A novel berbamine derivative inhibits cell viability and induces apoptosis in cancer stem-like cells of human glioblastoma, via up-regulation of miRNA-4284 and JNK/AP-1 signaling

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Yang, Fan ^a   Nam, Sangkil ^a   Brown, Christine E ^a   Zhao, Robin ^a   Starr, Renate ^a   Horne, David A ^a   Malkas, Linda H ^a   Jove, Richard ^b   Hickey, Robert J ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b Vaccine and Gene Therapy Institute of Florida   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BBMD 3; BERBAMINE; CASPASE 3; CD133 ANTIGEN; MICRORNA; MICRORNA 4284; NESTIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN C FOS; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; BENZYLISOQUINOLINE DERIVATIVE; MIRN27 MICRORNA, HUMAN; MIRN4284 MICRORNA, HUMAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER STEM CELL; CELL GROWTH; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; GLIOBLASTOMA; HUMAN; HUMAN CELL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEM CELL CULTURE; UPREGULATION; BRAIN NEOPLASMS; CELL SHAPE; CELL SURVIVAL; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MULTICELLULAR SPHEROID; NEURAL STEM CELL; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE;

APOPTOSIS; BENZYLISOQUINOLINES; BRAIN NEOPLASMS; CASPASE 3; CELL LINE, TUMOR; CELL SHAPE; CELL SURVIVAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICRORNAS; NEOPLASTIC STEM CELLS; NEURAL STEM CELLS; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; SIGNAL TRANSDUCTION; SPHEROIDS, CELLULAR; TRANSCRIPTION FACTOR AP-1; UP-REGULATION;

EID: 84899624549     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0094443     Document Type: Article

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