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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 1, 2014, Pages 108-112

Structure activity relationships of fused bicyclic and urea derivatives of spirocyclic compounds as potent CCR1 antagonists

(6) Hossain, Nafizal a Mensonides Harsema, Marguérite a Cooper, Martin E a Eriksson, Tomas a Ivanova, Svetlana a Bergström, Lena a

a ASTRAZENECA R AND D (Sweden)

Author keywords

Antagonists; CCR1; Chemokines; Receptor; Spirocyclic

Indexed keywords

CHEMOKINE RECEPTOR CCR1; UREA DERIVATIVE; CHEMOKINE RECEPTOR ANTAGONIST; COMPOUNDS ACCORDING TO CHEMICAL STRUCTURE; FUSED BICYCLIC COMPOUND; POTASSIUM CHANNEL HERG; UNCLASSIFIED DRUG; UREA DERIVATIVE SPIROCYCLIC COMPOUND;

ARTICLE; BINDING AFFINITY; HUMAN; HUMAN CELL; IC 50; LIVER CELL; MICROSOME; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL CELL; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; IC50; IN VITRO STUDY;

RATTUS; RODENTIA;

ANTAGONISTS; CCR1; CHEMOKINES; RECEPTOR; SPIROCYCLIC;

ANIMALS; BICYCLO COMPOUNDS; DOSE-RESPONSE RELATIONSHIP, DRUG; MOLECULAR STRUCTURE; RATS; RECEPTORS, CCR1; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 84891485988 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.11.062 Document Type: Article

Times cited : (8)

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