Combination of two pharmacophoric systems: Synthesis and pharmacological evaluation of spirocyclic pyranopyrazoles with high σ 1 receptor affinity

Journal of Medicinal Chemistry

Volumn 54, Issue 19, 2011, Pages 6704-6713

  Schläger, Torsten ^a   Schepmann, Dirk ^a   Lehmkuhl, Kirstin ^a   Holenz, Jörg ^b   Vela, Jose Miguel ^b   Buschmann, Helmut ^b   Wünsch, Bernhard ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b ESTEVE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 FLUOROBENZYL) 6' METHOXY 1' PHENYL 6',7' DIHYDRO 1'H SPIRO(PIPERIDINE 4,4' PYRANO[4,3 C]PYRAZOLE); 1 (CYCLOHEXYLMETHYL) 6' METHOXY 1' PHENYL 6',7' DIHYDRO 1'H SPIRO (PIPERIDINE 4,4' PYRANO[4,3 C]PYRAZOLE); 1 BENZYL 1' PHENYL 1'H SPIRO(PIPERIDINE 4,4' PYRANO[4,3 C]PYRAZOLE); 1 BENZYL 1' PHENYL 6',7' DIHYDRO 1'H SPIRO(PIPERIDINE 4,4' PYRANO[4,3 C]PYRAZOLE); 1 BENZYL 6' METHOXY 10 PHENYL 6',7' DIHYDRO 1'H SPIRO(PIPERIDINE 4,4' PYRANO[4,3 C]PYRAZOLE); 2 (1 PHENYLPYRAZOL 5 YL)ACETALDEHYDE DIMETHYL ACETAL; 2 (4 BROMO 1 PHENYLPYRAZOL 5 YL)ACETALDEHYDE DIMETHYL ACETAL; 2 [4 (1 BENZYL 4 HYDROXYPIPERIDIN 4 YL) 1 PHENYLPYRAZOL 5 YL]ACETALDEHYDE DIMETHYL ACETAL; 4 METHYLPYRAZOLE; 5 (2 METHOXYVINYL) 1 PHENYLPYRAZOLE; 6' METHOXY 1' PHENYL 6',7' DIHYDRO 1'H SPIRO(PIPERIDINE 4,4' PYRANO[4,3 C]PYRAZOLE); 6',7' DIHYDRO 1' H SPIRO(PIPERIDINE 4,4' PYRANO[4,3 C]PYRAZOLE); CAPSAICIN; CYCLOHEXYLMETHYL DERIVATIVE; METHYL GROUP; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PYRAZOLE DERIVATIVE; RECEPTOR PROTEIN; SPIROCYCLIC PYRANOPYRAZOLE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG BINDING; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; DRUG TOLERABILITY; ELECTRON; LIPOPHILICITY; NONHUMAN; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

ANALGESICS; ANIMALS; BRAIN; GUINEA PIGS; HYPERALGESIA; LIVER; MICE; PYRANS; PYRAZOLES; RADIOLIGAND ASSAY; RATS; RECEPTORS, OPIOID, DELTA; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; TOUCH;

EID: 80053900174     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200585k     Document Type: Article

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