Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 23, 2013, Pages 6325-6330

  Bondada, Lavanya ^a   Rondla, Ramu ^a   Pradere, Ugo ^a   Liu, Peng ^a   Li, Chengwei ^a   Bobeck, Drew ^b   McBrayer, Tamara ^b   Tharnish, Philip ^b   Courcambeck, Jerome ^c   Halfon, Philippe ^c   Whitaker, Tony ^b   Amblard, Franck ^a   Coats, Steven J ^b   Schinazi, Raymond F ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RFS Pharma LLC   (United States)

^c Genoscience Pharma   (France)

Author keywords

Antiviral; HCV; Protease inhibitor

Indexed keywords

AZETIDINE DERIVATIVE; BOCEPREVIR; PROTEINASE INHIBITOR; TELAPREVIR; VANIPREVIR;

ARTICLE; DECARBOXYLATION; DRUG CYTOTOXICITY; DRUG SYNTHESIS; EMBRYO DEVELOPMENT; ENANTIOMER; ENZYME SPECIFICITY; ESTERIFICATION; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; HYDROGENATION; HYDROLYSIS; IC 50; IMMUNE RESPONSE; NONHUMAN; OXIDATION; RNA REPLICATION; SAPONIFICATION; STRUCTURE ACTIVITY RELATION;

HEPATITIS C VIRUS;

ANTIVIRAL; HCV; PROTEASE INHIBITOR;

ANTIVIRAL AGENTS; AZETIDINES; DRUG DESIGN; HEPATITIS C; HUMANS; MODELS, MOLECULAR; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84886950721     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.09.068     Document Type: Article

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