Cycles of ubiquitination and deubiquitination critically regulate growth factor-mediated activation of Akt signaling

Science Signaling

Volumn 6, Issue 257, 2013, Pages

  Yang, Wei Lei ^a,b   Jin, Guoxiang ^a   Li, Chien Feng ^c,d,e   Jeong, Yun Seong ^a,b   Moten, Asad ^a,f   Xu, Dazhi ^a   Feng, Zizhen ^a   Chen, Wei ^a   Cai, Zhen ^a   Darnay, Bryant ^a   Gu, Wei ^g   Lin, Hui Kuan ^a,b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c Chi Mei Foundational Medical Center   (Taiwan)

^d NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^e SOUTHERN TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^f HARVARD UNIVERSITY   (United States)

^g Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYLINDROMATOSIS ENZYME; ENZYME; GROWTH FACTOR; PROTEIN KINASE B; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CELL MEMBRANE; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEUBIQUITINATION; EMBRYO; ENZYME ACTIVATION; ENZYME DEFICIENCY; ENZYME INDUCTION; ENZYME LOCALIZATION; ENZYME METABOLISM; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE TUMOR; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; SERUM; SIGNAL TRANSDUCTION; TUMOR GROWTH; UBIQUITINATION;

ANIMALS; CELL MEMBRANE; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; HEK293 CELLS; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STATISTICS, NONPARAMETRIC; TUMOR SUPPRESSOR PROTEINS; UBIQUITINATION;

MUS;

EID: 84872566774     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2003197     Document Type: Article

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