Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP

EMBO Journal

Volumn 21, Issue 21, 2002, Pages 5875-5885

  Zhang, Haidi ^a   Kolb, Fabrice A ^a   Brondani, Vincent ^a   Billy, Eric ^a   Filipowicz, Witold ^a  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

Author keywords

Gene silencing; Ribonucleases; RNAi; RNase III; siRNA

Indexed keywords

ADENOSINE TRIPHOSPHATE; CELL EXTRACT; DICER; DOUBLE STRANDED RNA; RECOMBINANT PROTEIN; RIBONUCLEASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME BINDING; ENZYME METABOLISM; ENZYME SUBSTRATE; GENE SILENCING; HUMAN; HUMAN CELL; MAMMAL CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; RNA CLEAVAGE; RNA PROCESSING; RNA PURIFICATION; TEMPERATURE DEPENDENCE;

ADENOSINE TRIPHOSPHATE; BASE SEQUENCE; DNA PRIMERS; ENDORIBONUCLEASES; HELA CELLS; HUMANS; HYDROLYSIS; RECOMBINANT PROTEINS; RIBONUCLEASE III; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, DOUBLE-STRANDED; RNA, SMALL INTERFERING;

ANIMALIA; MAMMALIA;

EID: 0036845374     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf582     Document Type: Article

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