Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease

Human Molecular Genetics

Volumn 20, Issue 11, 2011, Pages 2225-2237

  Gaughwin, Philip Michael ^a   Ciesla, Maciej ^a,c   Lahiri, Nayana ^b   Tabrizi, Sarah J ^b   Brundin, Patrik ^a   Björkqvist, Maria ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; BRAIN DERIVED NEUROTROPHIC FACTOR; CASPASE 3; CASPASE 7; DOPAMINE 2 RECEPTOR; HSA MICRORNA 34B; HUNTINGTIN; MICRORNA; MICRORNA 1285; NEUROGENIC DIFFERENTIATION FACTOR; OCTAMER TRANSCRIPTION FACTOR 4; TAU PROTEIN; TRANSCRIPTION FACTOR NANOG; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; EXON; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; IN VITRO STUDY; MALE; MICROARRAY ANALYSIS; NERVE CELL; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA DEGRADATION;

ADULT; AGED; BIOLOGICAL MARKERS; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; EXONS; FEMALE; HUMANS; HUNTINGTON DISEASE; IMMUNOHISTOCHEMISTRY; MALE; MICRORNAS; MIDDLE AGED; MUTATION; NEURONS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TRANSFECTION; UP-REGULATION; YOUNG ADULT;

EID: 79956032718     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddr111     Document Type: Article

References (56)

1. The Huntington's Disease Collaborative Research Group (HDCRG). (1993) A novel gene containing a tri-nucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell, 72, 971-983.
2. Tabrizi, S.J., Langbehn, D.R., Leavitt, B.R., Roos, R.A., Durr, A., Craufurd, D., Kennard, C., Hicks, S.L., Fox, N.C., Scahill, R.I. et al. (2009) Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study, cross-sectional analysis of baseline data. Lancet Neurol., 8, 791-801.
3. Walker, F.O. (2007) Huntington's disease. Lancet, 369, 218-228.
4. van der Burg, J.M., Bjorkqvist, M. and Brundin, P. (2009) Beyond the brain, widespread pathology in Huntington's disease. Lancet Neurol., 8, 765-774.
5. Vonsattel, J.P., Myers, R.H., Stevens, T.J., Ferrante, R.J., Bird, E.D. and Richardson, E.P. Jr. (1985) Neuropathological classification of Huntington's disease. J. Neuropathol. Exp. Neurol., 44, 559-577.
6. Petersen, A., Hult, S. and Kirik, D. (2009) Huntington's disease-new perspectives based on neuroendocrine changes in rodent models. Neurodegener. Dis., 6, 154-164.
7. Rosas, H.D., Salat, D.H., Lee, S.Y., Zaleta, A.K., Pappu, V., Fischl, B., Greve, D., Hevelone, N. and Hersch, S.M. (2008) Cerebral cortex and the clinical expression of Huntington's disease, complexity and heterogeneity. Brain, 131, 1057-1068.
8. Sassone, J., Colciago, C., Cislaghi, G., Silani, V. and Ciammola, A. (2009) Huntington's disease, the current state of research with peripheral tissues. Exp. Neurol., 219, 385-397.
9. Bates, G. (2003) Huntingtin aggregation and toxicity in Huntington's disease. Lancet, 361, 1642-1644.
10. Harjes, P. and Wanker, E.E. (2003) The hunt for Huntingtin function, interaction partners tell many different stories. Trends Biochem. Sci., 28, 425-433.
11. Hoffner, G. and Djian, P. (2002) Protein aggregation in Huntington's disease. Biochimie, 84, 273-278.
12. Sawa, A., Tomoda, T. and Bae, B.I. (2003) Mechanisms of neuronal cell death in Huntington's disease. Cytogenet. Genome Res., 100, 287-295.
13. Zeron, M.M., Chen, N., Moshaver, A., Lee, A.T., Wellington, C.L., Hayden, M.R. and Raymond, L.A. (2001) Mutant huntingtin enhances excitotoxic cell death. Mol. Cell Neurosci., 17, 41-53.
14. Niclis, J.C., Trounson, A.O., Dottori, M., Ellisdon, A.M., Bottomley, S.P., Verlinsky, Y. and Cram, D.S. (2009) Human embryonic stem cell models of Huntington disease. Reprod. Biomed. Online, 19, 106-113.
15. Park, I.H., Arora, N., Huo, H., Maherali, N., Ahfeldt, T., Shimamura, A., Lensch, M.W., Cowan, C., Hochedlinger, K. and Daley, G.Q. (2008) Disease-specific induced pluripotent stem cells. Cell, 134, 877-886.
16. Ruvkun, G. (2008) The perfect storm of tiny RNAs. Nat. Med., 14, 1041-1045.
17. Chen, X., Ba, Y., Ma, L., Cai, X., Yin, Y., Wang, K., Guo, J., Zhang, Y., Chen, J., Guo, X. et al. (2008) Characterization of microRNAs in serum, a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res., 18, 997-1006.
18. Cortez, M.A. and Calin, G.A. (2009) MicroRNA identification in plasma and serum, a new tool to diagnose and monitor diseases. Expert Opin. Biol. Ther., 9, 703-711.
19. Gilad, S., Meiri, E., Yogev, Y., Benjamin, S., Lebanony, D., Yerushalmi, N., Benjamin, H., Kushnir, M., Cholakh, H., Melamed, N. et al. (2008) Serum microRNAs are promising novel biomarkers. PLoS ONE, 3, e3148.
20. Mitchell, P.S., Parkin, R.K., Kroh, E.M., Fritz, B.R., Wyman, S.K., Pogosova-Agadjanyan, E.L., Peterson, A., Noteboom, J., O'Briant, K.C., Allen, A. et al. (2008) Circulating microRNAs as stable blood-based markers for cancer detection. Proc. Natl Acad. Sci. USA, 105, 10513-10518.
21. Corney, D.C., Flesken-Nikitin, A., Godwin, A.K., Wang, W. and Nikitin, A.Y. (2007) MicroRNA-34b and MicroRNA-34c are targets of P53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res., 67, 8433-8438.
22. Benn, C.L., Sun, T., Sadri-Vakili, G., McFarland, K.N., DiRocco, D.P., Yohrling, G.J., Clark, T.W., Bouzou, B. and Cha, J.H. (2008) Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner. J. Neurosci., 28, 10720-10733.
23. Bessert, D.A., Gutridge, K.L., Dunbar, J.C. and Carlock, L.R. (1995) The identification of a functional nuclear localization signal in the Huntington disease protein. Brain Res. Mol. Brain Res., 33, 165-173.
24. Carlock, L., Vo, T., Lorincz, M., Walker, P.D., Bessert, D., Wisniewski, D. and Dunbar, J.C. (1996) Variable sub-cellular localization of a neuron-specific protein during NTera 2 differentiation into post-mitotic human neurons. Brain Res. Mol. Brain Res., 42, 202-212.
25. Andrews, P.W. (1984) Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro. Dev. Biol., 103, 285-293.
26. Andrews, P.W., Damjanov, I., Simon, D., Banting, G.S., Carlin, C., Dracopoli, N.C. and Fogh, J. (1984) Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vivo and in vitro. Lab. Invest., 50, 147-162.
27. Subramaniam, S., Sixt, K.M., Barrow, R. and Snyder, S.H. (2009) Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity. Science, 324, 1327-1330.
28. He, C., Xiong, J., Xu, X., Lu, W., Liu, L., Xiao, D. and Wang, D. (2009) Functional elucidation of MiR-34 in osteosarcoma cells and primary tumor samples. Biochem. Biophys. Res. Commun., 388, 35-40.
29. Pigazzi, M., Manara, E., Baron, E. and Basso, G. (2009) miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia. Cancer Res., 69, 2471-2478.
30. Wild, E.J., Mudanohwo, E.E., Sweeney, M.G., Schneider, S.A., Beck, J., Bhatia, K.P., Rossor, M.N., Davis, M.B. and Tabrizi, S.J. (2008) Huntington's disease phenocopies are clinically and genetically heterogeneous. Mov. Disord., 23, 716-720.
31. Pfister, E.L. and Zamore, P.D. (2009) Huntington's disease, silencing a brutal killer. Exp. Neurol., 220, 226-229.
32. Roze, E., Saudou, F. and Caboche, J. (2008) Pathophysiology of Huntington's disease, from huntingtin functions to potential treatments. Curr. Opin. Neurol., 21, 497-503.
33. Borovecki, F., Lovrecic, L., Zhou, J., Jeong, H., Then, F., Rosas, H.D., Hersch, S.M., Hogarth, P., Bouzou, B., Jensen, R.V. et al. (2005) Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease. Proc. Natl Acad. Sci. USA, 102, 11023-11028.
34. Runne, H., Kuhn, A., Wild, E.J., Pratyaksha, W., Kristiansen, M., Isaacs, J.D., Regulier, E., Delorenzi, M., Tabrizi, S.J. and Luthi-Carter, R. (2007) Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood. Proc. Natl Acad. Sci. USA, 104, 14424-14429.
35. Lawinger, P., Venugopal, R., Guo, Z.S., Immaneni, A., Sengupta, D., Lu, W., Rastelli, L., Marin Dias Carneiro, A., Levin, V., Fuller, G.N. et al. (2000) The neuronal repressor REST/NRSF is an essential regulator in medulloblastoma cells. Nat. Med., 6, 826-831.
36. Steffan, J.S., Kazantsev, A., Spasic-Boskovic, O., Greenwald, M., Zhu, Y.Z., Gohler, H., Wanker, E.E., Bates, G.P., Housman, D.E. and Thomson, L.M. (2000) The Huntington's disease protein interacts with P53 and CREB-binding protein and represses transcription. Proc. Natl Acad. Sci. USA, 97, 6763-6768.
37. Curtin, J.C., Dragnev, K.H., Sekula, D., Christie, A.J., Dmitrovsky, E. and Spinella, M.J. (2001) Retinoic acid activates P53 in human embryonal carcinoma through retinoid receptor-dependent stimulation of P53 trans-activation function. Oncogene, 20, 2559-2569.
38. Bae, B.I., Xu, H., Igarashi, S., Fujimuro, M., Agrawal, N., Taya, Y., Hayward, S.D., Moran, T.H., Montell, C., Ross, C.A. et al. (2005) P53 mediates cellular dysfunction and behavioural abnormalities in Huntington's disease. Neuron, 47, 29-41.
39. Borel, C., Gagnebin, M., Gehrig, C., Kriventseva, E.V., Zdobnov, E.M. and Antonarakis, S.E. (2008) Mapping of small RNAs in the human ENCODE regions. Am. J. Hum. Genet., 82, 971-981.
40. Bithell, A., Johnson, R. and Buckley, N.J. (2009) Transcriptional dysregulation of coding and non-coding genes in cellular models of Huntington's disease. Biochem. Soc. Trans., 37, 1270-1275.
41. Johnson, R. and Buckley, N.J. (2009) Gene dysregulation in Huntington's disease, REST, microRNAs and beyond. Neuromolecular Med., 11, 183-199.
42. Leucci, E., Cocco, M., Onnis, A., De Falco, G., van Cleef, P., Bellan, C., van Rijk, A., Nyagol, J., Byakika, B., Lazzi, S. et al. (2008) MYC translocation-negative classical Burkitt lymphoma cases, an alternative pathogenetic mechanism involving miRNA deregulation. J. Pathol., 216, 440-450.
43. Hermeking, H. (2010) The miR-34 family in cancer and apoptosis. Cell Death Differ., 17, 193-199.
44. Hermeking, H. (2007) P53 enters the microRNA world. Cancer Cell, 12, 414-418.
45. Sumi, T., Tsuneyoshi, N., Nakatsuji, N. and Suemori, H. (2007) Apoptosis and differentiation of human embryonic stem cells induced by sustained activation of c-Myc. Oncogene, 26, 5564-5576.
46. Conaco, C., Otto, S., Han, J.J. and Mandel, G. (2006) Reciprocal actions of REST and a microRNA promote neuronal identity. Proc. Natl Acad. Sci. USA, 103, 2422-2427.
47. Johnson, R., Zuccato, C., Belyaev, N.D., Guest, D.J., Cattaneo, E. and Buckley, N.J. (2008) A microRNA-based gene dysregulation pathway in Huntington's disease. Neurobiol. Dis., 29, 438-445.
48. Wu, J. and Xie, X. (2006) Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression. Genome Biol., 7, R85.
49. Johnson, R., Teh, C.H., Kunarso, G., Wong, K.Y., Srinivasan, G., Cooper, M.L., Volta, M., Chan, S.S., Lipovich, L.L., Pollard, S.P. et al. (2008) REST regulates distinct transcriptional networks in embryonic and neural stem cells. PLoS Biol., 6, e256.
50. Buckley, N.J., Johnson, R., Sun, Y.M. and Stanton, L.W. (2009) Is REST a regulator of pluripotency? Nature, 457, E5-E6.
51. Jorgensen, H.F., Chen, Z.F., Merkenschlager, M. and Fisher, A.G. (2009) Is REST required for ESC pluripotency? Nature, 457, E4-E5 (discussion E7).
52. Singh, S.K., Kagalwala, M.N., Parker-Thornburg, J., Adams, H. and Majumder, S. (2008) REST maintains self-renewal and pluripotency of embryonic stem cells. Nature, 453, 223-227.
53. Jorgensen, H.F., Terry, A., Beretta, C., Pereira, C.F., Leleu, M., Chen, Z.F., Kelly, C., Merkenschlager, M. and Fisher, A.G. (2009) REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells. Development, 136, 715-721.
54. Dalrymple, A., Wild, E.J., Joubert, R., Sathasivam, K., Bjorkqvist, M., Petersen, A., Jackson, G.S., Isaacs, J.D., Kristiansen, M., Bates, G.P. et al. (2007) Proteomic profiling of plasma in Huntington's disease reveals neuro-inflammatory activation and biomarker candidates. J. Proteome Res., 6, 2833-2840.
55. Pattyn, F., Robbrecht, P., De Paepe, A., Speleman, F. and Vandesompele, J. (2006) RTPrimerDB, the real-time PCR primer and probe database. Nucleic Acids Res., 34, D684-D688.
56. Pradervand, S., Weber, J., Thomas, J., Bueno, M., Wirapati, P., Lefort, K., Dotto, G.P. and Harshman, K. (2009) Impact of normalization on miRNA microarray expression profiling. RNA, 15, 493-501.