Thiophene bioisosteres of spirocyclic σ receptor ligands: Relationships between substitution pattern and σ receptor affinity

Journal of Medicinal Chemistry

Volumn 55, Issue 11, 2012, Pages 5350-5360

  Oberdorf, Christoph ^a   Schepmann, Dirk ^a   Vela, Jose Miguel ^b   Buschmann, Helmut ^b   Holenz, Jörg ^b   Wünsch, Bernhard ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b ESTEVE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1 (CYCLOHEXZYLMETHYL) 6',7' DIHYDROSPIRO[PIPERIDINE 4,4' THIENO[3,2 C]PYRAN]; 1 BENZYL 6',7' DIHYDROSPIRO[PIPERIDINE 4,4' THIENO[3,2 C]PYRAN]; SIGMA 1 OPIATE RECEPTOR; SIGMA RECEPTOR LIGAND; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HYDROGEN BOND; LIPOPHILICITY; NONHUMAN; RAT; REACTION ANALYSIS; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; BRAIN; GUINEA PIGS; LIGANDS; LIVER; MODELS, MOLECULAR; PIPERIDINES; PYRANS; RADIOLIGAND ASSAY; RATS; RECEPTORS, SIGMA; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 84862285956     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300302p     Document Type: Article

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