Transformation of Pro-Leu-Gly-NH2 peptidomimetic positive allosteric modulators of the dopamine D2 receptor into negative modulators

ACS Chemical Neuroscience

Volumn 3, Issue 4, 2012, Pages 274-284

  Bhagwanth, Swapna ^a   Mishra, Satyendra ^a   Daya, Ritesh ^b   Mah, Jordan ^b   Mishra, Ram K ^b   Johnson, Rodney L ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

Allosteric modulation; Dopamine D2 receptor; Peptidomimetic; Pro Leu Gly NH 2; Spiro bicyclic lactam

Indexed keywords

BETA METHYLENE CARBON; CARBON; DOPAMINE 2 RECEPTOR; METHYL GROUP; PEPTIDOMIMETIC AGENT; PROLYLLEUCYLGLYCINAMIDE; THIAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; DRUG TRANSFORMATION; HYPOTHESIS; METHYLATION; NEUROMODULATION; NONHUMAN; PEPTIDOMICS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RING OPENING; STEREOSPECIFICITY;

ALLOSTERIC MODULATION; DOPAMINE D2 RECEPTOR; PEPTIDOMIMETIC; PRO-LEU-GLY-NH2; SPIRO BICYCLIC LACTAM;

ALLOSTERIC REGULATION; ANIMALS; CATTLE; DOSE-RESPONSE RELATIONSHIP, DRUG; MOLECULAR MIMICRY; MSH RELEASE-INHIBITING HORMONE; PEPTIDOMIMETICS; RECEPTORS, DOPAMINE D2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84859885147     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn200096u     Document Type: Article

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