Treatment of Na v1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker

Pain

Volumn 153, Issue 1, 2012, Pages 80-85

  Goldberg, Yigal Paul ^a   Price, Nicola ^a   Namdari, Rostam ^a   Cohen, Charles Jay ^a   Lamers, Mieke H ^b   Winters, Conrad ^a   Price, James ^c   Young, Clint E ^a   Verschoof, Henry ^a   Sherrington, Robin ^a   Pimstone, Simon Neil ^a   Hayden, Michael Reuben ^a,d  

^a Xenon Pharmaceuticals Inc   (Canada)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c Strength in Numbers Mathematical and Statistical Services   (Canada)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Clinical development; Congenital indifference to pain; Erythromelalgia; Neuropathic pain; Pain genetics; SCN9A; Sodium channel blockers

Indexed keywords

PLACEBO; SODIUM CHANNEL BLOCKING AGENT; SODIUM CHANNEL NAV1.7; UNCLASSIFIED DRUG; XEN 402;

ADULT; AGED; ANALGESIA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; ERYTHROMELALGIA; FEMALE; GENETIC DISORDER; HEAT; HUMAN; MALE; MORNING DOSAGE; MUTATIONAL ANALYSIS; NEUROPATHIC PAIN; PAIN ASSESSMENT; PHENOTYPE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; TREATMENT OUTCOME;

ADULT; DOUBLE-BLIND METHOD; ERYTHROMELALGIA; FEMALE; HUMANS; MALE; MIDDLE AGED; PAIN MEASUREMENT; PILOT PROJECTS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TREATMENT OUTCOME;

EID: 84155170863     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2011.09.008     Document Type: Article

References (16)

1. K. Beneng, T. Renton, Z. Yilmaz, Y. Yiangou, and P. Anand Sodium channel Na v 1.7 immunoreactivity in painful human dental pulp and burning mouth syndrome BMC Neurosci 11 2010 71
2. W.A. Catterall, S. Dib-Hajj, M.H. Meisler, and D. Pietrobon Inherited neuronal ion channelopathies: new windows on complex neurological diseases J Neurosci 28 2008 11768 11777
3. J.J. Cox, F. Reimann, A.K. Nicholas, G. Thornton, E. Roberts, K. Springell, G. Karbani, H. Jafri, J. Mannan, Y. Raashid, L. Al-Gazali, H. Hamamy, E.M. Valente, S. Gorman, R. Williams, D.P. McHale, J.N. Wood, F.M. Gribble, and C.G. Woods An SCN9A channelopathy causes congenital inability to experience pain Nature 444 2006 894 898 (Pubitemid 46024997)
4. N. Danziger, and J.C. Willer Congenital insensitivity to pain Rev Neurol (Paris) 165 2009 129 136
5. S.D. Dib-Hajj, A.M. Rush, T.R. Cummins, F.M. Hisama, S. Novella, L. Tyrrell, L. Marshall, and S.G. Waxman Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons Brain 128 2005 1847 1854 (Pubitemid 41373656)
6. J.P. Drenth, and S.G. Waxman Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders J Clin Invest 117 2007 3603 3609 (Pubitemid 350224065)
7. R.H. Dworkin, D.C. Turk, K.W. Wyrwich, D. Beaton, C.S. Cleeland, J.T. Farrar, J.A. Haythornthwaite, M.P. Jensen, R.D. Kerns, D.N. Ader, N. Brandenburg, L.B. Burke, D. Cella, J. Chandler, P. Cowan, R. Dimitrova, R. Dionne, S. Hertz, A.R. Jadad, N.P. Katz, H. Kehlet, L.D. Kramer, D.C. Manning, C. McCormick, M.P. McDermott, H.J. McQuay, S. Patel, L. Porter, S. Quessy, B.A. Rappaport, C. Rauschkolb, D.A. Revicki, M. Rothman, K.E. Schmader, B.R. Stacey, J.W. Stauffer, T. Von Stein, R.E. White, J. Witter, and S. Zavisic Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations J Pain 9 2008 105 121 (Pubitemid 351147828)
8. J.T. Farrar, R.K. Portenoy, J.A. Berlin, J.L. Kinman, and B.L. Strom Defining the clinically important difference in pain outcome measures Pain 88 2000 287 294
9. T.Z. Fischer, E.S. Gilmore, M. Estacion, E. Eastman, S. Taylor, M. Melanson, S.D. Dib-Hajj, and S.G. Waxman A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgia Ann Neurol 65 2009 733 741
10. T.Z. Fischer, and S.G. Waxman Familial pain syndromes from mutations of the NaV1.7 sodium channel Ann NY Acad Sci 1184 2010 196 207
11. Y.P. Goldberg, J. MacFarlane, M.L. MacDonald, J. Thompson, M.P. Dube, M. Mattice, R. Fraser, C. Young, S. Hossain, T. Pape, B. Payne, C. Radomski, G. Donaldson, E. Ives, J. Cox, H.B. Younghusband, R. Green, A. Duff, E. Boltshauser, G.A. Grinspan, J.H. Dimon, B.G. Sibley, G. Andria, E. Toscano, J. Kerdraon, D. Bowsher, S.N. Pimstone, M.E. Samuels, R. Sherrington, and M.R. Hayden Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations Clin Genet 71 2007 311 319 (Pubitemid 46690905)
12. A. Lampert, A.O. O'Reilly, P. Reeh, and A. Leffler Sodium channelopathies and pain Pflugers Arch 460 2010 249 263
13. F. Reimann, J.J. Cox, I. Belfer, L. Diatchenko, D.V. Zaykin, D.P. McHale, J.P. Drenth, F. Dai, J. Wheeler, F. Sanders, L. Wood, T.X. Wu, J. Karppinen, L. Nikolajsen, M. Mannikko, M.B. Max, C. Kiselycznyk, M. Poddar, R.H. Te Morsche, S. Smith, D. Gibson, A. Kelempisioti, W. Maixner, F.M. Gribble, and C.G. Woods Pain perception is altered by a nucleotide polymorphism in SCN9A Proc Natl Acad Sci USA 107 2010 5148 5153
14. S.G. Waxman Nav1.7, its mutations, and the syndromes that they cause Neurology 69 2007 505 507 (Pubitemid 47357256)
15. Y. Yang, Y. Wang, S. Li, Z. Xu, H. Li, L. Ma, J. Fan, D. Bu, B. Liu, Z. Fan, G. Wu, J. Jin, B. Ding, X. Zhu, and Y. Shen Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia J Med Genet 41 2004 171 174 (Pubitemid 38333793)
16. P. Zhao, T.P. Barr, Q. Hou, S.D. Dib-Hajj, J.A. Black, P.J. Albrecht, K. Petersen, E. Eisenberg, J.P. Wymer, F.L. Rice, and S.G. Waxman Voltage-gated sodium channel expression in rat and human epidermal keratinocytes: evidence for a role in pain Pain 139 2008 90 105