Novel lipophilic acetohydroxamic acid derivatives based on conformationally constrained spiro carbocyclic 2,6-diketopiperazine scaffolds with potent trypanocidal activity

Journal of Medicinal Chemistry

Volumn 54, Issue 14, 2011, Pages 5250-5254

  Fytas, Christos ^a   Zoidis, Grigoris ^a   Tzoutzas, Nikolaos ^a   Taylor, Martin C ^b   Fytas, George ^a   Kelly, John M ^b  

^a UNIVERSITY OF ATHENS   (Greece)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

6 BENZYL 3,5 DIOXOSPIRO[PIPERAZINE 2,2' ADAMANTANE]; ACETOHYDROXAMIC ACID; ADAMANTANE DERIVATIVE; ADAMANTANONE; ANTITRYPANOSOMAL AGENT; BENZYL DERIVATIVE; CYCLOHEPTANONE; CYCLOOCTANONE; HYDROXAMIC ACID DERIVATIVE; IMIDE; METAL CHELATE; MOLECULAR SCAFFOLD; NITROGEN; PIPERAZINEDIONE; SPIRO COMPOUND; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONFORMATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; ENANTIOMER; EPIMASTIGOTE; IC 50; LIPOPHILICITY; MAMMAL CELL; MYOBLAST; NONHUMAN; RAT; TRYPANOCIDAL ACTIVITY; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

ANIMALS; CELL LINE; HYDROXAMIC ACIDS; MOLECULAR CONFORMATION; PARASITIC SENSITIVITY TESTS; PIPERAZINES; RATS; SPIRO COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CRUZI;

EID: 79960623288     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200217m     Document Type: Article

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