SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 13, 2012, Pages 4281-4287

Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor

(24) Kung, Daniel W a Coffey, Steven B a Jones, Ryan M a Cabral, Shawn a Jiao, Wenhua a Fichtner, Michael a Carpino, Philip A a Rose, Colin R a Hank, Richard F a Lopaze, Michael G a Swartz, Roger a Chen, Hou Tommy a Hendsch, Zachary a Posner, Bruce a Wielis, Christopher F a Manning, Brian a Dubins, Jeffrey a Stock, Ingrid A a Varma, Sam a Campbell, Mary a more..

a PFIZER INC (United States)

Author keywords

Antagonist; Ghrelin; GHS R1a; Inverse agonist; Piperidine azetidine; Spirocyclic

Indexed keywords

AZETIDINE DERIVATIVE; GHRELIN RECEPTOR; PIPERIDINE DERIVATIVE;

ARTICLE; BINDING ASSAY; DRUG DETERMINATION; DRUG STRUCTURE; DRUG SYNTHESIS;

ANIMALS; AZETIDINES; DRUG INVERSE AGONISM; HUMANS; MICROSOMES, LIVER; PIPERIDINES; RATS; RECEPTORS, GHRELIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84862232471 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.05.024 Document Type: Article

Times cited : (24)

References (30)

1
- 0033540056
- M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa Nature 402 1999 656
- (1999) Nature , vol.402 , pp. 656
- Kojima, M.¹ Hosoda, H.² Date, Y.³ Nakazato, M.⁴ Matsuo, H.⁵ Kangawa, K.⁶

2
- 55749097801
- R. Nass, S.S. Pezzoli, M.C. Oliveri, J.T. Patrie, F.E. Harrell Jr., J.L. Clasey, S.B. Heymsfield, M.A. Bach, M.L. Vance, and M.O. Thorner Ann. Intern. Med. 149 2008 601
- (2008) Ann. Intern. Med. , vol.149 , pp. 601
- Nass, R.¹ Pezzoli, S.S.² Oliveri, M.C.³ Patrie, J.T.⁴ Harrell Jr., F.E.⁵ Clasey, J.L.⁶ Heymsfield, S.B.⁷ Bach, M.A.⁸ Vance, M.L.⁹ Thorner, M.O.¹⁰

3
- 0037249113
- P.A. Carpino, B.A. Lefker, S.M. Toler, L.C. Pan, J.R. Hadcock, E.R. Cook, J.N. DiBrino, A.M. Campeta, S.L. DeNinno, K.L. Chidsey-Frink, W.A. Hada, J. Inthavongsay, F.M. Mangano, M.A. Mullins, D.F. Nickerson, O. Ng, C.M. Pirie, J.A. Ragan, C.R. Rose, D.A. Tess, A.S. Wright, L. Yu, M.P. Zawistoski, P.A. DaSilva-Jardine, T.C. Wilson, and D.D. Thompson Bioorg. Med. Chem. 11 2003 581
- (2003) Bioorg. Med. Chem. , vol.11 , pp. 581
- Carpino, P.A.¹ Lefker, B.A.² Toler, S.M.³ Pan, L.C.⁴ Hadcock, J.R.⁵ Cook, E.R.⁶ Dibrino, J.N.⁷ Campeta, A.M.⁸ Deninno, S.L.⁹ Chidsey-Frink, K.L.¹⁰ Hada, W.A.¹¹ Inthavongsay, J.¹² Mangano, F.M.¹³ Mullins, M.A.¹⁴ Nickerson, D.F.¹⁵ Ng, O.¹⁶ Pirie, C.M.¹⁷ Ragan, J.A.¹⁸ Rose, C.R.¹⁹ Tess, D.A.²⁰ more..

4
- 84055221862
- H.R. Hoveyda, E. Marsault, R. Gagnon, A.P. Mathieu, M. Vézina, A. Landry, Z. Wang, K. Benakli, S. Beaubien, C. Saint-Louis, M. Brassard, J.-F. Pinault, L. Ouellet, S. Bhat, M. Ramaseshan, X. Peng, L. Foucher, S. Beauchemin, P. Bhérer, D.F. Veber, M.L. Peterson, and G.L. Fraser J. Med. Chem. 54 2011 8305
- (2011) J. Med. Chem. , vol.54 , pp. 8305
- Hoveyda, H.R.¹ Marsault, E.² Gagnon, R.³ Mathieu, A.P.⁴ Vézina, M.⁵ Landry, A.⁶ Wang, Z.⁷ Benakli, K.⁸ Beaubien, S.⁹ Saint-Louis, C.¹⁰ Brassard, M.¹¹ Pinault, J.-F.¹² Ouellet, L.¹³ Bhat, S.¹⁴ Ramaseshan, M.¹⁵ Peng, X.¹⁶ Foucher, L.¹⁷ Beauchemin, S.¹⁸ Bhérer, P.¹⁹ Veber, D.F.²⁰ Peterson, M.L.²¹ Fraser, G.L.²² more..

5
- 15444371950
- D.E. Cummings, K.E. Foster-Schubert, and J. Overduin Curr. Drug Targets 6 2005 153
- (2005) Curr. Drug Targets , vol.6 , pp. 153
- Cummings, D.E.¹ Foster-Schubert, K.E.² Overduin, J.³

6
- 63849244534
- S.-C. Lu, J. Xu, N. Chinookoswong, S. Liu, S. Steavenson, C. Gegg, D. Brankow, R. Lindberg, M. Veniant, and W. Gu Mol. Pharmacol. 75 2009 901
- (2009) Mol. Pharmacol. , vol.75 , pp. 901
- Lu, S.-C.¹ Xu, J.² Chinookoswong, N.³ Liu, S.⁴ Steavenson, S.⁵ Gegg, C.⁶ Brankow, D.⁷ Lindberg, R.⁸ Veniant, M.⁹ Gu, W.¹⁰

7
- 4444260060
- S. Helmling, C. Maasch, D. Eulberg, K. Buchner, W. Schroder, C. Lange, S. Vonhoff, B. Wlotzka, M.H. Tschop, S. Rosewicz, and S. Klussmann Proc. Natl. Acad. Sci. U.S.A. 101 2004 13174
- (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 13174
- Helmling, S.¹ Maasch, C.² Eulberg, D.³ Buchner, K.⁴ Schroder, W.⁵ Lange, C.⁶ Vonhoff, S.⁷ Wlotzka, B.⁸ Tschop, M.H.⁹ Rosewicz, S.¹⁰ Klussmann, S.¹¹

8
- 31044452189
- K.E. Wortley, J.P. del Rincon, J.D. Murray, K. Garcia, K. Iida, M.O. Thorner, and M.W. Sleeman J. Clin. Invest. 115 2005 3573
- (2005) J. Clin. Invest. , vol.115 , pp. 3573
- Wortley, K.E.¹ Del Rincon, J.P.² Murray, J.D.³ Garcia, K.⁴ Iida, K.⁵ Thorner, M.O.⁶ Sleeman, M.W.⁷

9
- 38549133092
- Y. Sun, N.F. Butte, J.M. Garcia, and R.G. Smith Endocrinology 149 2008 843
- (2008) Endocrinology , vol.149 , pp. 843
- Sun, Y.¹ Butte, N.F.² Garcia, J.M.³ Smith, R.G.⁴

10
- 79958168512
- R. Nass, B.D. Gaylinn, and M.O. Thorner Molec. Cell. Endocrinol. 340 2011 106
- (2011) Molec. Cell. Endocrinol. , vol.340 , pp. 106
- Nass, R.¹ Gaylinn, B.D.² Thorner, M.O.³

11
- 77956357163
- J. Tong, R.L. Prigeon, H.W. Davis, M. Bidlingmaier, S.E. Kahn, D.E. Cummings, M.H. Tschop, and D. D'Alessio Diabetes 59 2010 2145
- (2010) Diabetes , vol.59 , pp. 2145
- Tong, J.¹ Prigeon, R.L.² Davis, H.W.³ Bidlingmaier, M.⁴ Kahn, S.E.⁵ Cummings, D.E.⁶ Tschop, M.H.⁷ D'Alessio, D.⁸

12
- 35548949948
- W.P. Esler, J. Rudolph, T.H. Claus, W. Tang, N. Barucci, S.E. Brown, W. Bullock, M. Daly, L. Decarr, Y. Li, L. Milardo, D. Molstad, J. Zhu, S.J. Gardell, J.N. Livingston, and L.J. Sweet Endocrinology 148 2007 5175
- (2007) Endocrinology , vol.148 , pp. 5175
- Esler, W.P.¹ Rudolph, J.² Claus, T.H.³ Tang, W.⁴ Barucci, N.⁵ Brown, S.E.⁶ Bullock, W.⁷ Daly, M.⁸ Decarr, L.⁹ Li, Y.¹⁰ Milardo, L.¹¹ Molstad, D.¹² Zhu, J.¹³ Gardell, S.J.¹⁴ Livingston, J.N.¹⁵ Sweet, L.J.¹⁶

13
- 11144336036
- S.C. Khojasteh-Bakht, J.P. O'Donnell, H.G. Fouda, and M.J. Potchoiba Drug Metab. Dispos. 33 2005 190
- (2005) Drug Metab. Dispos. , vol.33 , pp. 190
- Khojasteh-Bakht, S.C.¹ O'Donnell, J.P.² Fouda, H.G.³ Potchoiba, M.J.⁴

14
- 4544380938
- B. Liu, G. Liu, Z. Xin, M.D. Serby, H. Zhao, V.G. Schaefer, H.D. Falls, W. Kaszubska, C.A. Collins, and H.L. Sham Bioorg. Med. Chem. Lett. 14 2004 5223
- (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 5223
- Liu, B.¹ Liu, G.² Xin, Z.³ Serby, M.D.⁴ Zhao, H.⁵ Schaefer, V.G.⁶ Falls, H.D.⁷ Kaszubska, W.⁸ Collins, C.A.⁹ Sham, H.L.¹⁰

15
- 11144244631
- H. Zhao, Z. Xin, G. Liu, V.G. Schaefer, H.D. Falls, W. Kaszubska, C.A. Collins, and H.L. Sham J. Med. Chem. 47 2004 6655
- (2004) J. Med. Chem. , vol.47 , pp. 6655
- Zhao, H.¹ Xin, Z.² Liu, G.³ Schaefer, V.G.⁴ Falls, H.D.⁵ Kaszubska, W.⁶ Collins, C.A.⁷ Sham, H.L.⁸

16
- 33646090850
- M.D. Serby, H. Zhao, B.G. Szczepankiewicz, C. Kosogof, Z. Xin, B. Liu, M. Liu, L.T. Nelson, W. Kaszubska, H.D. Falls, V. Schaefer, E.N. Bush, R. Shapiro, B.A. Droz, V.E. Knourek-Segel, T.A. Fey, M.E. Brune, D.W. Beno, T.M. Turner, C.A. Collins, P.B. Jacobson, H.L. Sham, and G. Liu J. Med. Chem. 49 2006 2568
- (2006) J. Med. Chem. , vol.49 , pp. 2568
- Serby, M.D.¹ Zhao, H.² Szczepankiewicz, B.G.³ Kosogof, C.⁴ Xin, Z.⁵ Liu, B.⁶ Liu, M.⁷ Nelson, L.T.⁸ Kaszubska, W.⁹ Falls, H.D.¹⁰ Schaefer, V.¹¹ Bush, E.N.¹² Shapiro, R.¹³ Droz, B.A.¹⁴ Knourek-Segel, V.E.¹⁵ Fey, T.A.¹⁶ Brune, M.E.¹⁷ Beno, D.W.¹⁸ Turner, T.M.¹⁹ Collins, C.A.²⁰ more..

17
- 35348825010
- J. Rudolph, W.P. Esler, S. O'Connor, P.D. Coish, P.L. Wickens, M. Brands, D.E. Bierer, B.T. Bloomquist, G. Bondar, L. Chen, C.Y. Chuang, T.H. Claus, Z. Fathi, W. Fu, U.R. Khire, J.A. Kristie, X.G. Liu, D.B. Lowe, A.C. McClure, M. Michels, A.A. Ortiz, P.D. Ramsden, R.W. Schoenleber, T.E. Shelekhin, A. Vakalopoulos, W. Tang, L. Wang, L. Yi, S.J. Gardell, J.N. Livingston, L.J. Sweet, and W.H. Bullock J. Med. Chem. 50 2007 5202
- (2007) J. Med. Chem. , vol.50 , pp. 5202
- Rudolph, J.¹ Esler, W.P.² O'Connor, S.³ Coish, P.D.⁴ Wickens, P.L.⁵ Brands, M.⁶ Bierer, D.E.⁷ Bloomquist, B.T.⁸ Bondar, G.⁹ Chen, L.¹⁰ Chuang, C.Y.¹¹ Claus, T.H.¹² Fathi, Z.¹³ Fu, W.¹⁴ Khire, U.R.¹⁵ Kristie, J.A.¹⁶ Liu, X.G.¹⁷ Lowe, D.B.¹⁸ McClure, A.C.¹⁹ Michels, M.²⁰ more..

18
- 71749098026
- A. Pasternak, S.D. Goble, R.K. de Jesus, D.L. Hreniuk, C.C. Chung, M.R. Tota, P. Mazur, S.D. Feighner, A.D. Howard, S.G. Mills, and L. Yang Bioorg. Med. Chem. Lett. 19 2009 6237
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 6237
- Pasternak, A.¹ Goble, S.D.² De Jesus, R.K.³ Hreniuk, D.L.⁴ Chung, C.C.⁵ Tota, M.R.⁶ Mazur, P.⁷ Feighner, S.D.⁸ Howard, A.D.⁹ Mills, S.G.¹⁰ Yang, L.¹¹

19
- 76649095334
- M. Yu, M. Lizarzaburu, H. Beckmann, R. Connors, K. Dai, K. Haller, C. Li, L. Liang, M. Lindstrom, J. Ma, A. Motani, M. Wanska, A. Zhang, L. Li, and J.C. Medina Bioorg. Med. Chem. Lett. 20 2010 1758
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 1758
- Yu, M.¹ Lizarzaburu, M.² Beckmann, H.³ Connors, R.⁴ Dai, K.⁵ Haller, K.⁶ Li, C.⁷ Liang, L.⁸ Lindstrom, M.⁹ Ma, J.¹⁰ Motani, A.¹¹ Wanska, M.¹² Zhang, A.¹³ Li, L.¹⁴ Medina, J.C.¹⁵

20
- 0034676324
- M.A. Bednarek, S.D. Feighner, S.-S. Pong, K.K. McKee, D.L. Hreniuk, M.V. Silva, V.A. Warren, A.D. Howard, L.H.Y. Van der Ploeg, and J.V. Heck J. Med. Chem. 43 2000 4370
- (2000) J. Med. Chem. , vol.43 , pp. 4370
- Bednarek, M.A.¹ Feighner, S.D.² Pong, S.-S.³ McKee, K.K.⁴ Hreniuk, D.L.⁵ Silva, M.V.⁶ Warren, V.A.⁷ Howard, A.D.⁸ Van Der Ploeg, L.H.Y.⁹ Heck, J.V.¹⁰

21
- 34447530948
- B. Holst, J. Mokrosinski, M. Lang, E. Brandt, R. Nygaard, T.M. Frimurer, A.G. Beck-Sickinger, and T.W. Schwartz J. Biol. Chem. 282 2007 15799
- (2007) J. Biol. Chem. , vol.282 , pp. 15799
- Holst, B.¹ Mokrosinski, J.² Lang, M.³ Brandt, E.⁴ Nygaard, R.⁵ Frimurer, T.M.⁶ Beck-Sickinger, A.G.⁷ Schwartz, T.W.⁸

22
- 0026554462
- H.W.G.M. Boddeke, A. Fargin, J.R. Raymonde, P. Schoeffter, and D. Hoyer Naunyn-Schmiedeberg's Arch. Pharmacol. 345 1992 257
- (1992) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.345 , pp. 257
- Boddeke, H.W.G.M.¹ Fargin, A.² Raymonde, J.R.³ Schoeffter, P.⁴ Hoyer, D.⁵

23
- 33646715920
- R. Morphy J. Med. Chem. 49 2006 2969
- (2006) J. Med. Chem. , vol.49 , pp. 2969
- Morphy, R.¹

24
- 79958266771
- S.T.M. Orr, S. Cabral, D.P. Fernando, and T. Makowski Tetrahedron Lett. 52 2011 3618
- (2011) Tetrahedron Lett. , vol.52 , pp. 3618
- Orr, S.T.M.¹ Cabral, S.² Fernando, D.P.³ Makowski, T.⁴

25
- 84862172723
- WO2011114271
- Bhattacharya, S.K.; Cameron, K.O.K.; Fernando, D.P.; Kung, D.W.-S.; Londregan, A.T.; McClure, K.F.; Simila, S.T.M. 2,3-Dihydro-1H-inden-1-yl-2,7- diazaspiro[3.6]nonane derivatives as ghrelin receptor antagonists or inverse agonists and their preparation and use for the treatment of ghrelin receptor-mediated diseases. WO2011114271, 2011.
- (2011) 2,3-Dihydro-1H-inden-1-yl-2,7-diazaspiro[3.6]nonane Derivatives As Ghrelin Receptor Antagonists or Inverse Agonists and Their Preparation and Use for the Treatment of Ghrelin Receptor-mediated Diseases
- Bhattacharya, S.K.¹ Cameron, K.O.K.² Fernando, D.P.³ Kung, D.W.-S.⁴ Londregan, A.T.⁵ McClure, K.F.⁶ Simila, S.T.M.⁷

26
- 0033621044
- I.D. Kuntz, K. Chen, K.A. Sharp, and P.A. Kollman Proc. Natl. Acad. Sci. U.S.A. 96 1999 9997
- (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 9997
- Kuntz, I.D.¹ Chen, K.² Sharp, K.A.³ Kollman, P.A.⁴

27
- 0035913059
- F. Lombardo, M.Y. Shalaeva, K.A. Tupper, and F. Gao J. Med. Chem. 44 2001 2490
- (2001) J. Med. Chem. , vol.44 , pp. 2490
- Lombardo, F.¹ Shalaeva, M.Y.² Tupper, K.A.³ Gao, F.⁴

28
- 0032900659
- M.K. Bayliss, and L.W. Frick Curr. Opin. Drug Disc. Dev. 2 1999 20
- (1999) Curr. Opin. Drug Disc. Dev. , vol.2 , pp. 20
- Bayliss, M.K.¹ Frick, L.W.²

29
- 0034955150
- R.E. White, and P. Manitpisitkul Drug Metab. Dispos. 29 2001 957
- (2001) Drug Metab. Dispos. , vol.29 , pp. 957
- White, R.E.¹ Manitpisitkul, P.²

30
- 0037478407
- X. Ding, and L.S. Kaminsky Annu. Rev. Pharmacol. Toxicol. 43 2003 149
- (2003) Annu. Rev. Pharmacol. Toxicol. , vol.43 , pp. 149
- Ding, X.¹ Kaminsky, L.S.²

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.