SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 1, 2014, Pages 258-261

(E)-Alkenes as replacements of amide bonds: Development of novel and potent acyclic CGRP receptor antagonists

(11) Kim, June J a Wood, Michael R a Stachel, Shawn J a De Leon, Pablo a Nomland, Ashley a Stump, Craig A a McWherter, Melody A a Schirripa, Kathy M a Moore, Eric L a Salvatore, Christopher A a Selnick, Harold G a

a MERCK RESEARCH LABORATORIES (United States)

Author keywords

(E) Alkene; CGRP; Migraine; P gp

Indexed keywords

ACETYLENE; ALKENE; AMIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; ETHANE; ETHYLENE; MULTIDRUG RESISTANCE PROTEIN; ALKENE DERIVATIVE; ALKYNE; ANILIDE;

ARTICLE; DRUG SYNTHESIS; PROTEIN BINDING; ACYLATION; BINDING AFFINITY; DRUG BIOAVAILABILITY; DRUG CONFORMATION; DRUG POTENCY; HALOGENATION; HECK REACTION; HYDROGEN BOND; MEMBRANE PERMEABILITY; NITRATION; RECEPTOR BINDING;

(E)-ALKENE; CGRP; MIGRAINE; P-GP;

ALKENES; AMIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; MOLECULAR STRUCTURE; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84891485774 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.11.027 Document Type: Article

Times cited : (6)

References (19)

1
- 51549089370
- S.J. Tepper, and M.J. Stillman Headache 48 2008 1259
- (2008) Headache , vol.48 , pp. 1259
- Tepper, S.J.¹ Stillman, M.J.²

2
- 0025116298
- L. Edvinsson, and P.J. Goadsby J. Intern. Med. 228 1990 299
- (1990) J. Intern. Med. , vol.228 , pp. 299
- Edvinsson, L.¹ Goadsby, P.J.²

3
- 0006644946
- Lippincott-Raven Publishers pp 3-9
- J. Olesen, and L. Edvinsson Headache Pathogenesis: Monoamines, Neuropeptides, Purines and Nitric Oxide 1997 Lippincott-Raven Publishers pp 3-9
- (1997) Headache Pathogenesis: Monoamines, Neuropeptides, Purines and Nitric Oxide
- Olesen, J.¹ Edvinsson, L.²

4
- 0027509161
- P.J. Goadsby, and L. Edvinsson Ann. Neurol. 33 1993 48
- (1993) Ann. Neurol. , vol.33 , pp. 48
- Goadsby, P.J.¹ Edvinsson, L.²

5
- 1542346238
- J. Olesen, H.-C. Diener, I.W. Husstedt, P.J. Goadsby, D. Hall, U. Meier, S. Pollentier, and L.M. Lesko N. Engl. J. Med. 350 2004 1104
- (2004) N. Engl. J. Med. , vol.350 , pp. 1104
- Olesen, J.¹ Diener, H.-C.² Husstedt, I.W.³ Goadsby, P.J.⁴ Hall, D.⁵ Meier, U.⁶ Pollentier, S.⁷ Lesko, L.M.⁸

6
- 42249087655
- T.W. Ho, L. Mannix, X. Fan, C. Assid, C. Furtek, C. Jones, and A. Rapoport Neurology 10 2008 1304
- (2008) Neurology , vol.10 , pp. 1304
- Ho, T.W.¹ Mannix, L.² Fan, X.³ Assid, C.⁴ Furtek, C.⁵ Jones, C.⁶ Rapoport, A.⁷

7
- 79954607744
- D.J. Hewitt, S.K. Aurora, D.W. Dodick, P.J. Goadsby, U. Ge, R. Bachman, D. Taraborelli, X. Fan, C. Assaid, C. Lines, and T.W. Ho Cephalalgia 31 2011 712
- (2011) Cephalalgia , vol.31 , pp. 712
- Hewitt, D.J.¹ Aurora, S.K.² Dodick, D.W.³ Goadsby, P.J.⁴ Ge, U.⁵ Bachman, R.⁶ Taraborelli, D.⁷ Fan, X.⁸ Assaid, C.⁹ Lines, C.¹⁰ Ho, T.W.¹¹

8
- 79953220801
- H.-C. Diener, P. Barbanti, C. Dahlof, U. Reuter, J. Habeck, and J. Podhoma Cephalalgia 31 2011 573
- (2011) Cephalalgia , vol.31 , pp. 573
- Diener, H.-C.¹ Barbanti, P.² Dahlof, C.³ Reuter, U.⁴ Habeck, J.⁵ Podhoma, J.⁶

9
- 84886024087
- E.D. Hostetler, A.D. Joshi, S. Sanabria-Bohorquez, H. Fan, Z. Zeng, M. Purcell, L. Gantert, K. Riffel, M. Williams, S. O'Malley, P. Miller, H.G. Selnick, S.N. Gallicchio, I.M. Bell, C. Salvatore, S.A. Kane, C.C. Li, R. Hargreaves, T. de Groot, G. Bormans, A. Van Hecken, I. Derdelinckx, J. de Hoon, T. Reynders, R. Declercq, I. De Lepeleire, W.D. Kennedy, R. Blanchard, E.E. Marcantonio, C. Sur, J.J. Cook, K. van Laere, and J.L. Evelhoch J. Pharmacol. Exp. Ther. 347 2013 478
- (2013) J. Pharmacol. Exp. Ther. , vol.347 , pp. 478
- Hostetler, E.D.¹ Joshi, A.D.² Sanabria-Bohorquez, S.³ Fan, H.⁴ Zeng, Z.⁵ Purcell, M.⁶ Gantert, L.⁷ Riffel, K.⁸ Williams, M.⁹ O'Malley, S.¹⁰ Miller, P.¹¹ Selnick, H.G.¹² Gallicchio, S.N.¹³ Bell, I.M.¹⁴ Salvatore, C.¹⁵ Kane, S.A.¹⁶ Li, C.C.¹⁷ Hargreaves, R.¹⁸ De Groot, T.¹⁹ Bormans, G.²⁰ more..

10
- 84884274090
- I.M. Bell, S.N. Gallicchio, C.A. Stump, J.G. Bruno, H. Fan, L.T. Gantert, E.D. Hostetler, A.L. Kemmerer, M.A. McWherter, E.L. Moore, S.D. Mosser, M.L. Purcell, K. Riffel, C.A. Salvatore, S. Sanabria-Bohorquez, D.D. Staas, R.B. White, M. Williams, C.B. Zartman, J.J. Cook, R.J. Hargreaves, S.A. Kane, S.L. Graham, and H.G. Selnick ACS Med. Chem. Lett. 4 9 2013 863
- (2013) ACS Med. Chem. Lett. , vol.4 , Issue.9 , pp. 863
- Bell, I.M.¹ Gallicchio, S.N.² Stump, C.A.³ Bruno, J.G.⁴ Fan, H.⁵ Gantert, L.T.⁶ Hostetler, E.D.⁷ Kemmerer, A.L.⁸ McWherter, M.A.⁹ Moore, E.L.¹⁰ Mosser, S.D.¹¹ Purcell, M.L.¹² Riffel, K.¹³ Salvatore, C.A.¹⁴ Sanabria-Bohorquez, S.¹⁵ Staas, D.D.¹⁶ White, R.B.¹⁷ Williams, M.¹⁸ Zartman, C.B.¹⁹ Cook, J.J.²⁰ more..

11
- 69949108860
- M.R. Wood, K.M. Schirripa, J.J. Kim, R.A. Bednar, J.F. Fay, J.G. Bruno, E.L. Moor, S.D. Mosser, S. Roller, C.A. Salvatore, S.A. Kane, J.P. Vacca, and H.G. Selnick Bioorg. Med. Chem. Lett. 19 2009 5787
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 5787
- Wood, M.R.¹ Schirripa, K.M.² Kim, J.J.³ Bednar, R.A.⁴ Fay, J.F.⁵ Bruno, J.G.⁶ Moor, E.L.⁷ Mosser, S.D.⁸ Roller, S.⁹ Salvatore, C.A.¹⁰ Kane, S.A.¹¹ Vacca, J.P.¹² Selnick, H.G.¹³

12
- 84891483375
- WO 2008/127584.
- Wood, M. R.; Kim, J. J.; McWherter, M.; Selnick, H. G.; Schirripa, K. M. WO 2008/127584.
- Wood, M.R.¹ Kim, J.J.² McWherter, M.³ Selnick, H.G.⁴ Schirripa, K.M.⁵

13
- 57849129258
- C.A. Stump, I.M. Bell, R.B. Bednar, J.G. Bruno, J.F. Fay, S.N. Gallicchio, V.K. Johnston, E.L. Moore, S.D. Mosser, A.G. Quigley, C.A. Salvatore, C.R. Theberge, C.B. Zartman, X.-F. Zhang, S.A. Kane, S.L. Graham, J.P. Vacca, and T.M. Williams Bioorg. Med. Chem. Lett. 19 2009 214
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 214
- Stump, C.A.¹ Bell, I.M.² Bednar, R.B.³ Bruno, J.G.⁴ Fay, J.F.⁵ Gallicchio, S.N.⁶ Johnston, V.K.⁷ Moore, E.L.⁸ Mosser, S.D.⁹ Quigley, A.G.¹⁰ Salvatore, C.A.¹¹ Theberge, C.R.¹² Zartman, C.B.¹³ Zhang, X.-F.¹⁴ Kane, S.A.¹⁵ Graham, S.L.¹⁶ Vacca, J.P.¹⁷ Williams, T.M.¹⁸

14
- 84862296187
- S.A. Hitchcock J. Med. Chem. 55 2012 4877
- (2012) J. Med. Chem. , vol.55 , pp. 4877
- Hitchcock, S.A.¹

15
- 77958068048
- M.R. Wood, K.M. Schirripa, J.J. Kim, R.A. Bednar, J.F. Fay, J.G. Bruno, E.L. Moore, S.D. Mosser, S. Roller, C.A. Salvatore, S.A. Kane, J.P. Vacca, and H.G. Selnick Bioorg. Med. Chem. Lett. 20 2010 6827
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 6827
- Wood, M.R.¹ Schirripa, K.M.² Kim, J.J.³ Bednar, R.A.⁴ Fay, J.F.⁵ Bruno, J.G.⁶ Moore, E.L.⁷ Mosser, S.D.⁸ Roller, S.⁹ Salvatore, C.A.¹⁰ Kane, S.A.¹¹ Vacca, J.P.¹² Selnick, H.G.¹³

16
- 0027658149
- Y.-K. Shue Bioorg. Med. Chem. 1 1993 161
- (1993) Bioorg. Med. Chem. , vol.1 , pp. 161
- Shue, Y.-K.¹

17
- 84891481520
- For compounds requiring substituted (R)-2-phenylethyl amine that are not commercially available, chiral amines are prepared from aldehyde or methyl ketone using Ellman's t-butylsulfinimine methodology.
- For compounds requiring substituted (R)-2-phenylethyl amine that are not commercially available, chiral amines are prepared from aldehyde or methyl ketone using Ellman's t-butylsulfinimine methodology.

18
- 84891489522
- Selnick, H. G.; Wood, M. R.; McWherter, M.; Hills, I. D.; Stump, C. R WO 2010/077755.
- Selnick, H. G.; Wood, M. R.; McWherter, M.; Hills, I. D.; Stump, C. R WO 2010/077755.

19
- 12344287392
- P. Wipf, and J. Xiao Org. Lett. 7 2005 103
- (2005) Org. Lett. , vol.7 , pp. 103
- Wipf, P.¹ Xiao, J.²

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.