Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration

Trends in Cell Biology

Volumn 16, Issue 9, 2006, Pages 461-466

  Stambolic, Vuk ^a   Woodgett, James R ^b  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ISOPROTEIN; PROTEIN KINASE B;

APOPTOSIS; CARCINOGENESIS; CELL METABOLISM; CELL MIGRATION; CELL MOTILITY; CELL POLARITY; CYTOSKELETON; EXTRACELLULAR MATRIX; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; TUMOR GROWTH;

ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; ENZYME ACTIVATION; HUMANS; ISOENZYMES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 33747889727     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tcb.2006.07.001     Document Type: Review

References (65)

1. Coffer P.J., et al. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem. J. 335 (1998) 1-13
2. Alessi D.R., et al. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15 (1996) 6541-6551
3. Katso R., et al. Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annu. Rev. Cell Dev. Biol. 17 (2001) 615-675
4. Vanhaesebroeck B., et al. Synthesis and function of 3-phosphorylated inositol lipids. Annu. Rev. Biochem. 70 (2001) 535-602
5. Alessi D.R., et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr. Biol. 7 (1997) 261-269
6. Stephens L., et al. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science 279 (1998) 710-714
7. Sarbassov D.D., et al. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307 (2005) 1098-1101
8. Birkenkamp K.U., and Coffer P.J. Regulation of cell survival and proliferation by the FOXO (Forkhead box, class O) subfamily of Forkhead transcription factors. Biochem. Soc. Trans. 31 (2003) 292-297
9. Datta S.R., et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91 (1997) 231-241
10. Wullschleger S., et al. TOR signaling in growth and metabolism. Cell 124 (2006) 471-484
11. Ishiki M., and Klip A. Minireview: recent developments in the regulation of glucose transporter-4 traffic: new signals, locations, and partners. Endocrinology 146 (2005) 5071-5078
12. Cheng J.Q., et al. AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 9267-9271
13. Cheng J.Q., et al. Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 3636-3641
14. Bellacosa A., et al. Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas. Int. J. Cancer 64 (1995) 280-285
15. Sun M., et al. AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. Am. J. Pathol. 159 (2001) 431-437
16. Tschopp O., et al. Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis. Development 132 (2005) 2943-2954
17. Cho H., et al. Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J. Biol. Chem. 276 (2001) 38349-38352
18. Cho H., et al. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 292 (2001) 1728-1731
19. Peng X.D., et al. Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev. 17 (2003) 1352-1365
20. Easton R.M., et al. Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Mol. Cell. Biol. 25 (2005) 1869-1878
21. Katome T., et al. Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions. J. Biol. Chem. 278 (2003) 28312-28323
22. Bae S.S., et al. Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B. J. Biol. Chem. 278 (2003) 49530-49536
23. Jiang Z.Y., et al. Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 7569-7574
24. Higuchi M., et al. Akt mediates Rac/Cdc42-regulated cell motility in growth factor-stimulated cells and in invasive PTEN knockout cells. Curr. Biol. 11 (2001) 1958-1962
25. Kim D., et al. Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production. FASEB J. 15 (2001) 1953-1962
26. Arboleda M.J., et al. Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells. Cancer Res. 63 (2003) 196-206
27. Hutchinson J.N., et al. Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion. Cancer Res. 64 (2004) 3171-3178
28. Yiu G.K., and Toker A. NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2. J. Biol. Chem. 281 (2006) 12210-12217
29. Yoeli-Lerner M., et al. Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol. Cell 20 (2005) 539-550
30. Ito H., et al. Fibronectin-induced COX-2 mediates MMP-2 expression and invasiveness of rhabdomyosarcoma. Biochem. Biophys. Res. Commun. 318 (2004) 594-600
31. Yazawa K., et al. Selective inhibition of cyclooxygenase-2 inhibits colon cancer cell adhesion to extracellular matrix by decreased expression of beta1 integrin. Cancer Sci. 96 (2005) 93-99
32. Dormond O., et al. NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis. Nat. Med. 7 (2001) 1041-1047
33. Dormond O., et al. Prostaglandin E2 promotes integrin alpha Vbeta 3-dependent endothelial cell adhesion, rac-activation, and spreading through cAMP/PKA-dependent signaling. J. Biol. Chem. 277 (2002) 45838-45846
34. Liu H., et al. Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 4134-4139
35. Astrinidis A., et al. Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration. Oncogene 21 (2002) 8470-8476
36. Lamb R.F., et al. The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho. Nat. Cell Biol. 2 (2000) 281-287
37. Enomoto A., et al. Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev. Cell 9 (2005) 389-402
38. Li J., et al. Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin beta1 to control cell migration. Dev. Cell 9 (2005) 663-673
39. Caswell P.T., and Norman J.C. Integrin trafficking and the control of cell migration. Traffic 7 (2006) 14-21
40. Cross D.A., et al. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378 (1995) 785-789
41. Kobayashi T., et al. Glycogen synthase kinase 3 and h-prune regulate cell migration by modulating focal adhesions. Mol. Cell. Biol. 26 (2006) 898-911
42. Roberts M.S., et al. Protein kinase B/Akt acts via glycogen synthase kinase 3 to regulate recycling of alpha v beta 3 and alpha 5 beta 1 integrins. Mol. Cell. Biol. 24 (2004) 1505-1515
43. Jiang H., et al. Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3beta and its upstream regulators. Cell 120 (2005) 123-135
44. Yoshimura T., et al. GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity. Cell 120 (2005) 137-149
45. Cole A.R., et al. GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons. J. Biol. Chem. 279 (2004) 50176-50180
46. Merlot S., and Firtel R.A. Leading the way: directional sensing through phosphatidylinositol 3-kinase and other signaling pathways. J. Cell Sci. 116 (2003) 3471-3478
47. Chung C.Y., et al. Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol. Cell 7 (2001) 937-947
48. DeFeo-Jones D., et al. Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members. Mol. Cancer Ther. 4 (2005) 271-279
49. Lindsley C.W., et al. Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors. Bioorg. Med. Chem. Lett. 15 (2005) 761-764
50. Barnett S.F., et al. Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors. Biochem. J. 385 (2005) 399-408
51. Lauffenburger D.A., and Horwitz A.F. Cell migration: a physically integrated molecular process. Cell 84 (1996) 359-369
52. Friedl P., and Wolf K. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat. Rev. Cancer 3 (2003) 362-374
53. Cramer L.P. Organization and polarity of actin filament networks in cells: implications for the mechanism of myosin-based cell motility. Biochem. Soc. Symp. 65 (1999) 173-205
54. Hynes R.O. Integrins: bidirectional, allosteric signaling machines. Cell 110 (2002) 673-687
55. Mueller S.C., et al. A novel protease-docking function of integrin at invadopodia. J. Biol. Chem. 274 (1999) 24947-24952
56. Dumin J.A., et al. Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen. J. Biol. Chem. 276 (2001) 29368-29374
57. Brooks P.C., et al. Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity. Cell 92 (1998) 391-400
58. Galvez B.G., et al. ECM regulates MT1-MMP localization with beta1 or alphavbeta3 integrins at distinct cell compartments modulating its internalization and activity on human endothelial cells. J. Cell Biol. 159 (2002) 509-521
59. Byers H.R., and Fujiwara K. Stress fibers in cells in situ: immunofluorescence visualization with antiactin, antimyosin, and anti-alpha-actinin. J. Cell Biol. 93 (1982) 804-811
60. Zamir E., and Geiger B. Molecular complexity and dynamics of cell-matrix adhesions. J. Cell Sci. 114 (2001) 3583-3590
61. Wear M.A., and Cooper J.A. Capping protein: new insights into mechanism and regulation. Trends Biochem. Sci. 29 (2004) 418-428
62. Wear M.A., et al. Actin dynamics: assembly and disassembly of actin networks. Curr. Biol. 10 (2000) R891-R895
63. Potter D.A., et al. Calpain regulates actin remodeling during cell spreading. J. Cell Biol. 141 (1998) 647-662
64. Pfaff M., et al. Calpain cleavage of integrin beta cytoplasmic domains. FEBS Lett. 460 (1999) 17-22
65. Irie, et al. Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J. Cell Biol. 171 (2005) 1023-1034