1,3,8-triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia

Journal of Medicinal Chemistry

Volumn 55, Issue 7, 2012, Pages 2945-2959

  Vachal, Petr ^a   Miao, Shouwu ^a   Pierce, Joan M ^a   Guiadeen, Deodial ^a   Colandrea, Vincent J ^a   Wyvratt, Matthew J ^a   Salowe, Scott P ^a   Sonatore, Lisa M ^a   Milligan, James A ^a   Hajdu, Richard ^a   Gollapudi, Anantha ^a   Keohane, Carol A ^a   Lingham, Russell B ^a   Mandala, Suzanne M ^a   Demartino, Julie A ^a   Tong, Xinchun ^a   Wolff, Michael ^a   Steinhuebel, Dietrich ^a   Kieczykowski, Gerard R ^a   Fleitz, Fred J ^a   Chapman, Kevin ^a   Athanasopoulos, John ^a   Adam, Gregory ^a   Akyuz, Can D ^a   Jena, Dhirendra K ^a   Lusen, Jeffrey W ^a   Meng, Juncai ^a   Stein, Benjamin D ^a   Xia, Lei ^a   Sherer, Edward C ^a   Hale, Jeffrey J ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,3,8 TRIAZASPIRO[4.5]DECANE 2,4 DIONE; ALANINE AMINOTRANSFERASE; ANTIANEMIC AGENT; CARBON; ERYTHROPOIETIN; HYPOXIA INDUCIBLE FACTOR; LEAD; NITROGEN; POTASSIUM CHANNEL HERG; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; UNCLASSIFIED DRUG;

ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; EXPERIMENTATION; MASS SPECTROMETRY; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; UPREGULATION;

ANEMIA; ANIMALS; AZA COMPOUNDS; DOGS; ERYTHROPOIETIN; ETHER-A-GO-GO POTASSIUM CHANNELS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; HYDANTOINS; HYPOXIA-INDUCIBLE FACTOR 1; INDOLES; LIVER; MACACA MULATTA; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; PROCOLLAGEN-PROLINE DIOXYGENASE; PROTEIN BINDING; RATS; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; UP-REGULATION;

EID: 84859805859     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201542d     Document Type: Article

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