Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1)

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 3, 2013, Pages 791-796

  Deng, Yongqi ^a   Yang, Zhiwei ^a   Shipps, Gerald W ^a   Lo, Sie Mun ^a   West, Robert ^a   Hwa, Joyce ^a   Zheng, Shuqin ^a   Farley, Constance ^a   Lachowicz, Jean ^a   Van Heek, Margaret ^a   Bass, Alan S ^a   Sinha, Dinesh P ^a   Mahon, Craig R ^a   Cartwright, Mark E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Liver targeted inhibitors; Saturated fatty acids; Spirocyclic oxazepine; Stearoyl coenzyme A desaturase 1; Unsaturated fatty acids

Indexed keywords

ACYL COENZYME A DESATURASE 1; GLYCINAMIDE; OXAZEPINE DERIVATIVE; OXYGENASE INHIBITOR; PIPERIDINE; THIAZOLE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; FATTY ACID DESATURATION; IN VIVO STUDY; LIVER; MALE; MOUSE; NONHUMAN; RAT; SINGLE DRUG DOSE;

ANIMALS; CYCLIZATION; DIBENZOXAZEPINES; DRUG DELIVERY SYSTEMS; ENZYME ACTIVATION; ENZYME INHIBITORS; LIVER; MICE; MODELS, ANIMAL; MOLECULAR STRUCTURE; RATS; SPIRO COMPOUNDS; STEAROYL-COA DESATURASE;

RATTUS;

EID: 84872358339     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.11.075     Document Type: Article

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