MiR-137 inhibits the proliferation of lung cancer cells by targeting Cdc42 and Cdk6

FEBS Letters

Volumn 587, Issue 1, 2013, Pages 73-81

  Zhu, Xiaolan ^a   Li, Yuefeng ^b   Shen, Huiling ^a   Li, Hao ^a   Long, Lulu ^a   Hui, Lulu ^a   Xu, Wenlin ^a  

^a Fourth Affiliated Hospital of Jiangsu University   (China)

^b AFFILIATED HOSPITAL OF JIANGSU UNIVERSITY   (China)

Author keywords

Cdc42; Cdk6; Lung cancer; miR 137

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CYCLIN DEPENDENT KINASE 6; MICRORNA; MICRORNA 137; PROTEIN CDC42; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; DRUG TARGETING; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; LUNG CARCINOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; CDC42 GTP-BINDING PROTEIN; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE 6; DNA MODIFICATION METHYLASES; DOWN-REGULATION; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENE TRANSFER TECHNIQUES; HISTONE DEACETYLASE INHIBITORS; HUMANS; LUNG; LUNG NEOPLASMS; MICE; MICRORNAS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84871716820     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.11.004     Document Type: Article

References (39)

1. A. Jemal, R. Siegel, E. Ward, Y. Hao, J. Xu, T. Murray, and M.J. Thun Cancer statistics, 2008 CA Cancer J. Clin. 58 2008 71 96
2. I. Behm-Ansmant, J. Rehwinkel, and E. Izaurralde MicroRNAs silence gene expression by repressing protein expression and/or by promoting mRNA decay Cold Spring Harb. Symp. Quant. Biol. 71 2006 523 530
3. F. Balaguer, A. Link, J.J. Lozano, M. Cuatrecasas, T. Nagasaka, C.R. Boland, and A. Goel Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis Cancer Res. 70 2010 6609 6618
4. M. Liu MiR-137 targets Cdc42 expression, induces cell cycle G1 arrest and inhibits invasion in colorectal cancer cells Int J Cancer. 128 2011 1269 1279
5. L. Chen MiR-137 is frequently down-regulated in glioblastoma and is a negative regulator of Cox-2 Eur. J. Cancer 48 2011 3104 3111
6. J. Silber MiR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells BMC Med. 6 2008 14
7. Q. Chen, X. Chen, M. Zhang, Q. Fan, S. Luo, and X. Cao MiR-137 is frequently down-regulated in gastric cancer and is a negative regulator of Cdc42 Dig. Dis. Sci. 56 2011 2009 2016
8. Y. Deng, H. Deng, F. Bi, J. Liu, L.T. Bemis, D. Norris, X.J. Wang, and Q. Zhang MicroRNA-137 targets carboxyl-terminal binding protein 1 in melanoma cell lines Int. J. Biol. Sci. 7 2011 133 137
9. L.T. Bemis MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell lines Cancer Res. 68 2008 1362 1368
10. E.D. Wiklund MicroRNA alterations and associated aberrant DNA methylation patterns across multiple sample types in oral squamous cell carcinoma PLoS One 6 2011 e27840
11. Y. Zhao, Y. Li, G. Lou, L. Zhao, Z. Xu, Y. Zhang, and F. He MiR-137 targets estrogen-related receptor alpha and impairs the proliferative and migratory capacity of breast cancer cells PLoS One 7 2012 e39102
12. S.M. Langevin MicroRNA-137 promoter methylation is associated with poorer overall survival in patients with squamous cell carcinoma of the head and neck Br. J. Cancer 117 2011 1454 1462
13. S.M. Langevin, R.A. Stone, C.H. Bunker, J.R. Grandis, R.W. Sobol, and E. Taioli MicroRNA-137 promoter methylation in oral rinses from patients with squamous cell carcinoma of the head and neck is associated with gender and body mass index Carcinogenesis 31 2010 864 870
14. K. Kozaki, I. Imoto, S. Mogi, K. Omura, and J. Inazawa Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer Cancer Res. 68 2008 2094 2105
15. X. Chen Epigenetics, microRNAs, and carcinogenesis: functional role of microRNA-137 in uveal melanoma Invest. Ophthalmol. Vis. Sci. 52 2011 1193 1199
16. S. Dacic, L. Kelly, Y. Shuai, and M.N. Nikiforova MiRNA expression profiling of lung adenocarcinomas: correlation with mutational status Mod. Pathol. 23 2010 1577 1582
17. J.Y. Zhang, D. Zhang, and E.H. Wang Overexpression of small GTPases directly correlates with expression of delta-catenin and their coexpression predicts a poor clinical outcome in nonsmall cell lung cancer Mol. Carcinog. 2011 10.1002/mc.21854
18. K.T. Hua N-alpha-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity Cancer Cell 19 2011 218 231
19. D.S. Hirsch, Y. Shen, and W.J. Wu Growth and motility inhibition of breast cancer cells by epidermal growth factor receptor degradation is correlated with inactivation of Cdc42 Cancer Res. 66 2006 3523 3530
20. O. Zugasti, W. Rul, P. Roux, C. Peyssonnaux, A. Eychene, T.F. Franke, P. Fort, and U. Hibner Raf-MEK-Erk cascade in anoikis is controlled by Rac1 and Cdc42 via Akt Mol. Cell. Biol. 21 2001 6706 6717
21. T.O. Khor Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice Cancer Res. 66 2006 613 621
22. J. Sridhar, N. Akula, and N. Pattabiraman Selectivity and potency of cyclin-dependent kinase inhibitors AAPS J. 8 2006 E204-221
23. P.Y. Lam, E. Di Tomaso, H.K. Ng, J.C. Pang, M.F. Roussel, and N.M. Hjelm Expression of p19INK4d, CDK4, CDK6 in glioblastoma multiforme Br. J. Neurosurg. 14 2000 28 32
24. F. Mendrzyk Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma J. Clin. Oncol. 23 2005 8853 8862
25. K. Igarashi Activation of cyclin D1-related kinase in human lung adenocarcinoma Br. J. Cancer 81 1999 705 711
26. E.I. Schwartz Cell cycle activation in postmitotic neurons is essential for DNA repair Cell Cycle 6 2007 318 329
27. X. Zhu, H. Li, L. Long, L. Hui, H. Chen, X. Wang, H. Shen, and W. Xu MiR-126 enhances the sensitivity of non-small cell lung cancer cells to anticancer agents by targeting vascular endothelial growth factor A Acta Biochim. Biophys. Sin. (Shanghai) 44 2012 519 526
28. O. Kovalchuk, J. Filkowski, J. Meservy, Y. Ilnytskyy, V.P. Tryndyak, V.F. Chekhun, and I.P. Pogribny Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin Mol. Cancer Ther. 7 2008 2152 2159
29. H. Li, L. Hui, and W. Xu MiR-181a sensitizes a multidrug-resistant leukemia cell line K562/A02 to daunorubicin by targeting BCL-2 Acta Biochim. Biophys. Sin. (Shanghai) 44 2012 269 277
30. A. Esquela-Kerscher The let-7 microRNA reduces tumor growth in mouse models of lung cancer Cell Cycle 7 2008 759 764
31. Y. Li MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes Cancer Res. 69 2009 7569 7576
32. D. Yan, E. Dong Xda, X. Chen, L. Wang, C. Lu, J. Wang, J. Qu, and L. Tu MicroRNA-1/206 targets c-Met and inhibits rhabdomyosarcoma development J. Biol. Chem. 284 2009 29596 29604
33. M.J. Grossel, and P.W. Hinds From cell cycle to differentiation: an expanding role for cdk6 Cell Cycle 5 2006 266 270
34. C.F. Welsh Rho GTPases as key transducers of proliferative signals in g1 cell cycle regulation Breast Cancer Res. Treat. 84 2004 33 42
35. M. Svoboda, L. Izakovicova Holla, R. Sefr, I. Vrtkova, I. Kocakova, B. Tichy, and J. Dvorak Micro-RNAs miR125b and miR137 are frequently upregulated in response to capecitabine chemoradiotherapy of rectal cancer Int. J. Oncol. 33 2008 541 547
36. T. Huang, M. Jiang, X. Kong, and Y.D. Cai Dysfunctions associated with methylation, microRNA expression and gene expression in lung cancer PLoS One 7 2012 e43441
37. H. Ma, J. Chen, S. Pan, J. Dai, G. Jin, Z. Hu, H. Shen, and Y. Shu Potentially functional polymorphisms in cell cycle genes and the survival of non-small cell lung cancer in a Chinese population Lung Cancer 73 2011 32 37
38. W.A. Braden, A.K. McClendon, and E.S. Knudsen Cyclin-dependent kinase 4/6 activity is a critical determinant of pre-replication complex assembly Oncogene 27 2008 7083 7093
39. K.J. Patel, S.E. Pambuccian, F.G. Ondrey, G.L. Adams, and P.M. Gaffney Genes associated with early development, apoptosis and cell cycle regulation define a gene expression profile of adenoid cystic carcinoma Oral Oncol. 42 2006 994 1004