Akt is negatively regulated by the MULAN E3 ligase

Cell Research

Volumn 22, Issue 5, 2012, Pages 873-885

  Bae, Seunghee ^a   Kim, Sun Yong ^a   Jung, Jin Hyuk ^a   Yoon, Yeongmin ^a   Cha, Hwa Jun ^a   Lee, Hyunjin ^a   Kim, Karam ^a   Kim, Jongran ^a   An, In Sook ^a   Kim, Jongdoo ^b   Um, Hong Duck ^b   Park, In Chul ^b   Lee, Su Jae ^c   Nam, Seon Young ^d   Jin, Young Woo ^d   Lee, Jae Ho ^e   An, Sungkwan ^a  

^a Konkuk University   (South Korea)

^b Korea Institute of Radiation and Medical Science   (South Korea)

^c Hanyang University   (South Korea)

^d Korea Hydro & Nuclear Power Co   (South Korea)

^e Catholic Kwandong University   (South Korea)

Author keywords

growth regulation; inhibition; ubiquitin E3 ligase

Indexed keywords

HYBRID PROTEIN; PROTEIN KINASE B; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CELL PROLIFERATION; CELL STRAIN HEK293; CELL SURVIVAL; DRUG ANTAGONISM; GENETICS; HELA CELL; HUMAN; METABOLISM; PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UBIQUITINATION;

CELL PROLIFERATION; CELL SURVIVAL; HEK293 CELLS; HELA CELLS; HUMANS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECOMBINANT FUSION PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84862808614     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2012.38     Document Type: Article

References (49)

1. Jones PF, Jakubowicz T, Pitossi FJ, Maurer F, Hemmings BA. Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. Proc Natl Acad Sci USA 1991; 88:4171-4175.
2. Burgering BM, Coffer PJ. Protein kinase B (c-Akt) in phosphatidylinositol- 3-OH kinase signal transduction. Nature 1995; 376:599-602.
3. Franke TF. PI3K/Akt: getting it right matters. Oncogene 2008; 27:6473-6488.
4. Franke TF, Yang SI, Chan TO, et al. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGFactivated phosphatidylinositol 3-kinase. Cell 1995; 81:727-736.
5. Kohn AD, Kovacina KS, Roth RA. Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase. EMBO J 1995; 14:4288-4295.
6. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995; 378:785-789.
7. Lustig B, Behrens J. The Wnt signaling pathway and its role in tumor development. J Cancer Res Clin Oncol 2003; 129:199-221.
8. Behrens J, von Kries JP, Kuhl M, et al. Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 1996; 382:638-642.
9. Huber O, Korn R, McLaughlin J, et al. Nuclear localization of beta-catenin by interaction with transcription factor LEF-1. Mech Dev 1996; 59:3-10.
10. Brazil DP, Hemmings BA. Ten years of protein kinase B signalling: A hard Akt to follow. Trends Biochem Sci 2001; 26:657-664.
11. Luo J, Manning BD, Cantley LC. Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell 2003; 4:257-262.
12. Hafizi S, Ibraimi F, Dahlback B. C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration. FASEB J 2005; 19:971-973.
13. Maira SM, Galetic I, Brazil DP, et al. Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane. Science 2001; 294:374-380.
14. Du K, Herzig S, Kulkarni RN, Montminy M. TRB3: A tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 2003; 300:1574-1577.
15. Paramio JM, Segrelles C, Ruiz S, Jorcano JL. Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10- induced cell cycle arrest. Mol Cell Biol 2001; 21:7449-7459.
16. Mani A, Gelmann EP. The ubiquitin-proteasome pathway and its role in cancer. J Clin Oncol 2005; 23:4776-4789.
17. Basso AD, Solit DB, Chiosis G, et al. Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. J Biol Chem 2002; 277:39858-39866.
18. Solit DB, Basso AD, Olshen AB, Scher HI, Rosen N. Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol. Cancer Res 2003; 63:2139-2144.
19. Dickey CA, Koren J, Zhang YJ, et al. Akt and CHIP coregulate tau degradation through coordinated interactions. Proc Natl Acad Sci USA 2008; 105:3622-3627.
20. Suizu F, Hiramuki Y, Okumura F, et al. The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. Dev Cell 2009; 17:800-810.
21. Xiang T, Ohashi A, Huang Y, et al. Negative Regulation of AKT Activation by BRCA1. Cancer Res 2008; 68:10040-10044.
22. Yang WL, Wang J, Chan CH, et al. The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 2009; 325:1134-1138.
23. Li W, Bengtson MH, Ulbrich A, et al. Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling. PLoS One 2008; 3:e1487.
24. Santi SA, Lee H. The Akt isoforms are present at distinct subcellular locations. Am J Cell Physiol 2010; 298:C580-C591.
25. Antico Arciuch VG, Galli S, Franco MC, et al. Akt1 intramitochondrial cycling is a crucial step in the redox modulation of cell cycle progression. PloS One 2009; 4:e7523.
26. Yang JY, Yeh HY, Lin K, Wang PH. Insulin stimulates Akt translocation to mitochondria: implications on dysregulation of mitochondrial oxidative phosphorylation in diabetic myocardium. J Mol Cell Cardiol 2009; 46:919-926.
27. Firestone GL, Giampaolo JR, O'Keeffe BA. Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity. Cell Physiol Biochem 2003; 13:1-12.
28. Sadowski M, Sarcevic B. Mechanisms of mono- and polyubiquitination: Ubiquitination specificity depends on compatibility between the E2 catalytic core and amino acid residue proximal to the lysine. Cell Div 2010; 5:19.
29. Alessi DR, Andjelkovic M, Caudwell B, et al. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 1996; 15:6541-6551.
30. Cohen PT, Cohen P. Discovery of a protein phosphatase activity encoded in the genome of bacteriophage lambda. Probable identity with open reading frame 221. Biochem J 1989; 260:931-934.
31. Zhuo S, Clemens JC, Hakes DJ, Barford D, Dixon JE. Expression, purification, crystallization, and biochemical characterization of a recombinant protein phosphatase. J Biol Chem 1993; 268:17754-17761.
32. Stokoe D, Stephens LR, Copeland T, et al. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science 1997; 277:567-570.
33. Huang BX, Kim HY. Interdomain conformational changes in Akt activation revealed by chemical cross-linking and tandem mass spectrometry. Mol Cell Proteomics 2006; 5:1045-1053.
34. Majumder PK, Yeh JJ, George DJ, et al. Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model. Proc Natl Acad Sci USA 2003; 100:7841-7846.
35. Arcaro A, Wymann MP. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem J 1993; 296(Pt 2):297-301.
36. Hanada M, Feng J, Hemmings BA. Structure, regulation and function of PKB/AKT - a major therapeutic target. Biochim Biophys Acta 2004; 1697:3-16.
37. Stephens L, Anderson K, Stokoe D, et al. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphatedependent activation of protein kinase B. Science 1998; 279:710-714.
38. Whiteman EL, Cho H, Birnbaum MJ. Role of Akt/protein kinase B in metabolism. Trends Endocrinol Metab 2002; 13:444-451.
39. Weston CR, Davis RJ. Signal transduction: signaling specificity - a complex affair. Science 2001; 292:2439-2440.
40. Meier R, Hemmings BA. Regulation of protein kinase B. J Recept Signal Transduct Res 1999; 19:121-128.
41. Alessi DR, Deak M, Casamayor A, et al. 3-Phosphoinositidedependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. Curr Biol 1997; 7:776-789.
42. Riesterer O, Zingg D, Hummerjohann J, Bodis S, Pruschy M. Degradation of PKB/Akt protein by inhibition of the VEGF receptor/mTOR pathway in endothelial cells. Oncogene 2004; 23:4624-4635.
43. Yan D, Guo L, Wang Y. Requirement of dendritic Akt degradation by the ubiquitin-proteasome system for neuronal polarity. J Cell Biol 2006; 174:415-424.
44. Sasaki K, Sato M, Umezawa Y. Fluorescent indicators for Akt/protein kinase B and dynamics of Akt activity visualized in living cells. J Biol Chem 2003; 278:30945-30951.
45. Zhang B, Huang J, Li HL, et al. GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth. Cell Res 2008; 18:900-910.
46. Rokudai S, Fujita N, Hashimoto Y, Tsuruo T. Cleavage and inactivation of antiapoptotic Akt/PKB by caspases during apoptosis. J Cell Physiol 2000; 182:290-296.
47. Jope RS, Yuskaitis CJ, Beurel E. Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics. Neurochem Res 2007; 32:577-595.
48. Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell 2007; 12:9-22.
49. Potter CJ, Pedraza LG, Xu T. Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol 2002; 4:658-665.