Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 14, 2012, Pages 4769-4772

  Kamata, Makoto ^a   Yamashita, Tohru ^a   Kina, Asato ^a   Tawada, Michiko ^a   Endo, Satoshi ^a   Mizukami, Atsushi ^a   Sasaki, Masako ^a   Tani, Akiyoshi ^a   Nakano, Yoshihide ^a   Watanabe, Yuuki ^a   Furuyama, Naoki ^a   Funami, Miyuki ^a   Amano, Nobuyuki ^a   Fukatsu, Kohji ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

ACC; Acetyl CoA carboxylase; Fatty acid oxidation; Obesity; Spiro pyrazolidinedione; Spiro pyrazolo 1,2 a pyridazine

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; BENZOTHIOPHENE; ENZYME INHIBITOR; PYRAZOLE DERIVATIVE; PYRIDAZINE DERIVATIVE; SPIRO PYRAZOLO[1,2 ALPHA]PYRIDAZINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHIRALITY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG STRUCTURE; FATTY ACID OXIDATION; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; RESPIRATORY QUOTIENT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ACETYL-COA CARBOXYLASE; ANIMALS; ENZYME INHIBITORS; HUMANS; MICROSOMES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRAZOLES; RATS; SPIRO COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 84863428644     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.05.062     Document Type: Article

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