Synthesis and antiviral activity of cyclopropyl-spirocarbocyclic adenosine, (4R,5S,6R,7R)-4-(6-amino-9H-purin-9-yl)-7-(hydroxymethyl)spiro[2.4]heptane-5,6- diol against hepatitis C virus

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 13, 2011, Pages 3982-3985

  Gadthula, Srinivas ^a   Rawal, Ravindra K ^a   Sharon, Ashoke ^a   Wu, Dong ^a   Korba, Brent ^b   Chu, Chung K ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Anti HCV; Carbocyclic nucleoside; NS5B; X ray structure

Indexed keywords

4 (6 AMINO 9 PURIN 9 YL) 7 (HYDROXYMETHYL)SPIRO[2.4]HEPTANE 5,6 DIOL; 6 EXOCYCLIC METHYLENE; ANTIVIRUS AGENT; ARISTEROMYCIN; CARBENE; CARBOVIR; CYCLOPROPYL SPIROCARBOCYCLIC NUCLEOSIDE; ENTECAVIR; NUCLEOSIDE ANALOG; PSI 7977; PSI 938; UNCLASSIFIED DRUG;

ADENOVIRUS; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; GENOTYPE; HEPATITIS C VIRUS; MEASLES VIRUS; NONHUMAN; SIMMONS SMITH REACTION; VACCINIA VIRUS; VIRUS REPLICATION;

ADENOSINE; ANTIVIRAL AGENTS; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; HEPACIVIRUS; HEPTANES; HUMANS; INHIBITORY CONCENTRATION 50; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

HEPATITIS C VIRUS;

EID: 79958760220     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.05.012     Document Type: Article

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