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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 16, 2014, Pages 3673-3682

The use of spirocyclic scaffolds in drug discovery

(3) Zheng, Yajun a Tice, Colin M a Singh, Suresh B a

a Vitae Pharmaceuticals Inc (United States)

Author keywords

Drug discovery; Scaffold; Spirocyclic

Indexed keywords

HETEROCYCLIC COMPOUND; SPIRO COMPOUND;

ARTICLE; BINDING AFFINITY; DRUG CONFORMATION; DRUG PROTEIN BINDING; DRUG SYNTHESIS; HUMAN; LIGAND BINDING; NONHUMAN; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; MEDICINAL CHEMISTRY; SYNTHESIS;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; DRUG DISCOVERY; HETEROCYCLIC COMPOUNDS; HUMANS; MOLECULAR STRUCTURE; SPIRO COMPOUNDS;

EID: 84905924558 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.06.081 Document Type: Review

Times cited : (803)

References (101)

1
- 0004169648
- Elsevier Academic Press San Diego
- C.G. Wermuth The Practice of Medicinal Chemistry 2003 Elsevier Academic Press San Diego
- (2003) The Practice of Medicinal Chemistry
- Wermuth, C.G.¹

2
- 33845185080
- F. Perron, and K.F. Albizati Chem. Rev. 89 1989 1617
- (1989) Chem. Rev. , vol.89 , pp. 1617
- Perron, F.¹ Albizati, K.F.²

3
- 78651287426
- C. Knox, V. Law, T. Jewison, P. Liu, S. Ly, A. Frolkis, A. Pon, K. Banco, C. Mak, V. Neveu, Y. Djoumbou, R. Eisner, A.C. Guo, and D.S. Wishart Nucleic Acids Res. 39 2011 D1035 http://www.drugbank.ca.
- (2011) Nucleic Acids Res. , vol.39 , pp. 1035
- Knox, C.¹ Law, V.² Jewison, T.³ Liu, P.⁴ Ly, S.⁵ Frolkis, A.⁶ Pon, A.⁷ Banco, K.⁸ Mak, C.⁹ Neveu, V.¹⁰ Djoumbou, Y.¹¹ Eisner, R.¹² Guo, A.C.¹³ Wishart, D.S.¹⁴

4
- 84898999830
- M. Aldeghi, S. Malhotra, D.L. Selwood, and A.W.E. Chan Chem. Biol. Drug Des. 83 2014 450
- (2014) Chem. Biol. Drug Des. , vol.83 , pp. 450
- Aldeghi, M.¹ Malhotra, S.² Selwood, D.L.³ Chan, A.W.E.⁴

5
- 70350409235
- T.J. Richie, S.J. Macdonald, R.J. Young, and S.D. Pickett Drug Discovery Today 14 2009 1011
- (2009) Drug Discovery Today , vol.14 , pp. 1011
- Richie, T.J.¹ Macdonald, S.J.² Young, R.J.³ Pickett, S.D.⁴

6
- 71049126548
- F. Lovering, J. Bikker, and C. Humblet J. Med. Chem. 52 2009 6752
- (2009) J. Med. Chem. , vol.52 , pp. 6752
- Lovering, F.¹ Bikker, J.² Humblet, C.³

7
- 84874464077
- F. Lovering Med. Chem. Commun. 4 2013 515
- (2013) Med. Chem. Commun. , vol.4 , pp. 515
- Lovering, F.¹

8
- 80054970242
- C.M. Marson Chem. Soc. Rev. 40 2011 5514
- (2011) Chem. Soc. Rev. , vol.40 , pp. 5514
- Marson, C.M.¹

9
- 84892747265
- J.L. Jat, M.P. Paudyal, H. Gao, Q.-L. Xu, M. Yousufuddin, D. Devarajan, D.H. Ess, L. Kurti, and J.R. Falck Science 343 2014 61
- (2014) Science , vol.343 , pp. 61
- Jat, J.L.¹ Paudyal, M.P.² Gao, H.³ Xu, Q.-L.⁴ Yousufuddin, M.⁵ Devarajan, D.⁶ Ess, D.H.⁷ Kurti, L.⁸ Falck, J.R.⁹

10
- 84879092042
- Y. Wang, J. Liu, P.J. Dransfield, L. Zhu, Z. Wang, X. Du, X. Jiao, Y. Su, A.-R. Li, S.P. Brown, A. Kasparian, M. Vimolratana, M. Yu, V. Pattaropong, J.B. Houze, G. Swaminath, T. Tran, K. Nguyen, Q. Guo, J. Zhang, R. Zhuang, F. Li, L. Miao, M.D. Bartberger, T.L. Correll, D. Chow, S. Wong, J. Luo, D.C.-H. Lin, and J.C. Medina ACS Med. Chem. Lett. 4 2013 551
- (2013) ACS Med. Chem. Lett. , vol.4 , pp. 551
- Wang, Y.¹ Liu, J.² Dransfield, P.J.³ Zhu, L.⁴ Wang, Z.⁵ Du, X.⁶ Jiao, X.⁷ Su, Y.⁸ Li, A.-R.⁹ Brown, S.P.¹⁰ Kasparian, A.¹¹ Vimolratana, M.¹² Yu, M.¹³ Pattaropong, V.¹⁴ Houze, J.B.¹⁵ Swaminath, G.¹⁶ Tran, T.¹⁷ Nguyen, K.¹⁸ Guo, Q.¹⁹ Zhang, J.²⁰ more..

11
- 84891829171
- H. Tanaka, S. Yoshida, H. Minoura, K. Negoro, A. Shimaya, T. Shimokawa, and M. Shibasaki Life Sci. 94 2014 115
- (2014) Life Sci. , vol.94 , pp. 115
- Tanaka, H.¹ Yoshida, S.² Minoura, H.³ Negoro, K.⁴ Shimaya, A.⁵ Shimokawa, T.⁶ Shibasaki, M.⁷

12
- 84891323481
- C. Lagisetti, G. Palacios, T. Goronga, B. Freeman, W. Caufield, and T.R. Webb J. Med. Chem. 56 2013 10033
- (2013) J. Med. Chem. , vol.56 , pp. 10033
- Lagisetti, C.¹ Palacios, G.² Goronga, T.³ Freeman, B.⁴ Caufield, W.⁵ Webb, T.R.⁶

13
- 84896295869
- J.O. Link, J.G. Taylor, L. Xu, M. Mitchell, H. Guo, H. Liu, D. Kato, T. Kirschberg, J. Sun, N. Squires, J. Parrish, T. Keller, Z.-Y. Yang, C. Yang, M. Matles, Y. Wang, K. Wang, G. Cheng, Y. Tian, E. Mogalian, E. Mondou, M. Cornpropst, J. Perry, and M.C. Desai J. Med. Chem. 57 2014 2033
- (2014) J. Med. Chem. , vol.57 , pp. 2033
- Link, J.O.¹ Taylor, J.G.² Xu, L.³ Mitchell, M.⁴ Guo, H.⁵ Liu, H.⁶ Kato, D.⁷ Kirschberg, T.⁸ Sun, J.⁹ Squires, N.¹⁰ Parrish, J.¹¹ Keller, T.¹² Yang, Z.-Y.¹³ Yang, C.¹⁴ Matles, M.¹⁵ Wang, Y.¹⁶ Wang, K.¹⁷ Cheng, G.¹⁸ Tian, Y.¹⁹ Mogalian, E.²⁰ more..

14
- 84894065452
- D.G. Brown, P.R. Bernstein, A. Griffin, S. Wesolowski, D. Labrecque, M.C. Tremblay, M. Sylvester, R. Mauger, P.D. Edwards, S.R. Throner, J.J. Folmer, J. Cacciola, C. Scott, L.A. Lazor, M. Pourashraf, V. Santhakumar, W.M. Potts, S. Sydserff, P. Giguère, C. Lévesque, M. Dasser, and T. Groblewski J. Med. Chem. 57 2014 733
- (2014) J. Med. Chem. , vol.57 , pp. 733
- Brown, D.G.¹ Bernstein, P.R.² Griffin, A.³ Wesolowski, S.⁴ Labrecque, D.⁵ Tremblay, M.C.⁶ Sylvester, M.⁷ Mauger, R.⁸ Edwards, P.D.⁹ Throner, S.R.¹⁰ Folmer, J.J.¹¹ Cacciola, J.¹² Scott, C.¹³ Lazor, L.A.¹⁴ Pourashraf, M.¹⁵ Santhakumar, V.¹⁶ Potts, W.M.¹⁷ Sydserff, S.¹⁸ Giguère, P.¹⁹ Lévesque, C.²⁰ Dasser, M.²¹ Groblewski, T.²² more..

15
- 79958760220
- S. Gadthula, R.K. Rawal, A. Sharon, D. Wu, B. Korba, and C.K. Chu Bioorg. Med. Chem. Lett. 21 2011 3982
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 3982
- Gadthula, S.¹ Rawal, R.K.² Sharon, A.³ Wu, D.⁴ Korba, B.⁵ Chu, C.K.⁶

16
- 84896270981
- J. Du, B.-K. Chun, R.T. Mosley, S. Bansal, H. Bao, C. Espiritu, A.M. Lam, E. Murakami, C. Niu, H.M. Micolochick Steuer, P.A. Furman, and M.J. Sofia J. Med. Chem. 57 2014 1826
- (2014) J. Med. Chem. , vol.57 , pp. 1826
- Du, J.¹ Chun, B.-K.² Mosley, R.T.³ Bansal, S.⁴ Bao, H.⁵ Espiritu, C.⁶ Lam, A.M.⁷ Murakami, E.⁸ Niu, C.⁹ Micolochick Steuer, H.M.¹⁰ Furman, P.A.¹¹ Sofia, M.J.¹²

17
- 84896304978
- T.H.M. Jonckers, K. Vandyck, L. Vandekerckhove, L. Hu, A. Tahri, S. Van Hoof, T.-I. Lin, L. Vijgen, J.M. Berke, S. Lachau-Durand, B. Stoops, L. Leclercq, G. Fanning, B. Samuelsson, M. Nilsson, Å. Rosenquist, K. Simmen, and P. Raboisson J. Med. Chem. 57 2014 1836
- (2014) J. Med. Chem. , vol.57 , pp. 1836
- Jonckers, T.H.M.¹ Vandyck, K.² Vandekerckhove, L.³ Hu, L.⁴ Tahri, A.⁵ Van Hoof, S.⁶ Lin, T.-I.⁷ Vijgen, L.⁸ Berke, J.M.⁹ Lachau-Durand, S.¹⁰ Stoops, B.¹¹ Leclercq, L.¹² Fanning, G.¹³ Samuelsson, B.¹⁴ Nilsson, M.¹⁵ Rosenquist, Å.¹⁶ Simmen, K.¹⁷ Raboisson, P.¹⁸

18
- 78649510531
- T.H.M. Jonckers, T.-I. Lin, C. Buyck, S. Lachau-Durand, K. Vandyck, S. Van Hoof, L.A.M. Vandekerckhove, L. Hu, J.M. Berke, L. Vijgen, L.L.A. Dillen, M.D. Cummings, H. de Kock, M. Nilsson, C. Sund, C. Rydegård, B. Samuelsson, Å. Rosenquist, G. Fanning, K. Van Emelen, K. Simmen, and P. Raboisson J. Med. Chem. 53 2010 8150
- (2010) J. Med. Chem. , vol.53 , pp. 8150
- Jonckers, T.H.M.¹ Lin, T.-I.² Buyck, C.³ Lachau-Durand, S.⁴ Vandyck, K.⁵ Van Hoof, S.⁶ Vandekerckhove, L.A.M.⁷ Hu, L.⁸ Berke, J.M.⁹ Vijgen, L.¹⁰ Dillen, L.L.A.¹¹ Cummings, M.D.¹² De Kock, H.¹³ Nilsson, M.¹⁴ Sund, C.¹⁵ Rydegård, C.¹⁶ Samuelsson, B.¹⁷ Rosenquist, Å.¹⁸ Fanning, G.¹⁹ Van Emelen, K.²⁰ Simmen, K.²¹ Raboisson, P.²² more..

19
- 78649550137
- J.A. Burkhard, G. Wuitschik, M. Rogers-Evans, K. Müller, and E.M. Carreira Angew. Chem., Int. Ed. 49 2010 9052
- (2010) Angew. Chem., Int. Ed. , vol.49 , pp. 9052
- Burkhard, J.A.¹ Wuitschik, G.² Rogers-Evans, M.³ Müller, K.⁴ Carreira, E.M.⁵

20
- 84886950721
- L. Bondada, R. Rondla, U. Pradere, P. Liu, C. Li, D. Bobeck, T. McBrayer, P. Tharnish, J. Courcambeck, P. Halfon, T. Whitaker, F. Amblard, S.J. Coats, and R.F. Schinazi Bioorg. Med. Chem. Lett. 23 2013 6325
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 6325
- Bondada, L.¹ Rondla, R.² Pradere, U.³ Liu, P.⁴ Li, C.⁵ Bobeck, D.⁶ McBrayer, T.⁷ Tharnish, P.⁸ Courcambeck, J.⁹ Halfon, P.¹⁰ Whitaker, T.¹¹ Amblard, F.¹² Coats, S.J.¹³ Schinazi, R.F.¹⁴

21
- 84888871269
- H. Xiong, M. Foulk, L. Aschenbrenner, J. Fan, C.L. Tiong-Yip, K.D. Johnson, D. Moustakas, P.R. Fleming, D.G. Brown, M. Zhang, D. Ferguson, D. Wu, and Q. Yu Bioorg. Med. Chem. Lett. 23 2013 6789
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 6789
- Xiong, H.¹ Foulk, M.² Aschenbrenner, L.³ Fan, J.⁴ Tiong-Yip, C.L.⁵ Johnson, K.D.⁶ Moustakas, D.⁷ Fleming, P.R.⁸ Brown, D.G.⁹ Zhang, M.¹⁰ Ferguson, D.¹¹ Wu, D.¹² Yu, Q.¹³

22
- 84862232471
- D.W. Kung, S.B. Coffey, R.M. Jones, S. Cabral, W. Jiao, M. Fichtner, P.A. Carpino, C.R. Rose, R.F. Hank, M.G. Lopaze, R. Swartz, H.T. Chen, Z. Hendsch, B. Posner, C.F. Wielis, B. Manning, J. Dubins, I.A. Stock, S. Varma, M. Campbell, D. DeBartola, R. Kosa-Maines, S.J. Steyn, and K.F. McClure Bioorg. Med. Chem. Lett. 22 2012 4281
- (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 4281
- Kung, D.W.¹ Coffey, S.B.² Jones, R.M.³ Cabral, S.⁴ Jiao, W.⁵ Fichtner, M.⁶ Carpino, P.A.⁷ Rose, C.R.⁸ Hank, R.F.⁹ Lopaze, M.G.¹⁰ Swartz, R.¹¹ Chen, H.T.¹² Hendsch, Z.¹³ Posner, B.¹⁴ Wielis, C.F.¹⁵ Manning, B.¹⁶ Dubins, J.¹⁷ Stock, I.A.¹⁸ Varma, S.¹⁹ Campbell, M.²⁰ more..

23
- 84883488003
- K.F. McClure, M. Jackson, K.O. Cameron, D.W. Kung, D.A. Perry, S.T. Orr, Y. Zhang, J. Kohrt, M. Tu, H. Gao, D. Fernando, R. Jones, N. Erasga, G. Wang, J. Polivkova, W. Jiao, R. Swartz, H. Ueno, S.K. Bhattacharya, I.A. Stock, S. Varma, V. Bagdasarian, S. Perez, D. Kelly-Sullivan, R. Wang, J. Kong, P. Cornelius, L. Michael, E. Lee, A. Janssen, S.J. Steyn, K. Lapham, and T. Goosen Bioorg. Med. Chem. Lett. 23 2013 5410
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 5410
- McClure, K.F.¹ Jackson, M.² Cameron, K.O.³ Kung, D.W.⁴ Perry, D.A.⁵ Orr, S.T.⁶ Zhang, Y.⁷ Kohrt, J.⁸ Tu, M.⁹ Gao, H.¹⁰ Fernando, D.¹¹ Jones, R.¹² Erasga, N.¹³ Wang, G.¹⁴ Polivkova, J.¹⁵ Jiao, W.¹⁶ Swartz, R.¹⁷ Ueno, H.¹⁸ Bhattacharya, S.K.¹⁹ Stock, I.A.²⁰ more..

24
- 84900394010
- S.K. Bhattacharya, K. Andrews, R. Beveridge, K.O. Cameron, C. Chen, M. Dunn, D. Fernando, H. Gao, D.V. Hepworth, M. Jackson, V. Khot, J. Kong, R.E. Kosa, K. Lapham, P.M. Loria, A.T. Londregan, K.F. McClure, S.T.M. Orr, J. Patel, C. Rose, J. Saenz, I.A. Stock, G. Storer, M. VanVolkenburg, D. Vrieze, G. Wang, J. Xiao, and Y. Zhang ACS Med. Chem. Lett. 5 2014 474
- (2014) ACS Med. Chem. Lett. , vol.5 , pp. 474
- Bhattacharya, S.K.¹ Andrews, K.² Beveridge, R.³ Cameron, K.O.⁴ Chen, C.⁵ Dunn, M.⁶ Fernando, D.⁷ Gao, H.⁸ Hepworth, D.V.⁹ Jackson, M.¹⁰ Khot, V.¹¹ Kong, J.¹² Kosa, R.E.¹³ Lapham, K.¹⁴ Loria, P.M.¹⁵ Londregan, A.T.¹⁶ McClure, K.F.¹⁷ Orr, S.T.M.¹⁸ Patel, J.¹⁹ Rose, C.²⁰ more..

25
- 84893685653
- J.M. Keith, W.M. Jones, J.M. Pierce, M. Seierstad, J.A. Palmer, M. Webb, M.J. Karbarz, B.P. Scott, S.J. Wilson, M.L. Wennerholm, L. Change, S.M. Brown, M. Rizzolio, R. Rynberg, S.R. Chaplan, and J.G. Britenbucher Bioorg. Med. Chem. Lett. 24 2014 737
- (2014) Bioorg. Med. Chem. Lett. , vol.24 , pp. 737
- Keith, J.M.¹ Jones, W.M.² Pierce, J.M.³ Seierstad, M.⁴ Palmer, J.A.⁵ Webb, M.⁶ Karbarz, M.J.⁷ Scott, B.P.⁸ Wilson, S.J.⁹ Wennerholm, M.L.¹⁰ Change, L.¹¹ Brown, S.M.¹² Rizzolio, M.¹³ Rynberg, R.¹⁴ Chaplan, S.R.¹⁵ Britenbucher, J.G.¹⁶

26
- 84894065529
- R.F. Sweis, M. Pliushchev, P.J. Brown, J. Guo, F. Li, D. Maag, A.M. Petros, N.B. Soni, C. Tse, M. Vedadi, M.R. Michaelides, G.G. Chiang, and W.N. Pappano ACS Med. Chem. Lett. 5 2014 205
- (2014) ACS Med. Chem. Lett. , vol.5 , pp. 205
- Sweis, R.F.¹ Pliushchev, M.² Brown, P.J.³ Guo, J.⁴ Li, F.⁵ Maag, D.⁶ Petros, A.M.⁷ Soni, N.B.⁸ Tse, C.⁹ Vedadi, M.¹⁰ Michaelides, M.R.¹¹ Chiang, G.G.¹² Pappano, W.N.¹³

27
- 84879067500
- J. Yuan, S. Venkatraman, Y. Zheng, B.M. McKeever, L.W. Dillard, and S.B. Singh J. Med. Chem. 56 2013 4156
- (2013) J. Med. Chem. , vol.56 , pp. 4156
- Yuan, J.¹ Venkatraman, S.² Zheng, Y.³ McKeever, B.M.⁴ Dillard, L.W.⁵ Singh, S.B.⁶

28
- 84867590210
- T.A. Dineen, M.M. Weiss, T. Williamson, P. Acton, S. Babu-Khan, M.D. Bartberger, J. Brown, K. Chen, Y. Cheng, M. Citron, M.D. Croghan, R.T. Dunn, J. Esmay, R.F. Graceffa, S.S. Harried, D. Hickman, S.A. Hitchcock, D.B. Horne, H. Huang, R. Imbeah-Ampiah, T. Judd, M.R. Kaller, C.R. Kreiman, D.S. La, V. Li, P. Lopez, S. Louie, H. Monenschein, T.T. Nguyen, L.D. Pennington, T. San Miguel, E.A. Sickmier, H.M. Vargas, R.C. Wahl, P.H. Wen, D.A. Whittington, S. Wood, Q. Xue, B.H. Yang, V.F. Patel, and W. Zhong J. Med. Chem. 55 2012 9025
- (2012) J. Med. Chem. , vol.55 , pp. 9025
- Dineen, T.A.¹ Weiss, M.M.² Williamson, T.³ Acton, P.⁴ Babu-Khan, S.⁵ Bartberger, M.D.⁶ Brown, J.⁷ Chen, K.⁸ Cheng, Y.⁹ Citron, M.¹⁰ Croghan, M.D.¹¹ Dunn, R.T.¹² Esmay, J.¹³ Graceffa, R.F.¹⁴ Harried, S.S.¹⁵ Hickman, D.¹⁶ Hitchcock, S.A.¹⁷ Horne, D.B.¹⁸ Huang, H.¹⁹ Imbeah-Ampiah, R.²⁰ more..

29
- 84867516398
- M.M. Weiss, T. Williamson, S. Babu-Khan, M.D. Bartberger, J. Brown, K. Chen, Y. Cheng, M. Citron, M.D. Croghan, T.A. Dineen, J. Esmay, R.F. Graceffa, S.S. Harried, D. Hickman, S.A. Hitchcock, D.B. Horne, H. Huang, R. Imbeah-Ampiah, T. Judd, M.R. Kaller, C.R. Kreiman, D.S. La, V. Li, P. Lopez, S. Louie, H. Monenschein, T.T. Nguyen, L.D. Pennington, C. Rattan, T. San Miguel, E.A. Sickmier, R.C. Wahl, P.H. Wen, S. Wood, Q. Xue, B.H. Yang, V.F. Patel, and W. Zhong J. Med. Chem. 55 2012 9009
- (2012) J. Med. Chem. , vol.55 , pp. 9009
- Weiss, M.M.¹ Williamson, T.² Babu-Khan, S.³ Bartberger, M.D.⁴ Brown, J.⁵ Chen, K.⁶ Cheng, Y.⁷ Citron, M.⁸ Croghan, M.D.⁹ Dineen, T.A.¹⁰ Esmay, J.¹¹ Graceffa, R.F.¹² Harried, S.S.¹³ Hickman, D.¹⁴ Hitchcock, S.A.¹⁵ Horne, D.B.¹⁶ Huang, H.¹⁷ Imbeah-Ampiah, R.¹⁸ Judd, T.¹⁹ Kaller, M.R.²⁰ more..

30
- 84868526878
- I.V. Efremov, F.F. Vajdos, K.A. Borzilleri, S. Capetta, H. Chen, P.H. Dorff, J.K. Dutra, S.W. Goldstein, M. Mansour, A. McColl, S. Noell, C.E. Oborski, T.N. O'Connell, T.J. O'Sullivan, J. Pandit, H. Wang, B. Wei, and J.M. Withka J. Med. Chem. 55 2012 9069
- (2012) J. Med. Chem. , vol.55 , pp. 9069
- Efremov, I.V.¹ Vajdos, F.F.² Borzilleri, K.A.³ Capetta, S.⁴ Chen, H.⁵ Dorff, P.H.⁶ Dutra, J.K.⁷ Goldstein, S.W.⁸ Mansour, M.⁹ McColl, A.¹⁰ Noell, S.¹¹ Oborski, C.E.¹² O'Connell, T.N.¹³ O'Sullivan, T.J.¹⁴ Pandit, J.¹⁵ Wang, H.¹⁶ Wei, B.¹⁷ Withka, J.M.¹⁸

31
- 84887865883
- S. Lee, J.-H. Song, C.M. Park, J.-S. Kim, J.-H. Jeong, W.-Y. Cho, and D.-C. Lim ACS Med. Chem. Lett. 4 2013 1054
- (2013) ACS Med. Chem. Lett. , vol.4 , pp. 1054
- Lee, S.¹ Song, J.-H.² Park, C.M.³ Kim, J.-S.⁴ Jeong, J.-H.⁵ Cho, W.-Y.⁶ Lim, D.-C.⁷

32
- 84892550956
- G. Hostetler, D. Dunn, B.A. McKenna, K. Kopec, and S. Chatterjee Chem. Biol. Drug Des. 83 2014 149
- (2014) Chem. Biol. Drug Des. , vol.83 , pp. 149
- Hostetler, G.¹ Dunn, D.² McKenna, B.A.³ Kopec, K.⁴ Chatterjee, S.⁵

33
- 84876147318
- J.-C. Carry, and C. Garcia-Echeverria Bioorg. Med. Chem. Lett. 23 2013 2480
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 2480
- Carry, J.-C.¹ Garcia-Echeverria, C.²

34
- 84880169797
- Y. Zhao, S. Yu, W. Sun, L. Liu, J. Lu, D. McEachern, S. Shargary, D. Bernard, X. Li, T. Zhao, P. Zou, D. Sun, and S. Wang J. Med. Chem. 56 2013 5553
- (2013) J. Med. Chem. , vol.56 , pp. 5553
- Zhao, Y.¹ Yu, S.² Sun, W.³ Liu, L.⁴ Lu, J.⁵ McEachern, D.⁶ Shargary, S.⁷ Bernard, D.⁸ Li, X.⁹ Zhao, T.¹⁰ Zou, P.¹¹ Sun, D.¹² Wang, S.¹³

35
- 84880165688
- A. Bertamino, M. Soprano, S. Musella, M.R. Rusciano, M. Sala, E. Vernieri, V.D. Sarno, A. Limatola, A. Carotenuto, S. Cosconati, P. Grieco, E. Novellino, M. Illario, P. Campiglia, and I. Gomez-Monterrey J. Med. Chem. 56 2013 5407
- (2013) J. Med. Chem. , vol.56 , pp. 5407
- Bertamino, A.¹ Soprano, M.² Musella, S.³ Rusciano, M.R.⁴ Sala, M.⁵ Vernieri, E.⁶ Sarno, V.D.⁷ Limatola, A.⁸ Carotenuto, A.⁹ Cosconati, S.¹⁰ Grieco, P.¹¹ Novellino, E.¹² Illario, M.¹³ Campiglia, P.¹⁴ Gomez-Monterrey, I.¹⁵

36
- 84891490447
- C.J. Ribeiro, J.D. Amaral, C.M. Rodrigues, R. Moreira, and M.M. Santos Bioorg. Med. Chem. 22 2014 577
- (2014) Bioorg. Med. Chem. , vol.22 , pp. 577
- Ribeiro, C.J.¹ Amaral, J.D.² Rodrigues, C.M.³ Moreira, R.⁴ Santos, M.M.⁵

37
- 84894062274
- Z. Zhang, X.-J. Chu, J.-J. Liu, Q. Ding, J. Zhang, D. Bartkovitz, N. Jiang, P. Karnachi, S.-S. So, C. Tovar, Z.M. Filipovic, B. Higgins, K. Glenn, K. Packman, L. Vassilev, and B. Graves ACS Med. Chem. Lett. 5 2014 124
- (2014) ACS Med. Chem. Lett. , vol.5 , pp. 124
- Zhang, Z.¹ Chu, X.-J.² Liu, J.-J.³ Ding, Q.⁴ Zhang, J.⁵ Bartkovitz, D.⁶ Jiang, N.⁷ Karnachi, P.⁸ So, S.-S.⁹ Tovar, C.¹⁰ Filipovic, Z.M.¹¹ Higgins, B.¹² Glenn, K.¹³ Packman, K.¹⁴ Vassilev, L.¹⁵ Graves, B.¹⁶

38
- 77952041008
- S.H. Watterson, Z. Xiao, D.S. Dodd, D.R. Tortolani, W. Vaccaro, D. Potin, M. Launay, D.K. Stetsko, S. Skala, P.M. Davis, D. Lee, X. Yang, K.W. McIntyre, P. Balimane, K. Patel, Z. Yang, P. Marathe, P. Kadiyala, A.J. Tebben, S. Sheriff, C.Y. Chang, T. Ziemba, H. Zhang, B.C. Chen, A.J. DelMonte, N. Aranibar, M. McKinnon, J.C. Barrish, S.J. Suchard, and T.G. Murali Dhar J. Med. Chem. 53 2010 3814
- (2010) J. Med. Chem. , vol.53 , pp. 3814
- Watterson, S.H.¹ Xiao, Z.² Dodd, D.S.³ Tortolani, D.R.⁴ Vaccaro, W.⁵ Potin, D.⁶ Launay, M.⁷ Stetsko, D.K.⁸ Skala, S.⁹ Davis, P.M.¹⁰ Lee, D.¹¹ Yang, X.¹² McIntyre, K.W.¹³ Balimane, P.¹⁴ Patel, K.¹⁵ Yang, Z.¹⁶ Marathe, P.¹⁷ Kadiyala, P.¹⁸ Tebben, A.J.¹⁹ Sheriff, S.²⁰ more..

39
- 84155170863
- Y.P. Goldberg, N. Price, R. Namdari, C.J. Cohen, M.H. Lamers, C. Winters, J. Price, C.E. Young, H. Verschoof, R. Sherrington, S.N. Pimstone, and M.R. Hayden Pain 153 2012 80
- (2012) Pain , vol.153 , pp. 80
- Goldberg, Y.P.¹ Price, N.² Namdari, R.³ Cohen, C.J.⁴ Lamers, M.H.⁵ Winters, C.⁶ Price, J.⁷ Young, C.E.⁸ Verschoof, H.⁹ Sherrington, R.¹⁰ Pimstone, S.N.¹¹ Hayden, M.R.¹²

40
- 84873907894
- S.K. Bagal, A.D. Vrown, P.J. Cox, K. Omoto, R.M. Owen, D.C. Pryde, B. Sidders, S.E. Skeratt, E.B. Stevens, R.I. Storer, and N.A. Swain J. Med. Chem. 56 2013 593
- (2013) J. Med. Chem. , vol.56 , pp. 593
- Bagal, S.K.¹ Vrown, A.D.² Cox, P.J.³ Omoto, K.⁴ Owen, R.M.⁵ Pryde, D.C.⁶ Sidders, B.⁷ Skeratt, S.E.⁸ Stevens, E.B.⁹ Storer, R.I.¹⁰ Swain, N.A.¹¹

41
- 84655164835
- N.A. Powell, J.T. Kohrt, K.J. Filipski, M. Kaufman, D. Sheehan, J.E. Edmunds, A. Delaney, Y. Wang, F. Bourbonais, D.Y. Lee, F. Schwende, F. Sun, P. McConnell, C. Catana, H. Chen, J. Ohren, and L.A. Perrin Bioorg. Med. Chem. Lett. 22 2012 190
- (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 190
- Powell, N.A.¹ Kohrt, J.T.² Filipski, K.J.³ Kaufman, M.⁴ Sheehan, D.⁵ Edmunds, J.E.⁶ Delaney, A.⁷ Wang, Y.⁸ Bourbonais, F.⁹ Lee, D.Y.¹⁰ Schwende, F.¹¹ Sun, F.¹² McConnell, P.¹³ Catana, C.¹⁴ Chen, H.¹⁵ Ohren, J.¹⁶ Perrin, L.A.¹⁷

42
- 84874651029
- M.S. Poslusney, B.J. Melancon, P.R. Gentry, D.J. Sheffler, T.M. Bridges, T.J. Utley, J.S. Daniels, C.M. Niswender, P.J. Conn, C.W. Lindsley, and M.R. Wood Bioorg. Med. Chem. Lett. 23 2013 1860
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 1860
- Poslusney, M.S.¹ Melancon, B.J.² Gentry, P.R.³ Sheffler, D.J.⁴ Bridges, T.M.⁵ Utley, T.J.⁶ Daniels, J.S.⁷ Niswender, C.M.⁸ Conn, P.J.⁹ Lindsley, C.W.¹⁰ Wood, M.R.¹¹

43
- 84891485774
- J.J. Kim, M.R. Wood, S.J. Stachel, P. de Leon, A. Nomland, C.A. Stump, M.A. McWherter, K.M. Schirripa, E.L. Moore, C.A. Salvatore, and H.G. Selnick Bioorg. Med. Chem. Lett. 24 2014 258
- (2014) Bioorg. Med. Chem. Lett. , vol.24 , pp. 258
- Kim, J.J.¹ Wood, M.R.² Stachel, S.J.³ De Leon, P.⁴ Nomland, A.⁵ Stump, C.A.⁶ McWherter, M.A.⁷ Schirripa, K.M.⁸ Moore, E.L.⁹ Salvatore, C.A.¹⁰ Selnick, H.G.¹¹

44
- 80051926925
- P. Eastwood, J. González, E. Gómez, F. Caturla, C. Balagué, A. Orellana, and M. Domínguez Bioorg. Med. Chem. Lett. 21 2011 5270
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 5270
- Eastwood, P.¹ González, J.² Gómez, E.³ Caturla, F.⁴ Balagué, C.⁵ Orellana, A.⁶ Domínguez, M.⁷

45
- 84896279723
- W.M. Kazmierski, A. Maynard, M. Duan, S. Baskaran, J. Botyanzki, R. Crosby, S. Dickerson, M. Tallant, R. Grimes, R. Hamatake, M. Leivers, C.D. Roberts, and J. Walker J. Med. Chem. 57 2014 2058
- (2014) J. Med. Chem. , vol.57 , pp. 2058
- Kazmierski, W.M.¹ Maynard, A.² Duan, M.³ Baskaran, S.⁴ Botyanzki, J.⁵ Crosby, R.⁶ Dickerson, S.⁷ Tallant, M.⁸ Grimes, R.⁹ Hamatake, R.¹⁰ Leivers, M.¹¹ Roberts, C.D.¹² Walker, J.¹³

46
- 84881392189
- J. Li, N. Wu, Y. Tian, J. Zhang, and S. Wu ACS Med. Chem. Lett. 4 2013 806
- (2013) ACS Med. Chem. Lett. , vol.4 , pp. 806
- Li, J.¹ Wu, N.² Tian, Y.³ Zhang, J.⁴ Wu, S.⁵

47
- 84866336965
- Y. Ohtake, T. Sato, T. Kobayashi, M. Nishimoto, N. Taka, K. Takano, K. Yamamoto, M. Ohmori, M. Yamaguchi, K. Takami, S.Y. Yeu, K.H. Ahn, H. Matsuoka, K. Morikawa, M. Suzuki, H. Hagita, K. Ozawa, K. Yamaguchi, M. Kato, and S. Ikeda J. Med. Chem. 55 2012 7828
- (2012) J. Med. Chem. , vol.55 , pp. 7828
- Ohtake, Y.¹ Sato, T.² Kobayashi, T.³ Nishimoto, M.⁴ Taka, N.⁵ Takano, K.⁶ Yamamoto, K.⁷ Ohmori, M.⁸ Yamaguchi, M.⁹ Takami, K.¹⁰ Yeu, S.Y.¹¹ Ahn, K.H.¹² Matsuoka, H.¹³ Morikawa, K.¹⁴ Suzuki, M.¹⁵ Hagita, H.¹⁶ Ozawa, K.¹⁷ Yamaguchi, K.¹⁸ Kato, M.¹⁹ Ikeda, S.²⁰ more..

48
- 84894070010
- J.S. Scott, F.W. Goldberg, and A.V. Turnbull J. Med. Chem. 57 2014 4466
- (2014) J. Med. Chem. , vol.57 , pp. 4466
- Scott, J.S.¹ Goldberg, F.W.² Turnbull, A.V.³

49
- 74049128380
- C.M. Tice, W. Zhao, Z. Xu, S.T. Cacatian, R.D. Simpson, Y. Ye, S.B. Singh, B.M. McKeever, P. Lindblom, J. Guo, P.M. Krosky, B.A. Kruk, J. Berbaum, R.K. Harrison, J.J. Johnson, Y. Bukhtiyarov, R. Panemangalore, B.B. Scott, Y. Zhao, J.G. Bruno, L. Zhuang, G.M. McGeehan, W. He, and D.A. Claremon Bioorg. Med. Chem. Lett. 20 2010 881
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 881
- Tice, C.M.¹ Zhao, W.² Xu, Z.³ Cacatian, S.T.⁴ Simpson, R.D.⁵ Ye, Y.⁶ Singh, S.B.⁷ McKeever, B.M.⁸ Lindblom, P.⁹ Guo, J.¹⁰ Krosky, P.M.¹¹ Kruk, B.A.¹² Berbaum, J.¹³ Harrison, R.K.¹⁴ Johnson, J.J.¹⁵ Bukhtiyarov, Y.¹⁶ Panemangalore, R.¹⁷ Scott, B.B.¹⁸ Zhao, Y.¹⁹ Bruno, J.G.²⁰ more..

50
- 84859885147
- S. Bhagwanth, S. Mishra, R. Daya, J. Mah, R.K. Mishra, and R.L. Johnson ACS Chem. Neurosci. 3 2012 274
- (2012) ACS Chem. Neurosci. , vol.3 , pp. 274
- Bhagwanth, S.¹ Mishra, S.² Daya, R.³ Mah, J.⁴ Mishra, R.K.⁵ Johnson, R.L.⁶

51
- 84871647116
- B. Wellenzohn, U. Lessel, A. Beller, T. Isambert, C. Hoenke, and B. Nosse J. Med. Chem. 55 2012 11031
- (2012) J. Med. Chem. , vol.55 , pp. 11031
- Wellenzohn, B.¹ Lessel, U.² Beller, A.³ Isambert, T.⁴ Hoenke, C.⁵ Nosse, B.⁶

52
- 84859805859
- P. Vachal, S. Miao, J.M. Pierce, D. Guiadeen, V.J. Colandrea, M.J. Wyvratt, S.P. Salowe, L.M. Sonatore, J.A. Milligan, R. Hajdu, A. Gollapudi, C.A. Keohane, R.B. Lingham, S.M. Mandala, J.A. DeMartino, X. Tong, M. Wolff, D. Steinhuebel, G.R. Kieczykowski, F.J. Fleitz, K. Chapman, J. Athanasopoulos, G. Adam, C.D. Akyuz, D.K. Jena, J.W. Lusen, J. Meng, B.D. Stein, L. Xia, E.C. Sherer, and J.J. Hale J. Med. Chem. 55 2012 2945
- (2012) J. Med. Chem. , vol.55 , pp. 2945
- Vachal, P.¹ Miao, S.² Pierce, J.M.³ Guiadeen, D.⁴ Colandrea, V.J.⁵ Wyvratt, M.J.⁶ Salowe, S.P.⁷ Sonatore, L.M.⁸ Milligan, J.A.⁹ Hajdu, R.¹⁰ Gollapudi, A.¹¹ Keohane, C.A.¹² Lingham, R.B.¹³ Mandala, S.M.¹⁴ Demartino, J.A.¹⁵ Tong, X.¹⁶ Wolff, M.¹⁷ Steinhuebel, D.¹⁸ Kieczykowski, G.R.¹⁹ Fleitz, F.J.²⁰ more..

53
- 84875704159
- M.C. O'Reilly, S.A. Scott, K.A. Brown, T.H. Oguin 3rd, P.G. Thomas, J.S. Daniels, R. Morrison, H.A. Brown, and C.W. Lindsley J. Med. Chem. 56 2013 2695
- (2013) J. Med. Chem. , vol.56 , pp. 2695
- O'Reilly, M.C.¹ Scott, S.A.² Brown, K.A.³ Oguin III, T.H.⁴ Thomas, P.G.⁵ Daniels, J.S.⁶ Morrison, R.⁷ Brown, H.A.⁸ Lindsley, C.W.⁹

54
- 79961149912
- G. Liang, Y.M. Choi-Sledeski, G.B. Poli, X. Chen, A. Minnich, Q. Wang, J. Tsay, K. Sides, and R.J. Vaz Med. Chem. Commun. 2 2011 794
- (2011) Med. Chem. Commun. , vol.2 , pp. 794
- Liang, G.¹ Choi-Sledeski, Y.M.² Poli, G.B.³ Chen, X.⁴ Minnich, A.⁵ Wang, Q.⁶ Tsay, J.⁷ Sides, K.⁸ Vaz, R.J.⁹

55
- 84897441737
- D. DeMong, X. Dai, J. Hwa, M. Miller, S.-I. Lin, L. Kang, A. Stamford, W. Greenlee, W. Yu, M. Wong, B. Lavey, J. Kozlowski, G. Zhou, D.-Y. Yang, B. Patel, A. Soriano, Y. Zhai, C. Sondey, H. Zhang, J. Lachowicz, D. Grotz, K. Cox, R. Morrison, T. Andreani, Y. Cao, M. Liang, T. Meng, P. McNamara, J. Wong, P. Bradley, K.-I. Feng, J. Belani, P. Chen, P. Dai, J. Gauuan, P. Lin, and H. Zhao J. Med. Chem. 57 2014 2601
- (2014) J. Med. Chem. , vol.57 , pp. 2601
- Demong, D.¹ Dai, X.² Hwa, J.³ Miller, M.⁴ Lin, S.-I.⁵ Kang, L.⁶ Stamford, A.⁷ Greenlee, W.⁸ Yu, W.⁹ Wong, M.¹⁰ Lavey, B.¹¹ Kozlowski, J.¹² Zhou, G.¹³ Yang, D.-Y.¹⁴ Patel, B.¹⁵ Soriano, A.¹⁶ Zhai, Y.¹⁷ Sondey, C.¹⁸ Zhang, H.¹⁹ Lachowicz, J.²⁰ more..

56
- 84874655840
- N. Hossain, S. Ivanova, J. Bergare, and T. Eriksson Bioorg. Med. Chem. Lett. 23 2013 1883
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 1883
- Hossain, N.¹ Ivanova, S.² Bergare, J.³ Eriksson, T.⁴

57
- 84891485988
- N. Hossain, M. Mensonides-Harsema, M.E. Cooper, T. Eriksson, S. Ivanova, and L. Bergstrom Bioorg. Med. Chem. Lett. 24 2014 108
- (2014) Bioorg. Med. Chem. Lett. , vol.24 , pp. 108
- Hossain, N.¹ Mensonides-Harsema, M.² Cooper, M.E.³ Eriksson, T.⁴ Ivanova, S.⁵ Bergstrom, L.⁶

58
- 84868517170
- H. Huang, D.S. La, A.C. Cheng, D.A. Whittington, V.F. Patel, K. Chen, T.A. Dineen, O. Epstein, R. Graceffa, D. Hickman, Y.H. Kiang, S. Louie, Y. Luo, R.C. Wahl, P.H. Wen, S. Wood, and R.T. Fremeau Jr. J. Med. Chem. 55 2012 9156
- (2012) J. Med. Chem. , vol.55 , pp. 9156
- Huang, H.¹ La, D.S.² Cheng, A.C.³ Whittington, D.A.⁴ Patel, V.F.⁵ Chen, K.⁶ Dineen, T.A.⁷ Epstein, O.⁸ Graceffa, R.⁹ Hickman, D.¹⁰ Kiang, Y.H.¹¹ Louie, S.¹² Luo, Y.¹³ Wahl, R.C.¹⁴ Wen, P.H.¹⁵ Wood, S.¹⁶ Fremeau Jr., R.T.¹⁷

59
- 84894081459
- A.A. Thomas, K.W. Hunt, M. Volgraf, R.J. Watts, X. Liu, G. Vigers, D. Smith, D. Sammond, T.P. Tang, S.P. Rhodes, A.T. Metcalf, K.D. Brown, J.N. Otten, M. Burkard, A.A. Cox, M.K.G. Do, D. Dutcher, S. Rana, R.K. DeLisle, K. Regal, A.D. Wright, R. Groneberg, K. Scearce-Levie, M. Siu, H.E. Purkey, J.P. Lyssikatos, and I.W. Gunawardana J. Med. Chem. 57 2014 878
- (2014) J. Med. Chem. , vol.57 , pp. 878
- Thomas, A.A.¹ Hunt, K.W.² Volgraf, M.³ Watts, R.J.⁴ Liu, X.⁵ Vigers, G.⁶ Smith, D.⁷ Sammond, D.⁸ Tang, T.P.⁹ Rhodes, S.P.¹⁰ Metcalf, A.T.¹¹ Brown, K.D.¹² Otten, J.N.¹³ Burkard, M.¹⁴ Cox, A.A.¹⁵ Do, M.K.G.¹⁶ Dutcher, D.¹⁷ Rana, S.¹⁸ Delisle, R.K.¹⁹ Regal, K.²⁰ more..

60
- 84876854153
- K.W. Hunt, A.W. Cook, R.J. Watts, C.T. Clark, G. Vigers, D. Smith, A.T. Metcalf, I.W. Gunawardana, M. Burkard, A.A. Cox, M.K. Geck Do, D. Dutcher, A.A. Thomas, S. Rana, N.C. Kallan, R.K. DeLisle, J.P. Rizzi, K. Regal, D. Sammond, R. Groneberg, M. Siu, H. Purkey, J.P. Lyssikatos, A. Marlow, X. Liu, and T.P. Tang J. Med. Chem. 56 2013 3379
- (2013) J. Med. Chem. , vol.56 , pp. 3379
- Hunt, K.W.¹ Cook, A.W.² Watts, R.J.³ Clark, C.T.⁴ Vigers, G.⁵ Smith, D.⁶ Metcalf, A.T.⁷ Gunawardana, I.W.⁸ Burkard, M.⁹ Cox, A.A.¹⁰ Geck Do, M.K.¹¹ Dutcher, D.¹² Thomas, A.A.¹³ Rana, S.¹⁴ Kallan, N.C.¹⁵ Delisle, R.K.¹⁶ Rizzi, J.P.¹⁷ Regal, K.¹⁸ Sammond, D.¹⁹ Groneberg, R.²⁰ more..

61
- 84655164337
- S.J. Stachel, T.G. Steele, A. Petrocchi, S.J. Haugabook, G. McGaughey, M. Katharine Holloway, T. Allison, S. Munshi, P. Zuck, D. Colussi, K. Tugasheva, A. Wolfe, S.L. Graham, and J.P. Vacca Bioorg. Med. Chem. Lett. 22 2011 240
- (2011) Bioorg. Med. Chem. Lett. , vol.22 , pp. 240
- Stachel, S.J.¹ Steele, T.G.² Petrocchi, A.³ Haugabook, S.J.⁴ McGaughey, G.⁵ Katharine Holloway, M.⁶ Allison, T.⁷ Munshi, S.⁸ Zuck, P.⁹ Colussi, D.¹⁰ Tugasheva, K.¹¹ Wolfe, A.¹² Graham, S.L.¹³ Vacca, J.P.¹⁴

62
- 84868550667
- M.A. Brodney, G. Barreiro, K. Ogilvie, E. Hajos-Korcsok, J. Murray, F. Vajdos, C. Ambroise, C. Christoffersen, K. Fisher, L. Lanyon, J. Liu, C.E. Nolan, J.M. Withka, K.A. Borzilleri, I. Efremov, C.E. Oborski, A. Varghese, and B.T. O'Neill J. Med. Chem. 55 2012 9224
- (2012) J. Med. Chem. , vol.55 , pp. 9224
- Brodney, M.A.¹ Barreiro, G.² Ogilvie, K.³ Hajos-Korcsok, E.⁴ Murray, J.⁵ Vajdos, F.⁶ Ambroise, C.⁷ Christoffersen, C.⁸ Fisher, K.⁹ Lanyon, L.¹⁰ Liu, J.¹¹ Nolan, C.E.¹² Withka, J.M.¹³ Borzilleri, K.A.¹⁴ Efremov, I.¹⁵ Oborski, C.E.¹⁶ Varghese, A.¹⁷ O'Neill, B.T.¹⁸

63
- 84889238958
- J.X. Qiao, T.C. Wang, R. Ruel, C. Thibeault, A. L'Heureux, W.A. Schumacher, S.A. Spronk, S. Hiebert, G. Bouthillier, J. Lloyd, Z. Pi, D.M. Schnur, L.M. Abell, J. Hua, L.A. Price, E. Liu, Q. Wu, T.E. Steinbacher, J.S. Bostwick, M. Chang, J. Zheng, Q. Gao, B. Ma, P.A. McDonnell, C.S. Huang, R. Rehfusms, R.R. Wexler, and P.Y. Lam J. Med. Chem. 56 2013 9275
- (2013) J. Med. Chem. , vol.56 , pp. 9275
- Qiao, J.X.¹ Wang, T.C.² Ruel, R.³ Thibeault, C.⁴ L'Heureux, A.⁵ Schumacher, W.A.⁶ Spronk, S.A.⁷ Hiebert, S.⁸ Bouthillier, G.⁹ Lloyd, J.¹⁰ Pi, Z.¹¹ Schnur, D.M.¹² Abell, L.M.¹³ Hua, J.¹⁴ Price, L.A.¹⁵ Liu, E.¹⁶ Wu, Q.¹⁷ Steinbacher, T.E.¹⁸ Bostwick, J.S.¹⁹ Chang, M.²⁰ more..

64
- 84894600266
- Y.T. Jeon, J.X. Qiao, L. Li, R. Ruel, C. Thibeault, S. Hiebert, T.C. Wang, Y. Wnag, Y. Liu, C.G. Clark, H.S. Wong, J. Zhu, D.-R. Wu, D. Sun, B.-C. Chen, A. Mathur, S.A. Chacko, M. Malley, X.-Q. Chen, H. Shen, C.S. Huang, W.A. Schumacher, J.S. Bostwick, A.B. Stewart, L.A. Price, J. Hua, D. Li, P.C. Levesque, D.A. Seiffert, R. Rehfuss, R.R. Wexler, and P.Y.S. Lam Bioorg. Med. Chem. Lett. 24 2014 1294
- (2014) Bioorg. Med. Chem. Lett. , vol.24 , pp. 1294
- Jeon, Y.T.¹ Qiao, J.X.² Li, L.³ Ruel, R.⁴ Thibeault, C.⁵ Hiebert, S.⁶ Wang, T.C.⁷ Wnag, Y.⁸ Liu, Y.⁹ Clark, C.G.¹⁰ Wong, H.S.¹¹ Zhu, J.¹² Wu, D.-R.¹³ Sun, D.¹⁴ Chen, B.-C.¹⁵ Mathur, A.¹⁶ Chacko, S.A.¹⁷ Malley, M.¹⁸ Chen, X.-Q.¹⁹ Shen, H.²⁰ more..

65
- 82555175799
- A.A. Mazurov, J.D. Speake, and D. Yohannes J. Med. Chem. 54 2011 7943
- (2011) J. Med. Chem. , vol.54 , pp. 7943
- Mazurov, A.A.¹ Speake, J.D.² Yohannes, D.³

66
- 84886532899
- X.T. Chen, P. Pitis, G. Liu, C. Yuan, D. Gotchev, C.L. Cowan, D.H. Rominger, M. Koblish, S.M. Dewire, A.L. Crombie, J.D. Violin, and D.S. Yamashita J. Med. Chem. 56 2013 8019
- (2013) J. Med. Chem. , vol.56 , pp. 8019
- Chen, X.T.¹ Pitis, P.² Liu, G.³ Yuan, C.⁴ Gotchev, D.⁵ Cowan, C.L.⁶ Rominger, D.H.⁷ Koblish, M.⁸ Dewire, S.M.⁹ Crombie, A.L.¹⁰ Violin, J.D.¹¹ Yamashita, D.S.¹²

67
- 81255192119
- A. Chen, R. Aspiotis, L.C. Campeau, E. Cauchon, A. Chefson, Y. Ducharme, J.P. Falgueyret, S. Gagné, Y. Han, R. Houle, S. Laliberté, G. Larouche, J.F. Lévesque, D. McKay, and D. Percival Bioorg. Med. Chem. Lett. 21 2011 7399
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 7399
- Chen, A.¹ Aspiotis, R.² Campeau, L.C.³ Cauchon, E.⁴ Chefson, A.⁵ Ducharme, Y.⁶ Falgueyret, J.P.⁷ Gagné, S.⁸ Han, Y.⁹ Houle, R.¹⁰ Laliberté, S.¹¹ Larouche, G.¹² Lévesque, J.F.¹³ McKay, D.¹⁴ Percival, D.¹⁵

68
- 80054786841
- T. Fujimoto, Y. Tomata, J. Kunitomo, M. Hirozane, and S. Marui Bioorg. Med. Chem. Lett. 21 2011 6409
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 6409
- Fujimoto, T.¹ Tomata, Y.² Kunitomo, J.³ Hirozane, M.⁴ Marui, S.⁵

69
- 84859439320
- M. Fichtner, E. Lee, E. Tomlinson, D. Scott, P. Cornelius, T.A. Patterson, and P.A. Carpino Bioorg. Med. Chem. Lett. 22 2011 2738
- (2011) Bioorg. Med. Chem. Lett. , vol.22 , pp. 2738
- Fichtner, M.¹ Lee, E.² Tomlinson, E.³ Scott, D.⁴ Cornelius, P.⁵ Patterson, T.A.⁶ Carpino, P.A.⁷

70
- 84873729569
- H. Zhou, S.W. Topiol, M. Grenon, H.N. Jimenez, M.A. Uberti, D.G. Smith, R.M. Brodbeck, G. Chandrasena, H. Pedersen, J.C. Madsen, D. Doller, and G. Li Bioorg. Med. Chem. Lett. 23 2013 1398
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 1398
- Zhou, H.¹ Topiol, S.W.² Grenon, M.³ Jimenez, H.N.⁴ Uberti, M.A.⁵ Smith, D.G.⁶ Brodbeck, R.M.⁷ Chandrasena, G.⁸ Pedersen, H.⁹ Madsen, J.C.¹⁰ Doller, D.¹¹ Li, G.¹²

71
- 84877715641
- Y. Li, X. Wang, J. Zhang, W. Deuther-Conrad, F. Xie, X. Zhang, J. Liu, J. Qiao, M. Cui, J. Steinbach, P. Brust, B. Liu, and H. Jia J. Med. Chem. 56 2013 3478
- (2013) J. Med. Chem. , vol.56 , pp. 3478
- Li, Y.¹ Wang, X.² Zhang, J.³ Deuther-Conrad, W.⁴ Xie, F.⁵ Zhang, X.⁶ Liu, J.⁷ Qiao, J.⁸ Cui, M.⁹ Steinbach, J.¹⁰ Brust, P.¹¹ Liu, B.¹² Jia, H.¹³

72
- 84893334934
- S. Mohan, P.S. Kerry, N. Bance, M. Niikura, and B.M. Pinto Angew. Chem., Int. Ed. 53 2014 1076
- (2014) Angew. Chem., Int. Ed. , vol.53 , pp. 1076
- Mohan, S.¹ Kerry, P.S.² Bance, N.³ Niikura, M.⁴ Pinto, B.M.⁵

73
- 80051914543
- H.A. Abramson J. Med. Chem. 54 2011 5615
- (2011) J. Med. Chem. , vol.54 , pp. 5615
- Abramson, H.A.¹

74
- 84861193920
- M. Kamata, T. Yamashita, A. Kina, M. Funata, A. Mizukami, M. Sasaki, A. Tani, M. Funami, N. Amano, and K. Fukatsu Bioorg. Med. Chem. Lett. 22 2012 3643
- (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 3643
- Kamata, M.¹ Yamashita, T.² Kina, A.³ Funata, M.⁴ Mizukami, A.⁵ Sasaki, M.⁶ Tani, A.⁷ Funami, M.⁸ Amano, N.⁹ Fukatsu, K.¹⁰

75
- 84863428644
- M. Kamat, T. Yamashita, A. Kina, M. Tawada, S. Endo, A. Mizukami, M. Sasaki, A. Tani, Y. Nakano, Y. Watanabe, N. Furuyama, M. Funami, N. Amano, and K. Fukatsu Bioorg. Med. Chem. Lett. 22 2012 4769
- (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 4769
- Kamat, M.¹ Yamashita, T.² Kina, A.³ Tawada, M.⁴ Endo, S.⁵ Mizukami, A.⁶ Sasaki, M.⁷ Tani, A.⁸ Nakano, Y.⁹ Watanabe, Y.¹⁰ Furuyama, N.¹¹ Funami, M.¹² Amano, N.¹³ Fukatsu, K.¹⁴

76
- 84884231101
- D.A. Griffith, R.L. Dow, K. Huard, D.J. Edmonds, S.W. Bagley, J. Polivkova, D. Zeng, C.N. Garcia-Irizarry, J.A. Southers, W. Esler, P. Amor, K. Loomis, K. McPherson, K.B. Bahnck, C. Préville, T. Banks, D.E. Moore, A.M. Mathiowetz, E. Menhaji-Klotz, A.C. Smith, S.D. Doran, D.A. Beebe, and M.F. Dunn J. Med. Chem. 56 2013 7110
- (2013) J. Med. Chem. , vol.56 , pp. 7110
- Griffith, D.A.¹ Dow, R.L.² Huard, K.³ Edmonds, D.J.⁴ Bagley, S.W.⁵ Polivkova, J.⁶ Zeng, D.⁷ Garcia-Irizarry, C.N.⁸ Southers, J.A.⁹ Esler, W.¹⁰ Amor, P.¹¹ Loomis, K.¹² McPherson, K.¹³ Bahnck, K.B.¹⁴ Préville, C.¹⁵ Banks, T.¹⁶ Moore, D.E.¹⁷ Mathiowetz, A.M.¹⁸ Menhaji-Klotz, E.¹⁹ Smith, A.C.²⁰ more..

77
- 84885618102
- C. Betschart, S. Hintermann, D. Behnke, S. Cotesta, M. Fendt, C.E. Gee, L.H. Jacobson, G. Laue, S. Ofner, V. Chaudhari, S. Badiger, C. Pandit, J. Wagner, and D. Hoyer J. Med. Chem. 56 2013 7590
- (2013) J. Med. Chem. , vol.56 , pp. 7590
- Betschart, C.¹ Hintermann, S.² Behnke, D.³ Cotesta, S.⁴ Fendt, M.⁵ Gee, C.E.⁶ Jacobson, L.H.⁷ Laue, G.⁸ Ofner, S.⁹ Chaudhari, V.¹⁰ Badiger, S.¹¹ Pandit, C.¹² Wagner, J.¹³ Hoyer, D.¹⁴

78
- 80053900174
- T. Schläger, D. Schepmann, K. Lehmkuhl, J. Holenz, J.M. Vela, H. Buschmann, and B. Wünsch J. Med. Chem. 54 2011 6704
- (2011) J. Med. Chem. , vol.54 , pp. 6704
- Schläger, T.¹ Schepmann, D.² Lehmkuhl, K.³ Holenz, J.⁴ Vela, J.M.⁵ Buschmann, H.⁶ Wünsch, B.⁷

79
- 84862285956
- C. Oberdorf, D. Schepmann, J.M. Vela, H. Buschmann, J. Holenz, and B. Wünsch J. Med. Chem. 55 2012 5350
- (2012) J. Med. Chem. , vol.55 , pp. 5350
- Oberdorf, C.¹ Schepmann, D.² Vela, J.M.³ Buschmann, H.⁴ Holenz, J.⁵ Wünsch, B.⁶

80
- 79960623288
- C. Fytas, G. Zoidis, N. Tzoutzas, M.C. Taylor, G. Fytas, and M. John J. Med. Chem. 54 2011 5250
- (2011) J. Med. Chem. , vol.54 , pp. 5250
- Fytas, C.¹ Zoidis, G.² Tzoutzas, N.³ Taylor, M.C.⁴ Fytas, G.⁵ John, M.⁶

81
- 79955451248
- M. Varasi, F. Thaler, A. Abate, C. Bigogno, R. Boggio, G. Carenzi, T. Cataudella, R.D. Zuffo, M.C. Fulco, M.G. Rozio, A. Mai, G. Dondio, S. Minucci, and C. Mercurio J. Med. Chem. 54 2011 3051
- (2011) J. Med. Chem. , vol.54 , pp. 3051
- Varasi, M.¹ Thaler, F.² Abate, A.³ Bigogno, C.⁴ Boggio, R.⁵ Carenzi, G.⁶ Cataudella, T.⁷ Zuffo, R.D.⁸ Fulco, M.C.⁹ Rozio, M.G.¹⁰ Mai, A.¹¹ Dondio, G.¹² Minucci, S.¹³ Mercurio, C.¹⁴

82
- 84857913204
- R.R. Dandu, J.A. Lyons, R. Raddatz, Z. Huang, L.D. Aimone, and R.L. Hudkins Bioorg. Med. Chem. Lett. 22 2012 2151
- (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 2151
- Dandu, R.R.¹ Lyons, J.A.² Raddatz, R.³ Huang, Z.⁴ Aimone, L.D.⁵ Hudkins, R.L.⁶

83
- 84891888679
- Y. Kato, N. Fuchi, Y. Nishimura, A. Watanabe, M. Yagi, Y. Nakadera, E. Higashi, M. Yamada, T. Aoki, and H. Kigoshi Bioorg. Med. Chem. Lett. 24 2014 565
- (2014) Bioorg. Med. Chem. Lett. , vol.24 , pp. 565
- Kato, Y.¹ Fuchi, N.² Nishimura, Y.³ Watanabe, A.⁴ Yagi, M.⁵ Nakadera, Y.⁶ Higashi, E.⁷ Yamada, M.⁸ Aoki, T.⁹ Kigoshi, H.¹⁰

84
- 84882901491
- C.E. Allen, C.L. Chow, J.J. Caldwell, I.M. Westwood, R.L. Mvan Montfort, and I. Collins Bioorg. Med. Chem. 21 2013 5707
- (2013) Bioorg. Med. Chem. , vol.21 , pp. 5707
- Allen, C.E.¹ Chow, C.L.² Caldwell, J.J.³ Westwood, I.M.⁴ Mvan Montfort, R.L.⁵ Collins, I.⁶

85
- 79957803610
- A. Kaptein, A. Oubrie, E. de Zwart, N. Hoogenboom, J. de Wit, B. van de Kar, M. van Hoek, G. Vogel, V. de Kimpe, C. Schultz-Fademrecht, J. Borsboom, M. van Zeeland, J. Versteegh, B. Kazemier, J. de Roos, F. Wijnands, J. Dulos, M. Jaeger, P. Leandro-Garcia, and T. Barf Bioorg. Med. Chem. Lett. 21 2011 3823
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 3823
- Kaptein, A.¹ Oubrie, A.² De Zwart, E.³ Hoogenboom, N.⁴ De Wit, J.⁵ Van De Kar, B.⁶ Van Hoek, M.⁷ Vogel, G.⁸ De Kimpe, V.⁹ Schultz-Fademrecht, C.¹⁰ Borsboom, J.¹¹ Van Zeeland, M.¹² Versteegh, J.¹³ Kazemier, B.¹⁴ De Roos, J.¹⁵ Wijnands, F.¹⁶ Dulos, J.¹⁷ Jaeger, M.¹⁸ Leandro-Garcia, P.¹⁹ Barf, T.²⁰ more..

86
- 84900461848
- S. Hanessian, T. Jennequin, N. Boyer, V. Babonneau, U. Soma, C.M. la Cour, M.J. Millan, and G. De Nanteuil ACS Med. Chem. Lett. 5 2014 550
- (2014) ACS Med. Chem. Lett. , vol.5 , pp. 550
- Hanessian, S.¹ Jennequin, T.² Boyer, N.³ Babonneau, V.⁴ Soma, U.⁵ La Cour, C.M.⁶ Millan, M.J.⁷ De Nanteuil, G.⁸

87
- 84872358339
- Y. Deng, Z. Yang, G.W. Shipps Jr., S.M. Lo, R. West, J. Hwa, S. Zheng, C. Farley, J. Lachowicz, M. van Heek, A.S. Bass, D.P. Sinha, C.R. Mahon, and Ms.E. Cartwright Bioorg. Med. Chem. Lett. 23 2013 791
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 791
- Deng, Y.¹ Yang, Z.² Shipps Jr., G.W.³ Lo, S.M.⁴ West, R.⁵ Hwa, J.⁶ Zheng, S.⁷ Farley, C.⁸ Lachowicz, J.⁹ Van Heek, M.¹⁰ Bass, A.S.¹¹ Sinha, D.P.¹² Mahon, C.R.¹³ Cartwright, Ms.E.¹⁴

88
- 79953193427
- Y. Uto, Y. Ueno, Y. Kiyotsuka, Y. Miyazawa, H. Kurata, T. Ogata, T. Takagi, S. Wakimoto, and J. Ohsumi Eur. J. Med. Chem. 46 2011 1892
- (2011) Eur. J. Med. Chem. , vol.46 , pp. 1892
- Uto, Y.¹ Ueno, Y.² Kiyotsuka, Y.³ Miyazawa, Y.⁴ Kurata, H.⁵ Ogata, T.⁶ Takagi, T.⁷ Wakimoto, S.⁸ Ohsumi, J.⁹

89
- 84903553831
- Z. Zhang, N.A. Dales, and M.D. Winther J. Med. Chem. 57 2014 5039
- (2014) J. Med. Chem. , vol.57 , pp. 5039
- Zhang, Z.¹ Dales, N.A.² Winther, M.D.³

90
- 84886533505
- A.F. Donnell, C. Michoud, K.C. Rupert, X. Han, D. Aguilar, K.B. Frank, A.J. Fretland, L. Gao, B. Goggin, J.H. Hogg, K. Hong, C.A. Janson, R.F. Kester, N. Kong, K. Le, S. Li, W. Liang, L.J. Lombardo, Y. Lou, C.M. Lukacs, S. Mischke, J.A. Moliterni, A. Polonskaia, A.D. Schutt, D.S. Solis, A. Specian, R. Taylor, M. Weisel, and S.W. Remiszewski J. Med. Chem. 56 2013 7772
- (2013) J. Med. Chem. , vol.56 , pp. 7772
- Donnell, A.F.¹ Michoud, C.² Rupert, K.C.³ Han, X.⁴ Aguilar, D.⁵ Frank, K.B.⁶ Fretland, A.J.⁷ Gao, L.⁸ Goggin, B.⁹ Hogg, J.H.¹⁰ Hong, K.¹¹ Janson, C.A.¹² Kester, R.F.¹³ Kong, N.¹⁴ Le, K.¹⁵ Li, S.¹⁶ Liang, W.¹⁷ Lombardo, L.J.¹⁸ Lou, Y.¹⁹ Lukacs, C.M.²⁰ more..

91
- 84856228492
- S. Seto, K. Yumoto, K. Okada, Y. Asahina, A. Iwan, M. Iwago, R. Terasawa, K.R. Shreder, K. Murakami, and Y. Kohno Bioorg. Med. Chem. 20 2012 1188
- (2012) Bioorg. Med. Chem. , vol.20 , pp. 1188
- Seto, S.¹ Yumoto, K.² Okada, K.³ Asahina, Y.⁴ Iwan, A.⁵ Iwago, M.⁶ Terasawa, R.⁷ Shreder, K.R.⁸ Murakami, K.⁹ Kohno, Y.¹⁰

92
- 0032112610
- J. Boström, P.O. Norrby, and T. Liljefors J. Comput. Aided Mol. Des. 4 1998 383
- (1998) J. Comput. Aided Mol. Des. , vol.4 , pp. 383
- Boström, J.¹ Norrby, P.O.² Liljefors, T.³

93
- 0032550642
- J.H. Meyer, and P.A. Bartlett J. Am. Chem. Soc. 120 1998 4600
- (1998) J. Am. Chem. Soc. , vol.120 , pp. 4600
- Meyer, J.H.¹ Bartlett, P.A.²

94
- 0032550656
- J. Ding, M.E. Fraser, J.H. Meyer, P.A. Bartlett, and M.N.G. James J. Am. Chem. Soc. 120 1998 4610
- (1998) J. Am. Chem. Soc. , vol.120 , pp. 4610
- Ding, J.¹ Fraser, M.E.² Meyer, J.H.³ Bartlett, P.A.⁴ James, M.N.G.⁵

95
- 0032550658
- W.W. Smith, and P.A. Bartlett J. Am. Chem. Soc. 120 1998 4622
- (1998) J. Am. Chem. Soc. , vol.120 , pp. 4622
- Smith, W.W.¹ Bartlett, P.A.²

96
- 0037030653
- D.F. Veber, S.R. Johnson, H.-Y. Cheng, B.R. Smith, K.W. Ward, and K.D. Kopple J. Med. Chem. 45 2002 2615
- (2002) J. Med. Chem. , vol.45 , pp. 2615
- Veber, D.F.¹ Johnson, S.R.² Cheng, H.-Y.³ Smith, B.R.⁴ Ward, K.W.⁵ Kopple, K.D.⁶

97
- 77951095524
- G. Wuitschik, E.M. Carreira, B. Wagner, H. Fischer, I. Parrilla, F. Schuler, M. Rogers-Evans, and K. Müller J. Med. Chem. 53 2010 3227
- (2010) J. Med. Chem. , vol.53 , pp. 3227
- Wuitschik, G.¹ Carreira, E.M.² Wagner, B.³ Fischer, H.⁴ Parrilla, I.⁵ Schuler, F.⁶ Rogers-Evans, M.⁷ Müller, K.⁸

98
- 84884575325
- D.B. Li, M. Rogers-Evans, and E.M. Carreira Org. Lett. 15 2013 4766
- (2013) Org. Lett. , vol.15 , pp. 4766
- Li, D.B.¹ Rogers-Evans, M.² Carreira, E.M.³

99
- 77952381703
- J.A. Burkhard, B. Wagner, H. Fischer, F. Schuler, K. Müller, and E.M. Carreira Angew. Chem., Int. Ed. 49 2010 3524
- (2010) Angew. Chem., Int. Ed. , vol.49 , pp. 3524
- Burkhard, J.A.¹ Wagner, B.² Fischer, H.³ Schuler, F.⁴ Müller, K.⁵ Carreira, E.M.⁶

100
- 79955566051
- A.W. Hung, A. Ramek, Y. Wang, T. Kaya, J.A. Wilson, P.A. Clemons, and D.W. Young Proc. Natl. Acad. Sci. 108 2011 6799
- (2011) Proc. Natl. Acad. Sci. , vol.108 , pp. 6799
- Hung, A.W.¹ Ramek, A.² Wang, Y.³ Kaya, T.⁴ Wilson, J.A.⁵ Clemons, P.A.⁶ Young, D.W.⁷

101
- 84949325006
- WO-2010/105179
- Cacatian, S.; Claremon, D. A.; Dillard, L. W.; Fuchs, K.; Heine, N.; Jia, L.; Leftheris, K.; McKeever, B.; Morales, R. A.; Singh, S.; Venkatraman, S.; Wu, G.; Wu, Z.; Xu, Z.; Yuan, J.; Zheng, Y. WO-2010/105179.
- Cacatian, S.¹ Claremon, D.A.² Dillard, L.W.³ Fuchs, K.⁴ Heine, N.⁵ Jia, L.⁶ Leftheris, K.⁷ McKeever, B.⁸ Morales, R.A.⁹ Singh, S.¹⁰ Venkatraman, S.¹¹ Wu, G.¹² Wu, Z.¹³ Xu, Z.¹⁴ Yuan, J.¹⁵ Zheng, Y.¹⁶

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