Discovery and evaluation of spirocyclic derivatives as antagonists of the neuropeptide Y5 receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 8, 2012, Pages 2738-2743

  Fichtner, Michael ^a   Lee, Eunsun ^a   Tomlinson, Elizabeth ^a   Scott, Dennis ^a   Cornelius, Peter ^a   Patterson, Terrell A ^a   Carpino, Philip A ^a  

^a PFIZER INC   (United States)

Author keywords

Drug discovery; MK 0557; Neuropeptide Y; NPY Y5R; Obesity; Velneperit

Indexed keywords

1 METHYL 1 [10 OXOSPIRO[CYCLOHEXANE 1,30(10H) FURO[3,4 C]PYRIDIN] 4 YL] 3 (5 PHENYLPYR AZIN 2 YL) UREA; NEUROPEPTIDE Y5 RECEPTOR; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ARTICLE; BINDING ASSAY; CONTROLLED STUDY; DIET; HUMAN; LIVER MICROSOME; NONHUMAN; OBESITY; RAT;

ANIMALS; ANTI-OBESITY AGENTS; CYCLOHEXANES; DISEASE MODELS, ANIMAL; DRUG DISCOVERY; DRUG STABILITY; HUMANS; MICROSOMES, LIVER; MOLECULAR STRUCTURE; PROTEIN BINDING; PYRAZOLES; RATS; RECEPTORS, NEUROPEPTIDE Y; SPIRO COMPOUNDS;

RATTUS;

EID: 84859439320     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.02.098     Document Type: Article

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