-
1
-
-
0026095665
-
A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
-
1833819
-
Bellacosa A, Testa JR, Staal SP, Tsichlis PN. A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science 1991, 254:274-277. 10.1126/science.1833819, 1833819.
-
(1991)
Science
, vol.254
, pp. 274-277
-
-
Bellacosa, A.1
Testa, J.R.2
Staal, S.P.3
Tsichlis, P.N.4
-
2
-
-
0027470177
-
Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications
-
Bellacosa A, Franke TF, Gonzalez-Portal ME, Datta K, Taguchi T, Gardner J, Cheng JQ, Testa JR, Tsichlis PN. Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications. Oncogene 1993, 8:745-754.
-
(1993)
Oncogene
, vol.8
, pp. 745-754
-
-
Bellacosa, A.1
Franke, T.F.2
Gonzalez-Portal, M.E.3
Datta, K.4
Taguchi, T.5
Gardner, J.6
Cheng, J.Q.7
Testa, J.R.8
Tsichlis, P.N.9
-
3
-
-
0026006501
-
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families
-
1718748
-
Coffer PJ, Woodgett JR. Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. Eur J Biochem 1991, 201:475-481. 10.1111/j.1432-1033.1991.tb16305.x, 1718748.
-
(1991)
Eur J Biochem
, vol.201
, pp. 475-481
-
-
Coffer, P.J.1
Woodgett, J.R.2
-
4
-
-
0025882091
-
Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily
-
51620, 1851997
-
Jones PF, Jakubowicz T, Pitossi FJ, Maurer F, Hemmings BA. Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. Proc Natl Acad Sci U S A 1991, 88:4171-4175. 10.1073/pnas.88.10.4171, 51620, 1851997.
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, pp. 4171-4175
-
-
Jones, P.F.1
Jakubowicz, T.2
Pitossi, F.J.3
Maurer, F.4
Hemmings, B.A.5
-
5
-
-
34250788809
-
AKT/PKB signaling: navigating downstream
-
2756685, 17604717
-
Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007, 129:1261-1274. 10.1016/j.cell.2007.06.009, 2756685, 17604717.
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
6
-
-
84872899284
-
FOXOs: signalling integrators for homeostasis maintenance
-
23325358
-
Eijkelenboom A, Burgering BM. FOXOs: signalling integrators for homeostasis maintenance. Nat Rev Mol Cell Biol 2013, 14:83-97. 10.1038/nrm3507, 23325358.
-
(2013)
Nat Rev Mol Cell Biol
, vol.14
, pp. 83-97
-
-
Eijkelenboom, A.1
Burgering, B.M.2
-
7
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
-
8524413
-
Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995, 378:785-789. 10.1038/378785a0, 8524413.
-
(1995)
Nature
, vol.378
, pp. 785-789
-
-
Cross, D.A.1
Alessi, D.R.2
Cohen, P.3
Andjelkovich, M.4
Hemmings, B.A.5
-
8
-
-
33747819801
-
MTOR and cancer: insights into a complex relationship
-
16915295
-
Sabatini DM. mTOR and cancer: insights into a complex relationship. Nat Rev Cancer 2006, 6:729-734. 10.1038/nrc1974, 16915295.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 729-734
-
-
Sabatini, D.M.1
-
9
-
-
84859778293
-
MTOR signaling in growth control and disease
-
3331679, 22500797
-
Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell 2012, 149:274-293. 10.1016/j.cell.2012.03.017, 3331679, 22500797.
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
10
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
9346240
-
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997, 91:231-241. 10.1016/S0092-8674(00)80405-5, 9346240.
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
Masters, S.4
Fu, H.5
Gotoh, Y.6
Greenberg, M.E.7
-
11
-
-
0033517189
-
NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
-
10485710
-
Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 1999, 401:82-85. 10.1038/43466, 10485710.
-
(1999)
Nature
, vol.401
, pp. 82-85
-
-
Ozes, O.N.1
Mayo, L.D.2
Gustin, J.A.3
Pfeffer, S.R.4
Pfeffer, L.M.5
Donner, D.B.6
-
12
-
-
64049086572
-
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction
-
2910589, 19270695
-
Gao D, Inuzuka H, Tseng A, Chin RY, Toker A, Wei W. Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. Nat Cell Biol 2009, 11:397-408. 10.1038/ncb1847, 2910589, 19270695.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 397-408
-
-
Gao, D.1
Inuzuka, H.2
Tseng, A.3
Chin, R.Y.4
Toker, A.5
Wei, W.6
-
13
-
-
64049087382
-
Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB
-
2830812, 19270694
-
Lin HK, Wang G, Chen Z, Teruya-Feldstein J, Liu Y, Chan CH, Yang WL, Erdjument-Bromage H, Nakayama KI, Nimer S, Tempst P, Pandolfi PP. Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB. Nat Cell Biol 2009, 11:420-432. 10.1038/ncb1849, 2830812, 19270694.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 420-432
-
-
Lin, H.K.1
Wang, G.2
Chen, Z.3
Teruya-Feldstein, J.4
Liu, Y.5
Chan, C.H.6
Yang, W.L.7
Erdjument-Bromage, H.8
Nakayama, K.I.9
Nimer, S.10
Tempst, P.11
Pandolfi, P.P.12
-
14
-
-
77951978532
-
Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis
-
3855841, 20383141
-
Chan CH, Lee SW, Li CF, Wang J, Yang WL, Wu CY, Wu J, Nakayama KI, Kang HY, Huang HY, Hung MC, Pandolfi PP, Lin HK. Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis. Nat Cell Biol 2010, 12:457-467. 10.1038/ncb2047, 3855841, 20383141.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 457-467
-
-
Chan, C.H.1
Lee, S.W.2
Li, C.F.3
Wang, J.4
Yang, W.L.5
Wu, C.Y.6
Wu, J.7
Nakayama, K.I.8
Kang, H.Y.9
Huang, H.Y.10
Hung, M.C.11
Pandolfi, P.P.12
Lin, H.K.13
-
15
-
-
77955883766
-
Regulation of Skp2 expression and activity and its role in cancer progression
-
Chan CH, Lee SW, Wang J, Lin HK. Regulation of Skp2 expression and activity and its role in cancer progression. The Scientific World JOURNAL 2010, 10:1001-1015.
-
(2010)
The Scientific World JOURNAL
, vol.10
, pp. 1001-1015
-
-
Chan, C.H.1
Lee, S.W.2
Wang, J.3
Lin, H.K.4
-
16
-
-
80052462118
-
Novel ARF/p53-independent senescence pathways in cancer repression
-
3296232, 21594579
-
Chan CH, Gao Y, Moten A, Lin HK. Novel ARF/p53-independent senescence pathways in cancer repression. J Mol Med 2011, 89:857-867. 10.1007/s00109-011-0766-y, 3296232, 21594579.
-
(2011)
J Mol Med
, vol.89
, pp. 857-867
-
-
Chan, C.H.1
Gao, Y.2
Moten, A.3
Lin, H.K.4
-
17
-
-
64049090611
-
Skp2: caught in the Akt
-
19337320
-
Ecker K, Hengst L. Skp2: caught in the Akt. Nat Cell Biol 2009, 11:377-379. 10.1038/ncb0409-377, 19337320.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 377-379
-
-
Ecker, K.1
Hengst, L.2
-
18
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
15016963
-
Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004, 304:554. 10.1126/science.1096502, 15016963.
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
Yan, H.7
Gazdar, A.8
Powell, S.M.9
Riggins, G.J.10
Willson, J.K.11
Markowitz, S.12
Kinzler, K.W.13
Vogelstein, B.14
Velculescu, V.E.15
-
19
-
-
33644513730
-
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
-
16453012
-
Cully M, You H, Levine AJ, Mak TW. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 2006, 6:184-192. 10.1038/nrc1819, 16453012.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 184-192
-
-
Cully, M.1
You, H.2
Levine, A.J.3
Mak, T.W.4
-
20
-
-
84893249799
-
PI3K and cancer: lessons, challenges and opportunities
-
3994981, 24481312
-
Fruman DA, Rommel C. PI3K and cancer: lessons, challenges and opportunities. Nat Rev Drug Discov 2014, 13:140-156. 10.1038/nrd4204, 3994981, 24481312.
-
(2014)
Nat Rev Drug Discov
, vol.13
, pp. 140-156
-
-
Fruman, D.A.1
Rommel, C.2
-
21
-
-
69249208791
-
The Akt kinases: isoform specificity in metabolism and cancer
-
2997486, 19597332
-
Gonzalez E, McGraw TE. The Akt kinases: isoform specificity in metabolism and cancer. Cell Cycle 2009, 8:2502-2508. 10.4161/cc.8.16.9335, 2997486, 19597332.
-
(2009)
Cell Cycle
, vol.8
, pp. 2502-2508
-
-
Gonzalez, E.1
McGraw, T.E.2
-
22
-
-
66349098674
-
Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling
-
2678468, 19372382
-
Gonzalez E, McGraw TE. Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling. Proc Natl Acad Sci U S A 2009, 106:7004-7009. 10.1073/pnas.0901933106, 2678468, 19372382.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 7004-7009
-
-
Gonzalez, E.1
McGraw, T.E.2
-
23
-
-
34247116441
-
Physiological roles of PKB/Akt isoforms in development and disease
-
17371246
-
Dummler B, Hemmings BA. Physiological roles of PKB/Akt isoforms in development and disease. Biochem Soc Trans 2007, 35:231-235. 10.1042/BST0350231, 17371246.
-
(2007)
Biochem Soc Trans
, vol.35
, pp. 231-235
-
-
Dummler, B.1
Hemmings, B.A.2
-
24
-
-
0036849331
-
PKB binding proteins. Getting in on the Akt
-
12419241
-
Brazil DP, Park J, Hemmings BA. PKB binding proteins. Getting in on the Akt. Cell 2002, 111:293-303. 10.1016/S0092-8674(02)01083-8, 12419241.
-
(2002)
Cell
, vol.111
, pp. 293-303
-
-
Brazil, D.P.1
Park, J.2
Hemmings, B.A.3
-
25
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
12040186
-
Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002, 296:1655-1657. 10.1126/science.296.5573.1655, 12040186.
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
26
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
452479, 8978681
-
Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 1996, 15:6541-6551. 452479, 8978681.
-
(1996)
EMBO J
, vol.15
, pp. 6541-6551
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, B.3
Cron, P.4
Morrice, N.5
Cohen, P.6
Hemmings, B.A.7
-
27
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
15718470
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005, 307:1098-1101. 10.1126/science.1106148, 15718470.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
28
-
-
42949165854
-
PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival
-
18439899
-
Bozulic L, Surucu B, Hynx D, Hemmings BA. PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival. Mol Cell 2008, 30:203-213. 10.1016/j.molcel.2008.02.024, 18439899.
-
(2008)
Mol Cell
, vol.30
, pp. 203-213
-
-
Bozulic, L.1
Surucu, B.2
Hynx, D.3
Hemmings, B.A.4
-
29
-
-
4644359805
-
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase
-
15262962
-
Feng J, Park J, Cron P, Hess D, Hemmings BA. Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase. J Biol Chem 2004, 279:41189-41196. 10.1074/jbc.M406731200, 15262962.
-
(2004)
J Biol Chem
, vol.279
, pp. 41189-41196
-
-
Feng, J.1
Park, J.2
Cron, P.3
Hess, D.4
Hemmings, B.A.5
-
30
-
-
0034724443
-
Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells
-
16217, 10716737
-
Persad S, Attwell S, Gray V, Delcommenne M, Troussard A, Sanghera J, Dedhar S. Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proc Natl Acad Sci U S A 2000, 97:3207-3212. 10.1073/pnas.97.7.3207, 16217, 10716737.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 3207-3212
-
-
Persad, S.1
Attwell, S.2
Gray, V.3
Delcommenne, M.4
Troussard, A.5
Sanghera, J.6
Dedhar, S.7
-
31
-
-
30544453564
-
Protein kinase B/Akt at a glance
-
16339964
-
Fayard E, Tintignac LA, Baudry A, Hemmings BA. Protein kinase B/Akt at a glance. J Cell Sci 2005, 118:5675-5678. 10.1242/jcs.02724, 16339964.
-
(2005)
J Cell Sci
, vol.118
, pp. 5675-5678
-
-
Fayard, E.1
Tintignac, L.A.2
Baudry, A.3
Hemmings, B.A.4
-
32
-
-
84899484738
-
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
-
4076493, 24670654
-
Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L, Wei W. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature 2014, 508:541-545. 10.1038/nature13079, 4076493, 24670654.
-
(2014)
Nature
, vol.508
, pp. 541-545
-
-
Liu, P.1
Begley, M.2
Michowski, W.3
Inuzuka, H.4
Ginzberg, M.5
Gao, D.6
Tsou, P.7
Gan, W.8
Papa, A.9
Kim, B.M.10
Wan, L.11
Singh, A.12
Zhai, B.13
Yuan, M.14
Wang, Z.15
Gygi, S.P.16
Lee, T.H.17
Lu, K.P.18
Toker, A.19
Pandolfi, P.P.20
Asara, J.M.21
Kirschner, M.W.22
Sicinski, P.23
Cantley, L.24
Wei, W.25
more..
-
33
-
-
84903819690
-
Akt: a new activation mechanism
-
24797432
-
Gao Y, Moten A, Lin HK. Akt: a new activation mechanism. Cell Res 2014, 24:785-786. 10.1038/cr.2014.57, 24797432.
-
(2014)
Cell Res
, vol.24
, pp. 785-786
-
-
Gao, Y.1
Moten, A.2
Lin, H.K.3
-
34
-
-
0032475861
-
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
-
9778245
-
Stambolic V, Suzuki A, de la Pompa JL, Brothers GM, Mirtsos C, Sasaki T, Ruland J, Penninger JM, Siderovski DP, Mak TW. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 1998, 95:29-39. 10.1016/S0092-8674(00)81780-8, 9778245.
-
(1998)
Cell
, vol.95
, pp. 29-39
-
-
Stambolic, V.1
Suzuki, A.2
de la Pompa, J.L.3
Brothers, G.M.4
Mirtsos, C.5
Sasaki, T.6
Ruland, J.7
Penninger, J.M.8
Siderovski, D.P.9
Mak, T.W.10
-
35
-
-
43049128529
-
Tenets of PTEN tumor suppression
-
18455982
-
Salmena L, Carracedo A, Pandolfi PP. Tenets of PTEN tumor suppression. Cell 2008, 133:403-414. 10.1016/j.cell.2008.04.013, 18455982.
-
(2008)
Cell
, vol.133
, pp. 403-414
-
-
Salmena, L.1
Carracedo, A.2
Pandolfi, P.P.3
-
36
-
-
27944448894
-
Involvement of PP2A in viral and cellular transformation
-
16299534
-
Arroyo JD, Hahn WC. Involvement of PP2A in viral and cellular transformation. Oncogene 2005, 24:7746-7755. 10.1038/sj.onc.1209038, 16299534.
-
(2005)
Oncogene
, vol.24
, pp. 7746-7755
-
-
Arroyo, J.D.1
Hahn, W.C.2
-
37
-
-
15944406764
-
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
-
15808505
-
Gao T, Furnari F, Newton AC. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 2005, 18:13-24. 10.1016/j.molcel.2005.03.008, 15808505.
-
(2005)
Mol Cell
, vol.18
, pp. 13-24
-
-
Gao, T.1
Furnari, F.2
Newton, A.C.3
-
38
-
-
0000714961
-
Regulation of protein kinase cascades by protein phosphatase 2A
-
10322434
-
Millward TA, Zolnierowicz S, Hemmings BA. Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem Sci 1999, 24:186-191. 10.1016/S0968-0004(99)01375-4, 10322434.
-
(1999)
Trends Biochem Sci
, vol.24
, pp. 186-191
-
-
Millward, T.A.1
Zolnierowicz, S.2
Hemmings, B.A.3
-
39
-
-
33745316089
-
Identification of a tumour suppressor network opposing nuclear Akt function
-
1976603, 16680151
-
Trotman LC, Alimonti A, Scaglioni PP, Koutcher JA, Cordon-Cardo C, Pandolfi PP. Identification of a tumour suppressor network opposing nuclear Akt function. Nature 2006, 441:523-527. 10.1038/nature04809, 1976603, 16680151.
-
(2006)
Nature
, vol.441
, pp. 523-527
-
-
Trotman, L.C.1
Alimonti, A.2
Scaglioni, P.P.3
Koutcher, J.A.4
Cordon-Cardo, C.5
Pandolfi, P.P.6
-
40
-
-
37649023273
-
A beta-arrestin 2 signaling complex mediates lithium action on behavior
-
18191226
-
Beaulieu JM, Marion S, Rodriguiz RM, Medvedev IO, Sotnikova TD, Ghisi V, Wetsel WC, Lefkowitz RJ, Gainetdinov RR, Caron MG. A beta-arrestin 2 signaling complex mediates lithium action on behavior. Cell 2008, 132:125-136. 10.1016/j.cell.2007.11.041, 18191226.
-
(2008)
Cell
, vol.132
, pp. 125-136
-
-
Beaulieu, J.M.1
Marion, S.2
Rodriguiz, R.M.3
Medvedev, I.O.4
Sotnikova, T.D.5
Ghisi, V.6
Wetsel, W.C.7
Lefkowitz, R.J.8
Gainetdinov, R.R.9
Caron, M.G.10
-
41
-
-
22744449073
-
An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
-
16051150
-
Beaulieu JM, Sotnikova TD, Marion S, Lefkowitz RJ, Gainetdinov RR, Caron MG. An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell 2005, 122:261-273. 10.1016/j.cell.2005.05.012, 16051150.
-
(2005)
Cell
, vol.122
, pp. 261-273
-
-
Beaulieu, J.M.1
Sotnikova, T.D.2
Marion, S.3
Lefkowitz, R.J.4
Gainetdinov, R.R.5
Caron, M.G.6
-
42
-
-
69249228672
-
FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt
-
2755578, 19732725
-
Pei H, Li L, Fridley BL, Jenkins GD, Kalari KR, Lingle W, Petersen G, Lou Z, Wang L. FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. Cancer Cell 2009, 16:259-266. 10.1016/j.ccr.2009.07.016, 2755578, 19732725.
-
(2009)
Cancer Cell
, vol.16
, pp. 259-266
-
-
Pei, H.1
Li, L.2
Fridley, B.L.3
Jenkins, G.D.4
Kalari, K.R.5
Lingle, W.6
Petersen, G.7
Lou, Z.8
Wang, L.9
-
43
-
-
0035943677
-
Regulation of Akt/PKB activation by tyrosine phosphorylation
-
11445557
-
Chen R, Kim O, Yang J, Sato K, Eisenmann KM, McCarthy J, Chen H, Qiu Y. Regulation of Akt/PKB activation by tyrosine phosphorylation. J Biol Chem 2001, 276:31858-31862. 10.1074/jbc.C100271200, 11445557.
-
(2001)
J Biol Chem
, vol.276
, pp. 31858-31862
-
-
Chen, R.1
Kim, O.2
Yang, J.3
Sato, K.4
Eisenmann, K.M.5
McCarthy, J.6
Chen, H.7
Qiu, Y.8
-
44
-
-
77956620778
-
Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor
-
2937549, 20606012
-
Zheng Y, Peng M, Wang Z, Asara JM, Tyner AL. Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor. Mol Cell Biol 2010, 30:4280-4292. 10.1128/MCB.00024-10, 2937549, 20606012.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 4280-4292
-
-
Zheng, Y.1
Peng, M.2
Wang, Z.3
Asara, J.M.4
Tyner, A.L.5
-
45
-
-
61349130027
-
Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance
-
19122674
-
Luan B, Zhao J, Wu H, Duan B, Shu G, Wang X, Li D, Jia W, Kang J, Pei G. Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance. Nature 2009, 457:1146-1149. 10.1038/nature07617, 19122674.
-
(2009)
Nature
, vol.457
, pp. 1146-1149
-
-
Luan, B.1
Zhao, J.2
Wu, H.3
Duan, B.4
Shu, G.5
Wang, X.6
Li, D.7
Jia, W.8
Kang, J.9
Pei, G.10
-
46
-
-
77954607192
-
Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation
-
2841635, 20333297
-
Mahajan K, Coppola D, Challa S, Fang B, Chen YA, Zhu W, Lopez AS, Koomen J, Engelman RW, Rivera C, Muraoka-Cook RS, Cheng JQ, Schonbrunn E, Sebti SM, Earp HS, Mahajan NP. Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation. PLoS One 2010, 5:e9646. 10.1371/journal.pone.0009646, 2841635, 20333297.
-
(2010)
PLoS One
, vol.5
, pp. e9646
-
-
Mahajan, K.1
Coppola, D.2
Challa, S.3
Fang, B.4
Chen, Y.A.5
Zhu, W.6
Lopez, A.S.7
Koomen, J.8
Engelman, R.W.9
Rivera, C.10
Muraoka-Cook, R.S.11
Cheng, J.Q.12
Schonbrunn, E.13
Sebti, S.M.14
Earp, H.S.15
Mahajan, N.P.16
-
47
-
-
34547172596
-
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
-
17611497
-
Carpten JD, Faber AL, Horn C, Donoho GP, Briggs SL, Robbins CM, Hostetter G, Boguslawski S, Moses TY, Savage S, Uhlik M, Lin A, Du J, Qian YW, Zeckner DJ, Tucker-Kellogg G, Touchman J, Patel K, Mousses S, Bittner M, Schevitz R, Lai MH, Blanchard KL, Thomas JE. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 2007, 448:439-444. 10.1038/nature05933, 17611497.
-
(2007)
Nature
, vol.448
, pp. 439-444
-
-
Carpten, J.D.1
Faber, A.L.2
Horn, C.3
Donoho, G.P.4
Briggs, S.L.5
Robbins, C.M.6
Hostetter, G.7
Boguslawski, S.8
Moses, T.Y.9
Savage, S.10
Uhlik, M.11
Lin, A.12
Du, J.13
Qian, Y.W.14
Zeckner, D.J.15
Tucker-Kellogg, G.16
Touchman, J.17
Patel, K.18
Mousses, S.19
Bittner, M.20
Schevitz, R.21
Lai, M.H.22
Blanchard, K.L.23
Thomas, J.E.24
more..
-
48
-
-
51049118140
-
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer
-
2680495, 18676830
-
Stemke-Hale K, Gonzalez-Angulo AM, Lluch A, Neve RM, Kuo WL, Davies M, Carey M, Hu Z, Guan Y, Sahin A, Symmans WF, Pusztai L, Nolden LK, Horlings H, Berns K, Hung MC, van de Vijver MJ, Valero V, Gray JW, Bernards R, Mills GB, Hennessy BT. An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res 2008, 68:6084-6091. 10.1158/0008-5472.CAN-07-6854, 2680495, 18676830.
-
(2008)
Cancer Res
, vol.68
, pp. 6084-6091
-
-
Stemke-Hale, K.1
Gonzalez-Angulo, A.M.2
Lluch, A.3
Neve, R.M.4
Kuo, W.L.5
Davies, M.6
Carey, M.7
Hu, Z.8
Guan, Y.9
Sahin, A.10
Symmans, W.F.11
Pusztai, L.12
Nolden, L.K.13
Horlings, H.14
Berns, K.15
Hung, M.C.16
van de Vijver, M.J.17
Valero, V.18
Gray, J.W.19
Bernards, R.20
Mills, G.B.21
Hennessy, B.T.22
more..
-
49
-
-
38349086652
-
PI3K/AKT pathway activation in acute myeloid leukaemias is not associated with AKT1 pleckstrin homology domain mutation
-
3385948, 18053070
-
Tibes R, Kornblau SM, Qiu Y, Mousses SM, Robbins C, Moses T, Carpten JD. PI3K/AKT pathway activation in acute myeloid leukaemias is not associated with AKT1 pleckstrin homology domain mutation. Br J Haematol 2008, 140:344-347. 10.1111/j.1365-2141.2007.06920.x, 3385948, 18053070.
-
(2008)
Br J Haematol
, vol.140
, pp. 344-347
-
-
Tibes, R.1
Kornblau, S.M.2
Qiu, Y.3
Mousses, S.M.4
Robbins, C.5
Moses, T.6
Carpten, J.D.7
-
50
-
-
36749022214
-
The DNA damage response: ten years after
-
18082599
-
Harper JW, Elledge SJ. The DNA damage response: ten years after. Mol Cell 2007, 28:739-745. 10.1016/j.molcel.2007.11.015, 18082599.
-
(2007)
Mol Cell
, vol.28
, pp. 739-745
-
-
Harper, J.W.1
Elledge, S.J.2
-
51
-
-
59649086030
-
Nonproteolytic functions of ubiquitin in cell signaling
-
19217402
-
Chen ZJ, Sun LJ. Nonproteolytic functions of ubiquitin in cell signaling. Mol Cell 2009, 33:275-286. 10.1016/j.molcel.2009.01.014, 19217402.
-
(2009)
Mol Cell
, vol.33
, pp. 275-286
-
-
Chen, Z.J.1
Sun, L.J.2
-
52
-
-
63649116570
-
Ubiquitylation in innate and adaptive immunity
-
19325622
-
Bhoj VG, Chen ZJ. Ubiquitylation in innate and adaptive immunity. Nature 2009, 458:430-437. 10.1038/nature07959, 19325622.
-
(2009)
Nature
, vol.458
, pp. 430-437
-
-
Bhoj, V.G.1
Chen, Z.J.2
-
53
-
-
84898727154
-
Ubiquitin in inflammation: the right linkage makes all the difference
-
24699077
-
Corn JE, Vucic D. Ubiquitin in inflammation: the right linkage makes all the difference. Nat Struct Mol Biol 2014, 21:297-300. 10.1038/nsmb.2808, 24699077.
-
(2014)
Nat Struct Mol Biol
, vol.21
, pp. 297-300
-
-
Corn, J.E.1
Vucic, D.2
-
54
-
-
63649086487
-
Targeting the ubiquitin system in cancer therapy
-
19325623
-
Hoeller D, Dikic I. Targeting the ubiquitin system in cancer therapy. Nature 2009, 458:438-444. 10.1038/nature07960, 19325623.
-
(2009)
Nature
, vol.458
, pp. 438-444
-
-
Hoeller, D.1
Dikic, I.2
-
55
-
-
58049088976
-
Think locally: control of ubiquitin-dependent protein degradation in neurons
-
2613211, 19079132
-
Segref A, Hoppe T. Think locally: control of ubiquitin-dependent protein degradation in neurons. EMBO Rep 2009, 10:44-50. 10.1038/embor.2008.229, 2613211, 19079132.
-
(2009)
EMBO Rep
, vol.10
, pp. 44-50
-
-
Segref, A.1
Hoppe, T.2
-
56
-
-
64549154396
-
Diversity of polyubiquitin chains
-
19386255
-
Adhikari A, Chen ZJ. Diversity of polyubiquitin chains. Dev Cell 2009, 16:485-486. 10.1016/j.devcel.2009.04.001, 19386255.
-
(2009)
Dev Cell
, vol.16
, pp. 485-486
-
-
Adhikari, A.1
Chen, Z.J.2
-
57
-
-
77951917753
-
Regulation of Akt signaling activation by ubiquitination
-
3077544, 20081374
-
Yang WL, Wu CY, Wu J, Lin HK. Regulation of Akt signaling activation by ubiquitination. Cell Cycle 2010, 9:487-497. 3077544, 20081374.
-
(2010)
Cell Cycle
, vol.9
, pp. 487-497
-
-
Yang, W.L.1
Wu, C.Y.2
Wu, J.3
Lin, H.K.4
-
58
-
-
0038404927
-
Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol
-
Solit DB, Basso AD, Olshen AB, Scher HI, Rosen N. Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol. Cancer Res 2003, 63:2139-2144.
-
(2003)
Cancer Res
, vol.63
, pp. 2139-2144
-
-
Solit, D.B.1
Basso, A.D.2
Olshen, A.B.3
Scher, H.I.4
Rosen, N.5
-
59
-
-
57749115897
-
Negative regulation of AKT activation by BRCA1
-
2605656, 19074868
-
Xiang T, Ohashi A, Huang Y, Pandita TK, Ludwig T, Powell SN, Yang Q. Negative regulation of AKT activation by BRCA1. Cancer Res 2008, 68:10040-10044. 10.1158/0008-5472.CAN-08-3009, 2605656, 19074868.
-
(2008)
Cancer Res
, vol.68
, pp. 10040-10044
-
-
Xiang, T.1
Ohashi, A.2
Huang, Y.3
Pandita, T.K.4
Ludwig, T.5
Powell, S.N.6
Yang, Q.7
-
60
-
-
71649104466
-
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt
-
20059950
-
Suizu F, Hiramuki Y, Okumura F, Matsuda M, Okumura AJ, Hirata N, Narita M, Kohno T, Yokota J, Bohgaki M, Obuse C, Hatakeyama S, Obata T, Noguchi M. The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. Dev Cell 2009, 17:800-810. 10.1016/j.devcel.2009.09.007, 20059950.
-
(2009)
Dev Cell
, vol.17
, pp. 800-810
-
-
Suizu, F.1
Hiramuki, Y.2
Okumura, F.3
Matsuda, M.4
Okumura, A.J.5
Hirata, N.6
Narita, M.7
Kohno, T.8
Yokota, J.9
Bohgaki, M.10
Obuse, C.11
Hatakeyama, S.12
Obata, T.13
Noguchi, M.14
-
61
-
-
84862808614
-
Akt is negatively regulated by the MULAN E3 ligase
-
3343661, 22410793
-
Bae S, Kim SY, Jung JH, Yoon Y, Cha HJ, Lee H, Kim K, Kim J, An IS, Kim J, Um HD, Park IC, Lee SJ, Nam SY, Jin YW, Lee JH, An S. Akt is negatively regulated by the MULAN E3 ligase. Cell Res 2012, 22:873-885. 10.1038/cr.2012.38, 3343661, 22410793.
-
(2012)
Cell Res
, vol.22
, pp. 873-885
-
-
Bae, S.1
Kim, S.Y.2
Jung, J.H.3
Yoon, Y.4
Cha, H.J.5
Lee, H.6
Kim, K.7
Kim, J.8
An, I.S.9
Kim, J.10
Um, H.D.11
Park, I.C.12
Lee, S.J.13
Nam, S.Y.14
Jin, Y.W.15
Lee, J.H.16
An, S.17
-
62
-
-
69549116880
-
The E3 ligase TRAF6 regulates Akt ubiquitination and activation
-
3008763, 19713527
-
Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG, Lin HK. The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 2009, 325:1134-1138. 10.1126/science.1175065, 3008763, 19713527.
-
(2009)
Science
, vol.325
, pp. 1134-1138
-
-
Yang, W.L.1
Wang, J.2
Chan, C.H.3
Lee, S.W.4
Campos, A.D.5
Lamothe, B.6
Hur, L.7
Grabiner, B.C.8
Lin, X.9
Darnay, B.G.10
Lin, H.K.11
-
63
-
-
84872736566
-
Ubiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 response
-
3548477, 23195959
-
Fan CD, Lum MA, Xu C, Black JD, Wang X. Ubiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 response. J Biol Chem 2013, 288:1674-1684. 10.1074/jbc.M112.416339, 3548477, 23195959.
-
(2013)
J Biol Chem
, vol.288
, pp. 1674-1684
-
-
Fan, C.D.1
Lum, M.A.2
Xu, C.3
Black, J.D.4
Wang, X.5
-
64
-
-
84861552793
-
The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis
-
3586339, 22632973
-
Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KK, Flores LG, Shao Y, Hazle JD, Yu D, Wei W, Sarbassov D, Hung MC, Nakayama KI, Lin HK. The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. Cell 2012, 149:1098-1111. 10.1016/j.cell.2012.02.065, 3586339, 22632973.
-
(2012)
Cell
, vol.149
, pp. 1098-1111
-
-
Chan, C.H.1
Li, C.F.2
Yang, W.L.3
Gao, Y.4
Lee, S.W.5
Feng, Z.6
Huang, H.Y.7
Tsai, K.K.8
Flores, L.G.9
Shao, Y.10
Hazle, J.D.11
Yu, D.12
Wei, W.13
Sarbassov, D.14
Hung, M.C.15
Nakayama, K.I.16
Lin, H.K.17
-
65
-
-
84890290884
-
TRAF4 is a critical molecule for Akt activation in lung cancer
-
24154876
-
Li W, Peng C, Lee MH, Lim D, Zhu F, Fu Y, Yang G, Sheng Y, Xiao L, Dong X, Ma W, Bode AM, Cao Y, Dong Z. TRAF4 is a critical molecule for Akt activation in lung cancer. Cancer Res 2013, 73:6938-6950. 10.1158/0008-5472.CAN-13-0913, 24154876.
-
(2013)
Cancer Res
, vol.73
, pp. 6938-6950
-
-
Li, W.1
Peng, C.2
Lee, M.H.3
Lim, D.4
Zhu, F.5
Fu, Y.6
Yang, G.7
Sheng, Y.8
Xiao, L.9
Dong, X.10
Ma, W.11
Bode, A.M.12
Cao, Y.13
Dong, Z.14
-
66
-
-
84860284249
-
CYLD negatively regulates transforming growth factor-beta-signalling via deubiquitinating Akt
-
3337989, 22491319
-
Lim JH, Jono H, Komatsu K, Woo CH, Lee J, Miyata M, Matsuno T, Xu X, Huang Y, Zhang W, Park SH, Kim YI, Choi YD, Shen H, Heo KS, Xu H, Bourne P, Koga T, Xu H, Yan C, Wang B, Chen LF, Feng XH, Li JD. CYLD negatively regulates transforming growth factor-beta-signalling via deubiquitinating Akt. Nat Commun 2012, 3:771. 3337989, 22491319.
-
(2012)
Nat Commun
, vol.3
, pp. 771
-
-
Lim, J.H.1
Jono, H.2
Komatsu, K.3
Woo, C.H.4
Lee, J.5
Miyata, M.6
Matsuno, T.7
Xu, X.8
Huang, Y.9
Zhang, W.10
Park, S.H.11
Kim, Y.I.12
Choi, Y.D.13
Shen, H.14
Heo, K.S.15
Xu, H.16
Bourne, P.17
Koga, T.18
Xu, H.19
Yan, C.20
Wang, B.21
Chen, L.F.22
Feng, X.H.23
Li, J.D.24
more..
-
67
-
-
84872566774
-
Cycles of ubiquitination and deubiquitination critically regulate growth factor-mediated activation of Akt signaling
-
3862898, 23300340
-
Yang WL, Jin G, Li CF, Jeong YS, Moten A, Xu D, Feng Z, Chen W, Cai Z, Darnay B, Gu W, Lin HK. Cycles of ubiquitination and deubiquitination critically regulate growth factor-mediated activation of Akt signaling. Sci Signal 2013, 6:ra3. 3862898, 23300340.
-
(2013)
Sci Signal
, vol.6
, pp. ra3
-
-
Yang, W.L.1
Jin, G.2
Li, C.F.3
Jeong, Y.S.4
Moten, A.5
Xu, D.6
Feng, Z.7
Chen, W.8
Cai, Z.9
Darnay, B.10
Gu, W.11
Lin, H.K.12
-
68
-
-
84884761456
-
Akt SUMOylation regulates cell proliferation and tumorigenesis
-
23884910
-
Li R, Wei J, Jiang C, Liu D, Deng L, Zhang K, Wang P. Akt SUMOylation regulates cell proliferation and tumorigenesis. Cancer Res 2013, 73:5742-5753. 10.1158/0008-5472.CAN-13-0538, 23884910.
-
(2013)
Cancer Res
, vol.73
, pp. 5742-5753
-
-
Li, R.1
Wei, J.2
Jiang, C.3
Liu, D.4
Deng, L.5
Zhang, K.6
Wang, P.7
-
69
-
-
84886683522
-
Modification of Akt by SUMO conjugation regulates alternative splicing and cell cycle
-
3865012, 24013425
-
Risso G, Pelisch F, Pozzi B, Mammi P, Blaustein M, Colman-Lerner A, Srebrow A. Modification of Akt by SUMO conjugation regulates alternative splicing and cell cycle. Cell Cycle 2013, 12:3165-3174. 3865012, 24013425.
-
(2013)
Cell Cycle
, vol.12
, pp. 3165-3174
-
-
Risso, G.1
Pelisch, F.2
Pozzi, B.3
Mammi, P.4
Blaustein, M.5
Colman-Lerner, A.6
Srebrow, A.7
-
70
-
-
79960620082
-
The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy
-
Sundaresan NR, Pillai VB, Wolfgeher D, Samant S, Vasudevan P, Parekh V, Raghuraman H, Cunningham JM, Gupta M, Gupta MP. The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy. Sci Signal 2011, 4:ra46.
-
(2011)
Sci Signal
, vol.4
, pp. ra46
-
-
Sundaresan, N.R.1
Pillai, V.B.2
Wolfgeher, D.3
Samant, S.4
Vasudevan, P.5
Parekh, V.6
Raghuraman, H.7
Cunningham, J.M.8
Gupta, M.9
Gupta, M.P.10
-
71
-
-
0037117511
-
Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes
-
122766, 11959983
-
Vosseller K, Wells L, Lane MD, Hart GW. Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A 2002, 99:5313-5318. 10.1073/pnas.072072399, 122766, 11959983.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 5313-5318
-
-
Vosseller, K.1
Wells, L.2
Lane, M.D.3
Hart, G.W.4
-
72
-
-
39749104251
-
Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance
-
18288188
-
Yang X, Ongusaha PP, Miles PD, Havstad JC, Zhang F, So WV, Kudlow JE, Michell RH, Olefsky JM, Field SJ, Evans RM. Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. Nature 2008, 451:964-969. 10.1038/nature06668, 18288188.
-
(2008)
Nature
, vol.451
, pp. 964-969
-
-
Yang, X.1
Ongusaha, P.P.2
Miles, P.D.3
Havstad, J.C.4
Zhang, F.5
So, W.V.6
Kudlow, J.E.7
Michell, R.H.8
Olefsky, J.M.9
Field, S.J.10
Evans, R.M.11
-
73
-
-
56049101623
-
Regulation of Akt signaling by O-GlcNAc in euglycemia
-
2575895, 18728220
-
Soesanto YA, Luo B, Jones D, Taylor R, Gabrielsen JS, Parker G, McClain DA. Regulation of Akt signaling by O-GlcNAc in euglycemia. Am J Physiol Endocrinol Metab 2008, 295:E974-E980. 10.1152/ajpendo.90366.2008, 2575895, 18728220.
-
(2008)
Am J Physiol Endocrinol Metab
, vol.295
, pp. E974-E980
-
-
Soesanto, Y.A.1
Luo, B.2
Jones, D.3
Taylor, R.4
Gabrielsen, J.S.5
Parker, G.6
McClain, D.A.7
-
74
-
-
84861306218
-
Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates Akt signaling
-
3358304, 22629392
-
Wang S, Huang X, Sun D, Xin X, Pan Q, Peng S, Liang Z, Luo C, Yang Y, Jiang H, Huang M, Chai W, Ding J, Geng M. Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates Akt signaling. PLoS One 2012, 7:e37427. 10.1371/journal.pone.0037427, 3358304, 22629392.
-
(2012)
PLoS One
, vol.7
, pp. e37427
-
-
Wang, S.1
Huang, X.2
Sun, D.3
Xin, X.4
Pan, Q.5
Peng, S.6
Liang, Z.7
Luo, C.8
Yang, Y.9
Jiang, H.10
Huang, M.11
Chai, W.12
Ding, J.13
Geng, M.14
-
75
-
-
84864287178
-
Diverse regulation of AKT and GSK-3beta by O-GlcNAcylation in various types of cells
-
3407308, 22687243
-
Shi J, Wu S, Dai CL, Li Y, Grundke-Iqbal I, Iqbal K, Liu F, Gong CX. Diverse regulation of AKT and GSK-3beta by O-GlcNAcylation in various types of cells. FEBS Lett 2012, 586:2443-2450. 10.1016/j.febslet.2012.05.063, 3407308, 22687243.
-
(2012)
FEBS Lett
, vol.586
, pp. 2443-2450
-
-
Shi, J.1
Wu, S.2
Dai, C.L.3
Li, Y.4
Grundke-Iqbal, I.5
Iqbal, K.6
Liu, F.7
Gong, C.X.8
-
76
-
-
32044466838
-
Exploiting the PI3K/AKT pathway for cancer drug discovery
-
16341064
-
Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov 2005, 4:988-1004. 10.1038/nrd1902, 16341064.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 988-1004
-
-
Hennessy, B.T.1
Smith, D.L.2
Ram, P.T.3
Lu, Y.4
Mills, G.B.5
-
77
-
-
68249093818
-
Targeting the phosphoinositide 3-kinase pathway in cancer
-
3142564, 19644473
-
Liu P, Cheng H, Roberts TM, Zhao JJ. Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov 2009, 8:627-644. 10.1038/nrd2926, 3142564, 19644473.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 627-644
-
-
Liu, P.1
Cheng, H.2
Roberts, T.M.3
Zhao, J.J.4
-
78
-
-
33646382364
-
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma
-
2925230, 16697955
-
Fan QW, Knight ZA, Goldenberg DD, Yu W, Mostov KE, Stokoe D, Shokat KM, Weiss WA. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell 2006, 9:341-349. 10.1016/j.ccr.2006.03.029, 2925230, 16697955.
-
(2006)
Cancer Cell
, vol.9
, pp. 341-349
-
-
Fan, Q.W.1
Knight, Z.A.2
Goldenberg, D.D.3
Yu, W.4
Mostov, K.E.5
Stokoe, D.6
Shokat, K.M.7
Weiss, W.A.8
-
79
-
-
51849111524
-
NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations
-
18829560
-
Serra V, Markman B, Scaltriti M, Eichhorn PJ, Valero V, Guzman M, Botero ML, Llonch E, Atzori F, Di Cosimo S, Maira M, Garcia-Echeverria C, Parra JL, Arribas J, Baselga J. NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. Cancer Res 2008, 68:8022-8030. 10.1158/0008-5472.CAN-08-1385, 18829560.
-
(2008)
Cancer Res
, vol.68
, pp. 8022-8030
-
-
Serra, V.1
Markman, B.2
Scaltriti, M.3
Eichhorn, P.J.4
Valero, V.5
Guzman, M.6
Botero, M.L.7
Llonch, E.8
Atzori, F.9
Di Cosimo, S.10
Maira, M.11
Garcia-Echeverria, C.12
Parra, J.L.13
Arribas, J.14
Baselga, J.15
-
80
-
-
67449168372
-
Suppression of HER2/HER3-mediated growth of breast cancer cells with combinations of GDC-0941 PI3K inhibitor, trastuzumab, and pertuzumab
-
19509167
-
Yao E, Zhou W, Lee-Hoeflich ST, Truong T, Haverty PM, Eastham-Anderson J, Lewin-Koh N, Gunter B, Belvin M, Murray LJ, Friedman LS, Sliwkowski MX, Hoeflich KP. Suppression of HER2/HER3-mediated growth of breast cancer cells with combinations of GDC-0941 PI3K inhibitor, trastuzumab, and pertuzumab. Clin Cancer Res 2009, 15:4147-4156. 10.1158/1078-0432.CCR-08-2814, 19509167.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4147-4156
-
-
Yao, E.1
Zhou, W.2
Lee-Hoeflich, S.T.3
Truong, T.4
Haverty, P.M.5
Eastham-Anderson, J.6
Lewin-Koh, N.7
Gunter, B.8
Belvin, M.9
Murray, L.J.10
Friedman, L.S.11
Sliwkowski, M.X.12
Hoeflich, K.P.13
-
81
-
-
58249120506
-
Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance
-
2613546, 19117997
-
Ihle NT, Lemos R, Wipf P, Yacoub A, Mitchell C, Siwak D, Mills GB, Dent P, Kirkpatrick DL, Powis G. Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance. Cancer Res 2009, 69:143-150. 10.1158/0008-5472.CAN-07-6656, 2613546, 19117997.
-
(2009)
Cancer Res
, vol.69
, pp. 143-150
-
-
Ihle, N.T.1
Lemos, R.2
Wipf, P.3
Yacoub, A.4
Mitchell, C.5
Siwak, D.6
Mills, G.B.7
Dent, P.8
Kirkpatrick, D.L.9
Powis, G.10
-
82
-
-
84901008792
-
Targeting PI3K/Akt/mTOR signaling in cancer
-
3995050, 24782981
-
Porta C, Paglino C, Mosca A. Targeting PI3K/Akt/mTOR signaling in cancer. Front Oncol 2014, 4:64. 3995050, 24782981.
-
(2014)
Front Oncol
, vol.4
, pp. 64
-
-
Porta, C.1
Paglino, C.2
Mosca, A.3
-
83
-
-
79955975429
-
Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
-
3142785, 21575859
-
Carver BS, Chapinski C, Wongvipat J, Hieronymus H, Chen Y, Chandarlapaty S, Arora VK, Le C, Koutcher J, Scher H, Scardino PT, Rosen N, Sawyers CL. Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell 2011, 19:575-586. 10.1016/j.ccr.2011.04.008, 3142785, 21575859.
-
(2011)
Cancer Cell
, vol.19
, pp. 575-586
-
-
Carver, B.S.1
Chapinski, C.2
Wongvipat, J.3
Hieronymus, H.4
Chen, Y.5
Chandarlapaty, S.6
Arora, V.K.7
Le, C.8
Koutcher, J.9
Scher, H.10
Scardino, P.T.11
Rosen, N.12
Sawyers, C.L.13
-
84
-
-
79958764107
-
Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth
-
3157296, 21620777
-
Mulholland DJ, Tran LM, Li Y, Cai H, Morim A, Wang S, Plaisier S, Garraway IP, Huang J, Graeber TG, Wu H. Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth. Cancer Cell 2011, 19:792-804. 10.1016/j.ccr.2011.05.006, 3157296, 21620777.
-
(2011)
Cancer Cell
, vol.19
, pp. 792-804
-
-
Mulholland, D.J.1
Tran, L.M.2
Li, Y.3
Cai, H.4
Morim, A.5
Wang, S.6
Plaisier, S.7
Garraway, I.P.8
Huang, J.9
Graeber, T.G.10
Wu, H.11
-
85
-
-
79957917078
-
PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer
-
21278786
-
Serra V, Scaltriti M, Prudkin L, Eichhorn PJ, Ibrahim YH, Chandarlapaty S, Markman B, Rodriguez O, Guzman M, Rodriguez S, Gili M, Russillo M, Parra JL, Singh S, Arribas J, Rosen N, Baselga J. PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer. Oncogene 2011, 30:2547-2557. 10.1038/onc.2010.626, 3107390,3107390, 21278786.
-
(2011)
Oncogene
, vol.30
, pp. 2547-2557
-
-
Serra, V.1
Scaltriti, M.2
Prudkin, L.3
Eichhorn, P.J.4
Ibrahim, Y.H.5
Chandarlapaty, S.6
Markman, B.7
Rodriguez, O.8
Guzman, M.9
Rodriguez, S.10
Gili, M.11
Russillo, M.12
Parra, J.L.13
Singh, S.14
Arribas, J.15
Rosen, N.16
Baselga, J.17
-
86
-
-
84896512807
-
FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacologic inhibition of the PI3K-AKT pathway
-
24448243
-
Lin A, Piao HL, Zhuang L, Sarbassov dos D, Ma L, Gan B. FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacologic inhibition of the PI3K-AKT pathway. Cancer Res 2014, 74:1682-1693. 10.1158/0008-5472.CAN-13-1729, 24448243.
-
(2014)
Cancer Res
, vol.74
, pp. 1682-1693
-
-
Lin, A.1
Piao, H.L.2
Zhuang, L.3
Sarbassov dos, D.4
Ma, L.5
Gan, B.6
-
87
-
-
84907509887
-
Current view on the mechanism of action of perifosine in cancer
-
Fensterle J, Aicher B, Seipelt I, Teifel M, Engel J. Current view on the mechanism of action of perifosine in cancer. Anti Cancer Agents Med Chem 2014, 14:629-635.
-
(2014)
Anti Cancer Agents Med Chem
, vol.14
, pp. 629-635
-
-
Fensterle, J.1
Aicher, B.2
Seipelt, I.3
Teifel, M.4
Engel, J.5
-
88
-
-
9244224608
-
In vivo molecular pharmacology and antitumor activity of the targeted Akt inhibitor PX-316
-
Meuillet EJ, Ihle N, Baker AF, Gard JM, Stamper C, Williams R, Coon A, Mahadevan D, George BL, Kirkpatrick L, Powis G. In vivo molecular pharmacology and antitumor activity of the targeted Akt inhibitor PX-316. Oncol Res 2004, 14:513-527.
-
(2004)
Oncol Res
, vol.14
, pp. 513-527
-
-
Meuillet, E.J.1
Ihle, N.2
Baker, A.F.3
Gard, J.M.4
Stamper, C.5
Williams, R.6
Coon, A.7
Mahadevan, D.8
George, B.L.9
Kirkpatrick, L.10
Powis, G.11
-
89
-
-
84897085768
-
Roles of F-box proteins in cancer
-
24658274
-
Wang Z, Liu P, Inuzuka H, Wei W. Roles of F-box proteins in cancer. Nat Rev Cancer 2014, 14:233-247. 10.1038/nrc3700, 24658274.
-
(2014)
Nat Rev Cancer
, vol.14
, pp. 233-247
-
-
Wang, Z.1
Liu, P.2
Inuzuka, H.3
Wei, W.4
-
90
-
-
84881192827
-
Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression
-
3845452, 23911321
-
Chan CH, Morrow JK, Li CF, Gao Y, Jin G, Moten A, Stagg LJ, Ladbury JE, Cai Z, Xu D, Logothetis CJ, Hung MC, Zhang S, Lin HK. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell 2013, 154:556-568. 10.1016/j.cell.2013.06.048, 3845452, 23911321.
-
(2013)
Cell
, vol.154
, pp. 556-568
-
-
Chan, C.H.1
Morrow, J.K.2
Li, C.F.3
Gao, Y.4
Jin, G.5
Moten, A.6
Stagg, L.J.7
Ladbury, J.E.8
Cai, Z.9
Xu, D.10
Logothetis, C.J.11
Hung, M.C.12
Zhang, S.13
Lin, H.K.14
-
91
-
-
84897995252
-
Skp2: a dream target in the coming age of cancer therapy
-
3979895, 24526126
-
Chan CH, Morrow JK, Zhang S, Lin HK. Skp2: a dream target in the coming age of cancer therapy. Cell Cycle 2014, 13:679-680. 10.4161/cc.27853, 3979895, 24526126.
-
(2014)
Cell Cycle
, vol.13
, pp. 679-680
-
-
Chan, C.H.1
Morrow, J.K.2
Zhang, S.3
Lin, H.K.4
-
92
-
-
0035448879
-
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene
-
312770, 11544177
-
Chen WS, Xu PZ, Gottlob K, Chen ML, Sokol K, Shiyanova T, Roninson I, Weng W, Suzuki R, Tobe K, Kadowaki T, Hay N. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev 2001, 15:2203-2208. 10.1101/gad.913901, 312770, 11544177.
-
(2001)
Genes Dev
, vol.15
, pp. 2203-2208
-
-
Chen, W.S.1
Xu, P.Z.2
Gottlob, K.3
Chen, M.L.4
Sokol, K.5
Shiyanova, T.6
Roninson, I.7
Weng, W.8
Suzuki, R.9
Tobe, K.10
Kadowaki, T.11
Hay, N.12
-
93
-
-
85047693348
-
Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta
-
164287, 12843127
-
Garofalo RS, Orena SJ, Rafidi K, Torchia AJ, Stock JL, Hildebrandt AL, Coskran T, Black SC, Brees DJ, Wicks JR, McNeish JD, Coleman KG. Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. J Clin Invest 2003, 112:197-208. 10.1172/JCI16885, 164287, 12843127.
-
(2003)
J Clin Invest
, vol.112
, pp. 197-208
-
-
Garofalo, R.S.1
Orena, S.J.2
Rafidi, K.3
Torchia, A.J.4
Stock, J.L.5
Hildebrandt, A.L.6
Coskran, T.7
Black, S.C.8
Brees, D.J.9
Wicks, J.R.10
McNeish, J.D.11
Coleman, K.G.12
-
94
-
-
23144449547
-
Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis
-
15930105
-
Tschopp O, Yang ZZ, Brodbeck D, Dummler BA, Hemmings-Mieszczak M, Watanabe T, Michaelis T, Frahm J, Hemmings BA. Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis. Development 2005, 132:2943-2954. 10.1242/dev.01864, 15930105.
-
(2005)
Development
, vol.132
, pp. 2943-2954
-
-
Tschopp, O.1
Yang, Z.Z.2
Brodbeck, D.3
Dummler, B.A.4
Hemmings-Mieszczak, M.5
Watanabe, T.6
Michaelis, T.7
Frahm, J.8
Hemmings, B.A.9
-
95
-
-
33747889727
-
Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration
-
16870447
-
Stambolic V, Woodgett JR. Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration. Trends Cell Biol 2006, 16:461-466. 10.1016/j.tcb.2006.07.001, 16870447.
-
(2006)
Trends Cell Biol
, vol.16
, pp. 461-466
-
-
Stambolic, V.1
Woodgett, J.R.2
-
96
-
-
29144488505
-
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition
-
2171329, 16365168
-
Irie HY, Pearline RV, Grueneberg D, Hsia M, Ravichandran P, Kothari N, Natesan S, Brugge JS. Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J Cell Biol 2005, 171:1023-1034. 10.1083/jcb.200505087, 2171329, 16365168.
-
(2005)
J Cell Biol
, vol.171
, pp. 1023-1034
-
-
Irie, H.Y.1
Pearline, R.V.2
Grueneberg, D.3
Hsia, M.4
Ravichandran, P.5
Kothari, N.6
Natesan, S.7
Brugge, J.S.8
-
97
-
-
27944446105
-
Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT
-
16307918
-
Yoeli-Lerner M, Yiu GK, Rabinovitz I, Erhardt P, Jauliac S, Toker A. Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol Cell 2005, 20:539-550. 10.1016/j.molcel.2005.10.033, 16307918.
-
(2005)
Mol Cell
, vol.20
, pp. 539-550
-
-
Yoeli-Lerner, M.1
Yiu, G.K.2
Rabinovitz, I.3
Erhardt, P.4
Jauliac, S.5
Toker, A.6
-
98
-
-
33846416534
-
Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice
-
17210696
-
Maroulakou IG, Oemler W, Naber SP, Tsichlis PN. Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice. Cancer Res 2007, 67:167-177. 10.1158/0008-5472.CAN-06-3782, 17210696.
-
(2007)
Cancer Res
, vol.67
, pp. 167-177
-
-
Maroulakou, I.G.1
Oemler, W.2
Naber, S.P.3
Tsichlis, P.N.4
|