioma cells Brain Res 1359 14 21 20816946 1:CAS:528:DC%2BC3cXhtlSgt7%2FF 10.1016/j.brainres.2010.08.074
106. F Wang X Xue J Wei Y An J Yao H Cai, et al. 2010 hsa-miR-520h downregulates ABCG2 in pancreatic cancer cells to inhibit migration, invasion, and side populations Br J Cancer 103 4 567 574 20628378 1:CAS:528: DC%2BC3cXhtVSmtb%2FF 10.1038/sj.bjc.6605724
107. N Tsuda K Kawano CL Efferson CG Ioannides 2005 Synthetic microRNA and double-stranded RNA targeting the 3′-untranslated region of HER-2/neu mRNA inhibit HER-2 protein expression in ovarian cancer cells Int J Oncol 27 5 1299 1306 16211225 1:CAS:528:DC%2BD2MXht1amtrnE
108. N Tsuda S Ishiyama Y Li CG Ioannides JL Abbruzzese DZ Chang 2006 Synthetic microRNA designed to target glioma-associated antigen 1 transcription factor inhibits division and induces late apoptosis in pancreatic tumor cells Clin Cancer Res 12 21 6557 6564 17085671 1:CAS:528:DC%2BD28XhtFKitbjO 10.1158/1078-0432.CCR-06-0588 (Pubitemid 44799731)
109. CR Sibley Y Seow MJ Wood 2010 Novel RNA-based strategies for therapeutic gene silencing Mol Ther 18 3 466 476 20087319 1:CAS:528:DC%2BC3cXntVCmtw%3D%3D 10.1038/mt.2009.306
110. J Godlewski MO Nowicki A Bronisz S Williams A Otsuki G Nuovo, et al. 2008 Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal Cancer Res 68 22 9125 9130 19010882 1:CAS:528:DC%2BD1cXhtlOmt7zL 10.1158/0008-5472.CAN-08-2629
111. M Sachdeva S Zhu F Wu H Wu V Walia S Kumar, et al. 2009 p53 represses c-Myc through induction of the tumor suppressor miR-145 Proc Natl Acad Sci U S A 106 9 3207 3212 19202062 1:CAS:528:DC%2BD1MXivF2jsrg%3D 10.1073/pnas.0808042106
112. Z Chen H Zeng Y Guo P Liu H Pan A Deng, et al. 2010 miRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-Myc J Exp Clin Cancer Res 29 151 21092188 10.1186/1756-9966-29-151 1:CAS:528:DC%2BC3cXhsFagt7jJ
113. D Yan E Dong Xda X Chen L Wang C Lu J Wang, et al. 2009 MicroRNA-1/206 targets c-Met and inhibits rhabdomyosarcoma development J Biol Chem 284 43 29596 29604 19710019 1:CAS:528:DC%2BD1MXht1KqurrF 10.1074/jbc.M109.020511
114. A Esquela-Kerscher P Trang JF Wiggins L Patrawala A Cheng L Ford, et al. 2008 The let-7 microRNA reduces tumor growth in mouse models of lung cancer Cell Cycle 7 6 759 764 18344688 1:CAS:528:DC%2BD1cXmvVWqtrk%3D 10.4161/cc.7.6.5834 (Pubitemid 351520040)
115. P Trang PP Medina JF Wiggins L Ruffino K Kelnar M Omotola, et al. 2010 Regression of murine lung tumors by the let-7 microRNA Oncogene 29 11 1580 1587 19966857 1:CAS:528:DC%2BD1MXhsFWrsbnF 10.1038/onc.2009.445
116. Y Sun Y Bai F Zhang Y Wang Y Guo L Guo 2010 MiR-126 inhibits non-small cell lung cancer cells proliferation by targeting EGFL7 Biochem Biophys Res Commun 391 3 1483 1489 20034472 1:CAS:528:DC%2BC3cXot1ymsg%3D%3D 10.1016/j.bbrc.2009.12.098
117. R Feng X Chen Y Yu L Su B Yu J Li, et al. 2010 MiR-126 functions as a tumour suppressor in human gastric cancer Cancer Lett 298 1 50 63 20619534 1:CAS:528:DC%2BC3cXht1SqtrnJ 10.1016/j.canlet.2010.06.004
118. HB Bian X Pan JS Yang ZX Wang W De 2011 Upregulation of microRNA-451 increases cisplatin sensitivity of non-small cell lung cancer cell line (A549) J Exp Clin Cancer Res 30 20 21329503 1:CAS:528:DC%2BC3MXjsFSisrk%3D 10.1186/1756-9966-30-20
119. X Zhang A Ladd E Dragoescu WT Budd JL Ware ZE Zehner 2009 MicroRNA-17-3p is a prostate tumor suppressor in vitro and in vivo, and is decreased in high grade prostate tumors analyzed by laser capture microdissection Clin Exp Metastasis 26 8 965 979 19771525 1:CAS:528:DC%2BD1MXhsVWlsrbF 10.1007/s10585-009-9287-2
120. Q Dong P Meng T Wang W Qin W Qin F Wang, et al. 2010 MicroRNA let-7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2 PLoS One 5 4 e10147 20418948 10.1371/journal.pone. 0010147 1:CAS:528:DC%2BC3cXltFyht78%3D
121. S Yu Z Lu C Liu Y Meng Y Ma W Zhao, et al. 2010 miRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic cancer Cancer Res 70 14 6015 6025 20610624 1:CAS:528:DC%2BC3cXovVamsro%3D 10.1158/0008-5472.CAN-09-4531
122. Dar AA, Majid S, de Semir D, Nosrati M, Bezrookove V, Kashani-Sabet M. MiR-205 suppresses melanoma cell proliferation and induces senescence via regulation of E2F1. J Biol Chem 2011 Mar 24.
123. SK Kota S Balasubramanian 2010 Cancer therapy via modulation of micro RNA levels: a promising future Drug Discov Today 15 17-18 733 740 20692360 1:CAS:528:DC%2BC3cXhtFCrurbI 10.1016/j.drudis.2010.07.003
124. Wang HJ, Ruan HJ, He XJ, Ma YY, Jiang XT, Xia YJ, et al. MicroRNA-101 is down-regulated in gastric cancer and involved in cell migration and invasion. Eur J Cancer 2010 Jun 5.
125. SR Viswanathan JT Powers W Einhorn Y Hoshida TL Ng S Toffanin, et al. 2009 Lin28 promotes transformation and is associated with advanced human malignancies Nat Genet 41 7 843 848 19483683 1:CAS:528:DC%2BD1MXms1aktrk%3D 10.1038/ng.392
126. Peacock H, Fucini RV, Jayalath P, Ibarra-Soza JM, Haringsma HJ, Flanagan WM, et al. Nucleobase and Ribose Modifications Control Immunostimulation by a MicroRNA-122-mimetic RNA. J Am Chem Soc 2011 Jun 1.