-
1
-
-
0025882091
-
Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily
-
Jones PF, Jakubowicz T, Pitossi FJ, Maurer F, Hemmings BA, (1991) Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. Proc Natl Acad Sci U S A 88: 4171-4175.
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, pp. 4171-4175
-
-
Jones, P.F.1
Jakubowicz, T.2
Pitossi, F.J.3
Maurer, F.4
Hemmings, B.A.5
-
2
-
-
34250788809
-
AKT/PKB signaling: navigating downstream
-
Manning BD, Cantley LC, (2007) AKT/PKB signaling: navigating downstream. Cell 129: 1261-1274.
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
3
-
-
32044466838
-
Exploiting the PI3K/AKT pathway for cancer drug discovery
-
Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB, (2005) Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov 4: 988-1004.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 988-1004
-
-
Hennessy, B.T.1
Smith, D.L.2
Ram, P.T.3
Lu, Y.4
Mills, G.B.5
-
4
-
-
37449024702
-
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
-
DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB, (2008) The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 7: 11-20.
-
(2008)
Cell Metab
, vol.7
, pp. 11-20
-
-
DeBerardinis, R.J.1
Lum, J.J.2
Hatzivassiliou, G.3
Thompson, C.B.4
-
5
-
-
77951917753
-
Regulation of Akt signaling activation by ubiquitination
-
Yang WL, Wu CY, Wu J, Lin HK, (2010) Regulation of Akt signaling activation by ubiquitination. Cell Cycle 9: 487-497.
-
(2010)
Cell Cycle
, vol.9
, pp. 487-497
-
-
Yang, W.L.1
Wu, C.Y.2
Wu, J.3
Lin, H.K.4
-
6
-
-
14844361808
-
Multisite protein modification and intramolecular signaling
-
Yang XJ, (2005) Multisite protein modification and intramolecular signaling. Oncogene 24: 1653-1662.
-
(2005)
Oncogene
, vol.24
, pp. 1653-1662
-
-
Yang, X.J.1
-
7
-
-
52449132322
-
Is there a code embedded in proteins that is based on post-translational modifications?
-
Sims RJ 3rd, Reinberg D, (2008) Is there a code embedded in proteins that is based on post-translational modifications? Nat Rev Mol Cell Biol 9: 815-820.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 815-820
-
-
Sims 3rd, R.J.1
Reinberg, D.2
-
8
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
Alessi DR, Andjelkovic M, Caudwell FB, Cron P, Morrice N, et al. (1996) Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15: 6541-6551.
-
(1996)
EMBO J
, vol.15
, pp. 6541-6551
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, F.B.3
Cron, P.4
Morrice, N.5
-
9
-
-
0032055131
-
Aberrant O-GlcNAcylation characterizes chronic lymphocytic leukemia
-
Walker KS, Deak M, Paterson A, Hudson K, Cohen P, et al. (1998) Aberrant O-GlcNAcylation characterizes chronic lymphocytic leukemia. Biochem J 331: 299-308.
-
(1998)
Biochem J
, vol.331
, pp. 299-308
-
-
Walker, K.S.1
Deak, M.2
Paterson, A.3
Hudson, K.4
Cohen, P.5
-
10
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM, (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307: 1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
12
-
-
27944448894
-
Involvement of PP2A in viral and cellular transformation
-
Arroyo JD, Hahn WC, (2005) Involvement of PP2A in viral and cellular transformation. Oncogene 24: 7746-7755.
-
(2005)
Oncogene
, vol.24
, pp. 7746-7755
-
-
Arroyo, J.D.1
Hahn, W.C.2
-
13
-
-
33947203621
-
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms
-
Brognard J, Sierecki E, Gao T, Newton AC, (2007) PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell 25: 917-931.
-
(2007)
Mol Cell
, vol.25
, pp. 917-931
-
-
Brognard, J.1
Sierecki, E.2
Gao, T.3
Newton, A.C.4
-
14
-
-
69549116880
-
The E3 ligase TRAF6 regulates Akt ubiquitination and activation
-
Yang WL, Wang J, Chan CH, Lee SW, Campos AD, et al. (2009) The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 325: 1134-1138.
-
(2009)
Science
, vol.325
, pp. 1134-1138
-
-
Yang, W.L.1
Wang, J.2
Chan, C.H.3
Lee, S.W.4
Campos, A.D.5
-
15
-
-
71649104466
-
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt
-
Suizu F, Hiramuki Y, Okumura F, Matsuda M, Okumura AJ, et al. (2009) The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. Dev Cell 17: 800-810.
-
(2009)
Dev Cell
, vol.17
, pp. 800-810
-
-
Suizu, F.1
Hiramuki, Y.2
Okumura, F.3
Matsuda, M.4
Okumura, A.J.5
-
16
-
-
34247583996
-
Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins
-
Hart GW, Housley MP, Slawson C, (2007) Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins. Nature 446: 1017-1022.
-
(2007)
Nature
, vol.446
, pp. 1017-1022
-
-
Hart, G.W.1
Housley, M.P.2
Slawson, C.3
-
17
-
-
33644874204
-
The hexosamine signaling pathway: deciphering the "O-GlcNAc code"
-
Love DC, Hanover JA, (2005) The hexosamine signaling pathway: deciphering the "O-GlcNAc code". Sci. STKE 312, re13.
-
(2005)
Sci. STKE
, vol.312
-
-
Love, D.C.1
Hanover, J.A.2
-
18
-
-
77956422977
-
Aberrant O-GlcNAcylation characterizes chronic lymphocytic leukemia
-
Shi Y, Tomic J, Wen F, Shaha S, Bahlo A, et al. (2010) Aberrant O-GlcNAcylation characterizes chronic lymphocytic leukemia. Leukemia 24: 1588-1598.
-
(2010)
Leukemia
, vol.24
, pp. 1588-1598
-
-
Shi, Y.1
Tomic, J.2
Wen, F.3
Shaha, S.4
Bahlo, A.5
-
19
-
-
0037117511
-
Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes
-
Vosseller K, Wells L, Lane MD, Hart GW, (2002) Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A 99: 5313-5318.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 5313-5318
-
-
Vosseller, K.1
Wells, L.2
Lane, M.D.3
Hart, G.W.4
-
20
-
-
39749104251
-
Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance
-
Yang X, Ongusaha PP, Miles PD, Havstad JC, Zhang F, et al. (2008) Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. Nature 451: 964-969.
-
(2008)
Nature
, vol.451
, pp. 964-969
-
-
Yang, X.1
Ongusaha, P.P.2
Miles, P.D.3
Havstad, J.C.4
Zhang, F.5
-
21
-
-
58049197848
-
Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance
-
Macauley MS, Bubb AK, Martinez-Fleites C, Davies GJ, Vocadlo DJ, (2008) Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance. J Biol Chem 283: 34687-34695.
-
(2008)
J Biol Chem
, vol.283
, pp. 34687-34695
-
-
Macauley, M.S.1
Bubb, A.K.2
Martinez-Fleites, C.3
Davies, G.J.4
Vocadlo, D.J.5
-
22
-
-
77956963665
-
Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes
-
Macauley MS, He Y, Gloster TM, Stubbs KA, Davies GJ, et al. (2010) Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes. Chem Biol 17: 937-948.
-
(2010)
Chem Biol
, vol.17
, pp. 937-948
-
-
Macauley, M.S.1
He, Y.2
Gloster, T.M.3
Stubbs, K.A.4
Davies, G.J.5
-
23
-
-
56049101623
-
Regulation of Akt signaling by O-GlcNAc in euglycemia
-
Soesanto YA, Luo B, Jones D, Taylor R, Gabrielsen JS, et al. (2008) Regulation of Akt signaling by O-GlcNAc in euglycemia. Am J Physiol Endocrinol Metab 295: E974-80.
-
(2008)
Am J Physiol Endocrinol Metab
, vol.295
-
-
Soesanto, Y.A.1
Luo, B.2
Jones, D.3
Taylor, R.4
Gabrielsen, J.S.5
-
24
-
-
45149112314
-
O-GlcNAc modulation at Akt1 Ser473 correlates with apoptosis of murine pancreatic beta cells
-
Kang ES, Han D, Park J, Kwak TK, Oh MA, et al. (2008) O-GlcNAc modulation at Akt1 Ser473 correlates with apoptosis of murine pancreatic beta cells. Exp Cell Res 314: 2238-2248.
-
(2008)
Exp Cell Res
, vol.314
, pp. 2238-2248
-
-
Kang, E.S.1
Han, D.2
Park, J.3
Kwak, T.K.4
Oh, M.A.5
-
25
-
-
33646581015
-
Akt1 is dynamically modified with O-GlcNAc following treatments with PUGNAc and insulin-like growth factor-1
-
Gandy JC, Rountree AE, Bijur GN, (2006) Akt1 is dynamically modified with O-GlcNAc following treatments with PUGNAc and insulin-like growth factor-1. FEBS Lett 580: 3051-3058.
-
(2006)
FEBS Lett
, vol.580
, pp. 3051-3058
-
-
Gandy, J.C.1
Rountree, A.E.2
Bijur, G.N.3
-
26
-
-
34247194251
-
Glucosamine-induced increase in Akt phosphorylation corresponds to increased endoplasmic reticulum stress in astroglial cells
-
Matthews JA, Belof JL, Acevedo-Duncan M, Potter RL, (2007) Glucosamine-induced increase in Akt phosphorylation corresponds to increased endoplasmic reticulum stress in astroglial cells. Mol Cell Biochem 298: 109-123.
-
(2007)
Mol Cell Biochem
, vol.298
, pp. 109-123
-
-
Matthews, J.A.1
Belof, J.L.2
Acevedo-Duncan, M.3
Potter, R.L.4
-
27
-
-
25444501339
-
Perturbations in O-linked beta-N-acetylglucosamine protein modification cause severe defects in mitotic progression and cytokinesis
-
Slawson C, Zachara NE, Vosseller K, Cheung WD, Lane MD, et al. (2005) Perturbations in O-linked beta-N-acetylglucosamine protein modification cause severe defects in mitotic progression and cytokinesis. J Biol Chem 280: 32944-32956.
-
(2005)
J Biol Chem
, vol.280
, pp. 32944-32956
-
-
Slawson, C.1
Zachara, N.E.2
Vosseller, K.3
Cheung, W.D.4
Lane, M.D.5
-
28
-
-
52949123249
-
Cross-talk between GlcNAcylation and phosphorylation: site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc
-
Wang Z, Gucek M, Hart GW, (2008) Cross-talk between GlcNAcylation and phosphorylation: site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc. Proc Natl Acad Sci U S A 105: 13793-13798.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 13793-13798
-
-
Wang, Z.1
Gucek, M.2
Hart, G.W.3
-
29
-
-
77951651658
-
Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis
-
Wang Z, Udeshi, ND, Slawson C, Compton PD, Sakabe K, et al. (2010) Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis. Sci Signal 3(104), ra2.
-
(2010)
Sci Signal
, vol.3
, Issue.104
-
-
Wang, Z.1
Udeshi, N.D.2
Slawson, C.3
Compton, P.D.4
Sakabe, K.5
-
30
-
-
84861325047
-
Comprehensive Analytical Chemistry
-
Whitelegge JP (ed) Elsevier B
-
Chalkley RJ, Wells L, Vosseller K, (2009) Comprehensive Analytical Chemistry, Volume 52. O-GlcNAc Proteomics Mass Spectrometric Analysis of O-GlcNAc Modifications on Proteins, Whitelegge JP (ed) 353-374. Elsevier B.
-
(2009)
O-GlcNAc Proteomics, Mass Spectrometric Analysis of O-GlcNAc Modifications on Proteins
, vol.52
, pp. 353-374
-
-
Chalkley, R.J.1
Wells, L.2
Vosseller, K.3
-
31
-
-
77955861078
-
Post-translational modifications: A shift for the O-GlcNAc paradigm
-
Kohler JJ, (2010) Post-translational modifications: A shift for the O-GlcNAc paradigm. Nat Chem Bio. 6: 634-635.
-
(2010)
Nat Chem Bio
, vol.6
, pp. 634-635
-
-
Kohler, J.J.1
-
32
-
-
77955865876
-
Quantification of O-glycosylation stoichiometry and dynamics using resolvable mass tags
-
Rexach JE, Rogers CJ, Yu SH, Tao J, Sun YE, et al. (2010) Quantification of O-glycosylation stoichiometry and dynamics using resolvable mass tags. Nat Chem Biol 6: 645-651.
-
(2010)
Nat Chem Biol
, vol.6
, pp. 645-651
-
-
Rexach, J.E.1
Rogers, C.J.2
Yu, S.H.3
Tao, J.4
Sun, Y.E.5
-
33
-
-
33644698706
-
Identification of the major site of O-linked beta-N-acetylglucosamine modification in the C terminus of insulin receptor substrate-1
-
Ball LE, Berkaw MN, Buse MG, (2006) Identification of the major site of O-linked beta-N-acetylglucosamine modification in the C terminus of insulin receptor substrate-1. Mol Cell Proteomics 5: 313-323.
-
(2006)
Mol Cell Proteomics
, vol.5
, pp. 313-323
-
-
Ball, L.E.1
Berkaw, M.N.2
Buse, M.G.3
-
34
-
-
33750456519
-
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks
-
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, et al. (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 127: 635-648.
-
(2006)
Cell
, vol.127
, pp. 635-648
-
-
Olsen, J.V.1
Blagoev, B.2
Gnad, F.3
Macek, B.4
Kumar, C.5
-
35
-
-
49449085504
-
A quantitative atlas of mitotic phosphorylation
-
Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105: 10762-10767.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 10762-10767
-
-
Dephoure, N.1
Zhou, C.2
Villen, J.3
Beausoleil, S.A.4
Bakalarski, C.E.5
-
36
-
-
44149113025
-
Synthesis and structure based optimization of novel Akt inhibitors
-
Lippa B, Pan G, Corbett M, Li C, Kauffman GS, et al. (2008) Synthesis and structure based optimization of novel Akt inhibitors. Bioorg Med Chem Lett 18: 3359-3363.
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 3359-3363
-
-
Lippa, B.1
Pan, G.2
Corbett, M.3
Li, C.4
Kauffman, G.S.5
-
37
-
-
0037449805
-
Epidermal growth factor receptor-dependent and -independent cell-signaling pathways originating from the urokinase receptor
-
Jo M, Thomas KS, O'Donnell DM, Gonias SL, (2003) Epidermal growth factor receptor-dependent and-independent cell-signaling pathways originating from the urokinase receptor. J Biol Chem 278: 1642-1646.
-
(2003)
J Biol Chem
, vol.278
, pp. 1642-1646
-
-
Jo, M.1
Thomas, K.S.2
O'Donnell, D.M.3
Gonias, S.L.4
-
38
-
-
49349107518
-
Lysine acetylation: codified crosstalk with other posttranslational modifications
-
Yang XJ, Seto E, (2008) Lysine acetylation: codified crosstalk with other posttranslational modifications. Mol Cell 31: 449-461.
-
(2008)
Mol Cell
, vol.31
, pp. 449-461
-
-
Yang, X.J.1
Seto, E.2
-
39
-
-
36749010218
-
The age of crosstalk: phosphorylation, ubiquitination, and beyond
-
Hunter T, (2007) The age of crosstalk: phosphorylation, ubiquitination, and beyond. Mol Cell 28: 730-738.
-
(2007)
Mol Cell
, vol.28
, pp. 730-738
-
-
Hunter, T.1
-
40
-
-
78751629039
-
Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein
-
Carr SM, Munro S, Kessler B, Oppermann U, La Thangue NB, (2011) Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein. EMBO J 30: 317-327.
-
(2011)
EMBO J
, vol.30
, pp. 317-327
-
-
Carr, S.M.1
Munro, S.2
Kessler, B.3
Oppermann, U.4
La Thangue, N.B.5
-
41
-
-
33749160125
-
Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability
-
Yang WH, Kim JE, Nam HW, Ju JW, Kim HS, et al. (2006) Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability. Nat Cell Biol 8: 1074-1083.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 1074-1083
-
-
Yang, W.H.1
Kim, J.E.2
Nam, H.W.3
Ju, J.W.4
Kim, H.S.5
-
42
-
-
78449288408
-
Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition
-
Park SY, Kim HS, Kim NH, Ji S, Cha SY, et al. (2010) Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition. EMBO J 29: 3787-3796.
-
(2010)
EMBO J
, vol.29
, pp. 3787-3796
-
-
Park, S.Y.1
Kim, H.S.2
Kim, N.H.3
Ji, S.4
Cha, S.Y.5
-
43
-
-
0036462599
-
The emerging significance of O-GlcNAc in cellular regulation
-
Zachara NE, Hart GW, (2002) The emerging significance of O-GlcNAc in cellular regulation. Chem Rev 102: 431-438.
-
(2002)
Chem Rev
, vol.102
, pp. 431-438
-
-
Zachara, N.E.1
Hart, G.W.2
-
44
-
-
72449170135
-
O-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple SH2 domain binding motifs
-
Klein A, Berkaw MN, Buse MG, Ball LE, (2009) O-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple SH2 domain binding motifs. Mol Cell Proteomics 8: 2733-2745.
-
(2009)
Mol Cell Proteomics
, vol.8
, pp. 2733-2745
-
-
Klein, A.1
Berkaw, M.N.2
Buse, M.G.3
Ball, L.E.4
-
45
-
-
0020445435
-
A one-step purification of membrane proteins using a high efficiency immunomatrix
-
Schneider C, Newman RA, Sutherland DR, Asser U, Greaves MF, (1982) A one-step purification of membrane proteins using a high efficiency immunomatrix. J Biol Chem 257: 10766-10769.
-
(1982)
J Biol Chem
, vol.257
, pp. 10766-10769
-
-
Schneider, C.1
Newman, R.A.2
Sutherland, D.R.3
Asser, U.4
Greaves, M.F.5
-
46
-
-
0028575316
-
Error-tolerant identification of peptides in sequence databases by peptide sequence tags
-
Mann M, Wilm M, (1994) Error-tolerant identification of peptides in sequence databases by peptide sequence tags. Anal Chem 66: 4390-4399.
-
(1994)
Anal Chem
, vol.66
, pp. 4390-4399
-
-
Mann, M.1
Wilm, M.2
-
47
-
-
0035222477
-
Subcellular fractionation of adipocytes and 3T3-L1 cells
-
Joost HG, Schürmann A, (2001) Subcellular fractionation of adipocytes and 3T3-L1 cells. Methods Mol Biol 155: 77-82.
-
(2001)
Methods Mol Biol
, vol.155
, pp. 77-82
-
-
Joost, H.G.1
Schürmann, A.2
|