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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 3, 2014, Pages 737-741

Heteroarylureas with spirocyclic diamine cores as inhibitors of fatty acid amide hydrolase

(17) Keith, John M a Jones, William M a Pierce, Joan M a Seierstad, Mark a Palmer, James A a Webb, Michael a Karbarz, Mark J a Scott, Brian P a Wilson, Sandy J a Luo, Lin a Wennerholm, Michelle L a Chang, Leon a Brown, Sean M a Rizzolio, Michele a Rynberg, Raymond a Chaplan, Sandra R a Breitenbucher, J Guy a

a JANSSEN RESEARCH AND DEVELOPMENT (Belgium)

Author keywords

Covalent inhibitor; FAAH; Hydrolase; Spirocycles

Indexed keywords

7 PHENYL 1 [5 (2 PYRIDINYL) 2 OXAZOLYL] 1 HEPTANONE; ANANDAMIDE; DIAMINE DERIVATIVE; FATTY ACID AMIDASE INHIBITOR; JNJ 1661010; JNJ 40355003; JNJ 42119779; N OLEOYLETHANOLAMINE; PALMIDROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG POTENCY; IC 50; MALE; NEUROPATHIC PAIN; NONHUMAN; RAT;

RATTUS;

COVALENT INHIBITOR; FAAH; HYDROLASE; SPIROCYCLES;

ADMINISTRATION, ORAL; AMIDOHYDROLASES; ANIMALS; AZETIDINES; BRAIN; CYCLIZATION; DIAMINES; ENZYME ACTIVATION; HETEROCYCLIC COMPOUNDS; MOLECULAR STRUCTURE; RATS; SPIRO COMPOUNDS; UREA;

EID: 84893685653 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.12.113 Document Type: Article

Times cited : (19)

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