-
1
-
-
77949512140
-
RNA targeting therapeutics: Molecular mechanisms of antisense oligonucleotides as a therapeutic platform
-
Bennett CF, Swayze EE. RNA targeting therapeutics: Molecular mechanisms of antisense oligonucleotides as a therapeutic platform. Annu. Rev. Pharmacol. Toxicol. 50, 259-293 (2010
-
(2010)
Annu. Rev. Pharmacol. Toxicol
, vol.50
, pp. 259-293
-
-
Bennett, C.F.1
Swayze, E.E.2
-
2
-
-
84856389509
-
RNA-based therapeutics: Current progress and future prospects
-
Burnett JC, Rossi JJ. RNA-based therapeutics: Current progress and future prospects. Chem. Biol. 19(1), 60-71 (2012
-
(2012)
Chem. Biol
, vol.19
, Issue.1
, pp. 60-71
-
-
Burnett, J.C.1
Rossi, J.J.2
-
3
-
-
79953254828
-
Antisense drug discovery and development
-
Yamamoto T, Nakatani M, Narukawa K, Obika S. Antisense drug discovery and development. Future Med. Chem. 3(3), 339-365 (2011
-
(2011)
Future Med. Chem
, vol.3
, Issue.3
, pp. 339-365
-
-
Yamamoto, T.1
Nakatani, M.2
Narukawa, K.3
Obika, S.4
-
4
-
-
84868658343
-
Exon-skipping drug pulls ahead in muscular dystrophy field
-
Opar A. Exon-skipping drug pulls ahead in muscular dystrophy field. Nat. Med. 18(9), 1314 (2012
-
(2012)
Nat. Med
, vol.18
, Issue.9
, pp. 1314
-
-
Opar, A.1
-
5
-
-
61349157969
-
Therapeutic potential of splice-switching oligonucleotides
-
Bauman J, Jearawiriyapaisarn N, Kole R. Therapeutic potential of splice-switching oligonucleotides. Oligonucleotides 19(1), 1-13 (2009
-
(2009)
Oligonucleotides
, vol.19
, Issue.1
, pp. 1-13
-
-
Bauman, J.1
Jearawiriyapaisarn, N.2
Kole, R.3
-
6
-
-
83555173596
-
RNA interference and cancer therapy
-
Wang Z, Rao DD, Senzer N, Nemunaitis J. RNA interference and cancer therapy. Pharm. Res. 28(12), 2983-2995 (2011
-
(2011)
Pharm. Res
, vol.28
, Issue.12
, pp. 2983-2995
-
-
Wang, Z.1
Rao, D.D.2
Senzer, N.3
Nemunaitis, J.4
-
7
-
-
83455206025
-
MicroRNAs and cancer therapeutics
-
Yeung ML, Jeang KT. MicroRNAs and cancer therapeutics. Pharm. Res. 28(12), 3043-3049 (2011
-
(2011)
Pharm. Res
, vol.28
, Issue.12
, pp. 3043-3049
-
-
Yeung, M.L.1
Jeang, K.T.2
-
9
-
-
84866773569
-
Structure-dependent immunostimulatory effect of CpG oligodeoxynucleotides and their delivery system
-
Hanagata N. Structure-dependent immunostimulatory effect of CpG oligodeoxynucleotides and their delivery system. Int. J. Nanomed. 7, 2181-2195 (2012
-
(2012)
Int. J. Nanomed
, vol.7
, pp. 2181-2195
-
-
Hanagata, N.1
-
10
-
-
84877908608
-
Influence of diverse chemical modifications on the ADME characteristics and toxicology of antisense oligonucleotides
-
Dirin M, Winkler J. Influence of diverse chemical modifications on the ADME characteristics and toxicology of antisense oligonucleotides. Expert Opin. Biol. Ther. 13(6), 875-888 (2013
-
(2013)
Expert Opin. Biol. Ther
, vol.13
, Issue.6
, pp. 875-888
-
-
Dirin, M.1
Winkler, J.2
-
11
-
-
79959479529
-
Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes
-
Koller E, Vincent TM, Chappell A, De S, Manoharan M, Bennett CF. Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes. Nucleic Acids Res. 39(11), 4795-4807 (2011
-
(2011)
Nucleic Acids Res
, vol.39
, Issue.11
, pp. 4795-4807
-
-
Koller, E.1
Vincent, T.M.2
Chappell, A.3
De S Manoharan, M.4
Bennett, C.F.5
-
12
-
-
84944408943
-
Off-Target effects and safety aspects of phosphorothioate oligonucleotides
-
Erdmann VA, Barciszewski J (Eds Springer Verlag, Berlin, Germany
-
Stessl M, Noe CR, Winkler J. Off-Target effects and safety aspects of phosphorothioate oligonucleotides. In: From Nucleic Acids Sequences to Molecular Medicine, RNA Technologies. Erdmann VA, Barciszewski J (Eds). Springer Verlag, Berlin, Germany, 67-83 (2012
-
(2012)
From Nucleic Acids Sequences to Molecular Medicine, RNA Technologies
, pp. 67-83
-
-
Stessl, M.1
Noe, C.R.2
Winkler, J.3
-
13
-
-
84863922166
-
Lipid-based nanoparticles for siRNA delivery in cancer therapy: Paradigms and challenges
-
Gomes-da-Silva LC, Fonseca NA, Moura V, Pedroso de Lima MC, Simões S, Moreira JN. Lipid-based nanoparticles for siRNA delivery in cancer therapy: Paradigms and challenges. Acc. Chem. Res. 45(7), 1163-1171 (2012
-
(2012)
Acc. Chem. Res
, vol.45
, Issue.7
, pp. 1163-1171
-
-
Gomes-da-Silva, L.C.1
Fonseca, N.A.2
Moura, V.3
Pedroso De Lima, M.C.4
Simões, S.5
Moreira, J.N.6
-
14
-
-
84869039132
-
Randomized, placebo-controlled trial of mipomersen in patients with severe hypercholesterolemia receiving maximally tolerated lipid-lowering therapy
-
McGowan MP, Tardif J-C, Ceska R et al. Randomized, placebo-controlled trial of mipomersen in patients with severe hypercholesterolemia receiving maximally tolerated lipid-lowering therapy. PLoS ONE 7(11), e49006 (2012
-
(2012)
PLoS ONE
, vol.7
, Issue.11
-
-
McGowan, M.P.1
Tardif, J.-C.2
Ceska, R.3
-
15
-
-
84864239186
-
Therapeutic potential of mipomersen in the management of familial hypercholesterolaemia
-
Gelsinger C, Steinhagen-Thiessen E, Kassner U. Therapeutic potential of mipomersen in the management of familial hypercholesterolaemia. Drugs 72(11), 1445-1455 (2012
-
(2012)
Drugs
, vol.72
, Issue.11
, pp. 1445-1455
-
-
Gelsinger, C.1
Steinhagen-Thiessen, E.2
Kassner, U.3
-
16
-
-
84870409612
-
Mipomersen: Evidence-based review of its potential in the treatment of homozygous and severe heterozygous familial hypercholesterolemia
-
Parhofer KG. Mipomersen: Evidence-based review of its potential in the treatment of homozygous and severe heterozygous familial hypercholesterolemia. Core Evid. 7, 29-38 (2012
-
(2012)
Core Evid
, vol.7
, pp. 29-38
-
-
Parhofer, K.G.1
-
17
-
-
84860615159
-
Mipomersen, an apolipoprotein B synthesis inhibitor, lowers low-density lipoprotein cholesterol in high-risk statin-intolerant patients: A randomized, double-blind, placebo-controlled trial
-
Visser ME, Wagener G, Baker BF et al. Mipomersen, an apolipoprotein B synthesis inhibitor, lowers low-density lipoprotein cholesterol in high-risk statin-intolerant patients: A randomized, double-blind, placebo-controlled trial. Eur. Heart J. 33(9), 1142-1149 (2012
-
(2012)
Eur. Heart J.
, vol.33
, Issue.9
, pp. 1142-1149
-
-
Visser, M.E.1
Wagener, G.2
Baker, B.F.3
-
18
-
-
84877879081
-
Survival in a Phase III, randomized, double-blind study of dacarbazine with or without oblimersen (Bcl-2 antisense) in patients with advanced melanoma and low-normal serum lactate dehydrogenase (LDH; AGENDA
-
SUPPL
-
Bedikian AY, Lebbé; C, Robert C et al. Survival in a Phase III, randomized, double-blind study of dacarbazine with or without oblimersen (Bcl-2 antisense) in patients with advanced melanoma and low-normal serum lactate dehydrogenase (LDH; AGENDA). J. Clin. Oncol. 29(15 Suppl.), 8531 (2011
-
(2011)
J. Clin. Oncol
, vol.29
, Issue.15
, pp. 8531
-
-
Bedikian, A.Y.1
Lebbé2
, C.3
Robert, C.4
-
19
-
-
79955158683
-
Systemic administration of PRO051 in Duchenne's muscular dystrophy
-
Goemans NM, Tulinius M, van den Akker JT et al. Systemic administration of PRO051 in Duchenne's muscular dystrophy. N. Engl. J. Med. 364(16), 1513-1522 (2011
-
(2011)
N. Engl. J. Med
, vol.364
, Issue.16
, pp. 1513-1522
-
-
Goemans, N.M.1
Tulinius, M.2
Van Den Akker, J.T.3
-
20
-
-
80051690306
-
Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: An open-label, Phase 2, dose-escalation study
-
Cirak S, Arechavala-Gomeza V, Guglieri M et al. Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: An open-label, Phase 2, dose-escalation study. Lancet 378(9791), 595-605 (2011
-
(2011)
Lancet
, vol.378
, Issue.9791
, pp. 595-605
-
-
Cirak, S.1
Arechavala-Gomeza, V.2
Guglieri, M.3
-
21
-
-
84856546632
-
Restoration of the dystrophin-Associated glycoprotein complex after exon skipping therapy in Duchenne muscular dystrophy
-
Cirak S, Feng L, Anthony K et al. Restoration of the dystrophin- Associated glycoprotein complex after exon skipping therapy in Duchenne muscular dystrophy. Mol. Ther. 20(2), 462-467 (2012
-
(2012)
Mol. Ther
, vol.20
, Issue.2
, pp. 462-467
-
-
Cirak, S.1
Feng, L.2
Anthony, K.3
-
22
-
-
31544440989
-
Zwitterionic oligonucleotides: A study on binding properties of 2́;-O-Aminohexyl modifications
-
Noe CR, Winkler J, Urban E, Gilbert M, Haberhauer G, Brunar H. Zwitterionic oligonucleotides: A study on binding properties of 2́;-O-Aminohexyl modifications. Nucleosides Nucleotides Nucleic Acids 24(8), 1167-1185. (2005
-
(2005)
Nucleosides Nucleotides Nucleic Acids
, vol.24
, Issue.8
, pp. 1167-1185
-
-
Noe, C.R.1
Winkler, J.2
Urban, E.3
Gilbert, M.4
Haberhauer, G.5
Brunar, H.6
-
23
-
-
22644446801
-
Oligonucleotides conjugated to short lysine chains
-
Winkler J, Urban E, Noe CR. Oligonucleotides conjugated to short lysine chains. Bioconjug. Chem. 16(4), 1038-1044. (2005
-
(2005)
Bioconjug. Chem
, vol.16
, Issue.4
, pp. 1038-1044
-
-
Winkler, J.1
Urban, E.2
Noe, C.R.3
-
24
-
-
48149099287
-
2́;-O-Lysylaminohexyl oligonucleotides: Modifications for antisense and siRNA
-
Winkler J, Gilbert M, Kocourková; A, Stessl M, Noe CR. 2́;-O-Lysylaminohexyl oligonucleotides: Modifications for antisense and siRNA. ChemMedChem 3(1), 102-110 (2008
-
(2008)
ChemMedChem
, vol.3
, Issue.1
, pp. 102-110
-
-
Winkler, J.1
Gilbert, M.2
Kocourková3
, A.4
Stessl, M.5
Noe, C.R.6
-
25
-
-
75649138331
-
Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents
-
Stein CA, Hansen JB, Lai J et al. Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents. Nucleic Acids Res. 38(1), e3 (2010
-
(2010)
Nucleic Acids Res
, vol.38
, Issue.1
-
-
Stein, C.A.1
Hansen, J.B.2
Lai, J.3
-
26
-
-
76349111051
-
Rational design of cationic lipids for siRNA delivery
-
Semple SC, Akinc A, Chen J et al. Rational design of cationic lipids for siRNA delivery. Nat. Biotechnol. 28(2), 172-176 (2010
-
(2010)
Nat. Biotechnol
, vol.28
, Issue.2
, pp. 172-176
-
-
Semple, S.C.1
Akinc, A.2
Chen, J.3
-
27
-
-
84865079107
-
Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo
-
Jayaraman M, Ansell SM, Mui BL et al. Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo. Angew. Chem. Int. Ed. Engl. 51(34), 8529-8533 (2011
-
(2011)
Angew. Chem. Int. Ed. Engl
, vol.51
, Issue.34
, pp. 8529-8533
-
-
Jayaraman, M.1
Ansell, S.M.2
Mui, B.L.3
-
28
-
-
84872863485
-
Nanoparticle-based delivery of RNAi therapeutics: Progress and challenges
-
Zhou J, Shum K-T, Burnett J, Rossi J. Nanoparticle-based delivery of RNAi therapeutics: Progress and challenges. Pharmaceuticals 6(1), 85-107 (2013
-
(2013)
Pharmaceuticals
, vol.6
, Issue.1
, pp. 85-107
-
-
Zhou, J.1
Shum, K.-T.2
Burnett, J.3
Rossi, J.4
-
29
-
-
84862902835
-
Polymers for siRNA delivery: Inspired by viruses to be targeted, dynamic, and precise
-
Wagner E. Polymers for siRNA delivery: Inspired by viruses to be targeted, dynamic, and precise. Acc. Chem. Res. 45(7), 1005-1013 (2011
-
(2011)
Acc. Chem. Res
, vol.45
, Issue.7
, pp. 1005-1013
-
-
Wagner, E.1
-
30
-
-
79961203099
-
Nanomedicines based on recombinant fusion proteins for targeting therapeutic siRNA oligonucleotides
-
Winkler J. Nanomedicines based on recombinant fusion proteins for targeting therapeutic siRNA oligonucleotides. Ther. Deliv. 2(7), 891-905 (2011
-
(2011)
Ther. Deliv
, vol.2
, Issue.7
, pp. 891-905
-
-
Winkler, J.1
-
31
-
-
78649877710
-
Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates
-
Straarup EM, Fisker N, Hedtjärn M et al. Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates. Nucleic Acids Res. 38(20), 7100-7111 (2010
-
(2010)
Nucleic Acids Res
, vol.38
, Issue.20
, pp. 7100-7111
-
-
Straarup, E.M.1
Fisker, N.2
Hedtjärn, M.3
-
32
-
-
84869120708
-
Discovering the first microRNA-Targeted drug
-
Lindow M, Kauppinen S. Discovering the first microRNA-Targeted drug. J. Cell Biol. 199(3), 407-412 (2012
-
(2012)
J. Cell Biol
, vol.199
, Issue.3
, pp. 407-412
-
-
Lindow, M.1
Kauppinen, S.2
-
33
-
-
43249099500
-
Twenty-five years of quantitative PCR for gene expression analysis
-
VanGuilder HD, Vrana KE, Freeman WM. Twenty-five years of quantitative PCR for gene expression analysis. Biotechniques 44(5), 619-626 (2008
-
(2008)
Biotechniques
, vol.44
, Issue.5
, pp. 619-626
-
-
VanGuilder, H.D.1
Vrana, K.E.2
Freeman, W.M.3
-
34
-
-
42349093774
-
Single-cell identification in microbial communities by improved fluorescence in situ hybridization techniques
-
Amann R, Fuchs BM. Single-cell identification in microbial communities by improved fluorescence in situ hybridization techniques. Nat. Rev. Microbiol. 6(5), 339-348 (2008
-
(2008)
Nat. Rev. Microbiol
, vol.6
, Issue.5
, pp. 339-348
-
-
Amann, R.1
Fuchs, B.M.2
-
35
-
-
84860707063
-
The chemistry and biology of oligonucleotide conjugates
-
Juliano RL, Ming X, Nakagawa O. The chemistry and biology of oligonucleotide conjugates. Acc. Chem. Res. 45(7), 1067-1076 (2012
-
(2012)
Acc. Chem. Res
, vol.45
, Issue.7
, pp. 1067-1076
-
-
Juliano, R.L.1
Ming, X.2
Nakagawa, O.3
-
36
-
-
84856834692
-
Cellular uptake and intracellular trafficking of antisense and siRNA oligonucleotides
-
Juliano RL, Ming X, Nakagawa O. Cellular uptake and intracellular trafficking of antisense and siRNA oligonucleotides. Bioconjug. Chem. 23(2), 147-157 (2012
-
(2012)
Bioconjug. Chem
, vol.23
, Issue.2
, pp. 147-157
-
-
Juliano, R.L.1
Ming, X.2
Nakagawa, O.3
-
37
-
-
9144247189
-
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
-
Soutschek J, Akinc A, Bramlage B et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432(7014), 173-178 (2004
-
(2004)
Nature
, vol.432
, Issue.7014
, pp. 173-178
-
-
Soutschek, J.1
Akinc, A.2
Bramlage, B.3
-
38
-
-
35148815670
-
Mechanisms and optimization of in vivo delivery of lipophilic siRNAs
-
Wolfrum C, Shi S, Jayaprakash KN et al. Mechanisms and optimization of in vivo delivery of lipophilic siRNAs. Nat. Biotechnol. 25(10), 1149-1157 (2007
-
(2007)
Nat. Biotechnol
, vol.25
, Issue.10
, pp. 1149-1157
-
-
Wolfrum, C.1
Shi, S.2
Jayaprakash, K.N.3
-
39
-
-
84870570270
-
Co-injection of a targeted, reversibly masked endosomolytic polymer dramatically improves the efficacy of cholesterol-conjugated small interfering RNAs in vivo
-
Wong SC, Klein JJ, Hamilton HL et al. Co-injection of a targeted, reversibly masked endosomolytic polymer dramatically improves the efficacy of cholesterol-conjugated small interfering RNAs in vivo. Nucleic Acids Therap. 22(6), 380-390 (2012
-
(2012)
Nucleic Acids Therap
, vol.22
, Issue.6
, pp. 380-390
-
-
Wong, S.C.1
Klein, J.J.2
Hamilton, H.L.3
-
40
-
-
33646185371
-
RNAi-mediated gene silencing in non-human primates
-
Zimmermann TS, Lee AC, Akinc A et al. RNAi-mediated gene silencing in non-human primates. Nature 441(7089), 111-114 (2006
-
(2006)
Nature
, vol.441
, Issue.7089
, pp. 111-114
-
-
Zimmermann, T.S.1
Lee, A.C.2
Akinc, A.3
-
41
-
-
43049176170
-
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
-
Akinc A, Zumbuehl A, Goldberg M et al. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat. Biotechnol. 26(5), 561-569 (2008
-
(2008)
Nat. Biotechnol
, vol.26
, Issue.5
, pp. 561-569
-
-
Akinc, A.1
Zumbuehl, A.2
Goldberg, M.3
-
42
-
-
23444453219
-
Lipid modification of GRN163, an N3́;→P5́; thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition
-
Herbert B-S, Gellert GC, Hochreiter A et al. Lipid modification of GRN163, an N3́;→P5́; thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition. Oncogene 24(33), 5262-5268 (2005
-
(2005)
Oncogene
, vol.24
, Issue.33
, pp. 5262-5268
-
-
Herbert, B.-S.1
Gellert, G.C.2
Hochreiter, A.3
-
43
-
-
77949729607
-
Oligonucleotide N3́;→P5́; phosphoramidates and thio-phoshoramidates as potential therapeutic agents
-
Gryaznov SM. Oligonucleotide N3́;→P5́; phosphoramidates and thio-phoshoramidates as potential therapeutic agents. Chem. Biodivers. 7(3), 477-493 (2010
-
(2010)
Chem. Biodivers
, vol.7
, Issue.3
, pp. 477-493
-
-
Gryaznov, S.M.1
-
44
-
-
41149179660
-
Efficient in vivo delivery of siRNA to the liver by conjugation of alpha-Tocopherol
-
Nishina K, Unno T, Uno Y et al. Efficient in vivo delivery of siRNA to the liver by conjugation of alpha-Tocopherol. Mol. Ther. 16(4), 734-740 (2008
-
(2008)
Mol. Ther
, vol.16
, Issue.4
, pp. 734-740
-
-
Nishina, K.1
Unno, T.2
Uno, Y.3
-
45
-
-
79958208753
-
High-density lipoprotein facilitates in vivo delivery of a-Tocopherol-conjugated short-interfering RNA to the brain
-
Uno Y, Piao W, Miyata K, Nishina K, Mizusawa H, Yokota T. High-density lipoprotein facilitates in vivo delivery of a-Tocopherol-conjugated short-interfering RNA to the brain. Hum. Gene Ther. 22(6), 711-719 (2010
-
(2010)
Hum. Gene Ther
, vol.22
, Issue.6
, pp. 711-719
-
-
Uno, Y.1
Piao, W.2
Miyata, K.3
Nishina, K.4
Mizusawa, H.5
Yokota, T.6
-
46
-
-
77949890248
-
Cell penetrating peptides: Overview and applications to the delivery of oligonucleotides
-
Said Hassane F, Saleh AF, Abes R, Gait MJ, Lebleu B. Cell penetrating peptides: Overview and applications to the delivery of oligonucleotides. Cell. Mol. Life Sci. 67(5), 715-726 (2010
-
(2010)
Cell. Mol. Life Sci
, vol.67
, Issue.5
, pp. 715-726
-
-
Said Hassane, F.1
Saleh, A.F.2
Abes, R.3
Gait, M.J.4
Lebleu, B.5
-
47
-
-
82755194760
-
Protein transduction domain delivery of therapeutic macromolecules
-
van den Berg A, Dowdy SF. Protein transduction domain delivery of therapeutic macromolecules. Curr. Opin. Biotechnol. 22(6), 888-893 (2011
-
(2011)
Curr. Opin. Biotechnol
, vol.226
, pp. 888-893
-
-
Van Den Berg, A.1
Dowdy, S.F.2
-
48
-
-
67649408951
-
SiRNA delivery using peptide transduction domains
-
Eguchi A, Dowdy SF. siRNA delivery using peptide transduction domains. Trends Pharmacol. Sci. 30(7), 341-345 (2009
-
(2009)
Trends Pharmacol. Sci
, vol.30
, Issue.7
, pp. 341-345
-
-
Eguchi, A.1
Dowdy, S.F.2
-
49
-
-
74049160383
-
Revised role of glycosaminoglycans in TAT protein transduction domain-mediated cellular transduction
-
Gump JM, June RK, Dowdy SF. Revised role of glycosaminoglycans in TAT protein transduction domain-mediated cellular transduction. J. Biol. Chem. 285(2), 1500-1507 (2010
-
(2010)
J. Biol. Chem
, vol.285
, Issue.2
, pp. 1500-1507
-
-
Gump, J.M.1
June, R.K.2
Dowdy, S.F.3
-
50
-
-
79954490100
-
Therapeutic delivery opportunities, obstacles and applications for cell-penetrating peptides
-
Lindberg S, Copolovici DM, Langel Ü. Therapeutic delivery opportunities, obstacles and applications for cell-penetrating peptides. Ther. Deliv. 2(1), 71-82 (2011
-
(2011)
Ther. Deliv
, vol.2
, Issue.1
, pp. 71-82
-
-
Lindberg, S.1
Copolovici, D.M.2
Langel, Ü.3
-
51
-
-
56649113066
-
Improved cell-penetrating peptide-PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle
-
Ivanova GD, Arzumanov A, Abes R et al. Improved cell-penetrating peptide-PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle. Nucleic Acids Res. 36(20), 6418-6428 (2008
-
(2008)
Nucleic Acids Res
, vol.36
, Issue.20
, pp. 6418-6428
-
-
Ivanova, G.D.1
Arzumanov, A.2
Abes, R.3
-
52
-
-
34548150237
-
Cell-penetrating-peptide-based delivery of oligonucleotides: An overview
-
Abes R, Arzumanov AA, Moulton HM et al. Cell-penetrating-peptide-based delivery of oligonucleotides: An overview. Biochem. Soc. Trans. 35(Pt 4), 775-779 (2007
-
(2007)
Biochem. Soc. Trans
, vol.35
, Issue.PART 4
, pp. 775-779
-
-
Abes, R.1
Arzumanov, A.A.2
Moulton, H.M.3
-
53
-
-
63449133262
-
Gene knockdowns in adult animals: PPMOs and vivo-morpholinos
-
Moulton JD, Jiang S. Gene knockdowns in adult animals: PPMOs and vivo-morpholinos. Molecules 14(3), 1304-1323 (2009
-
(2009)
Molecules
, vol.14
, Issue.3
, pp. 1304-1323
-
-
Moulton, J.D.1
Jiang, S.2
-
54
-
-
77958152873
-
Morpholinos and their peptide conjugates: Therapeutic promise and challenge for duchenne muscular dystrophy
-
Moulton HM, Moulton JD. Morpholinos and their peptide conjugates: Therapeutic promise and challenge for Duchenne muscular dystrophy. Biochim. Biophys. Acta 1798(12), 2296-2303 (2010
-
(2010)
Biochim. Biophys. Acta
, vol.1798
, Issue.12
, pp. 2296-2303
-
-
Moulton, H.M.1
Moulton, J.D.2
-
55
-
-
57049102809
-
Cell-penetrating peptide-conjugated antisense oligonucleotides restore systemic muscle and cardiac dystrophin expression and function
-
Yin H, Moulton HM, Seow Y et al. Cell-penetrating peptide-conjugated antisense oligonucleotides restore systemic muscle and cardiac dystrophin expression and function. Hum. Mol. Genet. 17(24), 3909-3918 (2008
-
(2008)
Hum. Mol. Genet
, vol.17
, Issue.24
, pp. 3909-3918
-
-
Yin, H.1
Moulton, H.M.2
Seow, Y.3
-
56
-
-
70350697818
-
A fusion peptide directs enhanced systemic dystrophin exon skipping and functional restoration in dystrophin-deficient mdx mice
-
Yin H, Moulton HM, Betts C et al. A fusion peptide directs enhanced systemic dystrophin exon skipping and functional restoration in dystrophin-deficient mdx mice. Hum. Mol. Genet. 18(22), 4405-4414 (2009
-
(2009)
Hum. Mol. Genet
, vol.18
, Issue.22
, pp. 4405-4414
-
-
Yin, H.1
Moulton, H.M.2
Betts, C.3
-
57
-
-
63449099709
-
Chemical modifications of antisense morpholino oligomers enhance their efficacy against Ebola virus infection
-
Swenson DL, Warfield KL, Warren TK et al. Chemical modifications of antisense morpholino oligomers enhance their efficacy against Ebola virus infection. Antimicrob. Agents Chemother. 53(5), 2089-2099 (2009
-
(2009)
Antimicrob. Agents Chemother
, vol.53
, Issue.5
, pp. 2089-2099
-
-
Swenson, D.L.1
Warfield, K.L.2
Warren, T.K.3
-
58
-
-
33747197740
-
Online synthesis of diblock cationic oligonucleotides for enhanced hybridization to their complementary sequence
-
Pons B, Kotera M, Zuber G, Behr J-P. Online synthesis of diblock cationic oligonucleotides for enhanced hybridization to their complementary sequence. ChemBioChem 7(8), 1173-1176 (2006
-
(2006)
ChemBioChem
, vol.7
, Issue.8
, pp. 1173-1176
-
-
Pons, B.1
Kotera, M.2
Zuber, G.3
Behr, J.-P.4
-
59
-
-
53549134010
-
Oligonucleotide-oligospermine conjugates (zip nucleic acids): A convenient means of finely tuning hybridization temperatures
-
Noir R, Kotera M, Pons B, Remy JS, Behr JP. Oligonucleotide-oligospermine conjugates (zip nucleic acids): A convenient means of finely tuning hybridization temperatures. J. Am. Chem. Soc. 130(40), 13500-13505 (2008
-
(2008)
J. Am. Chem. Soc
, vol.130
, Issue.40
, pp. 13500-13505
-
-
Noir, R.1
Kotera, M.2
Pons, B.3
Remy, J.S.4
Behr, J.P.5
-
60
-
-
60149108149
-
Oligonucleotide polyamine conjugates: Influence of length and position of 2́;-Attached polyamines on duplex stability and antisense effect
-
Winkler J, Saadat K, Dí;az Gavilá;n M, Urban E, Noe CR. Oligonucleotide polyamine conjugates: Influence of length and position of 2́;-Attached polyamines on duplex stability and antisense effect. Eur. J. Med. Chem. 44(2), 670-677 (2009
-
(2009)
Eur. J. Med. Chem
, vol.44
, Issue.2
, pp. 670-677
-
-
Winkler, J.1
Saadat, K.2
Dí3
az Gavilá4
n, M.5
Urban, E.6
Noe, C.R.7
-
61
-
-
33645095226
-
Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease
-
Ng EWM, Shima DT, Calias P, Cunningham ET Jr, Guyer DR, Adamis AP. Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease. Nat. Rev. Drug Discov. 5(2), 123-132 (2006
-
(2006)
Nat. Rev. Drug Discov
, vol.5
, Issue.2
, pp. 123-132
-
-
Ng, E.W.M.1
Shima, D.T.2
Calias, P.3
Cunningham Jr., E.T.4
Guyer, D.R.5
Adamis, A.P.6
-
63
-
-
33845216721
-
PEG conjugated VEGF siRNA for anti-Angiogenic gene therapy
-
Kim SH, Jeong JH, Lee SH, Kim SW, Park TG. PEG conjugated VEGF siRNA for anti-Angiogenic gene therapy. J. Control. Release 116(2), 123-129 (2006
-
(2006)
J. Control. Release
, vol.116
, Issue.2
, pp. 123-129
-
-
Kim, S.H.1
Jeong, J.H.2
Lee, S.H.3
Kim, S.W.4
Park, T.G.5
-
64
-
-
77955331645
-
Design of next-generation protein therapeutics
-
Caravella J, Lugovskoy A. Design of next-generation protein therapeutics. Curr. Opin. Chem. Biol. 14(4), 520-528 (2010
-
(2010)
Curr. Opin. Chem. Biol
, vol.14
, Issue.4
, pp. 520-528
-
-
Caravella, J.1
Lugovskoy, A.2
-
65
-
-
77955690974
-
Multivalent antibodies: When design surpasses evolution
-
Cuesta Á;.M, Sainz-Pastor N, Bonet J, Oliva B, Á;lvarez-Vallina L. Multivalent antibodies: When design surpasses evolution. Trends Biotechnol. 28(7), 355-362 (2010
-
(2010)
Trends Biotechnol
, vol.28
, Issue.7
, pp. 355-362
-
-
Cuesta, Á1
.M.2
Sainz-Pastor, N.3
Bonet, J.4
Oliva, B.5
Á6
lvarez-Vallina, L.7
-
66
-
-
80054856259
-
DARPins and other repeat protein scaffolds: Advances in engineering and applications
-
Boersma YL, Plückthun A. DARPins and other repeat protein scaffolds: Advances in engineering and applications. Curr. Opin. Biotechnol. 22(6), 849-857 (2011
-
(2011)
Curr. Opin. Biotechnol
, vol.22
, Issue.6
, pp. 849-857
-
-
Boersma, Y.L.1
Plückthun, A.2
-
67
-
-
23844474160
-
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
-
Song E, Zhu P, Lee SK et al. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat. Biotechnol. 23(6), 709-717 (2005
-
(2005)
Nat. Biotechnol
, vol.23
, Issue.6
, pp. 709-717
-
-
Song, E.1
Zhu, P.2
Lee, S.K.3
-
68
-
-
84860211700
-
Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis
-
Yao YD, Sun TM, Huang SY et al. Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis. Sci. Transl Med. 4(130), 130-148 (2012
-
(2012)
Sci. Transl Med
, vol.4
, Issue.130
, pp. 130-148
-
-
Yao, Y.D.1
Sun, T.M.2
Huang, S.Y.3
-
69
-
-
70349512496
-
EpCAM-Targeted delivery of nanocomplexed siRNA to tumor cells with designed ankyrin repeat proteins
-
Winkler J, Martin-Killias P, Pluckthun A, Zangemeister-Wittke U. EpCAM-Targeted delivery of nanocomplexed siRNA to tumor cells with designed ankyrin repeat proteins. Mol. Cancer Ther. 8(9), 2674-2683 (2009
-
(2009)
Mol. Cancer Ther
, vol.8
, Issue.9
, pp. 2674-2683
-
-
Winkler, J.1
Martin-Killias, P.2
Pluckthun, A.3
Zangemeister-Wittke, U.4
-
70
-
-
67249098401
-
Antibody-mediated targeting of siRNA via the human insulin receptor using avidin-biotin technology
-
Xia C-F, Boado RJ, Pardridge WM. Antibody-mediated targeting of siRNA via the human insulin receptor using avidin-biotin technology. Mol. Pharm. 6(3), 747-751 (2008
-
(2008)
Mol. Pharm
, vol.6
, Issue.3
, pp. 747-751
-
-
Xia, C.-F.1
Boado, R.J.2
Pardridge, W.M.3
-
71
-
-
79951944060
-
Antibody derivatization and conjugation strategies: Application in preparation of stealth immunoliposome to target chemotherapeutics to tumor
-
Manjappa AS, Chaudhari KR, Venkataraju MP et al. Antibody derivatization and conjugation strategies: Application in preparation of stealth immunoliposome to target chemotherapeutics to tumor. J. Control. Release 150(1), 2-22 (2011
-
(2011)
J. Control. Release
, vol.150
, Issue.1
, pp. 2-22
-
-
Manjappa, A.S.1
Chaudhari, K.R.2
Venkataraju, M.P.3
-
72
-
-
84860774962
-
Challenges in development of targeted liposomal therapeutics
-
Sawant R, Torchilin V. Challenges in development of targeted liposomal therapeutics. AAPS J. 14(2), 303-315 (2012
-
(2012)
AAPS J.
, vol.14
, Issue.2
, pp. 303-315
-
-
Sawant, R.1
Torchilin, V.2
-
73
-
-
34247863385
-
An improved method for covalently conjugating morpholino oligomers to antitumor antibodies
-
He J, Liu G, Dou S, Gupta S, Rusckowski M, Hnatowich D. An improved method for covalently conjugating morpholino oligomers to antitumor antibodies. Bioconjug. Chem. 18(3), 983-988 (2007
-
(2007)
Bioconjug. Chem
, vol.18
, Issue.3
, pp. 983-988
-
-
He, J.1
Liu, G.2
Dou, S.3
Gupta, S.4
Rusckowski, M.5
Hnatowich, D.6
-
74
-
-
84855307641
-
Comparing the intracellular fate of components within a noncovalent streptavidin nanoparticle with covalent conjugation
-
Liu Y, Cheng D, Liu X et al. Comparing the intracellular fate of components within a noncovalent streptavidin nanoparticle with covalent conjugation. Nucl. Med. Biol. 39(1), 101-107 (2012
-
(2012)
Nucl. Med. Biol
, vol.39
, Issue.1
, pp. 101-107
-
-
Liu, Y.1
Cheng, D.2
Liu, X.3
-
75
-
-
33746931297
-
Ligand-Targeted delivery of therapeutic siRNA
-
Ikeda Y, Taira K. Ligand-Targeted delivery of therapeutic siRNA. Pharm. Res. 23(8), 1631-1640 (2006
-
(2006)
Pharm. Res
, vol.23
, Issue.8
, pp. 1631-1640
-
-
Ikeda, Y.1
Taira, K.2
-
76
-
-
65549111789
-
Targeted delivery systems for oligonucleotide therapeutics
-
Yu B, Zhao X, Lee LJ, Lee R. Targeted delivery systems for oligonucleotide therapeutics. AAPS J. 11(1), 195-203 (2009
-
(2009)
AAPS J.
, vol.11
, Issue.1
, pp. 195-203
-
-
Yu, B.1
Zhao, X.2
Lee, L.J.3
Lee, R.4
-
77
-
-
84867702136
-
Novel protein scaffolds as emerging therapeutic proteins: From discovery to clinical proof-of-concept
-
Wurch T, Pierré; A, Depil S. Novel protein scaffolds as emerging therapeutic proteins: From discovery to clinical proof-of-concept. Trends Biotechnol. 30(11), 575-582 (2012
-
(2012)
Trends Biotechnol
, vol.30
, Issue.11
, pp. 575-582
-
-
Wurch, T.1
Pierré2
, A.3
Depil, S.4
-
78
-
-
84855599223
-
-
Wittrup KD, Gregory LV (Eds). Academic Press, MA, USA
-
Tamaskovic R, Simon M, Stefan N, Schwill M, Plückthun A. Designed ankyrin repeat proteins (DARPins): From research to therapy. In: Methods Enzymol. Wittrup KD, Gregory LV (Eds). Academic Press, MA, USA, 101-134 (2012
-
(2012)
Designed Ankyrin Repeat Proteins (DARPins): From Research To Therapy Methods Enzymol
, pp. 101-134
-
-
Tamaskovic, R.1
Simon, M.2
Stefan, N.3
Schwill, M.4
Plückthun, A.5
-
79
-
-
84855591894
-
Facile double-functionalization of designed ankyrin repeat proteins using click and thiol chemistries
-
Simon M, Zangemeister-Wittke U, Plückthun A. Facile double-functionalization of designed ankyrin repeat proteins using click and thiol chemistries. Bioconjug. Chem. 23(2), 279-286 (2012
-
(2012)
Bioconjug. Chem
, vol.23
, Issue.2
, pp. 279-286
-
-
Simon, M.1
Zangemeister-Wittke, U.2
Plückthun, A.3
-
80
-
-
84871815371
-
Rational design of an immunoconjugate for selective knock-down of leukemia-specific E2A-PBX1 fusion gene expression in human Pre-B leukemia
-
Uckun FM, Qazi S, Dibirdik I, Myers DE. Rational design of an immunoconjugate for selective knock-down of leukemia-specific E2A-PBX1 fusion gene expression in human Pre-B leukemia. Integr. Biol. 5(1), 122-132 (2013
-
(2013)
Integr. Biol
, vol.5
, Issue.1
, pp. 122-132
-
-
Uckun, F.M.1
Qazi, S.2
Dibirdik, I.3
Myers, D.E.4
-
81
-
-
84862326949
-
Defined folate-PEG-siRNA conjugates for receptor-specific gene silencing
-
Dohmen C, Frohlich T, Lachelt U et al. Defined folate-PEG-siRNA conjugates for receptor-specific gene silencing. Mol. Ther. Nucleic Acids 1, e7 (2012
-
(2012)
Mol. Ther. Nucleic Acids
, vol.1
-
-
Dohmen, C.1
Frohlich, T.2
Lachelt, U.3
-
82
-
-
77954298422
-
Targeted intracellular delivery of antisense oligonucleotides via conjugation with small-molecule ligands
-
Nakagawa O, Ming X, Huang L, Juliano RL. Targeted intracellular delivery of antisense oligonucleotides via conjugation with small-molecule ligands. J. Am. Chem. Soc. 132(26), 8848-8849 (2010
-
(2010)
J. Am. Chem. Soc
, vol.132
, Issue.26
, pp. 8848-8849
-
-
Nakagawa, O.1
Ming, X.2
Huang, L.3
Juliano, R.L.4
-
83
-
-
38949215454
-
Discovery and development of folic-Acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases
-
Low PS, Henne WA, Doorneweerd DD. Discovery and development of folic-Acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases. Acc. Chem. Res. 41(1), 120-129 (2007
-
(2007)
Acc. Chem. Res
, vol.41
, Issue.1
, pp. 120-129
-
-
Low, P.S.1
Henne, W.A.2
Doorneweerd, D.D.3
-
84
-
-
70349451255
-
Ligand-Targeted delivery of small interfering RNAs to malignant cells and tissues
-
Thomas M, Kularatne SA, Qi L et al. Ligand-Targeted delivery of small interfering RNAs to malignant cells and tissues. Ann. NY Acad. Sci. 1175, 32-39 (2009
-
(2009)
Ann. NY Acad. Sci
, vol.1175
, pp. 32-39
-
-
Thomas, M.1
Kularatne, S.A.2
Qi, L.3
-
85
-
-
43049125473
-
Trivalent Gal/GalNAc-containing ligands designed for the asialoglycoprotein receptor
-
Khorev O, Stokmaier D, Schwardt O, Cutting B, Ernst B. Trivalent, Gal/GalNAc-containing ligands designed for the asialoglycoprotein receptor. Bioorg. Med. Chem. 16(9), 5216-5231 (2008
-
(2008)
Bioorg. Med. Chem
, vol.16
, Issue.9
, pp. 5216-5231
-
-
Khorev, O.1
Stokmaier, D.2
Schwardt, O.3
Cutting, B.4
Ernst, B.5
-
86
-
-
77954243341
-
Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms
-
Akinc A, Querbes W, De S et al. Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms. Mol. Ther. 18(7), 1357-1364 (2010
-
(2010)
Mol. Ther
, vol.18
, Issue.7
, pp. 1357-1364
-
-
Akinc, A.1
Querbes W De, S.2
-
87
-
-
25444518193
-
Membrane activity and transfection ability of amphipathic polycations as a function of alkyl group size
-
Wakefield DH, Klein JJ, Wolff JA, Rozema DB. Membrane activity and transfection ability of amphipathic polycations as a function of alkyl group size. Bioconjug. Chem. 16(5), 1204-1208 (2005
-
(2005)
Bioconjug. Chem
, vol.16
, Issue.5
, pp. 1204-1208
-
-
Wakefield, D.H.1
Klein, J.J.2
Wolff, J.A.3
Rozema, D.B.4
-
88
-
-
34548735210
-
Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes
-
Rozema DB, Lewis DL, Wakefield DH et al. Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes. Proc. Natl Acad. Sci. USA 104(32), 12982-12987 (2007
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, Issue.32
, pp. 12982-12987
-
-
Rozema, D.B.1
Lewis, D.L.2
Wakefield, D.H.3
-
89
-
-
84877026189
-
Hepatocyte-Targeted RNAi therapeutics for the treatment of chronic hepatitis B virus infection
-
Wooddell CI, Rozema DB, Hossbach M et al. Hepatocyte-Targeted RNAi therapeutics for the treatment of chronic hepatitis B virus infection. Mol. Ther. 21(5), 973-985 (2013
-
(2013)
Mol. Ther
, vol.21
, Issue.5
, pp. 973-985
-
-
Wooddell, C.I.1
Rozema, D.B.2
Hossbach, M.3
-
90
-
-
42549142820
-
Efficient oncogene silencing and metastasis inhibition via systemic delivery of siRNA
-
Li SD, Chono S, Huang L. Efficient oncogene silencing and metastasis inhibition via systemic delivery of siRNA. Mol. Ther. 16(5), 942-946 (2008
-
(2008)
Mol. Ther
, vol.16
, Issue.5
, pp. 942-946
-
-
Li, S.D.1
Chono, S.2
Huang, L.3
-
91
-
-
70350337962
-
PAMAM-RGD conjugates enhance siRNA delivery through a multicellular spheroid model of malignant glioma
-
Waite CL, Roth CM. PAMAM-RGD conjugates enhance siRNA delivery through a multicellular spheroid model of malignant glioma. Bioconjug. Chem. 20(10), 1908-1916 (2009
-
(2009)
Bioconjug. Chem
, vol.20
, Issue.10
, pp. 1908-1916
-
-
Waite, C.L.1
Roth, C.M.2
-
92
-
-
33748922791
-
Cell adhesion molecules for targeted drug delivery
-
Dunehoo AL, Anderson M, Majumdar S, Kobayashi N, Berkland C, Siahaan TJ. Cell adhesion molecules for targeted drug delivery. J. Pharm. Sci. 95(9), 1856-1872 (2006
-
(2006)
J. Pharm. Sci
, vol.95
, Issue.9
, pp. 1856-1872
-
-
Dunehoo, A.L.1
Anderson, M.2
Majumdar, S.3
Kobayashi, N.4
Berkland, C.5
Siahaan, T.J.6
-
93
-
-
43349103903
-
Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis
-
Alam MR, Dixit V, Kang H et al. Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis. Nucleic Acids Res. 36(8), 2764-2776 (2008
-
(2008)
Nucleic Acids Res
, vol.36
, Issue.8
, pp. 2764-2776
-
-
Alam, M.R.1
Dixit, V.2
Kang, H.3
-
94
-
-
80051769247
-
Multivalent cyclic RGD conjugates for targeted delivery of small interfering RNA
-
Alam MR, Ming X, Fisher M et al. Multivalent cyclic RGD conjugates for targeted delivery of small interfering RNA. Bioconjug. Chem. 22(8), 1673-1681 (2011
-
(2011)
Bioconjug. Chem
, vol.22
, Issue.8
, pp. 1673-1681
-
-
Alam, M.R.1
Ming, X.2
Fisher, M.3
-
95
-
-
23044479980
-
Anandamide transport: A critical review
-
Glaser ST, Kaczocha M, Deutsch DG. Anandamide transport: A critical review. Life Sci. 77(14), 1584-1604 (2005
-
(2005)
Life Sci
, vol.77
, Issue.14
, pp. 1584-1604
-
-
Glaser, S.T.1
Kaczocha, M.2
Deutsch, D.G.3
-
96
-
-
84864418967
-
Click-modified anandamide siRNA enables delivery and gene silencing in neuronal and immune cells
-
Willibald J, Harder J, Sparrer K, Conzelmann K-K, Carell T. Click-modified anandamide siRNA enables delivery and gene silencing in neuronal and immune cells. J. Am. Chem. Soc. 134(30), 12330-12333 (2012
-
(2012)
J. Am. Chem. Soc
, vol.134
, Issue.30
, pp. 12330-12333
-
-
Willibald, J.1
Harder, J.2
Sparrer, K.3
Conzelmann, K.-K.4
Carell, T.5
-
97
-
-
36849081485
-
Insulin receptor substrate 1 knockdown in human MCF7 ER+ breast cancer cells by nuclease-resistant IRS1 siRNA conjugated to a disulfide-bridged D-peptide analogue of insulin-like growth factor 1
-
Cesarone G, Edupuganti OP, Chen CP, Wickstrom E. Insulin receptor substrate 1 knockdown in human MCF7 ER+ breast cancer cells by nuclease-resistant IRS1 siRNA conjugated to a disulfide-bridged D-peptide analogue of insulin-like growth factor 1. Bioconjug. Chem. 18(6), 1831-1840 (2007
-
(2007)
Bioconjug. Chem
, vol.18
, Issue.6
, pp. 1831-1840
-
-
Cesarone, G.1
Edupuganti, O.P.2
Chen, C.P.3
Wickstrom, E.4
-
98
-
-
78049363846
-
Intracellular delivery of an antisense oligonucleotide via endocytosis of a G protein-coupled receptor
-
Ming X, Alam MR, Fisher M, Yan Y, Chen X, Juliano RL. Intracellular delivery of an antisense oligonucleotide via endocytosis of a G protein-coupled receptor. Nucleic Acids Res. 38(19), 6567-6576 (2010
-
(2010)
Nucleic Acids Res
, vol.38
, Issue.19
, pp. 6567-6576
-
-
Ming, X.1
Alam, M.R.2
Fisher, M.3
Yan, Y.4
Chen, X.5
Juliano, R.L.6
-
99
-
-
70349786346
-
The chemical biology of aptamers
-
Mayer G. The chemical biology of aptamers. Angew. Chem. Int. Ed. Engl. 48(15), 2672-2689 (2009
-
(2009)
Angew. Chem. Int. Ed. Engl
, vol.48
, Issue.15
, pp. 2672-2689
-
-
Mayer, G.1
-
100
-
-
77956682609
-
Development of DNA aptamers using Cell-SELEX
-
Sefah K, Shangguan D, Xiong X, O'Donoghue MB, Tan W. Development of DNA aptamers using Cell-SELEX. Nat. Protocols 5(6), 1169-1185 (2010
-
(2010)
Nat. Protocols
, vol.5
, Issue.6
, pp. 1169-1185
-
-
Sefah, K.1
Shangguan, D.2
Xiong, X.3
O'Donoghue, M.B.4
Tan, W.5
-
101
-
-
33747031960
-
Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras
-
McNamara JO, Andrechek ER, Wang Y et al. Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. Nat. Biotechnol. 24(8), 1005-1015 (2006
-
(2006)
Nat. Biotechnol
, vol.24
, Issue.8
, pp. 1005-1015
-
-
McNamara, J.O.1
Andrechek, E.R.2
Wang, Y.3
-
102
-
-
70249110439
-
Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors
-
Dassie JP, Liu XY, Thomas GS et al. Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors. Nat. Biotechnol. 27(9), 839-849 (2009
-
(2009)
Nat. Biotechnol
, vol.27
, Issue.9
, pp. 839-849
-
-
Dassie, J.P.1
Liu, X.Y.2
Thomas, G.S.3
-
103
-
-
77954362096
-
Aptamer-Targeted cell-specific RNA interference
-
Zhou J, Rossi J. Aptamer-Targeted cell-specific RNA interference. Silence 1(1), 4 (2010
-
(2010)
Silence
, vol.1
, Issue.1
, pp. 4
-
-
Zhou, J.1
Rossi, J.2
-
104
-
-
67649231388
-
Solid-phase synthesis of oligonucleotide conjugates useful for delivery and targeting of potential nucleic acid therapeutics
-
Lonnberg H. Solid-phase synthesis of oligonucleotide conjugates useful for delivery and targeting of potential nucleic acid therapeutics. Bioconjug. Chem. 20(6), 1065-1094 (2009
-
(2009)
Bioconjug. Chem
, vol.20
, Issue.6
, pp. 1065-1094
-
-
Lonnberg, H.1
-
105
-
-
18044364215
-
Molecular mechanisms of RNAi: Implications for development and disease
-
Rao M, Sockanathan S. Molecular mechanisms of RNAi: Implications for development and disease. Birth Defects Res. C Embryo Today 75(1), 28-42. (2005
-
(2005)
Birth Defects Res. C Embryo Today
, vol.75
, Issue.1
, pp. 28-42
-
-
Rao, M.1
Sockanathan, S.2
-
106
-
-
77049090297
-
Chemical strategies for the synthesis of peptide-oligonucleotide conjugates
-
Lu K, Duan Q-P, Ma L, Zhao D-X. Chemical strategies for the synthesis of peptide-oligonucleotide conjugates. Bioconjug. Chem. 21(2), 187-202 (2009
-
(2009)
Bioconjug. Chem
, vol.21
, Issue.2
, pp. 187-202
-
-
Lu, K.1
Duan, Q.-P.2
Ma, L.3
Zhao, D.-X.4
-
107
-
-
1342327656
-
A novel concept for ligand attachment to oligonucleotides via a 2́;-succinyl linker
-
Winkler J, Urban E, Losert D, Wacheck V, Pehamberger H, Noe CR. A novel concept for ligand attachment to oligonucleotides via a 2́;-succinyl linker. Nucleic Acids Res. 32(2), 710-718 (2004
-
(2004)
Nucleic Acids Res
, vol.32
, Issue.2
, pp. 710-718
-
-
Winkler, J.1
Urban, E.2
Losert, D.3
Wacheck, V.4
Pehamberger, H.5
Noe, C.R.6
-
108
-
-
78149408523
-
2́;-O-lysylaminohexyladenosine modified oligonucleotides
-
Winkler J, Giessrigl B, Novak C, Urban E, Noe CR. 2́;-O- lysylaminohexyladenosine modified oligonucleotides. Monatsh. Chem. 141(7), 809-815 (2010
-
(2010)
Monatsh. Chem
, vol.141
, Issue.7
, pp. 809-815
-
-
Winkler, J.1
Giessrigl, B.2
Novak, C.3
Urban, E.4
Noe, C.R.5
-
109
-
-
77952811232
-
Recent developments in oligonucleotide conjugation
-
Singh Y, Murat P, Defrancq E. Recent developments in oligonucleotide conjugation. Chem. Soc. Rev. 39(6), 2054-2070 (2010
-
(2010)
Chem. Soc. Rev
, vol.39
, Issue.6
, pp. 2054-2070
-
-
Singh, Y.1
Murat, P.2
Defrancq, E.3
-
110
-
-
0347926091
-
Drug delivery strategy utilizing conjugation via reversible disulfide linkages: Role and site of cellular reducing activities
-
Saito G, Swanson JA, Lee K-D. Drug delivery strategy utilizing conjugation via reversible disulfide linkages: Role and site of cellular reducing activities. Adv. Drug Deliv. Rev. 55(2), 199-215 (2003
-
(2003)
Adv. Drug Deliv. Rev
, vol.55
, Issue.2
, pp. 199-215
-
-
Saito, G.1
Swanson, J.A.2
Lee, K.-D.3
-
111
-
-
77949779995
-
Click chemistry with DNA
-
El-Sagheer AH, Brown T. Click chemistry with DNA. Chem. Soc. Rev. 39(4), 1388-1405 (2010
-
(2010)
Chem. Soc. Rev
, vol.39
, Issue.4
, pp. 1388-1405
-
-
El-Sagheer, A.H.1
Brown, T.2
-
112
-
-
77954095160
-
In situ visualization and dynamics of newly synthesized proteins in rat hippocampal neurons
-
Dieterich DC, Hodas JJL, Gouzer G et al. In situ visualization and dynamics of newly synthesized proteins in rat hippocampal neurons. Nat. Neurosci. 13(7), 897-905 (2010
-
(2010)
Nat. Neurosci
, vol.13
, Issue.7
, pp. 897-905
-
-
Dieterich, D.C.1
Hodas, J.J.L.2
Gouzer, G.3
-
113
-
-
0037307787
-
Chemical proteomics and its application to drug discovery
-
Jeffery DA, Bogyo M. Chemical proteomics and its application to drug discovery. Curr. Opin. Biotechnol. 14(1), 87-95 (2003
-
(2003)
Curr. Opin. Biotechnol
, vol.14
, Issue.1
, pp. 87-95
-
-
Jeffery, D.A.1
Bogyo, M.2
-
114
-
-
0037362655
-
Effect of pegylation on pharmaceuticals
-
Harris JM, Chess RB. Effect of pegylation on pharmaceuticals. Nat. Rev. Drug Discov. 2(3), 214-221 (2003
-
(2003)
Nat. Rev. Drug Discov
, vol.2
, Issue.3
, pp. 214-221
-
-
Harris, J.M.1
Chess, R.B.2
-
115
-
-
77949271604
-
Endocytosis unplugged: Multiple ways to enter the cell
-
Kumari S, Mg S, Mayor S. Endocytosis unplugged: Multiple ways to enter the cell. Cell Res. 20(3), 256-275 (2010
-
(2010)
Cell Res
, vol.20
, Issue.3
, pp. 256-275
-
-
Kumari, S.1
Mg, S.2
Mayor, S.3
-
117
-
-
79960379735
-
Clathrin-independent endocytosis: Mechanisms and function
-
Sandvig K, Pust S, Skotland T, van Deurs B. Clathrin-independent endocytosis: Mechanisms and function. Curr. Opin. Cell Biol. 23(4), 413-420 (2011
-
(2011)
Curr. Opin. Cell Biol
, vol.23
, Issue.4
, pp. 413-420
-
-
Sandvig, K.1
Pust, S.2
Skotland, T.3
Van Deurs, B.4
-
118
-
-
34547114456
-
Pathways of clathrin-independent endocytosis
-
Mayor S, Pagano RE. Pathways of clathrin-independent endocytosis. Nat. Rev. Mol. Cell Biol. 8(8), 603-612 (2007
-
(2007)
Nat. Rev. Mol. Cell Biol
, vol.8
, Issue.8
, pp. 603-612
-
-
Mayor, S.1
Pagano, R.E.2
-
119
-
-
0032539676
-
Identification and characterization of a cell membrane nucleic acid channel
-
Hanss B, Leal-Pinto E, Bruggeman LA, Copeland TD, Klotman PE. Identification and characterization of a cell membrane nucleic acid channel. Proc. Natl Acad. Sci USA 95(4), 1921-1926 (1998
-
(1998)
Proc. Natl Acad. Sci USA
, vol.95
, Issue.4
, pp. 1921-1926
-
-
Hanss, B.1
Leal-Pinto, E.2
Bruggeman, L.A.3
Copeland, T.D.4
Klotman, P.E.5
-
120
-
-
77951957881
-
The biological effect of an antisense oligonucleotide depends on its route of endocytosis and trafficking
-
Alam MR, Ming X, Dixit V, Fisher M, Chen X, Juliano RL. The biological effect of an antisense oligonucleotide depends on its route of endocytosis and trafficking. Oligonucleotides 20(2), 103-109 (2010
-
(2010)
Oligonucleotides
, vol.20
, Issue.2
, pp. 103-109
-
-
Alam, M.R.1
Ming, X.2
Dixit, V.3
Fisher, M.4
Chen, X.5
Juliano, R.L.6
-
121
-
-
65749101352
-
Effect of dose and plasma concentration on liver uptake and pharmacologic activity of a 2́;-methoxyethyl modified chimeric antisense oligonucleotide targeting PTEN
-
Geary RS, Wancewicz E, Matson J et al. Effect of dose and plasma concentration on liver uptake and pharmacologic activity of a 2́;-methoxyethyl modified chimeric antisense oligonucleotide targeting PTEN. Biochem. Pharmacol. 78(3), 284-291 (2009
-
(2009)
Biochem. Pharmacol
, vol.78
, Issue.3
, pp. 284-291
-
-
Geary, R.S.1
Wancewicz, E.2
Matson, J.3
-
122
-
-
14544306526
-
Clathrin-independent endocytosis of ubiquitinated cargos
-
Sigismund S, Woelk T, Puri C et al. Clathrin-independent endocytosis of ubiquitinated cargos. Proc. Natl Acad. Sci. USA 102(8), 2760-2765 (2005
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, Issue.8
, pp. 2760-2765
-
-
Sigismund, S.1
Woelk, T.2
Puri, C.3
-
123
-
-
79957460418
-
Endosomal escape pathways for delivery of biologicals
-
Varkouhi AK, Scholte M, Storm G, Haisma HJ. Endosomal escape pathways for delivery of biologicals. J. Control. Release 151(3), 220-228 (2011
-
(2011)
J. Control. Release
, vol.151
, Issue.3
, pp. 220-228
-
-
Varkouhi, A.K.1
Scholte, M.2
Storm, G.3
Haisma, H.J.4
-
124
-
-
19744372388
-
Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis
-
Akinc A, Thomas M, Klibanov AM, Langer R. Exploring polyethylenimine- mediated DNA transfection and the proton sponge hypothesis. J. Gene Med. 7(5), 657-663 (2005
-
(2005)
J. Gene Med
, vol.7
, Issue.5
, pp. 657-663
-
-
Akinc, A.1
Thomas, M.2
Klibanov, A.M.3
Langer, R.4
-
125
-
-
77951168054
-
Breaking down the barriers: SiRNA delivery and endosome escape
-
Dominska M, Dykxhoorn DM. Breaking down the barriers: SiRNA delivery and endosome escape. J. Cell Sci. 123(8), 1183-1189 (2010
-
(2010)
J. Cell Sci
, vol.123
, Issue.8
, pp. 1183-1189
-
-
Dominska, M.1
Dykxhoorn, D.M.2
-
126
-
-
31944439998
-
Cleavage of the papillomavirus minor capsid protein, L2, at a furin consensus site is necessary for infection
-
Richards RM, Lowy DR, Schiller JT, Day PM. Cleavage of the papillomavirus minor capsid protein, L2, at a furin consensus site is necessary for infection. Proc. Natl Acad. Sci. USA 103(5), 1522-1527 (2006
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, Issue.5
, pp. 1522-1527
-
-
Richards, R.M.1
Lowy, D.R.2
Schiller, J.T.3
Day, P.M.4
-
127
-
-
77955098945
-
Off-Target effects related to the phosphorothioate modification of nucleic acids
-
Winkler J, Stessl M, Amartey J, Noe CR. Off-Target effects related to the phosphorothioate modification of nucleic acids. ChemMedChem 5(8), 1344-1352 (2010
-
(2010)
ChemMedChem
, vol.5
, Issue.8
, pp. 1344-1352
-
-
Winkler, J.1
Stessl, M.2
Amartey, J.3
Noe, C.R.4
|