Discovery and development of potent and selective inhibitors of histone methyltransferase G9a

ACS Medicinal Chemistry Letters

Volumn 5, Issue 2, 2014, Pages 205-209

  Sweis, Ramzi F ^a   Pliushchev, Marina ^a   Brown, Peter J ^b   Guo, Jun ^a   Li, Fengling ^b   Maag, David ^a   Petros, Andrew M ^a   Soni, Nirupama B ^a   Tse, Chris ^a   Vedadi, Masoud ^b   Michaelides, Michael R ^a   Chiang, Gary G ^a   Pappano, William N ^a  

^a ABBVIE INC   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

A 366; epigenetics; G9a; methylation; methyltransferase

Indexed keywords

A 366; HISTONE METHYLTRANSFERASE; HISTONE METHYLTRANSFERASE G9A; METHYLTRANSFERASE INHIBITOR; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; BIOLOGICAL ACTIVITY; COMPARATIVE STUDY; COMPETITIVE INHIBITION; CONFORMATION; CONTROLLED STUDY; CYCLIZATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; HISTONE METHYLATION; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROGENATION; IC 50; MALE; PRIORITY JOURNAL; SCINTILLATION;

EID: 84894065529     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml400496h     Document Type: Article

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