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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 6, 2013, Pages 1860-1864

Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: The continued optimization of an MLPCN probe molecule

(11) Poslusney, Michael S a,c Melancon, Bruce J a,c Gentry, Patrick R a,c Sheffler, Douglas J a Bridges, Thomas M a,c Utley, Thomas J a,c Daniels, J Scott a,c Niswender, Colleen M a,c Conn, P Jeffrey a,c Lindsley, Craig W a,b,c Wood, Michael R a,b,c

a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE (United States)

b VANDERBILT UNIVERSITY (United States)

c VANDERBILT UNIVERSITY MEDICAL CENTER (United States)

Author keywords

M1; ML137; Muscarinic acetylcholine receptor 1; Positive allosteric modulator (PAM); Spirocyclic; VU0413162

Indexed keywords

ISATIN; ML 137; MUSCARINIC M1 RECEPTOR; MUSCARINIC M1 RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ALKYLATION; ALLOSTERISM; ARTICLE; CONCENTRATION RESPONSE; CYCLIZATION; CYCLOADDITION; DRUG EFFICACY; DRUG POTENCY; FLUORINATION; HUMAN; MOLECULAR PROBE; NONHUMAN; PROCESS OPTIMIZATION; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION;

ALLOSTERIC REGULATION; ANIMALS; HUMANS; ISATIN; PROTEIN BINDING; PYRROLIDINES; RATS; RECEPTOR, MUSCARINIC M1; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 84874651029 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.01.017 Document Type: Article

Times cited : (29)

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