SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 1, 2014, Pages 577-584

Synthesis and evaluation of spiroisoxazoline oxindoles as anticancer agents

(5) Ribeiro, Carlos J A a Amaral, Joana D a Rodrigues, Cecília M P a Moreira, Rui a Santos, Maria M M a

a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA (Portugal)

Author keywords

Cancer; MDM2; p53; Protein protein interactions; Spiro compounds

Indexed keywords

3' (4 METHOXYPHENYL) 4' PHENYLSPIRO[INDOLINE 3,5' ISOXAZOLINE] 2 ONE; 3' (4 NITROPHENYL) 4' PHENYLSPIRO[INDOLINE 3,5' ISOXAZOLINE] 2 ONE; 3',4' BIS(4 METHOXYPHENYL) SPIRO[INDOLINE 3,5' ISOXAZOLINE] 2 ONE; 3',4' DIPHENYLSPIRO[INDOLINE 3,5' ISOXAZOLINE] 2 ONE; 4' (4 METHOXYPHENYL) 1 METHYL 3' PHENYLSPIRO[INDOLINE 3,5' ISOXAZOLINE] 2 ONE; 4' (4 METHOXYPHENYL) 3' PHENYLSPIRO[INDOLINE 3,5' ISOXAZOLINE] 2 ONE; 5 NITRO 3' (4 METHOXYPHENYL) 4' PHENYLSPIRO[INDOLINE 3,5' ISOXAZOLINE] 2 ONE; 5 NITRO 3',4' DIPHENYLSPIRO[INDOLINE 3,5' ISOXAZOLINE] 2 ONE; 6 BROMO 3' (4 METHOXYPHENYL) 4' PHENYLSPIRO[INDOLINE 3,5' ISOXAZOLINE] 2 ONE; 6 BROMO 3',4' DIPHENYLSPIRO[INDOLINE 3,5' ISOXAZOLINE] 2 ONE; 6 CHLORO 3' (2 METHOXYPHENYL) 4' PHENYLSPIRO[INDOLINE 3,5' ISOXAZOLINE] 2 ONE; 6 CHLORO 3' (4 METHOXYPHENYL) 4' PHENYLSPIRO[INDOLINE 3,5' ISOXAZOLINE] 2 ONE; 6 CHLORO 3' (4 NITROPHENYL) 4' PHENYLSPIRO[INDOLINE 3,5' ISOXAZOLINE] 2 ONE; 6 CHLORO 3',4' BIS(4 METHOXYPHENYL) SPIRO[INDOLINE 3,5' ISOXAZOLINE] 2 ONE; 6 CHLORO 3',4' DIPHENYLSPIRO[INDOLINE 3,5' ISOXAZOLINE] 2 ONE; 6 CHLORO 4' PHENYL 3' (4 TOLYL)SPIRO[INDOLINE 3,5' ISOXAZOLINE] 2 ONE; 7 CHLORO 3' (4 METHOXYPHENYL) 4' PHENYLSPIRO[INDOLINE 3,5' ISOXAZOLINE] 2 ONE; 7 CHLORO 3' (4 NITROPHENYL) 4' PHENYLSPIRO[INDOLINE 3,5' ISOXAZOLINE] 2 ONE; ANTINEOPLASTIC AGENT; NUTLIN 3; PROTEIN MDM2; PROTEIN P53; SPIROISOXAZOLINE OXINDOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; CYCLOADDITION; CYTOTOXICITY; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; PROTEIN PROTEIN INTERACTION; X RAY CRYSTALLOGRAPHY;

CANCER; MDM2; P53; PROTEIN-PROTEIN INTERACTIONS; SPIRO COMPOUNDS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL PROLIFERATION; HUMANS; INDOLES; SPIRO COMPOUNDS;

EID: 84891490447 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2013.10.048 Document Type: Article

Times cited : (56)

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