메뉴 건너뛰기




Volumn 1, Issue , 2014, Pages 59-77

Molecular profiling of childhood cancer: Biomarkers and novel therapies

Author keywords

Biomarkers; Childhood cancer; Molecular diagnostics; Targeted therapy

Indexed keywords

1 CYCLOPROPYL 3 [3 (5 MORPHOLINOMETHYL 1H BENZIMIDAZOL 2 YL) 1H PYRAZOL 4 YL] UREA; 1 CYCLOPROPYL 3 [3 (5 MORPHOLINOMETHYL 1H BENZIMIDAZOL 2 YL) 1H PYRAZOL 4 YL]UREA; BLINATUMOMAB; BORTEZOMIB; CD19 ANTIBODY; CEDIRANIB; CERITINIB; CLOFARABINE; CRIZOTINIB; CYCLOPHOSPHAMIDE; CYTARABINE; DASATINIB; ERLOTINIB; ETOPOSIDE; EVEROLIMUS; FENRETINIDE; FOSTAMATINIB; GEMTUZUMAB OZOGAMICIN; IRINOTECAN; MIDOSTAURIN; MYC PROTEIN; PERIFOSINE; PERTUZUMAB; PILARALISIB; QUIZARTINIB; SELUMETINIB; SORAFENIB; TIPIFARNIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORINOSTAT; [1 (4 OXO 8 PHENYL 4H 1 BENZOPYRAN 2 YL) MORPHOLINIO] METHOXYSUCCINYLARGINYLGLYCYLASPARTYLSERINE ACETATE; [1 (4 OXO 8 PHENYL 4H 1 BENZOPYRAN 2 YL)MORPHOLINIO]METHOXYSUCCINYLARGINYLGLYCYLASPARTYLSERINE ACETATE;

EID: 84904875806     PISSN: 22146474     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbacli.2014.06.003     Document Type: Review
Times cited : (36)

References (329)
  • 1
    • 54549122971 scopus 로고    scopus 로고
    • American Cancer Society, Atlanta, Ga, American Cancer Society
    • American Cancer Society Cancer Facts & Figs. 2014 2014, American Cancer Society, Atlanta, Ga.
    • (2014) Cancer Facts & Figs. 2014
  • 2
    • 84863707351 scopus 로고    scopus 로고
    • Cancer treatment and survivorship statistics, 2012
    • Siegel R., et al. Cancer treatment and survivorship statistics, 2012. CA Cancer J. Clin. 2012, 62(4):220-241.
    • (2012) CA Cancer J. Clin. , vol.62 , Issue.4 , pp. 220-241
    • Siegel, R.1
  • 3
    • 34247222092 scopus 로고    scopus 로고
    • Emerging treatments and gene expression profiling in high-risk medulloblastoma
    • Sardi I., Cavalieri D., Massimino M. Emerging treatments and gene expression profiling in high-risk medulloblastoma. Paediatr. Drugs 2007, 9(2):81-96.
    • (2007) Paediatr. Drugs , vol.9 , Issue.2 , pp. 81-96
    • Sardi, I.1    Cavalieri, D.2    Massimino, M.3
  • 4
    • 84861668164 scopus 로고    scopus 로고
    • Neuroblastoma: the impact of biology and cooperation leading to personalized treatments
    • Owens C., Irwin M. Neuroblastoma: the impact of biology and cooperation leading to personalized treatments. Crit. Rev. Clin. Lab. Sci. 2012, 49(3):85-115.
    • (2012) Crit. Rev. Clin. Lab. Sci. , vol.49 , Issue.3 , pp. 85-115
    • Owens, C.1    Irwin, M.2
  • 5
    • 84861146158 scopus 로고    scopus 로고
    • Advances in the genetics of high-risk childhood B-progenitor acute lymphoblastic leukemia and juvenile myelomonocytic leukemia: implications for therapy
    • Loh M.L., Mullighan C.G. Advances in the genetics of high-risk childhood B-progenitor acute lymphoblastic leukemia and juvenile myelomonocytic leukemia: implications for therapy. Clin. Cancer Res. 2012, 18(10):2754-2767.
    • (2012) Clin. Cancer Res. , vol.18 , Issue.10 , pp. 2754-2767
    • Loh, M.L.1    Mullighan, C.G.2
  • 6
    • 79955518862 scopus 로고    scopus 로고
    • Targeted therapy in pediatric and adolescent oncology
    • Bernstein M.L. Targeted therapy in pediatric and adolescent oncology. Cancer 2011, 117(10 Suppl.):2268-2274.
    • (2011) Cancer , vol.117 , Issue.10 SUPPL. , pp. 2268-2274
    • Bernstein, M.L.1
  • 7
    • 0033984235 scopus 로고    scopus 로고
    • The Ki-67 protein: from the known and the unknown
    • Scholzen T., Gerdes J. The Ki-67 protein: from the known and the unknown. J. Cell. Physiol. 2000, 182(3):311-322.
    • (2000) J. Cell. Physiol. , vol.182 , Issue.3 , pp. 311-322
    • Scholzen, T.1    Gerdes, J.2
  • 8
    • 80655127696 scopus 로고    scopus 로고
    • The MYCN oncogene and differentiation in neuroblastoma
    • Westermark U.K., et al. The MYCN oncogene and differentiation in neuroblastoma. Semin. Cancer Biol. 2011, 21(4):256-266.
    • (2011) Semin. Cancer Biol. , vol.21 , Issue.4 , pp. 256-266
    • Westermark, U.K.1
  • 9
    • 0030996579 scopus 로고    scopus 로고
    • Serum S100-a marker for disease monitoring in metastatic melanoma
    • Henze G., et al. Serum S100-a marker for disease monitoring in metastatic melanoma. Dermatology 1997, 194(3):208-212.
    • (1997) Dermatology , vol.194 , Issue.3 , pp. 208-212
    • Henze, G.1
  • 10
    • 77951494873 scopus 로고    scopus 로고
    • Targeted cancer therapies in the twenty-first century: lessons from imatinib
    • Stegmeier F., et al. Targeted cancer therapies in the twenty-first century: lessons from imatinib. Clin. Pharmacol. Ther. 2010, 87(5):543-552.
    • (2010) Clin. Pharmacol. Ther. , vol.87 , Issue.5 , pp. 543-552
    • Stegmeier, F.1
  • 11
    • 70449711127 scopus 로고    scopus 로고
    • Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a children's oncology group study
    • Schultz K.R., et al. Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a children's oncology group study. J. Clin. Oncol. 2009, 27(31):5175-5181.
    • (2009) J. Clin. Oncol. , vol.27 , Issue.31 , pp. 5175-5181
    • Schultz, K.R.1
  • 12
    • 84872277710 scopus 로고    scopus 로고
    • Targeting ALK: a promising strategy for the treatment of non-small cell lung cancer, non-Hodgkin's lymphoma, and neuroblastoma
    • La Madrid A.M., et al. Targeting ALK: a promising strategy for the treatment of non-small cell lung cancer, non-Hodgkin's lymphoma, and neuroblastoma. Target. Oncol. 2012, 7(3):199-210.
    • (2012) Target. Oncol. , vol.7 , Issue.3 , pp. 199-210
    • La Madrid, A.M.1
  • 13
    • 84859124139 scopus 로고    scopus 로고
    • Crizotinib: a novel and first-in-class multitargeted tyrosine kinase inhibitor for the treatment of anaplastic lymphoma kinase rearranged non-small cell lung cancer and beyond
    • Ou S.H. Crizotinib: a novel and first-in-class multitargeted tyrosine kinase inhibitor for the treatment of anaplastic lymphoma kinase rearranged non-small cell lung cancer and beyond. Drug Des. Dev. Ther. 2011, 5:471-485.
    • (2011) Drug Des. Dev. Ther. , vol.5 , pp. 471-485
    • Ou, S.H.1
  • 14
    • 0031829833 scopus 로고    scopus 로고
    • Genetic predispositions and childhood cancer
    • Shannon K. Genetic predispositions and childhood cancer. Environ. Health Perspect. 1998, 106(Suppl. 3):801-806.
    • (1998) Environ. Health Perspect. , vol.106 , Issue.SUPPL. 3 , pp. 801-806
    • Shannon, K.1
  • 15
    • 84878849948 scopus 로고    scopus 로고
    • Clinically relevant cancer biomarkers and pharmacogenetic assays
    • Patel J.N., Mandock K., McLeod H.L. Clinically relevant cancer biomarkers and pharmacogenetic assays. J. Oncol. Pharm. Pract. 2014, 20:65-72.
    • (2014) J. Oncol. Pharm. Pract. , vol.20 , pp. 65-72
    • Patel, J.N.1    Mandock, K.2    McLeod, H.L.3
  • 16
    • 33845982216 scopus 로고    scopus 로고
    • Risk factors for acute leukemia in children: a review
    • Belson M., Kingsley B., Holmes A. Risk factors for acute leukemia in children: a review. Environ. Health Perspect. 2007, 115(1):138-145.
    • (2007) Environ. Health Perspect. , vol.115 , Issue.1 , pp. 138-145
    • Belson, M.1    Kingsley, B.2    Holmes, A.3
  • 17
    • 20444449204 scopus 로고    scopus 로고
    • Molecular biomarkers for the study of childhood leukemia
    • Smith M.T., et al. Molecular biomarkers for the study of childhood leukemia. Toxicol. Appl. Pharmacol. 2005, 206(2):237-245.
    • (2005) Toxicol. Appl. Pharmacol. , vol.206 , Issue.2 , pp. 237-245
    • Smith, M.T.1
  • 18
    • 84859970467 scopus 로고    scopus 로고
    • Imatinib resistant BCR-ABL1 mutations at relapse in children with Ph+ ALL: a Children's Oncology Group (COG) study
    • Chang B.H., et al. Imatinib resistant BCR-ABL1 mutations at relapse in children with Ph+ ALL: a Children's Oncology Group (COG) study. Br. J. Haematol. 2012, 157(4):507-510.
    • (2012) Br. J. Haematol. , vol.157 , Issue.4 , pp. 507-510
    • Chang, B.H.1
  • 19
    • 79952749162 scopus 로고    scopus 로고
    • Dasatinib: an anti-tumour agent via Src inhibition
    • Gnoni A., et al. Dasatinib: an anti-tumour agent via Src inhibition. Curr. Drug Targets 2011, 12(4):563-578.
    • (2011) Curr. Drug Targets , vol.12 , Issue.4 , pp. 563-578
    • Gnoni, A.1
  • 20
    • 79952319155 scopus 로고    scopus 로고
    • Pediatric phase I trial and pharmacokinetic study of dasatinib: a report from the children's oncology group phase I consortium
    • Aplenc R., et al. Pediatric phase I trial and pharmacokinetic study of dasatinib: a report from the children's oncology group phase I consortium. J. Clin. Oncol. 2011, 29(7):839-844.
    • (2011) J. Clin. Oncol. , vol.29 , Issue.7 , pp. 839-844
    • Aplenc, R.1
  • 21
    • 60549098640 scopus 로고    scopus 로고
    • Sorafenib: a review of its use in advanced hepatocellular carcinoma
    • Keating G.M., Santoro A. Sorafenib: a review of its use in advanced hepatocellular carcinoma. Drugs 2009, 69(2):223-240.
    • (2009) Drugs , vol.69 , Issue.2 , pp. 223-240
    • Keating, G.M.1    Santoro, A.2
  • 22
    • 84868543745 scopus 로고    scopus 로고
    • A phase I trial and pharmacokinetic study of sorafenib in children with refractory solid tumors or leukemias: a Children's Oncology Group Phase I Consortium report
    • Widemann B.C., et al. A phase I trial and pharmacokinetic study of sorafenib in children with refractory solid tumors or leukemias: a Children's Oncology Group Phase I Consortium report. Clin. Cancer Res. 2012, 18(21):6011-6022.
    • (2012) Clin. Cancer Res. , vol.18 , Issue.21 , pp. 6011-6022
    • Widemann, B.C.1
  • 23
    • 77955980691 scopus 로고    scopus 로고
    • FLT3 and KIT mutated pediatric acute myeloid leukemia (AML) samples are sensitive in vitro to the tyrosine kinase inhibitor SU11657
    • Goemans B.F., et al. FLT3 and KIT mutated pediatric acute myeloid leukemia (AML) samples are sensitive in vitro to the tyrosine kinase inhibitor SU11657. Leuk. Res. 2010, 34(10):1302-1307.
    • (2010) Leuk. Res. , vol.34 , Issue.10 , pp. 1302-1307
    • Goemans, B.F.1
  • 24
    • 84862538656 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration approval: ruxolitinib for the treatment of patients with intermediate and high-risk myelofibrosis
    • Deisseroth A., et al. U.S. Food and Drug Administration approval: ruxolitinib for the treatment of patients with intermediate and high-risk myelofibrosis. Clin. Cancer Res. 2012, 18(12):3212-3217.
    • (2012) Clin. Cancer Res. , vol.18 , Issue.12 , pp. 3212-3217
    • Deisseroth, A.1
  • 25
    • 84868528389 scopus 로고    scopus 로고
    • Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia
    • Maude S.L., et al. Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia. Blood 2012, 120(17):3510-3518.
    • (2012) Blood , vol.120 , Issue.17 , pp. 3510-3518
    • Maude, S.L.1
  • 26
    • 84904865634 scopus 로고    scopus 로고
    • AACR 103rd Annual Meeting, Abstract 867: Therapeutic potential of small molecule SYK inhibitors for treatment of primary B cell acute lymphoblastic leukemia
    • Perova T., et al. AACR 103rd Annual Meeting, Abstract 867: Therapeutic potential of small molecule SYK inhibitors for treatment of primary B cell acute lymphoblastic leukemia. Cancer Res. 2012, 72(8, Supp 1).
    • (2012) Cancer Res. , vol.72 , Issue.8 SUPP. 1
    • Perova, T.1
  • 27
    • 84880425231 scopus 로고    scopus 로고
    • Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia
    • Uckun F.M., et al. Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia. Blood 2013, 121(21):4348-4354.
    • (2013) Blood , vol.121 , Issue.21 , pp. 4348-4354
    • Uckun, F.M.1
  • 28
    • 79955723327 scopus 로고    scopus 로고
    • In vitro and in vivo chemosensitizing activity of LFM-A13, a dual-function inhibitor of Bruton's tyrosine kinase and polo-like kinases, against human leukemic B-cell precursors
    • Uckun F., et al. In vitro and in vivo chemosensitizing activity of LFM-A13, a dual-function inhibitor of Bruton's tyrosine kinase and polo-like kinases, against human leukemic B-cell precursors. Arzneimittelforschung 2011, 61(4):252-259.
    • (2011) Arzneimittelforschung , vol.61 , Issue.4 , pp. 252-259
    • Uckun, F.1
  • 29
    • 58649109966 scopus 로고    scopus 로고
    • Pediatric developmental therapies: interesting new drugs now in early-stage clinical trials
    • Macy M.E., et al. Pediatric developmental therapies: interesting new drugs now in early-stage clinical trials. Curr. Oncol. Rep. 2008, 10(6):477-490.
    • (2008) Curr. Oncol. Rep. , vol.10 , Issue.6 , pp. 477-490
    • Macy, M.E.1
  • 30
    • 78650091355 scopus 로고    scopus 로고
    • Phase 1 trial and pharmacokinetic study of the farnesyl transferase inhibitor tipifarnib in children and adolescents with refractory leukemias: a report from the Children's Oncology Group
    • Widemann B.C., et al. Phase 1 trial and pharmacokinetic study of the farnesyl transferase inhibitor tipifarnib in children and adolescents with refractory leukemias: a report from the Children's Oncology Group. Pediatr. Blood Cancer 2011, 56(2):226-233.
    • (2011) Pediatr. Blood Cancer , vol.56 , Issue.2 , pp. 226-233
    • Widemann, B.C.1
  • 31
    • 84863967243 scopus 로고    scopus 로고
    • Genetic disruption of the PI3K regulatory subunits, p85 alpha, p55 alpha, and p50 alpha, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF
    • Goodwin C.B., et al. Genetic disruption of the PI3K regulatory subunits, p85 alpha, p55 alpha, and p50 alpha, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF. Haematologica 2012, 97(7):1042-1047.
    • (2012) Haematologica , vol.97 , Issue.7 , pp. 1042-1047
    • Goodwin, C.B.1
  • 32
    • 84874999558 scopus 로고    scopus 로고
    • Initial testing (stage 1) of the phosphatidylinositol 3' kinase inhibitor, SAR245408 (XL147) by the pediatric preclinical testing program
    • Reynolds C.P., et al. Initial testing (stage 1) of the phosphatidylinositol 3' kinase inhibitor, SAR245408 (XL147) by the pediatric preclinical testing program. Pediatr. Blood Cancer 2013, 60(5):791-798.
    • (2013) Pediatr. Blood Cancer , vol.60 , Issue.5 , pp. 791-798
    • Reynolds, C.P.1
  • 33
    • 80051469823 scopus 로고    scopus 로고
    • Adaptation of the plasma inhibitory activity assay to detect Aurora, ABL and FLT3 kinase inhibition by AT9283 in pediatric leukemia
    • Podesta J.E., et al. Adaptation of the plasma inhibitory activity assay to detect Aurora, ABL and FLT3 kinase inhibition by AT9283 in pediatric leukemia. Leuk. Res. 2011, 35(9):1273-1275.
    • (2011) Leuk. Res. , vol.35 , Issue.9 , pp. 1273-1275
    • Podesta, J.E.1
  • 34
    • 84879347144 scopus 로고    scopus 로고
    • Occurrence and modulation of therapeutic targets of Aurora kinase inhibition in pediatric acute leukemia cells
    • Jayanthan A., et al. Occurrence and modulation of therapeutic targets of Aurora kinase inhibition in pediatric acute leukemia cells. Leuk. Lymphoma 2013, 54(7):1505-1516.
    • (2013) Leuk. Lymphoma , vol.54 , Issue.7 , pp. 1505-1516
    • Jayanthan, A.1
  • 35
    • 77952703733 scopus 로고    scopus 로고
    • Initial testing of the aurora Kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP)
    • Maris J.M., et al. Initial testing of the aurora Kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP). Pediatr. Blood Cancer 2010, 55(1):26-34.
    • (2010) Pediatr. Blood Cancer , vol.55 , Issue.1 , pp. 26-34
    • Maris, J.M.1
  • 36
    • 82455192242 scopus 로고    scopus 로고
    • Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer
    • Carol H., et al. Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer. Cancer Chemother. Pharmacol. 2011, 68(5):1291-1304.
    • (2011) Cancer Chemother. Pharmacol. , vol.68 , Issue.5 , pp. 1291-1304
    • Carol, H.1
  • 37
    • 67651205908 scopus 로고    scopus 로고
    • Initial testing (stage 1) of vorinostat (SAHA) by the pediatric preclinical testing program
    • Keshelava N., et al. Initial testing (stage 1) of vorinostat (SAHA) by the pediatric preclinical testing program. Pediatr. Blood Cancer 2009, 53(3):505-508.
    • (2009) Pediatr. Blood Cancer , vol.53 , Issue.3 , pp. 505-508
    • Keshelava, N.1
  • 38
    • 77955900071 scopus 로고    scopus 로고
    • Pediatric phase I trial and pharmacokinetic study of vorinostat: a Children's Oncology Group phase I consortium report
    • Fouladi M., et al. Pediatric phase I trial and pharmacokinetic study of vorinostat: a Children's Oncology Group phase I consortium report. J. Clin. Oncol. 2010, 28(22):3623-3629.
    • (2010) J. Clin. Oncol. , vol.28 , Issue.22 , pp. 3623-3629
    • Fouladi, M.1
  • 39
    • 14344255101 scopus 로고    scopus 로고
    • Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) on pediatric acute lymphoblastic leukemia (ALL) with respect to Bcr-Abl status and imatinib mesylate sensitivity
    • Hawkins L.M., Jayanthan A.A., Narendran A. Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) on pediatric acute lymphoblastic leukemia (ALL) with respect to Bcr-Abl status and imatinib mesylate sensitivity. Pediatr. Res. 2005, 57(3):430-437.
    • (2005) Pediatr. Res. , vol.57 , Issue.3 , pp. 430-437
    • Hawkins, L.M.1    Jayanthan, A.A.2    Narendran, A.3
  • 40
    • 84878264535 scopus 로고    scopus 로고
    • Initial testing (stage 1) of ganetespib, an Hsp90 inhibitor, by the pediatric preclinical testing program
    • Lock R.B., et al. Initial testing (stage 1) of ganetespib, an Hsp90 inhibitor, by the pediatric preclinical testing program. Pediatr. Blood Cancer 2013, 60(7):E42-E45.
    • (2013) Pediatr. Blood Cancer , vol.60 , Issue.7
    • Lock, R.B.1
  • 41
    • 33846442029 scopus 로고    scopus 로고
    • Safety of topotecan in the treatment of recurrent small-cell lung cancer and ovarian cancer
    • Garst J. Safety of topotecan in the treatment of recurrent small-cell lung cancer and ovarian cancer. Expert Opin. Drug Saf. 2007, 6(1):53-62.
    • (2007) Expert Opin. Drug Saf. , vol.6 , Issue.1 , pp. 53-62
    • Garst, J.1
  • 42
    • 42449146087 scopus 로고    scopus 로고
    • Phase II study of topotecan in combination with dexamethasone, asparaginase, and vincristine in pediatric patients with acute lymphoblastic leukemia in first relapse
    • Hijiya N., et al. Phase II study of topotecan in combination with dexamethasone, asparaginase, and vincristine in pediatric patients with acute lymphoblastic leukemia in first relapse. Cancer 2008, 112(9):1983-1991.
    • (2008) Cancer , vol.112 , Issue.9 , pp. 1983-1991
    • Hijiya, N.1
  • 43
    • 74549219368 scopus 로고    scopus 로고
    • Combination of cladribine plus topotecan for recurrent or refractory pediatric acute myeloid leukemia
    • Inaba H., et al. Combination of cladribine plus topotecan for recurrent or refractory pediatric acute myeloid leukemia. Cancer 2010, 116(1):98-105.
    • (2010) Cancer , vol.116 , Issue.1 , pp. 98-105
    • Inaba, H.1
  • 44
    • 30544454656 scopus 로고    scopus 로고
    • Front-line therapy for advanced colorectal cancer: emphasis on chemotherapy
    • Varadhachary G.R., Hoff P.M. Front-line therapy for advanced colorectal cancer: emphasis on chemotherapy. Semin. Oncol. 2005, 32(6 Suppl. 9):S40-S42.
    • (2005) Semin. Oncol. , vol.32 , Issue.6 SUPPL. 9
    • Varadhachary, G.R.1    Hoff, P.M.2
  • 45
    • 67649349587 scopus 로고    scopus 로고
    • Chemo-sensitivity in a panel of B-cell precursor acute lymphoblastic leukemia cell lines, YCUB series, derived from children
    • Goto H., et al. Chemo-sensitivity in a panel of B-cell precursor acute lymphoblastic leukemia cell lines, YCUB series, derived from children. Leuk. Res. 2009, 33(10):1386-1391.
    • (2009) Leuk. Res. , vol.33 , Issue.10 , pp. 1386-1391
    • Goto, H.1
  • 46
    • 74049150759 scopus 로고    scopus 로고
    • A multi-center phase I study of clofarabine, etoposide and cyclophosphamide in combination in pediatric patients with refractory or relapsed acute leukemia
    • Hijiya N., et al. A multi-center phase I study of clofarabine, etoposide and cyclophosphamide in combination in pediatric patients with refractory or relapsed acute leukemia. Leukemia 2009, 23(12):2259-2264.
    • (2009) Leukemia , vol.23 , Issue.12 , pp. 2259-2264
    • Hijiya, N.1
  • 47
    • 82955207681 scopus 로고    scopus 로고
    • Phase 2 trial of clofarabine in combination with etoposide and cyclophosphamide in pediatric patients with refractory or relapsed acute lymphoblastic leukemia
    • Hijiya N., et al. Phase 2 trial of clofarabine in combination with etoposide and cyclophosphamide in pediatric patients with refractory or relapsed acute lymphoblastic leukemia. Blood 2011, 118(23):6043-6049.
    • (2011) Blood , vol.118 , Issue.23 , pp. 6043-6049
    • Hijiya, N.1
  • 48
    • 36849020943 scopus 로고    scopus 로고
    • Initial testing (stage 1) of the proteasome inhibitor bortezomib by the pediatric preclinical testing program
    • Houghton P.J., et al. Initial testing (stage 1) of the proteasome inhibitor bortezomib by the pediatric preclinical testing program. Pediatr. Blood Cancer 2008, 50(1):37-45.
    • (2008) Pediatr. Blood Cancer , vol.50 , Issue.1 , pp. 37-45
    • Houghton, P.J.1
  • 49
    • 33947362982 scopus 로고    scopus 로고
    • A phase 1 study of the proteasome inhibitor bortezomib in pediatric patients with refractory leukemia: a Children's Oncology Group study
    • Horton T.M., et al. A phase 1 study of the proteasome inhibitor bortezomib in pediatric patients with refractory leukemia: a Children's Oncology Group study. Clin. Cancer Res. 2007, 13(5):1516-1522.
    • (2007) Clin. Cancer Res. , vol.13 , Issue.5 , pp. 1516-1522
    • Horton, T.M.1
  • 50
    • 33646003521 scopus 로고    scopus 로고
    • Bortezomib interactions with chemotherapy agents in acute leukemia in vitro
    • Horton T.M., et al. Bortezomib interactions with chemotherapy agents in acute leukemia in vitro. Cancer Chemother. Pharmacol. 2006, 58(1):13-23.
    • (2006) Cancer Chemother. Pharmacol. , vol.58 , Issue.1 , pp. 13-23
    • Horton, T.M.1
  • 51
    • 77955108100 scopus 로고    scopus 로고
    • Phase I study of bortezomib combined with chemotherapy in children with relapsed childhood acute lymphoblastic leukemia (ALL): a report from the therapeutic advances in childhood leukemia (TACL) consortium
    • Messinger Y., et al. Phase I study of bortezomib combined with chemotherapy in children with relapsed childhood acute lymphoblastic leukemia (ALL): a report from the therapeutic advances in childhood leukemia (TACL) consortium. Pediatr. Blood Cancer 2010, 55(2):254-259.
    • (2010) Pediatr. Blood Cancer , vol.55 , Issue.2 , pp. 254-259
    • Messinger, Y.1
  • 52
    • 84864045203 scopus 로고    scopus 로고
    • Bortezomib with chemotherapy is highly active in advanced B-precursor acute lymphoblastic leukemia: Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study
    • Messinger Y.H., et al. Bortezomib with chemotherapy is highly active in advanced B-precursor acute lymphoblastic leukemia: Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study. Blood 2012, 120(2):285-290.
    • (2012) Blood , vol.120 , Issue.2 , pp. 285-290
    • Messinger, Y.H.1
  • 54
    • 77955504706 scopus 로고    scopus 로고
    • Phase II window study on rituximab in newly diagnosed pediatric mature B-cell non-Hodgkin's lymphoma and Burkitt leukemia
    • Meinhardt A., et al. Phase II window study on rituximab in newly diagnosed pediatric mature B-cell non-Hodgkin's lymphoma and Burkitt leukemia. J. Clin. Oncol. 2010, 28(19):3115-3121.
    • (2010) J. Clin. Oncol. , vol.28 , Issue.19 , pp. 3115-3121
    • Meinhardt, A.1
  • 55
    • 59449087084 scopus 로고    scopus 로고
    • A study of rituximab and ifosfamide, carboplatin, and etoposide chemotherapy in children with recurrent/refractory B-cell (CD20+) non-Hodgkin lymphoma and mature B-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group
    • Griffin T.C., et al. A study of rituximab and ifosfamide, carboplatin, and etoposide chemotherapy in children with recurrent/refractory B-cell (CD20+) non-Hodgkin lymphoma and mature B-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group. Pediatr. Blood Cancer 2009, 52(2):177-181.
    • (2009) Pediatr. Blood Cancer , vol.52 , Issue.2 , pp. 177-181
    • Griffin, T.C.1
  • 56
    • 71049160105 scopus 로고    scopus 로고
    • A phase II study of Campath-1H in children with relapsed or refractory acute lymphoblastic leukemia: a Children's Oncology Group report
    • Angiolillo A.L., et al. A phase II study of Campath-1H in children with relapsed or refractory acute lymphoblastic leukemia: a Children's Oncology Group report. Pediatr. Blood Cancer 2009, 53(6):978-983.
    • (2009) Pediatr. Blood Cancer , vol.53 , Issue.6 , pp. 978-983
    • Angiolillo, A.L.1
  • 57
    • 84867528070 scopus 로고    scopus 로고
    • Busulfan, fludarabine, and alemtuzumab as a reduced toxicity regimen for children with malignant and nonmalignant diseases improves engraftment and graft-versus-host disease without delaying immune reconstitution
    • Law J., et al. Busulfan, fludarabine, and alemtuzumab as a reduced toxicity regimen for children with malignant and nonmalignant diseases improves engraftment and graft-versus-host disease without delaying immune reconstitution. Biol. Blood. Marrow. Transplant. 2012, 18(11):1656-1663.
    • (2012) Biol. Blood. Marrow. Transplant. , vol.18 , Issue.11 , pp. 1656-1663
    • Law, J.1
  • 59
    • 80054037204 scopus 로고    scopus 로고
    • Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates
    • FitzGerald D.J., et al. Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates. Cancer Res. 2011, 71(20):6300-6309.
    • (2011) Cancer Res. , vol.71 , Issue.20 , pp. 6300-6309
    • FitzGerald, D.J.1
  • 60
  • 61
    • 23744511263 scopus 로고    scopus 로고
    • Safety and efficacy of gemtuzumab ozogamicin in pediatric patients with advanced CD33+ acute myeloid leukemia
    • Arceci R.J., et al. Safety and efficacy of gemtuzumab ozogamicin in pediatric patients with advanced CD33+ acute myeloid leukemia. Blood 2005, 106(4):1183-1188.
    • (2005) Blood , vol.106 , Issue.4 , pp. 1183-1188
    • Arceci, R.J.1
  • 62
    • 44249087421 scopus 로고    scopus 로고
    • Safety and efficacy of gemtuzumab ozogamicin in combination with chemotherapy for pediatric acute myeloid leukemia: a report from the Children's Oncology Group
    • Aplenc R., et al. Safety and efficacy of gemtuzumab ozogamicin in combination with chemotherapy for pediatric acute myeloid leukemia: a report from the Children's Oncology Group. J. Clin. Oncol. 2008, 26(14):2390-3295.
    • (2008) J. Clin. Oncol. , vol.26 , Issue.14 , pp. 2390-3295
    • Aplenc, R.1
  • 63
    • 84859156821 scopus 로고    scopus 로고
    • A novel anti-CD22 immunotoxin, moxetumomab pasudotox: phase I study in pediatric acute lymphoblastic leukemia (ALL)
    • Abstract 248, (ASH Annual Meeting Abstracts)
    • Wayne A.S., et al. A novel anti-CD22 immunotoxin, moxetumomab pasudotox: phase I study in pediatric acute lymphoblastic leukemia (ALL). Blood 2011, 118. Abstract 248, (ASH Annual Meeting Abstracts).
    • (2011) Blood , pp. 118
    • Wayne, A.S.1
  • 64
    • 84890875516 scopus 로고    scopus 로고
    • Initial experience with CMC-544 (inotuzumab ozogamicin) in pediatric patients with relapsed B-cell acute lymphocytic leukaemia
    • Rytting M., et al. Initial experience with CMC-544 (inotuzumab ozogamicin) in pediatric patients with relapsed B-cell acute lymphocytic leukaemia. Pediatr. Blood Cancer 2014, 61(2):369-372.
    • (2014) Pediatr. Blood Cancer , vol.61 , Issue.2 , pp. 369-372
    • Rytting, M.1
  • 65
    • 84877100125 scopus 로고    scopus 로고
    • The anti-CD19 antibody-drug conjugate SAR3419 prevents hematolymphoid relapse postinduction therapy in preclinical models of pediatric acute lymphoblastic leukemia
    • Carol H., et al. The anti-CD19 antibody-drug conjugate SAR3419 prevents hematolymphoid relapse postinduction therapy in preclinical models of pediatric acute lymphoblastic leukemia. Clin. Cancer Res. 2013, 19(7):1795-1805.
    • (2013) Clin. Cancer Res. , vol.19 , Issue.7 , pp. 1795-1805
    • Carol, H.1
  • 66
    • 84901041371 scopus 로고    scopus 로고
    • Blinatumomab, a bi-specific anti-CD19/CD3 BiTE® antibody for the treatment of acute lymphoblastic leukemia: perspectives and current pediatric applications
    • Hoffman L.M., Gore L. Blinatumomab, a bi-specific anti-CD19/CD3 BiTE® antibody for the treatment of acute lymphoblastic leukemia: perspectives and current pediatric applications. Front. Oncol. 2014, 4:63.
    • (2014) Front. Oncol. , vol.4 , pp. 63
    • Hoffman, L.M.1    Gore, L.2
  • 67
    • 78651290248 scopus 로고    scopus 로고
    • Complete remission after blinatumomab-induced donor T-cell activation in three pediatric patients with post-transplant relapsed acute lymphoblastic leukemia
    • Handgretinger R., et al. Complete remission after blinatumomab-induced donor T-cell activation in three pediatric patients with post-transplant relapsed acute lymphoblastic leukemia. Leukemia 2011, 25(1):181-184.
    • (2011) Leukemia , vol.25 , Issue.1 , pp. 181-184
    • Handgretinger, R.1
  • 68
    • 84900991744 scopus 로고    scopus 로고
    • A phase 1/2 study of blinatumomab in pediatric patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia
    • von Stackelberg A., et al. A phase 1/2 study of blinatumomab in pediatric patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia. Blood 2013, 122(21):70.
    • (2013) Blood , vol.122 , Issue.21 , pp. 70
    • von Stackelberg, A.1
  • 69
    • 0024834988 scopus 로고
    • Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity
    • Gross G., Waks T., Eshhar Z. Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity. Proc. Natl. Acad. Sci. U. S. A. 1989, 86(24):10024-10028.
    • (1989) Proc. Natl. Acad. Sci. U. S. A. , vol.86 , Issue.24 , pp. 10024-10028
    • Gross, G.1    Waks, T.2    Eshhar, Z.3
  • 70
    • 84861122295 scopus 로고    scopus 로고
    • The future is now: chimeric antigen receptors as new targeted therapies for childhood cancer
    • Lee D.W., et al. The future is now: chimeric antigen receptors as new targeted therapies for childhood cancer. Clin. Cancer Res. 2012, 18(10):2780-2790.
    • (2012) Clin. Cancer Res. , vol.18 , Issue.10 , pp. 2780-2790
    • Lee, D.W.1
  • 71
    • 50549096284 scopus 로고    scopus 로고
    • Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells
    • Till B.G., et al. Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells. Blood 2008, 112(6):2261-2271.
    • (2008) Blood , vol.112 , Issue.6 , pp. 2261-2271
    • Till, B.G.1
  • 72
    • 84904899008 scopus 로고    scopus 로고
    • ASH Annual Meeting, Abstracts 120: CD19 targeted allogeneic EBV-specific T cells for the treatment of relapsed ALL in pediatric patients post HSCT
    • Abstract 353, (ASH Annual Meeting Abstracts)
    • Curran K.J., et al. ASH Annual Meeting, Abstracts 120: CD19 targeted allogeneic EBV-specific T cells for the treatment of relapsed ALL in pediatric patients post HSCT. Blood 2012, 120. Abstract 353, (ASH Annual Meeting Abstracts).
    • (2012) Blood , pp. 120
    • Curran, K.J.1
  • 73
    • 84876325876 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
    • Grupp S.A., et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N. Engl. J. Med. 2013, 368(16):1509-1518.
    • (2013) N. Engl. J. Med. , vol.368 , Issue.16 , pp. 1509-1518
    • Grupp, S.A.1
  • 75
    • 84876430459 scopus 로고    scopus 로고
    • Children's Oncology Group's 2013 blueprint for research: neuroblastoma
    • Park J.R., et al. Children's Oncology Group's 2013 blueprint for research: neuroblastoma. Pediatr. Blood Cancer 2013, 60(6):985-993.
    • (2013) Pediatr. Blood Cancer , vol.60 , Issue.6 , pp. 985-993
    • Park, J.R.1
  • 76
    • 84879289434 scopus 로고    scopus 로고
    • MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells
    • Zirath H., et al. MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells. Proc. Natl. Acad. Sci. U. S. A. 2013, 110(25):10258-10263.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , Issue.25 , pp. 10258-10263
    • Zirath, H.1
  • 77
    • 80053651202 scopus 로고    scopus 로고
    • Targeting MYC dependence in cancer by inhibiting BET bromodomains
    • Mertz J.A., et al. Targeting MYC dependence in cancer by inhibiting BET bromodomains. Proc. Natl. Acad. Sci. U. S. A. 2011, 108(40):16669-16674.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , Issue.40 , pp. 16669-16674
    • Mertz, J.A.1
  • 78
    • 34547858913 scopus 로고    scopus 로고
    • Structure and acetyl-lysine recognition of the bromodomain
    • Mujtaba S., Zeng L., Zhou M.M. Structure and acetyl-lysine recognition of the bromodomain. Oncogene 2007, 26(37):5521-5527.
    • (2007) Oncogene , vol.26 , Issue.37 , pp. 5521-5527
    • Mujtaba, S.1    Zeng, L.2    Zhou, M.M.3
  • 79
    • 80055000824 scopus 로고    scopus 로고
    • RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
    • Zuber J., et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature 2011, 478(7370):524-528.
    • (2011) Nature , vol.478 , Issue.7370 , pp. 524-528
    • Zuber, J.1
  • 80
    • 84876033650 scopus 로고    scopus 로고
    • Targeting MYCN in neuroblastoma by BET bromodomain inhibition
    • Puissant A., et al. Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 2013, 3(3):308-323.
    • (2013) Cancer Discov. , vol.3 , Issue.3 , pp. 308-323
    • Puissant, A.1
  • 81
    • 34547232986 scopus 로고    scopus 로고
    • Non-transcriptional control of DNA replication by c-Myc
    • Dominguez-Sola D., et al. Non-transcriptional control of DNA replication by c-Myc. Nature 2007, 448(7152):445-451.
    • (2007) Nature , vol.448 , Issue.7152 , pp. 445-451
    • Dominguez-Sola, D.1
  • 82
    • 79952775174 scopus 로고    scopus 로고
    • RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma
    • Cole K.A., et al. RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Proc. Natl. Acad. Sci. U. S. A. 2011, 108(8):3336-3341.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , Issue.8 , pp. 3336-3341
    • Cole, K.A.1
  • 83
    • 84867534947 scopus 로고    scopus 로고
    • CCT244747 is a novel potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs
    • Walton M.I., et al. CCT244747 is a novel potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs. Clin. Cancer Res. 2012, 18(20):5650-5661.
    • (2012) Clin. Cancer Res. , vol.18 , Issue.20 , pp. 5650-5661
    • Walton, M.I.1
  • 84
    • 0037767742 scopus 로고    scopus 로고
    • Retinoid therapy of high-risk neuroblastoma
    • Reynolds C.P., et al. Retinoid therapy of high-risk neuroblastoma. Cancer Lett. 2003, 197(1-2):185-192.
    • (2003) Cancer Lett. , vol.197 , Issue.1-2 , pp. 185-192
    • Reynolds, C.P.1
  • 85
    • 0033532912 scopus 로고    scopus 로고
    • Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)- retinamide in neuroblastoma cell lines
    • Maurer B.J., et al. Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)- retinamide in neuroblastoma cell lines. J. Natl. Cancer Inst. 1999, 91(13):1138-1146.
    • (1999) J. Natl. Cancer Inst. , vol.91 , Issue.13 , pp. 1138-1146
    • Maurer, B.J.1
  • 86
    • 0038176443 scopus 로고    scopus 로고
    • Phase I trial and pharmacokinetics of fenretinide in children with neuroblastoma
    • Garaventa A., et al. Phase I trial and pharmacokinetics of fenretinide in children with neuroblastoma. Clin. Cancer Res. 2003, 9(6):2032-2039.
    • (2003) Clin. Cancer Res. , vol.9 , Issue.6 , pp. 2032-2039
    • Garaventa, A.1
  • 87
    • 80455162314 scopus 로고    scopus 로고
    • Phase II study of oral capsular 4-hydroxyphenylretinamide (4-HPR/fenretinide) in pediatric patients with refractory or recurrent neuroblastoma: a report from the Children's Oncology Group
    • Villablanca J.G., et al. Phase II study of oral capsular 4-hydroxyphenylretinamide (4-HPR/fenretinide) in pediatric patients with refractory or recurrent neuroblastoma: a report from the Children's Oncology Group. Clin. Cancer Res. 2011, 17(21):6858-6866.
    • (2011) Clin. Cancer Res. , vol.17 , Issue.21 , pp. 6858-6866
    • Villablanca, J.G.1
  • 88
    • 84885124167 scopus 로고    scopus 로고
    • Enhanced anti-tumor and anti-angiogenic efficacy of a novel liposomal fenretinide on human neuroblastoma
    • Di Paolo D., et al. Enhanced anti-tumor and anti-angiogenic efficacy of a novel liposomal fenretinide on human neuroblastoma. J. Control. Release 2013, 170(3):445-451.
    • (2013) J. Control. Release , vol.170 , Issue.3 , pp. 445-451
    • Di Paolo, D.1
  • 89
    • 84873951706 scopus 로고    scopus 로고
    • Targeted immunotherapy for high-risk neuroblastoma-the role of monoclonal antibodies
    • Parsons K., et al. Targeted immunotherapy for high-risk neuroblastoma-the role of monoclonal antibodies. Ann. Pharmacother. 2013, 47(2):210-218.
    • (2013) Ann. Pharmacother. , vol.47 , Issue.2 , pp. 210-218
    • Parsons, K.1
  • 90
    • 77957341503 scopus 로고    scopus 로고
    • Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma
    • Yu A.L., et al. Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma. N. Engl. J. Med. 2010, 363(14):1324-1334.
    • (2010) N. Engl. J. Med. , vol.363 , Issue.14 , pp. 1324-1334
    • Yu, A.L.1
  • 91
    • 84902962349 scopus 로고    scopus 로고
    • Phase I trial of a novel anti-GD2 monoclonal antibody, Hu14.18K322A, designed to decrease toxicity in children with refractory or recurrent neuroblastoma
    • Navid F., et al. Phase I trial of a novel anti-GD2 monoclonal antibody, Hu14.18K322A, designed to decrease toxicity in children with refractory or recurrent neuroblastoma. J. Clin. Oncol. 2014, 32(14):1445-1452.
    • (2014) J. Clin. Oncol. , vol.32 , Issue.14 , pp. 1445-1452
    • Navid, F.1
  • 92
    • 70349115668 scopus 로고    scopus 로고
    • The PI3K/Akt/mTOR pathway as therapeutic target in neuroblastoma
    • Fulda S. The PI3K/Akt/mTOR pathway as therapeutic target in neuroblastoma. Curr. Cancer Drug Targets 2009, 9(6):729-737.
    • (2009) Curr. Cancer Drug Targets , vol.9 , Issue.6 , pp. 729-737
    • Fulda, S.1
  • 93
    • 79953319630 scopus 로고    scopus 로고
    • Analysis of PI3K/AKT/mTOR signalling pathway in high risk neuroblastic tumours
    • Izycka-Swieszewska E., et al. Analysis of PI3K/AKT/mTOR signalling pathway in high risk neuroblastic tumours. Pol. J. Pathol. 2010, 61(4):192-198.
    • (2010) Pol. J. Pathol. , vol.61 , Issue.4 , pp. 192-198
    • Izycka-Swieszewska, E.1
  • 94
    • 77953215965 scopus 로고    scopus 로고
    • In vitro and in vivo inhibition of neuroblastoma tumor cell growth by AKT inhibitor perifosine
    • Li Z., et al. In vitro and in vivo inhibition of neuroblastoma tumor cell growth by AKT inhibitor perifosine. J. Natl. Cancer Inst. 2010, 102(11):758-770.
    • (2010) J. Natl. Cancer Inst. , vol.102 , Issue.11 , pp. 758-770
    • Li, Z.1
  • 95
    • 80054752480 scopus 로고    scopus 로고
    • Perifosine-induced inhibition of Akt attenuates brain-derived neurotrophic factor/TrkB-induced chemoresistance in neuroblastoma in vivo
    • Li Z., et al. Perifosine-induced inhibition of Akt attenuates brain-derived neurotrophic factor/TrkB-induced chemoresistance in neuroblastoma in vivo. Cancer 2011, 117(23):5412-5422.
    • (2011) Cancer , vol.117 , Issue.23 , pp. 5412-5422
    • Li, Z.1
  • 97
    • 84858079914 scopus 로고    scopus 로고
    • PI3K/AKT/mTOR pathway in angiogenesis
    • Karar J., Maity A. PI3K/AKT/mTOR pathway in angiogenesis. Front. Mol. Neurosci. 2011, 4:51.
    • (2011) Front. Mol. Neurosci. , vol.4 , pp. 51
    • Karar, J.1    Maity, A.2
  • 98
    • 79960744694 scopus 로고    scopus 로고
    • Phase I study of temsirolimus in pediatric patients with recurrent/refractory solid tumors
    • Spunt S.L., et al. Phase I study of temsirolimus in pediatric patients with recurrent/refractory solid tumors. J. Clin. Oncol. 2011, 29(21):2933-2940.
    • (2011) J. Clin. Oncol. , vol.29 , Issue.21 , pp. 2933-2940
    • Spunt, S.L.1
  • 99
    • 84655175068 scopus 로고    scopus 로고
    • Phase II trial of temsirolimus in children with high-grade glioma, neuroblastoma and rhabdomyosarcoma
    • Geoerger B., et al. Phase II trial of temsirolimus in children with high-grade glioma, neuroblastoma and rhabdomyosarcoma. Eur. J. Cancer 2012, 48(2):253-262.
    • (2012) Eur. J. Cancer , vol.48 , Issue.2 , pp. 253-262
    • Geoerger, B.1
  • 100
    • 79960924027 scopus 로고    scopus 로고
    • The PI-3 kinase-Akt-MDM2-survivin signaling axis in high-risk neuroblastoma: a target for PI-3 kinase inhibitor intervention
    • Peirce S.K., et al. The PI-3 kinase-Akt-MDM2-survivin signaling axis in high-risk neuroblastoma: a target for PI-3 kinase inhibitor intervention. Cancer Chemother. Pharmacol. 2011, 68(2):325-335.
    • (2011) Cancer Chemother. Pharmacol. , vol.68 , Issue.2 , pp. 325-335
    • Peirce, S.K.1
  • 101
    • 79956017530 scopus 로고    scopus 로고
    • Targeting aberrant PI3K/Akt activation by PI103 restores sensitivity to TRAIL-induced apoptosis in neuroblastoma
    • Opel D., et al. Targeting aberrant PI3K/Akt activation by PI103 restores sensitivity to TRAIL-induced apoptosis in neuroblastoma. Clin. Cancer Res. 2011, 17(10):3233-3247.
    • (2011) Clin. Cancer Res. , vol.17 , Issue.10 , pp. 3233-3247
    • Opel, D.1
  • 102
    • 84855183683 scopus 로고    scopus 로고
    • Effects of small molecule inhibitors of PI3K/Akt/mTOR signaling on neuroblastoma growth in vitro and in vivo
    • Segerström L., et al. Effects of small molecule inhibitors of PI3K/Akt/mTOR signaling on neuroblastoma growth in vitro and in vivo. Int. J. Cancer 2011, 129(12):2958-2965.
    • (2011) Int. J. Cancer , vol.129 , Issue.12 , pp. 2958-2965
    • Segerström, L.1
  • 103
    • 84855374142 scopus 로고    scopus 로고
    • Paracrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma
    • (115ra3)
    • Chanthery Y.H., et al. Paracrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma. Sci. Transl. Med. 2012, 4(115). (115ra3).
    • (2012) Sci. Transl. Med. , vol.4 , Issue.115
    • Chanthery, Y.H.1
  • 104
    • 84875615728 scopus 로고    scopus 로고
    • The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosis via mitochondrial-lysosomal cross-talk
    • Seitz C., et al. The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosis via mitochondrial-lysosomal cross-talk. Int. J. Cancer 2013, 132(11):2682-2693.
    • (2013) Int. J. Cancer , vol.132 , Issue.11 , pp. 2682-2693
    • Seitz, C.1
  • 105
    • 54049094708 scopus 로고    scopus 로고
    • Identification of ALK as a major familial neuroblastoma predisposition gene
    • Mosse Y.P., et al. Identification of ALK as a major familial neuroblastoma predisposition gene. Nature 2008, 455(7215):930-935.
    • (2008) Nature , vol.455 , Issue.7215 , pp. 930-935
    • Mosse, Y.P.1
  • 106
    • 80655124524 scopus 로고    scopus 로고
    • Emerging importance of ALK in neuroblastoma
    • Azarova A.M., Gautam G., George R.E. Emerging importance of ALK in neuroblastoma. Semin. Cancer Biol. 2011, 21(4):267-275.
    • (2011) Semin. Cancer Biol. , vol.21 , Issue.4 , pp. 267-275
    • Azarova, A.M.1    Gautam, G.2    George, R.E.3
  • 107
    • 70349733112 scopus 로고    scopus 로고
    • Mutation-independent anaplastic lymphoma kinase overexpression in poor prognosis neuroblastoma patients
    • Passoni L., et al. Mutation-independent anaplastic lymphoma kinase overexpression in poor prognosis neuroblastoma patients. Cancer Res. 2009, 69(18):7338-7346.
    • (2009) Cancer Res. , vol.69 , Issue.18 , pp. 7338-7346
    • Passoni, L.1
  • 108
    • 84876966952 scopus 로고    scopus 로고
    • Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: a Children's Oncology Group phase 1 consortium study
    • Mosse Y.P., et al. Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: a Children's Oncology Group phase 1 consortium study. Lancet Oncol. 2013, 14(6):472-480.
    • (2013) Lancet Oncol. , vol.14 , Issue.6 , pp. 472-480
    • Mosse, Y.P.1
  • 109
    • 84904891305 scopus 로고    scopus 로고
    • ASCO Annual Meeting, Abstract 3007: First-in-human phase I study of the ALK inhibitor LDK378 in advanced solid tumours
    • Mehra R., et al. ASCO Annual Meeting, Abstract 3007: First-in-human phase I study of the ALK inhibitor LDK378 in advanced solid tumours. J. Clin. Oncol. 2012, 30(15 Suppl.).
    • (2012) J. Clin. Oncol. , vol.30 , Issue.15 SUPPL.
    • Mehra, R.1
  • 110
    • 54449085941 scopus 로고    scopus 로고
    • Pediatric phase I and pharmacokinetic study of erlotinib followed by the combination of erlotinib and temozolomide: a Children's Oncology Group Phase I Consortium Study
    • Jakacki R.I., et al. Pediatric phase I and pharmacokinetic study of erlotinib followed by the combination of erlotinib and temozolomide: a Children's Oncology Group Phase I Consortium Study. J. Clin. Oncol. 2008, 26(30):4921-4927.
    • (2008) J. Clin. Oncol. , vol.26 , Issue.30 , pp. 4921-4927
    • Jakacki, R.I.1
  • 111
    • 73349101900 scopus 로고    scopus 로고
    • Gefitinib in combination with oral topotecan and cyclophosphamide in relapsed neuroblastoma: pharmacological rationale and clinical response
    • Donfrancesco A., et al. Gefitinib in combination with oral topotecan and cyclophosphamide in relapsed neuroblastoma: pharmacological rationale and clinical response. Pediatr. Blood Cancer 2010, 54(1):55-61.
    • (2010) Pediatr. Blood Cancer , vol.54 , Issue.1 , pp. 55-61
    • Donfrancesco, A.1
  • 112
    • 84866734693 scopus 로고    scopus 로고
    • A single-arm pilot phase II study of gefitinib and irinotecan in children with newly diagnosed high-risk neuroblastoma
    • Furman W.L., et al. A single-arm pilot phase II study of gefitinib and irinotecan in children with newly diagnosed high-risk neuroblastoma. Invest. New Drugs 2012, 30(4):1660-1670.
    • (2012) Invest. New Drugs , vol.30 , Issue.4 , pp. 1660-1670
    • Furman, W.L.1
  • 113
    • 77954296673 scopus 로고    scopus 로고
    • Signaling of ERBB receptor tyrosine kinases promotes neuroblastoma growth in vitro and in vivo
    • Richards K.N., et al. Signaling of ERBB receptor tyrosine kinases promotes neuroblastoma growth in vitro and in vivo. Cancer 2010, 116(13):3233-3243.
    • (2010) Cancer , vol.116 , Issue.13 , pp. 3233-3243
    • Richards, K.N.1
  • 114
    • 80054754771 scopus 로고    scopus 로고
    • Phase I trial of lestaurtinib for children with refractory neuroblastoma: a new approaches to neuroblastoma therapy consortium study
    • Minturn J.E., et al. Phase I trial of lestaurtinib for children with refractory neuroblastoma: a new approaches to neuroblastoma therapy consortium study. Cancer Chemother. Pharmacol. 2011, 68(4):1057-1065.
    • (2011) Cancer Chemother. Pharmacol. , vol.68 , Issue.4 , pp. 1057-1065
    • Minturn, J.E.1
  • 115
    • 77649134988 scopus 로고    scopus 로고
    • Lestaurtinib enhances the antitumor efficacy of chemotherapy in murine xenograft models of neuroblastoma
    • Iyer R., et al. Lestaurtinib enhances the antitumor efficacy of chemotherapy in murine xenograft models of neuroblastoma. Clin. Cancer Res. 2010, 16(5):1478-1485.
    • (2010) Clin. Cancer Res. , vol.16 , Issue.5 , pp. 1478-1485
    • Iyer, R.1
  • 116
    • 84866361074 scopus 로고    scopus 로고
    • AZ64 inhibits TrkB and enhances the efficacy of chemotherapy and local radiation in neuroblastoma xenografts
    • Iyer R., et al. AZ64 inhibits TrkB and enhances the efficacy of chemotherapy and local radiation in neuroblastoma xenografts. Cancer Chemother. Pharmacol. 2012, 70(3):477-486.
    • (2012) Cancer Chemother. Pharmacol. , vol.70 , Issue.3 , pp. 477-486
    • Iyer, R.1
  • 117
    • 79952375922 scopus 로고    scopus 로고
    • The selective Trk inhibitor AZ623 inhibits brain-derived neurotrophic factor-mediated neuroblastoma cell proliferation and signaling and is synergistic with topotecan
    • Zage P.E., et al. The selective Trk inhibitor AZ623 inhibits brain-derived neurotrophic factor-mediated neuroblastoma cell proliferation and signaling and is synergistic with topotecan. Cancer 2011, 117(6):1321-1391.
    • (2011) Cancer , vol.117 , Issue.6 , pp. 1321-1391
    • Zage, P.E.1
  • 118
    • 77952577762 scopus 로고    scopus 로고
    • A novel therapeutic combination for neuroblastoma: the vascular endothelial growth factor receptor/epidermal growth factor receptor/rearranged during transfection inhibitor vandetanib with 13-cis-retinoic acid
    • Zage P.E., et al. A novel therapeutic combination for neuroblastoma: the vascular endothelial growth factor receptor/epidermal growth factor receptor/rearranged during transfection inhibitor vandetanib with 13-cis-retinoic acid. Cancer 2010, 116(10):2465-2475.
    • (2010) Cancer , vol.116 , Issue.10 , pp. 2465-2475
    • Zage, P.E.1
  • 119
    • 39749173077 scopus 로고    scopus 로고
    • Potent antitumor effects of ZD6474 on neuroblastoma via dual targeting of tumor cells and tumor endothelium
    • Beaudry P., et al. Potent antitumor effects of ZD6474 on neuroblastoma via dual targeting of tumor cells and tumor endothelium. Mol. Cancer Ther. 2008, 7(2):418-424.
    • (2008) Mol. Cancer Ther. , vol.7 , Issue.2 , pp. 418-424
    • Beaudry, P.1
  • 120
    • 38549164180 scopus 로고    scopus 로고
    • Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing program
    • Maris J.M., et al. Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing program. Pediatr. Blood Cancer 2008, 50(3):581-587.
    • (2008) Pediatr. Blood Cancer , vol.50 , Issue.3 , pp. 581-587
    • Maris, J.M.1
  • 121
    • 84863116086 scopus 로고    scopus 로고
    • Combination testing of cediranib (AZD2171) against childhood cancer models by the pediatric preclinical testing program
    • Morton C.L., et al. Combination testing of cediranib (AZD2171) against childhood cancer models by the pediatric preclinical testing program. Pediatr. Blood Cancer 2012, 58(4):566-571.
    • (2012) Pediatr. Blood Cancer , vol.58 , Issue.4 , pp. 566-571
    • Morton, C.L.1
  • 122
    • 79951833085 scopus 로고    scopus 로고
    • Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells
    • Grinshtein N., et al. Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells. Cancer Res. 2011, 71(4):1385-1395.
    • (2011) Cancer Res. , vol.71 , Issue.4 , pp. 1385-1395
    • Grinshtein, N.1
  • 123
    • 79958249194 scopus 로고    scopus 로고
    • An in-vitro evaluation of the polo-like kinase inhibitor GW843682X against paediatric malignancies
    • Spaniol K., Boos J., Lanvers-Kaminsky C. An in-vitro evaluation of the polo-like kinase inhibitor GW843682X against paediatric malignancies. Anticancer Drugs 2011, 22(6):531-542.
    • (2011) Anticancer Drugs , vol.22 , Issue.6 , pp. 531-542
    • Spaniol, K.1    Boos, J.2    Lanvers-Kaminsky, C.3
  • 124
    • 38749092531 scopus 로고    scopus 로고
    • In vitro antiproliferative and antimigratory activity of dasatinib in neuroblastoma and Ewing sarcoma cell lines
    • Timeus F., et al. In vitro antiproliferative and antimigratory activity of dasatinib in neuroblastoma and Ewing sarcoma cell lines. Oncol. Rep. 2008, 19(2):353-359.
    • (2008) Oncol. Rep. , vol.19 , Issue.2 , pp. 353-359
    • Timeus, F.1
  • 125
    • 70350721795 scopus 로고    scopus 로고
    • Activity of tyrosine kinase inhibitor dasatinib in neuroblastoma cells in vitro and in orthotopic mouse model
    • Vitali R., et al. Activity of tyrosine kinase inhibitor dasatinib in neuroblastoma cells in vitro and in orthotopic mouse model. Int. J. Cancer 2009, 125(11):2547-2555.
    • (2009) Int. J. Cancer , vol.125 , Issue.11 , pp. 2547-2555
    • Vitali, R.1
  • 126
    • 79952543555 scopus 로고    scopus 로고
    • Pazopanib: the newest tyrosine kinase inhibitor for the treatment of advanced or metastatic renal cell carcinoma
    • Keisner S.V., Shah S.R. Pazopanib: the newest tyrosine kinase inhibitor for the treatment of advanced or metastatic renal cell carcinoma. Drugs 2011, 71(4):443-454.
    • (2011) Drugs , vol.71 , Issue.4 , pp. 443-454
    • Keisner, S.V.1    Shah, S.R.2
  • 127
    • 80052495441 scopus 로고    scopus 로고
    • Metronomic oral topotecan with pazopanib is an active antiangiogenic regimen in mouse models of aggressive pediatric solid tumor
    • Kumar S., et al. Metronomic oral topotecan with pazopanib is an active antiangiogenic regimen in mouse models of aggressive pediatric solid tumor. Clin. Cancer Res. 2011, 17(17):5656-5667.
    • (2011) Clin. Cancer Res. , vol.17 , Issue.17 , pp. 5656-5667
    • Kumar, S.1
  • 128
    • 84864927220 scopus 로고    scopus 로고
    • Sorafenib inhibits neuroblastoma cell proliferation and signaling, blocks angiogenesis, and impairs tumor growth
    • Kakodkar N.C., et al. Sorafenib inhibits neuroblastoma cell proliferation and signaling, blocks angiogenesis, and impairs tumor growth. Pediatr. Blood Cancer 2012, 59(4):642-647.
    • (2012) Pediatr. Blood Cancer , vol.59 , Issue.4 , pp. 642-647
    • Kakodkar, N.C.1
  • 129
    • 33846440150 scopus 로고    scopus 로고
    • Food and Drug Administration drug approval summary: sunitinib malate for the treatment of gastrointestinal stromal tumor and advanced renal cell carcinoma
    • Rock E.P., et al. Food and Drug Administration drug approval summary: sunitinib malate for the treatment of gastrointestinal stromal tumor and advanced renal cell carcinoma. Oncologist 2007, 12(1):107-113.
    • (2007) Oncologist , vol.12 , Issue.1 , pp. 107-113
    • Rock, E.P.1
  • 130
    • 65949125105 scopus 로고    scopus 로고
    • In vivo antitumor and antimetastatic activity of sunitinib in preclinical neuroblastoma mouse model
    • Zhang L., et al. In vivo antitumor and antimetastatic activity of sunitinib in preclinical neuroblastoma mouse model. Neoplasia 2009, 11(5):426-435.
    • (2009) Neoplasia , vol.11 , Issue.5 , pp. 426-435
    • Zhang, L.1
  • 131
    • 78651064537 scopus 로고    scopus 로고
    • Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyraz ol-3-yl)p yrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway
    • Ioannidis S., et al. Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyraz ol-3-yl)p yrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway. J. Med. Chem. 2011, 54(1):262-276.
    • (2011) J. Med. Chem. , vol.54 , Issue.1 , pp. 262-276
    • Ioannidis, S.1
  • 132
    • 84879008076 scopus 로고    scopus 로고
    • Inhibition of STAT3 with orally active JAK inhibitor, AZD1480, decreases tumor growth in neuroblastoma and pediatric sarcomas in vitro and in vivo
    • Yan S., Li Z., Thiele C.J. Inhibition of STAT3 with orally active JAK inhibitor, AZD1480, decreases tumor growth in neuroblastoma and pediatric sarcomas in vitro and in vivo. Oncotarget 2013, 4(3):433-445.
    • (2013) Oncotarget , vol.4 , Issue.3 , pp. 433-445
    • Yan, S.1    Li, Z.2    Thiele, C.J.3
  • 133
    • 84868542839 scopus 로고    scopus 로고
    • Pediatric phase I trial and pharmacokinetic study of MLN8237, an investigational oral selective small-molecule inhibitor of Aurora kinase A: a Children's Oncology Group Phase I Consortium study
    • Mosse Y.P., et al. Pediatric phase I trial and pharmacokinetic study of MLN8237, an investigational oral selective small-molecule inhibitor of Aurora kinase A: a Children's Oncology Group Phase I Consortium study. Clin. Cancer Res. 2012, 18(21):6058-6064.
    • (2012) Clin. Cancer Res. , vol.18 , Issue.21 , pp. 6058-6064
    • Mosse, Y.P.1
  • 134
    • 84873094495 scopus 로고    scopus 로고
    • Additive effects of vorinostat and MLN8237 in pediatric leukemia, medulloblastoma, and neuroblastoma cell lines
    • Muscal J.A., et al. Additive effects of vorinostat and MLN8237 in pediatric leukemia, medulloblastoma, and neuroblastoma cell lines. Invest. New Drugs 2013, 31(1):39-45.
    • (2013) Invest. New Drugs , vol.31 , Issue.1 , pp. 39-45
    • Muscal, J.A.1
  • 135
    • 84872470330 scopus 로고    scopus 로고
    • A phase I trial of vorinostat and bortezomib in children with refractory or recurrent solid tumors: a Children's Oncology Group phase I consortium study (ADVL0916)
    • Muscal J.A., et al. A phase I trial of vorinostat and bortezomib in children with refractory or recurrent solid tumors: a Children's Oncology Group phase I consortium study (ADVL0916). Pediatr. Blood Cancer 2013, 60(3):390-395.
    • (2013) Pediatr. Blood Cancer , vol.60 , Issue.3 , pp. 390-395
    • Muscal, J.A.1
  • 136
    • 77953608384 scopus 로고    scopus 로고
    • Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells
    • Panicker J., et al. Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells. Cell Cycle 2010, 9(9):1830-1838.
    • (2010) Cell Cycle , vol.9 , Issue.9 , pp. 1830-1838
    • Panicker, J.1
  • 137
    • 0036828101 scopus 로고    scopus 로고
    • MS-27-275, an inhibitor of histone deacetylase, has marked in vitro and in vivo antitumor activity against pediatric solid tumors
    • Jaboin J., et al. MS-27-275, an inhibitor of histone deacetylase, has marked in vitro and in vivo antitumor activity against pediatric solid tumors. Cancer Res. 2002, 62(21):6108-6115.
    • (2002) Cancer Res. , vol.62 , Issue.21 , pp. 6108-6115
    • Jaboin, J.1
  • 138
    • 62449179465 scopus 로고    scopus 로고
    • Phase I trial of oral irinotecan and temozolomide for children with relapsed high-risk neuroblastoma: a new approach to neuroblastoma therapy consortium study
    • Wagner L.M., et al. Phase I trial of oral irinotecan and temozolomide for children with relapsed high-risk neuroblastoma: a new approach to neuroblastoma therapy consortium study. J. Clin. Oncol. 2009, 27(8):1290-1296.
    • (2009) J. Clin. Oncol. , vol.27 , Issue.8 , pp. 1290-1296
    • Wagner, L.M.1
  • 139
    • 79951975645 scopus 로고    scopus 로고
    • Phase II study of irinotecan and temozolomide in children with relapsed or refractory neuroblastoma: a Children's Oncology Group study
    • Bagatell R., et al. Phase II study of irinotecan and temozolomide in children with relapsed or refractory neuroblastoma: a Children's Oncology Group study. J. Clin. Oncol. 2011, 29(2):208-213.
    • (2011) J. Clin. Oncol. , vol.29 , Issue.2 , pp. 208-213
    • Bagatell, R.1
  • 140
    • 34247390662 scopus 로고    scopus 로고
    • Irinotecan plus temozolomide for relapsed or refractory neuroblastoma
    • Kushner B.H., et al. Irinotecan plus temozolomide for relapsed or refractory neuroblastoma. J. Clin. Oncol. 2006, 24(33):5271-5276.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.33 , pp. 5271-5276
    • Kushner, B.H.1
  • 141
    • 84862803693 scopus 로고    scopus 로고
    • Synthetic lethal screen identifies NF-kappaB as a target for combination therapy with topotecan for patients with neuroblastoma
    • Tsang P.S., et al. Synthetic lethal screen identifies NF-kappaB as a target for combination therapy with topotecan for patients with neuroblastoma. BMC Cancer 2012, 12:101.
    • (2012) BMC Cancer , vol.12 , pp. 101
    • Tsang, P.S.1
  • 142
    • 84867319101 scopus 로고    scopus 로고
    • A chemical screen identifies the chemotherapeutic drug topotecan as a specific inhibitor of the B-MYB/MYCN axis in neuroblastoma
    • Sottile F., et al. A chemical screen identifies the chemotherapeutic drug topotecan as a specific inhibitor of the B-MYB/MYCN axis in neuroblastoma. Oncotarget 2012, 3(5):535-545.
    • (2012) Oncotarget , vol.3 , Issue.5 , pp. 535-545
    • Sottile, F.1
  • 143
    • 33846840786 scopus 로고    scopus 로고
    • Topotecan and etoposide in the treatment of relapsed high-risk neuroblastoma: results of a phase 2 trial
    • Simon T., et al. Topotecan and etoposide in the treatment of relapsed high-risk neuroblastoma: results of a phase 2 trial. J. Pediatr. Hematol. Oncol. 2007, 29(2):101-106.
    • (2007) J. Pediatr. Hematol. Oncol. , vol.29 , Issue.2 , pp. 101-106
    • Simon, T.1
  • 144
    • 34447515226 scopus 로고    scopus 로고
    • Topotecan, cyclophosphamide, and etoposide (TCE) in the treatment of high-risk neuroblastoma. Results of a phase-II trial
    • Simon T., et al. Topotecan, cyclophosphamide, and etoposide (TCE) in the treatment of high-risk neuroblastoma. Results of a phase-II trial. J. Cancer Res. Clin. Oncol. 2007, 133(9):653-661.
    • (2007) J. Cancer Res. Clin. Oncol. , vol.133 , Issue.9 , pp. 653-661
    • Simon, T.1
  • 145
    • 77956245879 scopus 로고    scopus 로고
    • Phase II randomized comparison of topotecan plus cyclophosphamide versus topotecan alone in children with recurrent or refractory neuroblastoma: a Children's Oncology Group study
    • London W.B., et al. Phase II randomized comparison of topotecan plus cyclophosphamide versus topotecan alone in children with recurrent or refractory neuroblastoma: a Children's Oncology Group study. J. Clin. Oncol. 2010, 28(24):3808-3815.
    • (2010) J. Clin. Oncol. , vol.28 , Issue.24 , pp. 3808-3815
    • London, W.B.1
  • 146
    • 84872969840 scopus 로고    scopus 로고
    • Ifosfamide, carboplatin, and etoposide for neuroblastoma: a high-dose salvage regimen and review of the literature
    • Kushner B.H., et al. Ifosfamide, carboplatin, and etoposide for neuroblastoma: a high-dose salvage regimen and review of the literature. Cancer 2013, 119(3):665-671.
    • (2013) Cancer , vol.119 , Issue.3 , pp. 665-671
    • Kushner, B.H.1
  • 147
    • 84871240299 scopus 로고    scopus 로고
    • Preclinical evaluation of the novel 7-substituted camptothecin Namitecan (ST1968) in paediatric tumour models
    • Meco D., et al. Preclinical evaluation of the novel 7-substituted camptothecin Namitecan (ST1968) in paediatric tumour models. Cancer Chemother. Pharmacol. 2012, 70(6):811-822.
    • (2012) Cancer Chemother. Pharmacol. , vol.70 , Issue.6 , pp. 811-822
    • Meco, D.1
  • 148
    • 78149356720 scopus 로고    scopus 로고
    • Antitumor activity and pharmacokinetics of oral gimatecan on pediatric cancer xenografts
    • Zucchetti M., et al. Antitumor activity and pharmacokinetics of oral gimatecan on pediatric cancer xenografts. Cancer Chemother. Pharmacol. 2010, 66(4):635-641.
    • (2010) Cancer Chemother. Pharmacol. , vol.66 , Issue.4 , pp. 635-641
    • Zucchetti, M.1
  • 149
    • 24944437153 scopus 로고    scopus 로고
    • The novel lipophilic camptothecin analogue gimatecan is very active in vitro in human neuroblastoma: a comparative study with SN38 and topotecan
    • Di Francesco A.M., et al. The novel lipophilic camptothecin analogue gimatecan is very active in vitro in human neuroblastoma: a comparative study with SN38 and topotecan. Biochem. Pharmacol. 2005, 70(8):1125-1136.
    • (2005) Biochem. Pharmacol. , vol.70 , Issue.8 , pp. 1125-1136
    • Di Francesco, A.M.1
  • 150
    • 77957565495 scopus 로고    scopus 로고
    • Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I inhibitor
    • Pastorino F., et al. Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I inhibitor. Clin. Cancer Res. 2010, 16(19):4809-4821.
    • (2010) Clin. Cancer Res. , vol.16 , Issue.19 , pp. 4809-4821
    • Pastorino, F.1
  • 151
    • 78649638205 scopus 로고    scopus 로고
    • The quinoxaline anti-tumor agent (R+)XK469 inhibits neuroblastoma tumor growth
    • Kakodkar N.C., et al. The quinoxaline anti-tumor agent (R+)XK469 inhibits neuroblastoma tumor growth. Pediatr. Blood Cancer 2011, 56(1):164-167.
    • (2011) Pediatr. Blood Cancer , vol.56 , Issue.1 , pp. 164-167
    • Kakodkar, N.C.1
  • 152
    • 84876302002 scopus 로고    scopus 로고
    • Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma
    • Gamble L.D., et al. Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma. Front. Oncol. 2012, 2:162.
    • (2012) Front. Oncol. , vol.2 , pp. 162
    • Gamble, L.D.1
  • 153
    • 57149098994 scopus 로고    scopus 로고
    • ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma
    • Hogarty M.D., et al. ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma. Cancer Res. 2008, 68(23):9735-9745.
    • (2008) Cancer Res. , vol.68 , Issue.23 , pp. 9735-9745
    • Hogarty, M.D.1
  • 154
    • 10344225631 scopus 로고    scopus 로고
    • Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin
    • Bagatell R., et al. Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin. Int. J. Cancer 2005, 113(2):179-188.
    • (2005) Int. J. Cancer , vol.113 , Issue.2 , pp. 179-188
    • Bagatell, R.1
  • 155
    • 84858681081 scopus 로고    scopus 로고
    • Anti-tumor activity of the HSP90 inhibitor SNX-2112 in pediatric cancer cell lines
    • Chinn D.C., et al. Anti-tumor activity of the HSP90 inhibitor SNX-2112 in pediatric cancer cell lines. Pediatr. Blood Cancer 2012, 58(6):885-890.
    • (2012) Pediatr. Blood Cancer , vol.58 , Issue.6 , pp. 885-890
    • Chinn, D.C.1
  • 158
    • 84865402562 scopus 로고    scopus 로고
    • Pediatric neuro-oncology: current status and future directions
    • Heath J.A., Zacharoulis S., Kieran M.W. Pediatric neuro-oncology: current status and future directions. Asia Pac. J. Clin. Oncol. 2012, 8(3):223-231.
    • (2012) Asia Pac. J. Clin. Oncol. , vol.8 , Issue.3 , pp. 223-231
    • Heath, J.A.1    Zacharoulis, S.2    Kieran, M.W.3
  • 159
    • 33748112648 scopus 로고    scopus 로고
    • Temozolomide: a milestone in neuro-oncology and beyond?
    • Mutter N., Stupp R. Temozolomide: a milestone in neuro-oncology and beyond?. Expert. Rev. Anticancer. Ther. 2006, 6(8):1187-1204.
    • (2006) Expert. Rev. Anticancer. Ther. , vol.6 , Issue.8 , pp. 1187-1204
    • Mutter, N.1    Stupp, R.2
  • 160
    • 20044372154 scopus 로고    scopus 로고
    • MGMT gene silencing and benefit from temozolomide in glioblastoma
    • Hegi M.E., et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N. Engl. J. Med. 2005, 352(10):997-1003.
    • (2005) N. Engl. J. Med. , vol.352 , Issue.10 , pp. 997-1003
    • Hegi, M.E.1
  • 161
    • 0036499085 scopus 로고    scopus 로고
    • Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide
    • Stupp R., et al. Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide. J. Clin. Oncol. 2002, 20(5):1375-1382.
    • (2002) J. Clin. Oncol. , vol.20 , Issue.5 , pp. 1375-1382
    • Stupp, R.1
  • 162
    • 34147192979 scopus 로고    scopus 로고
    • Temozolomide in children with progressive low-grade glioma
    • Gururangan S., et al. Temozolomide in children with progressive low-grade glioma. Neuro Oncol. 2007, 9(2):161-168.
    • (2007) Neuro Oncol. , vol.9 , Issue.2 , pp. 161-168
    • Gururangan, S.1
  • 163
    • 79955760460 scopus 로고    scopus 로고
    • Temozolomide in the treatment of children with newly diagnosed diffuse intrinsic pontine gliomas: a report from the Children's Oncology Group
    • Cohen K.J., et al. Temozolomide in the treatment of children with newly diagnosed diffuse intrinsic pontine gliomas: a report from the Children's Oncology Group. Neuro Oncol. 2011, 13(4):410-416.
    • (2011) Neuro Oncol. , vol.13 , Issue.4 , pp. 410-416
    • Cohen, K.J.1
  • 164
    • 36749020617 scopus 로고    scopus 로고
    • Phase I trial of single-dose temozolomide and continuous administration of o6-benzylguanine in children with brain tumors: a pediatric brain tumor consortium report
    • Broniscer A., et al. Phase I trial of single-dose temozolomide and continuous administration of o6-benzylguanine in children with brain tumors: a pediatric brain tumor consortium report. Clin. Cancer Res. 2007, 13(22 Pt 1):6712-6718.
    • (2007) Clin. Cancer Res. , vol.13 , Issue.22 PART 1 , pp. 6712-6718
    • Broniscer, A.1
  • 165
    • 84857039925 scopus 로고    scopus 로고
    • A phase II study of O6-benzylguanine and temozolomide in pediatric patients with recurrent or progressive high-grade gliomas and brainstem gliomas: a Pediatric Brain Tumor Consortium study
    • Warren K.E., et al. A phase II study of O6-benzylguanine and temozolomide in pediatric patients with recurrent or progressive high-grade gliomas and brainstem gliomas: a Pediatric Brain Tumor Consortium study. J. Neurooncol. 2012, 106(3):643-649.
    • (2012) J. Neurooncol. , vol.106 , Issue.3 , pp. 643-649
    • Warren, K.E.1
  • 166
    • 84860902287 scopus 로고    scopus 로고
    • Extended survival of glioblastoma patients after chemoprotective HSC gene therapy
    • 133ra57
    • Adair J.E., et al. Extended survival of glioblastoma patients after chemoprotective HSC gene therapy. Sci. Transl. Med. 2012, 4(133):133ra57.
    • (2012) Sci. Transl. Med. , vol.4 , Issue.133
    • Adair, J.E.1
  • 167
    • 78149469318 scopus 로고    scopus 로고
    • Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699
    • Daniel R.A., et al. Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699. Br. J. Cancer 2010, 103(10):1588-1596.
    • (2010) Br. J. Cancer , vol.103 , Issue.10 , pp. 1588-1596
    • Daniel, R.A.1
  • 168
    • 84857129980 scopus 로고    scopus 로고
    • PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation
    • van Vuurden D.G., et al. PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation. Oncotarget 2011, 2(12):984-996.
    • (2011) Oncotarget , vol.2 , Issue.12 , pp. 984-996
    • van Vuurden, D.G.1
  • 169
    • 84864592871 scopus 로고    scopus 로고
    • Molecular subgroups of medulloblastoma
    • Northcott P.A., et al. Molecular subgroups of medulloblastoma. Expert. Rev. Neurother. 2012, 12(7):871-884.
    • (2012) Expert. Rev. Neurother. , vol.12 , Issue.7 , pp. 871-884
    • Northcott, P.A.1
  • 170
    • 77958060845 scopus 로고    scopus 로고
    • Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma
    • Buonamici S., et al. Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma. Sci. Transl. Med. 2010, 2(51):51ra70.
    • (2010) Sci. Transl. Med. , vol.2 , Issue.51
    • Buonamici, S.1
  • 171
    • 4544285754 scopus 로고    scopus 로고
    • Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice
    • Romer J.T., et al. Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice. Cancer Cell 2004, 6(3):229-240.
    • (2004) Cancer Cell , vol.6 , Issue.3 , pp. 229-240
    • Romer, J.T.1
  • 172
    • 34248573807 scopus 로고    scopus 로고
    • Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor
    • Sasai K., et al. Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor. Cancer Res. 2007, 67(8):3871-3877.
    • (2007) Cancer Res. , vol.67 , Issue.8 , pp. 3871-3877
    • Sasai, K.1
  • 173
    • 77952903058 scopus 로고    scopus 로고
    • Vismodegib, a small-molecule inhibitor of the hedgehog pathway for the treatment of advanced cancers
    • De Smaele E., Ferretti E., Gulino A. Vismodegib, a small-molecule inhibitor of the hedgehog pathway for the treatment of advanced cancers. Curr. Opin. Investig. Drugs 2010, 11(6):707-718.
    • (2010) Curr. Opin. Investig. Drugs , vol.11 , Issue.6 , pp. 707-718
    • De Smaele, E.1    Ferretti, E.2    Gulino, A.3
  • 174
    • 79960403317 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation
    • Wong H., et al. Pharmacokinetic-pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation. Clin. Cancer Res. 2011, 17(14):4682-4692.
    • (2011) Clin. Cancer Res. , vol.17 , Issue.14 , pp. 4682-4692
    • Wong, H.1
  • 175
    • 70349244812 scopus 로고    scopus 로고
    • Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
    • Rudin C.M., et al. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N. Engl. J. Med. 2009, 361(12):1173-1178.
    • (2009) N. Engl. J. Med. , vol.361 , Issue.12 , pp. 1173-1178
    • Rudin, C.M.1
  • 176
    • 84861614106 scopus 로고    scopus 로고
    • In vitro and in vivo characterization of a novel Hedgehog signaling antagonist in human glioblastoma cell lines
    • Ferruzzi P., et al. In vitro and in vivo characterization of a novel Hedgehog signaling antagonist in human glioblastoma cell lines. Int. J. Cancer 2012, 131(2):E33-E44.
    • (2012) Int. J. Cancer , vol.131 , Issue.2
    • Ferruzzi, P.1
  • 177
    • 84862908595 scopus 로고    scopus 로고
    • Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier
    • Rohner A., et al. Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier. Mol. Cancer Ther. 2012, 11(1):57-65.
    • (2012) Mol. Cancer Ther. , vol.11 , Issue.1 , pp. 57-65
    • Rohner, A.1
  • 178
    • 84870188356 scopus 로고    scopus 로고
    • A feasibility and efficacy study of rapamycin and erlotinib for recurrent pediatric low-grade glioma (LGG)
    • Yalon M., et al. A feasibility and efficacy study of rapamycin and erlotinib for recurrent pediatric low-grade glioma (LGG). Pediatr. Blood Cancer 2013, 60(1):71-76.
    • (2013) Pediatr. Blood Cancer , vol.60 , Issue.1 , pp. 71-76
    • Yalon, M.1
  • 179
    • 84873653141 scopus 로고    scopus 로고
    • Everolimus long-term safety and efficacy in subependymal giant cell astrocytoma
    • Krueger D.A., et al. Everolimus long-term safety and efficacy in subependymal giant cell astrocytoma. Neurology 2013, 80(6):574-580.
    • (2013) Neurology , vol.80 , Issue.6 , pp. 574-580
    • Krueger, D.A.1
  • 180
    • 77950232139 scopus 로고    scopus 로고
    • Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma
    • Becher O.J., et al. Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma. Cancer Res. 2010, 70(6):2548-2557.
    • (2010) Cancer Res. , vol.70 , Issue.6 , pp. 2548-2557
    • Becher, O.J.1
  • 181
    • 78149467927 scopus 로고    scopus 로고
    • Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas
    • Dougherty M.J., et al. Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas. Neuro Oncol. 2010, 12(7):621-630.
    • (2010) Neuro Oncol. , vol.12 , Issue.7 , pp. 621-630
    • Dougherty, M.J.1
  • 182
    • 77957071661 scopus 로고    scopus 로고
    • Initial testing (stage 1) of AZD6244 (ARRY-142886) by the Pediatric Preclinical Testing Program
    • Kolb E.A., et al. Initial testing (stage 1) of AZD6244 (ARRY-142886) by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 2010, 55(4):668-677.
    • (2010) Pediatr. Blood Cancer , vol.55 , Issue.4 , pp. 668-677
    • Kolb, E.A.1
  • 183
    • 33644838556 scopus 로고    scopus 로고
    • Phase I trial and pharmacokinetic study of the farnesyltransferase
    • Widemann B.C., et al. Phase I trial and pharmacokinetic study of the farnesyltransferase inhibitor tipifarnib in children with refractory solid tumors or neurofibromatosis type I and plexiform neurofibromas. J. Clin. Oncol. 2006, 24(3):507-516.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.3 , pp. 507-516
    • Widemann, B.C.1
  • 184
    • 79955773922 scopus 로고    scopus 로고
    • Phase II trial of tipifarnib and radiation in children with newly diagnosed diffuse intrinsic pontine gliomas
    • Haas-Kogan D.A., et al. Phase II trial of tipifarnib and radiation in children with newly diagnosed diffuse intrinsic pontine gliomas. Neuro Oncol. 2011, 13(3):298-306.
    • (2011) Neuro Oncol. , vol.13 , Issue.3 , pp. 298-306
    • Haas-Kogan, D.A.1
  • 185
    • 77649175483 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of cetuximab and irinotecan in children with refractory solid tumors: a study of the pediatric oncology experimental therapeutic investigators' consortium
    • Trippett T.M., et al. Phase I and pharmacokinetic study of cetuximab and irinotecan in children with refractory solid tumors: a study of the pediatric oncology experimental therapeutic investigators' consortium. J. Clin. Oncol. 2009, 27(30):5102-5108.
    • (2009) J. Clin. Oncol. , vol.27 , Issue.30 , pp. 5102-5108
    • Trippett, T.M.1
  • 186
    • 84855600808 scopus 로고    scopus 로고
    • Super-selective basilar artery infusion of bevacizumab and cetuximab for multiply recurrent pediatric ependymoma
    • Rajappa P., et al. Super-selective basilar artery infusion of bevacizumab and cetuximab for multiply recurrent pediatric ependymoma. Interv. Neuroradiol. 2011, 17(4):459-465.
    • (2011) Interv. Neuroradiol. , vol.17 , Issue.4 , pp. 459-465
    • Rajappa, P.1
  • 187
    • 84876520122 scopus 로고    scopus 로고
    • Treatment of children with high grade glioma with nimotuzumab: a 5-y institutional experience
    • Cabanas R., et al. Treatment of children with high grade glioma with nimotuzumab: a 5-y institutional experience. MAbs 2013, 5(2):202-207.
    • (2013) MAbs , vol.5 , Issue.2 , pp. 202-207
    • Cabanas, R.1
  • 188
    • 84855317387 scopus 로고    scopus 로고
    • Preparation and preclinical evaluation of 177Lu-nimotuzumab targeting epidermal growth factor receptor overexpressing tumors
    • Vera D.R., et al. Preparation and preclinical evaluation of 177Lu-nimotuzumab targeting epidermal growth factor receptor overexpressing tumors. Nucl. Med. Biol. 2012, 39(1):3-13.
    • (2012) Nucl. Med. Biol. , vol.39 , Issue.1 , pp. 3-13
    • Vera, D.R.1
  • 189
    • 33947191055 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma
    • Vredenburgh J.J., et al. Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin. Cancer Res. 2007, 13(4):1253-1259.
    • (2007) Clin. Cancer Res. , vol.13 , Issue.4 , pp. 1253-1259
    • Vredenburgh, J.J.1
  • 190
    • 77954134452 scopus 로고    scopus 로고
    • Bevacizumab in recurrent high-grade pediatric gliomas
    • Narayana A., et al. Bevacizumab in recurrent high-grade pediatric gliomas. Neuro Oncol. 2010, 12(9):985-990.
    • (2010) Neuro Oncol. , vol.12 , Issue.9 , pp. 985-990
    • Narayana, A.1
  • 191
    • 84868029000 scopus 로고    scopus 로고
    • Lack of efficacy of bevacizumab+irinotecan in cases of pediatric recurrent ependymoma-a Pediatric Brain Tumor Consortium study
    • Gururangan S., et al. Lack of efficacy of bevacizumab+irinotecan in cases of pediatric recurrent ependymoma-a Pediatric Brain Tumor Consortium study. Neuro Oncol. 2012, 14(11):1404-1412.
    • (2012) Neuro Oncol. , vol.14 , Issue.11 , pp. 1404-1412
    • Gururangan, S.1
  • 192
    • 66749085796 scopus 로고    scopus 로고
    • Objective response of multiply recurrent low-grade gliomas to bevacizumab and irinotecan
    • Packer R.J., et al. Objective response of multiply recurrent low-grade gliomas to bevacizumab and irinotecan. Pediatr. Blood Cancer 2009, 52(7):791-795.
    • (2009) Pediatr. Blood Cancer , vol.52 , Issue.7 , pp. 791-795
    • Packer, R.J.1
  • 193
    • 59449092893 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic studies of erlotinib administered concurrently with radiotherapy for children, adolescents, and young adults with high-grade glioma
    • Broniscer A., et al. Phase I and pharmacokinetic studies of erlotinib administered concurrently with radiotherapy for children, adolescents, and young adults with high-grade glioma. Clin. Cancer Res. 2009, 15(2):701-707.
    • (2009) Clin. Cancer Res. , vol.15 , Issue.2 , pp. 701-707
    • Broniscer, A.1
  • 194
    • 79951611374 scopus 로고    scopus 로고
    • Innovative Therapies for Children with Cancer pediatric phase I study of erlotinib in brainstem glioma and relapsing/refractory brain tumors
    • Geoerger B., et al. Innovative Therapies for Children with Cancer pediatric phase I study of erlotinib in brainstem glioma and relapsing/refractory brain tumors. Neuro Oncol. 2011, 13(1):109-118.
    • (2011) Neuro Oncol. , vol.13 , Issue.1 , pp. 109-118
    • Geoerger, B.1
  • 195
    • 67649628171 scopus 로고    scopus 로고
    • Antitumor effect in medulloblastoma cells by gefitinib: ectopic HER2 overexpression enhances gefitinib effects in vivo
    • Meco D., et al. Antitumor effect in medulloblastoma cells by gefitinib: ectopic HER2 overexpression enhances gefitinib effects in vivo. Neuro Oncol. 2009, 11(3):250-259.
    • (2009) Neuro Oncol. , vol.11 , Issue.3 , pp. 250-259
    • Meco, D.1
  • 196
    • 33646494170 scopus 로고    scopus 로고
    • Evaluation of gefitinib for treatment of refractory solid tumors and central nervous system malignancies in pediatric patients
    • Freeman B.B., et al. Evaluation of gefitinib for treatment of refractory solid tumors and central nervous system malignancies in pediatric patients. Cancer Invest. 2006, 24(3):310-317.
    • (2006) Cancer Invest. , vol.24 , Issue.3 , pp. 310-317
    • Freeman, B.B.1
  • 197
    • 79955751294 scopus 로고    scopus 로고
    • A phase II study of gefitinib and irradiation in children with newly diagnosed brainstem gliomas: a report from the Pediatric Brain Tumor Consortium
    • Pollack I.F., et al. A phase II study of gefitinib and irradiation in children with newly diagnosed brainstem gliomas: a report from the Pediatric Brain Tumor Consortium. Neuro Oncol. 2011, 13(3):290-297.
    • (2011) Neuro Oncol. , vol.13 , Issue.3 , pp. 290-297
    • Pollack, I.F.1
  • 198
    • 77957961667 scopus 로고    scopus 로고
    • Phase I trial of lapatinib in children with refractory CNS malignancies: a Pediatric Brain Tumor Consortium study
    • Fouladi M., et al. Phase I trial of lapatinib in children with refractory CNS malignancies: a Pediatric Brain Tumor Consortium study. J. Clin. Oncol. 2010, 28(27):4221-4227.
    • (2010) J. Clin. Oncol. , vol.28 , Issue.27 , pp. 4221-4227
    • Fouladi, M.1
  • 199
    • 84878115093 scopus 로고    scopus 로고
    • Profiling pathway-specific novel therapeutics in preclinical assessment for central nervous system atypical teratoid rhabdoid tumors (CNS ATRT): favorable activity of targeting EGFR-ErbB2 signaling with lapatinib
    • Singh A., et al. Profiling pathway-specific novel therapeutics in preclinical assessment for central nervous system atypical teratoid rhabdoid tumors (CNS ATRT): favorable activity of targeting EGFR-ErbB2 signaling with lapatinib. Mol. Oncol. 2013, 7(3):497-512.
    • (2013) Mol. Oncol. , vol.7 , Issue.3 , pp. 497-512
    • Singh, A.1
  • 200
    • 84863206336 scopus 로고    scopus 로고
    • Effects of epidermal growth factor receptor blockade on ependymoma stem cells in vitro and in orthotopic mouse models
    • Servidei T., et al. Effects of epidermal growth factor receptor blockade on ependymoma stem cells in vitro and in orthotopic mouse models. Int. J. Cancer 2012, 131(5):E791-E803.
    • (2012) Int. J. Cancer , vol.131 , Issue.5
    • Servidei, T.1
  • 201
    • 78449260118 scopus 로고    scopus 로고
    • Dual inhibitor AEE788 reduces tumor growth in preclinical models of medulloblastoma
    • Meco D., et al. Dual inhibitor AEE788 reduces tumor growth in preclinical models of medulloblastoma. Transl. Oncol. 2010, 3(5):326-335.
    • (2010) Transl. Oncol. , vol.3 , Issue.5 , pp. 326-335
    • Meco, D.1
  • 202
    • 67651006461 scopus 로고    scopus 로고
    • Kinome profiling in pediatric brain tumors as a new approach for target discovery
    • Sikkema A.H., et al. Kinome profiling in pediatric brain tumors as a new approach for target discovery. Cancer Res. 2009, 69(14):5987-5995.
    • (2009) Cancer Res. , vol.69 , Issue.14 , pp. 5987-5995
    • Sikkema, A.H.1
  • 203
    • 33644785805 scopus 로고    scopus 로고
    • Mutational analysis of PDGFR-RAS/MAPK pathway activation in childhood medulloblastoma
    • Gilbertson R.J., et al. Mutational analysis of PDGFR-RAS/MAPK pathway activation in childhood medulloblastoma. Eur. J. Cancer 2006, 42(5):646-649.
    • (2006) Eur. J. Cancer , vol.42 , Issue.5 , pp. 646-649
    • Gilbertson, R.J.1
  • 204
    • 79960983264 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of sunitinib in pediatric patients with refractory solid tumors: a Children's Oncology Group study
    • Dubois S.G., et al. Phase I and pharmacokinetic study of sunitinib in pediatric patients with refractory solid tumors: a Children's Oncology Group study. Clin. Cancer Res. 2011, 17(15):5113-5122.
    • (2011) Clin. Cancer Res. , vol.17 , Issue.15 , pp. 5113-5122
    • Dubois, S.G.1
  • 205
    • 78149258374 scopus 로고    scopus 로고
    • Phase I study of vandetanib during and after radiotherapy in children with diffuse intrinsic pontine glioma
    • Broniscer A., et al. Phase I study of vandetanib during and after radiotherapy in children with diffuse intrinsic pontine glioma. J. Clin. Oncol. 2010, 28(31):4762-4768.
    • (2010) J. Clin. Oncol. , vol.28 , Issue.31 , pp. 4762-4768
    • Broniscer, A.1
  • 206
    • 84878991908 scopus 로고    scopus 로고
    • Phase I trial, pharmacokinetics, and pharmacodynamics of vandetanib and dasatinib in children with newly diagnosed diffuse intrinsic pontine glioma
    • Broniscer A., et al. Phase I trial, pharmacokinetics, and pharmacodynamics of vandetanib and dasatinib in children with newly diagnosed diffuse intrinsic pontine glioma. Clin. Cancer Res. 2013, 19(11):3050-3058.
    • (2013) Clin. Cancer Res. , vol.19 , Issue.11 , pp. 3050-3058
    • Broniscer, A.1
  • 207
    • 84904880604 scopus 로고    scopus 로고
    • AACR 103rd Annual Meeting, Abstract 847: Foretinib, a multi-kinase inhibitor of cMET and PDGFRα, in the treatment of disseminated medulloblastoma
    • Faria C.C., et al. AACR 103rd Annual Meeting, Abstract 847: Foretinib, a multi-kinase inhibitor of cMET and PDGFRα, in the treatment of disseminated medulloblastoma. Cancer Res. 2012, 72(8 Suppl. 847).
    • (2012) Cancer Res. , vol.72 , Issue.8 SUPPL. 847
    • Faria, C.C.1
  • 208
    • 84857680603 scopus 로고    scopus 로고
    • Polo-like kinase 1 (PLK1) inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells
    • Harris P.S., et al. Polo-like kinase 1 (PLK1) inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells. BMC Cancer 2012, 12:80.
    • (2012) BMC Cancer , vol.12 , pp. 80
    • Harris, P.S.1
  • 209
    • 4344566362 scopus 로고    scopus 로고
    • Results of a phase II upfront window of pharmacokinetically guided topotecan in high-risk medulloblastoma and supratentorial primitive neuroectodermal tumor
    • Stewart C.F., et al. Results of a phase II upfront window of pharmacokinetically guided topotecan in high-risk medulloblastoma and supratentorial primitive neuroectodermal tumor. J. Clin. Oncol. 2004, 22(16):3357-3365.
    • (2004) J. Clin. Oncol. , vol.22 , Issue.16 , pp. 3357-3365
    • Stewart, C.F.1
  • 210
    • 77649150719 scopus 로고    scopus 로고
    • Thiotepa/topotecan/carboplatin with autologous stem cell rescue in recurrent/refractory/poor prognosis pediatric malignancies of the central nervous system
    • Gilheeney S.W., et al. Thiotepa/topotecan/carboplatin with autologous stem cell rescue in recurrent/refractory/poor prognosis pediatric malignancies of the central nervous system. Pediatr. Blood Cancer 2010, 54(4):591-595.
    • (2010) Pediatr. Blood Cancer , vol.54 , Issue.4 , pp. 591-595
    • Gilheeney, S.W.1
  • 211
    • 18344374653 scopus 로고    scopus 로고
    • Phase II study of irinotecan (CPT-11) in children with high-risk malignant brain tumors: the Duke experience
    • Turner C.D., et al. Phase II study of irinotecan (CPT-11) in children with high-risk malignant brain tumors: the Duke experience. Neuro Oncol. 2002, 4(2):102-108.
    • (2002) Neuro Oncol. , vol.4 , Issue.2 , pp. 102-108
    • Turner, C.D.1
  • 212
    • 35648981948 scopus 로고    scopus 로고
    • Phase II trial of irinotecan in children with refractory solid tumors: a Children's Oncology Group study
    • Bomgaars L.R., et al. Phase II trial of irinotecan in children with refractory solid tumors: a Children's Oncology Group study. J. Clin. Oncol. 2007, 25(29):4622-4627.
    • (2007) J. Clin. Oncol. , vol.25 , Issue.29 , pp. 4622-4627
    • Bomgaars, L.R.1
  • 213
    • 84876693211 scopus 로고    scopus 로고
    • Response to bevacizumab, irinotecan, and temozolomide in children with relapsed medulloblastoma: a multi-institutional experience
    • Aguilera D., et al. Response to bevacizumab, irinotecan, and temozolomide in children with relapsed medulloblastoma: a multi-institutional experience. Childs Nerv. Syst. 2013, 29(4):589-596.
    • (2013) Childs Nerv. Syst. , vol.29 , Issue.4 , pp. 589-596
    • Aguilera, D.1
  • 214
    • 78049256758 scopus 로고    scopus 로고
    • Phase I study of temozolomide combined with oral etoposide in children with recurrent or progressive medulloblastoma
    • Ruggiero A., et al. Phase I study of temozolomide combined with oral etoposide in children with recurrent or progressive medulloblastoma. Eur. J. Cancer 2010, 46(16):2943-2949.
    • (2010) Eur. J. Cancer , vol.46 , Issue.16 , pp. 2943-2949
    • Ruggiero, A.1
  • 215
    • 0036323367 scopus 로고    scopus 로고
    • Activity of postoperative carboplatin, etoposide, and high-dose methotrexate in pediatric CNS embryonal tumors: results of a phase II study in newly diagnosed children
    • Kellie S.J., et al. Activity of postoperative carboplatin, etoposide, and high-dose methotrexate in pediatric CNS embryonal tumors: results of a phase II study in newly diagnosed children. Med. Pediatr. Oncol. 2002, 39(3):168-174.
    • (2002) Med. Pediatr. Oncol. , vol.39 , Issue.3 , pp. 168-174
    • Kellie, S.J.1
  • 216
    • 83455188335 scopus 로고    scopus 로고
    • Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program
    • Houghton P.J., et al. Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program. Pediatr. Blood Cancer 2012, 58(2):200-209.
    • (2012) Pediatr. Blood Cancer , vol.58 , Issue.2 , pp. 200-209
    • Houghton, P.J.1
  • 217
    • 79551691082 scopus 로고    scopus 로고
    • Phase 1 study of valproic acid in pediatric patients with refractory solid or CNS tumors: a children's oncology group report
    • Su J.M., et al. Phase 1 study of valproic acid in pediatric patients with refractory solid or CNS tumors: a children's oncology group report. Clin. Cancer Res. 2011, 17(3):589-597.
    • (2011) Clin. Cancer Res. , vol.17 , Issue.3 , pp. 589-597
    • Su, J.M.1
  • 218
    • 84859520520 scopus 로고    scopus 로고
    • Histone deacetylase inhibition decreases proliferation and potentiates the effect of ionizing radiation in atypical teratoid/rhabdoid tumor cells
    • Knipstein J.A., et al. Histone deacetylase inhibition decreases proliferation and potentiates the effect of ionizing radiation in atypical teratoid/rhabdoid tumor cells. Neuro Oncol. 2012, 14(2):175-183.
    • (2012) Neuro Oncol. , vol.14 , Issue.2 , pp. 175-183
    • Knipstein, J.A.1
  • 219
    • 84871275799 scopus 로고    scopus 로고
    • HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment
    • Milde T., et al. HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment. J. Neurooncol 2012, 110(3):335-348.
    • (2012) J. Neurooncol , vol.110 , Issue.3 , pp. 335-348
    • Milde, T.1
  • 220
    • 84880349569 scopus 로고    scopus 로고
    • A pediatric phase 1 trial of vorinostat and temozolomide in relapsed or refractory primary brain or spinal cord tumors: a Children's Oncology Group phase 1 consortium study
    • Hummel T.R., et al. A pediatric phase 1 trial of vorinostat and temozolomide in relapsed or refractory primary brain or spinal cord tumors: a Children's Oncology Group phase 1 consortium study. Pediatr. Blood Cancer 2013, 60(9):1452-1457.
    • (2013) Pediatr. Blood Cancer , vol.60 , Issue.9 , pp. 1452-1457
    • Hummel, T.R.1
  • 221
    • 84876290812 scopus 로고    scopus 로고
    • Aurora kinase B is a potential therapeutic target in pediatric diffuse intrinsic pontine glioma
    • Buczkowicz P., et al. Aurora kinase B is a potential therapeutic target in pediatric diffuse intrinsic pontine glioma. Brain Pathol. 2013, 23(3):244-253.
    • (2013) Brain Pathol. , vol.23 , Issue.3 , pp. 244-253
    • Buczkowicz, P.1
  • 222
    • 84866437189 scopus 로고    scopus 로고
    • 17AEP-GA, an HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion
    • Miekus K., et al. 17AEP-GA, an HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion. Oncol. Rep. 2012, 28(5):1903-1909.
    • (2012) Oncol. Rep. , vol.28 , Issue.5 , pp. 1903-1909
    • Miekus, K.1
  • 223
    • 77952219448 scopus 로고    scopus 로고
    • Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma
    • (210)
    • Gaspar N., et al. Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma. Mol. Cancer Ther. 2010, 9(5):1219-1233. (210).
    • (2010) Mol. Cancer Ther. , vol.9 , Issue.5 , pp. 1219-1233
    • Gaspar, N.1
  • 224
    • 34250182069 scopus 로고    scopus 로고
    • A phase I study of 17-allylaminogeldanamycin in relapsed/refractory pediatric patients with solid tumors: a Children's Oncology Group study
    • Weigel B.J., et al. A phase I study of 17-allylaminogeldanamycin in relapsed/refractory pediatric patients with solid tumors: a Children's Oncology Group study. Clin. Cancer Res. 2007, 13(6):1789-1793.
    • (2007) Clin. Cancer Res. , vol.13 , Issue.6 , pp. 1789-1793
    • Weigel, B.J.1
  • 225
    • 84859545351 scopus 로고    scopus 로고
    • Biologically targeted therapeutics in pediatric brain tumors
    • Nageswara Rao A.A., et al. Biologically targeted therapeutics in pediatric brain tumors. Pediatr. Neurol. 2012, 46(4):203-211.
    • (2012) Pediatr. Neurol. , vol.46 , Issue.4 , pp. 203-211
    • Nageswara Rao, A.A.1
  • 226
    • 84864349591 scopus 로고    scopus 로고
    • Pediatric sarcomas: translating molecular pathogenesis of disease to novel therapeutic possibilities
    • Anderson J.L., et al. Pediatric sarcomas: translating molecular pathogenesis of disease to novel therapeutic possibilities. Pediatr. Res. 2012, 72(2):112-121.
    • (2012) Pediatr. Res. , vol.72 , Issue.2 , pp. 112-121
    • Anderson, J.L.1
  • 228
    • 84859079973 scopus 로고    scopus 로고
    • Childhood rhabdomyosarcoma: recent advances and prospective views
    • Wang C. Childhood rhabdomyosarcoma: recent advances and prospective views. J. Dent. Res. 2012, 91(4):341-350.
    • (2012) J. Dent. Res. , vol.91 , Issue.4 , pp. 341-350
    • Wang, C.1
  • 229
    • 47249160783 scopus 로고    scopus 로고
    • Ewing sarcoma: historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future
    • Ludwig J.A. Ewing sarcoma: historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future. Curr. Opin. Oncol. 2008, 20(4):412-418.
    • (2008) Curr. Opin. Oncol. , vol.20 , Issue.4 , pp. 412-418
    • Ludwig, J.A.1
  • 230
    • 3543026281 scopus 로고    scopus 로고
    • EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3
    • Prieur A., et al. EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Mol. Cell. Biol. 2004, 24(16):7275-7283.
    • (2004) Mol. Cell. Biol. , vol.24 , Issue.16 , pp. 7275-7283
    • Prieur, A.1
  • 231
    • 57749101153 scopus 로고    scopus 로고
    • EWS-Fli1 up-regulates expression of the Aurora A and Aurora B kinases
    • Wakahara K., et al. EWS-Fli1 up-regulates expression of the Aurora A and Aurora B kinases. Mol. Cancer Res. 2008, 6(12):1937-1945.
    • (2008) Mol. Cancer Res. , vol.6 , Issue.12 , pp. 1937-1945
    • Wakahara, K.1
  • 232
    • 84879591354 scopus 로고    scopus 로고
    • Type 1 insulin growth factor receptor targeted therapies in pediatric cancer
    • Wager M.J., Maki R.G. Type 1 insulin growth factor receptor targeted therapies in pediatric cancer. Front. Oncol. 2013, 3:9.
    • (2013) Front. Oncol. , vol.3 , pp. 9
    • Wager, M.J.1    Maki, R.G.2
  • 233
    • 73149120253 scopus 로고    scopus 로고
    • BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR
    • Carboni J.M., et al. BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR. Mol. Cancer Ther. 2009, 8(12):3341-3349.
    • (2009) Mol. Cancer Ther. , vol.8 , Issue.12 , pp. 3341-3349
    • Carboni, J.M.1
  • 234
    • 20944447905 scopus 로고    scopus 로고
    • Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors
    • Scotlandi K., et al. Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors. Cancer Res. 2005, 65(9):3868-3876.
    • (2005) Cancer Res. , vol.65 , Issue.9 , pp. 3868-3876
    • Scotlandi, K.1
  • 235
    • 73349099049 scopus 로고    scopus 로고
    • Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1
    • Tolcher A.W., et al. Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1. J. Clin. Oncol. 2009, 27(34):5800-5807.
    • (2009) J. Clin. Oncol. , vol.27 , Issue.34 , pp. 5800-5807
    • Tolcher, A.W.1
  • 236
    • 83255163333 scopus 로고    scopus 로고
    • R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research through Collaboration study
    • Pappo A.S., et al. R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research through Collaboration study. J. Clin. Oncol. 2011, 29(34):4541-4547.
    • (2011) J. Clin. Oncol. , vol.29 , Issue.34 , pp. 4541-4547
    • Pappo, A.S.1
  • 237
    • 80053062871 scopus 로고    scopus 로고
    • Preliminary efficacy of the anti-insulin-like growth factor type 1 receptor antibody figitumumab in patients with refractory Ewing sarcoma
    • Juergens H., et al. Preliminary efficacy of the anti-insulin-like growth factor type 1 receptor antibody figitumumab in patients with refractory Ewing sarcoma. J. Clin. Oncol. 2011, 29(34):4534-4540.
    • (2011) J. Clin. Oncol. , vol.29 , Issue.34 , pp. 4534-4540
    • Juergens, H.1
  • 238
    • 84862907964 scopus 로고    scopus 로고
    • Phase I/II trial and pharmacokinetic study of cixutumumab in pediatric patients with refractory solid tumors and Ewing sarcoma: a report from the Children's Oncology Group
    • Malempati S., et al. Phase I/II trial and pharmacokinetic study of cixutumumab in pediatric patients with refractory solid tumors and Ewing sarcoma: a report from the Children's Oncology Group. J. Clin. Oncol. 2012, 30(3):256-262.
    • (2012) J. Clin. Oncol. , vol.30 , Issue.3 , pp. 256-262
    • Malempati, S.1
  • 239
    • 80054000380 scopus 로고    scopus 로고
    • An integrated chemical biology approach identifies specific vulnerability of Ewing's sarcoma to combined inhibition of Aurora kinases A and B
    • Winter G.E., et al. An integrated chemical biology approach identifies specific vulnerability of Ewing's sarcoma to combined inhibition of Aurora kinases A and B. Mol. Cancer Ther. 2011, 10(10):1846-1856.
    • (2011) Mol. Cancer Ther. , vol.10 , Issue.10 , pp. 1846-1856
    • Winter, G.E.1
  • 240
    • 0037146220 scopus 로고    scopus 로고
    • Potential use of imatinib in Ewing's Sarcoma: evidence for in vitro and in vivo activity
    • Merchant M.S., et al. Potential use of imatinib in Ewing's Sarcoma: evidence for in vitro and in vivo activity. J. Natl. Cancer Inst. 2002, 94(22):1673-1679.
    • (2002) J. Natl. Cancer Inst. , vol.94 , Issue.22 , pp. 1673-1679
    • Merchant, M.S.1
  • 241
    • 37549041711 scopus 로고    scopus 로고
    • A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: a Children's Oncology Group study
    • Bond M., et al. A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: a Children's Oncology Group study. Pediatr. Blood Cancer 2008, 50(2):254-258.
    • (2008) Pediatr. Blood Cancer , vol.50 , Issue.2 , pp. 254-258
    • Bond, M.1
  • 242
    • 77950547753 scopus 로고    scopus 로고
    • Phase II clinical trial of imatinib mesylate in therapy of KIT and/or PDGFRalpha-expressing Ewing sarcoma family of tumors and desmoplastic small round cell tumors
    • Chao J., et al. Phase II clinical trial of imatinib mesylate in therapy of KIT and/or PDGFRalpha-expressing Ewing sarcoma family of tumors and desmoplastic small round cell tumors. Anticancer Res. 2010, 30(2):547-552.
    • (2010) Anticancer Res. , vol.30 , Issue.2 , pp. 547-552
    • Chao, J.1
  • 243
    • 84863861217 scopus 로고    scopus 로고
    • Initial testing of the multitargeted kinase inhibitor pazopanib by the Pediatric Preclinical Testing Program
    • Keir S.T., et al. Initial testing of the multitargeted kinase inhibitor pazopanib by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 2012, 59(3):586-588.
    • (2012) Pediatr. Blood Cancer , vol.59 , Issue.3 , pp. 586-588
    • Keir, S.T.1
  • 244
    • 39049101435 scopus 로고    scopus 로고
    • Proliferation of Ewing sarcoma cell lines is suppressed by the receptor tyrosine kinase inhibitors gefitinib and vandetanib
    • Andersson M.K., Aman P. Proliferation of Ewing sarcoma cell lines is suppressed by the receptor tyrosine kinase inhibitors gefitinib and vandetanib. Cancer Cell Int. 2008, 8:1.
    • (2008) Cancer Cell Int. , vol.8 , pp. 1
    • Andersson, M.K.1    Aman, P.2
  • 245
    • 84877829741 scopus 로고    scopus 로고
    • Expression and clinical relevance of MET and ALK in Ewing sarcomas
    • Fleuren E.D., et al. Expression and clinical relevance of MET and ALK in Ewing sarcomas. Int. J. Cancer 2013, 133(2):427-436.
    • (2013) Int. J. Cancer , vol.133 , Issue.2 , pp. 427-436
    • Fleuren, E.D.1
  • 246
    • 67651205908 scopus 로고    scopus 로고
    • Initial testing (stage 1) of vorinostat (SAHA) by the pediatric preclinical testing program
    • Keshelava N., et al. Initial testing (stage 1) of vorinostat (SAHA) by the pediatric preclinical testing program. Pediatr. Blood Cancer 2009, 53(3):505-508.
    • (2009) Pediatr. Blood Cancer , vol.53 , Issue.3 , pp. 505-508
    • Keshelava, N.1
  • 247
    • 84861203569 scopus 로고    scopus 로고
    • Initial testing (Stage 1) of AT13387, an HSP90 inhibitor, by the pediatric preclinical testing program
    • Kang M.H., et al. Initial testing (Stage 1) of AT13387, an HSP90 inhibitor, by the pediatric preclinical testing program. Pediatr. Blood Cancer 2012, 59(1):185-188.
    • (2012) Pediatr. Blood Cancer , vol.59 , Issue.1 , pp. 185-188
    • Kang, M.H.1
  • 248
    • 33646070305 scopus 로고    scopus 로고
    • High histologic and overall response to dose intensification of ifosfamide, carboplatin, and etoposide with cyclophosphamide, doxorubicin, and vincristine in patients with high-risk Ewing sarcoma family tumors: the Bambino Gesu Children's Hospital experience
    • Milano G.M., et al. High histologic and overall response to dose intensification of ifosfamide, carboplatin, and etoposide with cyclophosphamide, doxorubicin, and vincristine in patients with high-risk Ewing sarcoma family tumors: the Bambino Gesu Children's Hospital experience. Cancer 2006, 106(8):1838-1845.
    • (2006) Cancer , vol.106 , Issue.8 , pp. 1838-1845
    • Milano, G.M.1
  • 249
    • 71049179078 scopus 로고    scopus 로고
    • Irinotecan and temozolomide for Ewing sarcoma: the Memorial Sloan-Kettering experience
    • Casey D.A., et al. Irinotecan and temozolomide for Ewing sarcoma: the Memorial Sloan-Kettering experience. Pediatr. Blood Cancer 2009, 53(6):1029-1034.
    • (2009) Pediatr. Blood Cancer , vol.53 , Issue.6 , pp. 1029-1034
    • Casey, D.A.1
  • 250
    • 84880264480 scopus 로고    scopus 로고
    • Cyclophosphamide and topotecan as first-line salvage therapy in patients with relapsed Ewing sarcoma at a single institution
    • Farhat R., et al. Cyclophosphamide and topotecan as first-line salvage therapy in patients with relapsed Ewing sarcoma at a single institution. J. Pediatr. Hematol. Oncol. 2012, 35(5):356-360.
    • (2012) J. Pediatr. Hematol. Oncol. , vol.35 , Issue.5 , pp. 356-360
    • Farhat, R.1
  • 251
    • 84875154824 scopus 로고    scopus 로고
    • A modified protocol with vincristine, topotecan, and cyclophosphamide for recurrent/progressive Ewing sarcoma family tumors
    • Kebudi R., et al. A modified protocol with vincristine, topotecan, and cyclophosphamide for recurrent/progressive Ewing sarcoma family tumors. Pediatr. Hematol. Oncol. 2013, 30(3):170-177.
    • (2013) Pediatr. Hematol. Oncol. , vol.30 , Issue.3 , pp. 170-177
    • Kebudi, R.1
  • 252
    • 84861234062 scopus 로고    scopus 로고
    • The curative efficacy of namitecan (ST1968) in preclinical models of pediatric sarcoma is associated with antiangiogenic effects
    • Cassinelli G., et al. The curative efficacy of namitecan (ST1968) in preclinical models of pediatric sarcoma is associated with antiangiogenic effects. Biochem. Pharmacol. 2012, 84(2):163-171.
    • (2012) Biochem. Pharmacol. , vol.84 , Issue.2 , pp. 163-171
    • Cassinelli, G.1
  • 253
    • 84895999135 scopus 로고    scopus 로고
    • Targeting receptor tyrosine kinases in osteosarcoma and Ewing sarcoma: current hurdles and future perspectives
    • Fleuren E.D.G., et al. Targeting receptor tyrosine kinases in osteosarcoma and Ewing sarcoma: current hurdles and future perspectives. Biochim. Biophys. Acta 2014, 1845(2):266-276.
    • (2014) Biochim. Biophys. Acta , vol.1845 , Issue.2 , pp. 266-276
    • Fleuren, E.D.G.1
  • 255
    • 0029826488 scopus 로고    scopus 로고
    • Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins
    • Bernasconi M., et al. Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins. Proc. Natl. Acad. Sci. U. S. A. 1996, 93(23):13164-13169.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , Issue.23 , pp. 13164-13169
    • Bernasconi, M.1
  • 256
    • 0035141850 scopus 로고    scopus 로고
    • Regulating the neoplastic phenotype using engineered transcriptional repressors
    • Fredericks W.J., Ayyanathan K., Rauscher F.J. Regulating the neoplastic phenotype using engineered transcriptional repressors. Cancer Lett. 2001, 162(Suppl.):S23-S32.
    • (2001) Cancer Lett. , vol.162 , Issue.SUPPL.
    • Fredericks, W.J.1    Ayyanathan, K.2    Rauscher, F.J.3
  • 257
    • 18044369834 scopus 로고    scopus 로고
    • Lack of effective T-lymphocyte response to the PAX3/FKHR translocation area in alveolar rhabdomyosarcoma
    • Rodeberg D.A., et al. Lack of effective T-lymphocyte response to the PAX3/FKHR translocation area in alveolar rhabdomyosarcoma. Cancer Immunol. Immunother. 2005, 54(6):526-534.
    • (2005) Cancer Immunol. Immunother. , vol.54 , Issue.6 , pp. 526-534
    • Rodeberg, D.A.1
  • 258
    • 0026425601 scopus 로고
    • All-trans-retinoic acid inhibits the growth of human rhabdomyosarcoma cell lines
    • Crouch G.D., Helman L.J. All-trans-retinoic acid inhibits the growth of human rhabdomyosarcoma cell lines. Cancer Res. 1991, 51(18):4882-4887.
    • (1991) Cancer Res. , vol.51 , Issue.18 , pp. 4882-4887
    • Crouch, G.D.1    Helman, L.J.2
  • 259
    • 0027177647 scopus 로고
    • TPA-induced differentiation of human rhabdomyosarcoma cells: expression of the myogenic regulatory factors
    • Bouche M., et al. TPA-induced differentiation of human rhabdomyosarcoma cells: expression of the myogenic regulatory factors. Exp. Cell Res. 1993, 208(1):209-217.
    • (1993) Exp. Cell Res. , vol.208 , Issue.1 , pp. 209-217
    • Bouche, M.1
  • 260
    • 84872867292 scopus 로고    scopus 로고
    • A. Boro, and B.W. Schafer, Cell-based small-molecule compound screen identifies fenretinide as potential therapeutic for translocation-positive rhabdomyosarcoma
    • Herrero Martin D. A. Boro, and B.W. Schafer, Cell-based small-molecule compound screen identifies fenretinide as potential therapeutic for translocation-positive rhabdomyosarcoma. PLoS One 2013, 8(1):e55072.
    • (2013) PLoS One , vol.8 , Issue.1
    • Herrero Martin, D.1
  • 261
    • 0036851869 scopus 로고    scopus 로고
    • Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis
    • Sharp R., et al. Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis. Nat. Med. 2002, 8(11):1276-1280.
    • (2002) Nat. Med. , vol.8 , Issue.11 , pp. 1276-1280
    • Sharp, R.1
  • 262
    • 33646404053 scopus 로고    scopus 로고
    • Validation of met as a therapeutic target in alveolar and embryonal rhabdomyosarcoma
    • Taulli R., et al. Validation of met as a therapeutic target in alveolar and embryonal rhabdomyosarcoma. Cancer Res. 2006, 66(9):4742-4749.
    • (2006) Cancer Res. , vol.66 , Issue.9 , pp. 4742-4749
    • Taulli, R.1
  • 263
    • 79955897803 scopus 로고    scopus 로고
    • Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274
    • Hou J., et al. Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274. J. Transl. Med. 2011, 9:64.
    • (2011) J. Transl. Med. , vol.9 , pp. 64
    • Hou, J.1
  • 264
    • 0031861728 scopus 로고    scopus 로고
    • Tumor-specific PAX3-FKHR transcription factor, but not PAX3, activates the platelet-derived growth factor alpha receptor
    • Epstein J.A., et al. Tumor-specific PAX3-FKHR transcription factor, but not PAX3, activates the platelet-derived growth factor alpha receptor. Mol. Cell. Biol. 1998, 18(7):4118-4130.
    • (1998) Mol. Cell. Biol. , vol.18 , Issue.7 , pp. 4118-4130
    • Epstein, J.A.1
  • 265
    • 55249083566 scopus 로고    scopus 로고
    • PDGFR-A is a therapeutic target in alveolar rhabdomyosarcoma
    • Taniguchi E., et al. PDGFR-A is a therapeutic target in alveolar rhabdomyosarcoma. Oncogene 2008, 27(51):6550-6560.
    • (2008) Oncogene , vol.27 , Issue.51 , pp. 6550-6560
    • Taniguchi, E.1
  • 266
    • 84876010686 scopus 로고    scopus 로고
    • Distinct effects of ligand-induced PDGFRalpha and PDGFRbeta signaling in the human rhabdomyosarcoma tumor cell and stroma cell compartments
    • Ehnman M., et al. Distinct effects of ligand-induced PDGFRalpha and PDGFRbeta signaling in the human rhabdomyosarcoma tumor cell and stroma cell compartments. Cancer Res. 2013, 73(7):2139-2149.
    • (2013) Cancer Res. , vol.73 , Issue.7 , pp. 2139-2149
    • Ehnman, M.1
  • 267
    • 0028053410 scopus 로고
    • In vivo treatment with antibody against IGF-1 receptor suppresses growth of human rhabdomyosarcoma and down-regulates p34cdc2
    • Kalebic T., Tsokos M., Helman L.J. In vivo treatment with antibody against IGF-1 receptor suppresses growth of human rhabdomyosarcoma and down-regulates p34cdc2. Cancer Res. 1994, 54(21):5531-5534.
    • (1994) Cancer Res. , vol.54 , Issue.21 , pp. 5531-5534
    • Kalebic, T.1    Tsokos, M.2    Helman, L.J.3
  • 268
    • 77951747892 scopus 로고    scopus 로고
    • Initial testing of a monoclonal antibody (IMC-A12) against IGF-1R by the Pediatric Preclinical Testing Program
    • Houghton P.J., et al. Initial testing of a monoclonal antibody (IMC-A12) against IGF-1R by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 2010, 54(7):921-926.
    • (2010) Pediatr. Blood Cancer , vol.54 , Issue.7 , pp. 921-926
    • Houghton, P.J.1
  • 269
    • 78649846572 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 receptor antibody induces rhabdomyosarcoma cell death via a process involving AKT and Bcl-x(L)
    • Mayeenuddin L.H., et al. Insulin-like growth factor 1 receptor antibody induces rhabdomyosarcoma cell death via a process involving AKT and Bcl-x(L). Oncogene 2010, 29(48):6367-6377.
    • (2010) Oncogene , vol.29 , Issue.48 , pp. 6367-6377
    • Mayeenuddin, L.H.1
  • 270
    • 33947538050 scopus 로고    scopus 로고
    • Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism
    • Wan X., et al. Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene 2007, 26(13):1932-1940.
    • (2007) Oncogene , vol.26 , Issue.13 , pp. 1932-1940
    • Wan, X.1
  • 271
    • 33748757159 scopus 로고    scopus 로고
    • Down-regulation of c-Myc following MEK/ERK inhibition halts the expression of malignant phenotype in rhabdomyosarcoma and in non muscle-derived human tumors
    • Marampon F., Ciccarelli C., Zani B.M. Down-regulation of c-Myc following MEK/ERK inhibition halts the expression of malignant phenotype in rhabdomyosarcoma and in non muscle-derived human tumors. Mol. Cancer 2006, 5:31.
    • (2006) Mol. Cancer , vol.5 , pp. 31
    • Marampon, F.1    Ciccarelli, C.2    Zani, B.M.3
  • 272
    • 66449129841 scopus 로고    scopus 로고
    • MEK/ERK inhibitor U0126 affects in vitro and in vivo growth of embryonal rhabdomyosarcoma
    • Marampon F., et al. MEK/ERK inhibitor U0126 affects in vitro and in vivo growth of embryonal rhabdomyosarcoma. Mol. Cancer Ther. 2009, 8(3):543-551.
    • (2009) Mol. Cancer Ther. , vol.8 , Issue.3 , pp. 543-551
    • Marampon, F.1
  • 273
    • 84855993158 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase aberrations in rhabdomyosarcoma: clinical and prognostic implications
    • van Gaal J.C., et al. Anaplastic lymphoma kinase aberrations in rhabdomyosarcoma: clinical and prognostic implications. J. Clin. Oncol. 2012, 30(3):308-315.
    • (2012) J. Clin. Oncol. , vol.30 , Issue.3 , pp. 308-315
    • van Gaal, J.C.1
  • 274
    • 84885182752 scopus 로고    scopus 로고
    • Simultaneous targeting of insulin-like growth factor-1 receptor and anaplastic lymphoma kinase in embryonal and alveolar rhabdomyosarcoma: a rational choice
    • van Gaal J.C., et al. Simultaneous targeting of insulin-like growth factor-1 receptor and anaplastic lymphoma kinase in embryonal and alveolar rhabdomyosarcoma: a rational choice. Eur. J. Cancer 2013, 49(16):3462-3470.
    • (2013) Eur. J. Cancer , vol.49 , Issue.16 , pp. 3462-3470
    • van Gaal, J.C.1
  • 275
    • 79959349882 scopus 로고    scopus 로고
    • Preclinical testing of erlotinib in a transgenic alveolar rhabdomyosarcoma mouse model
    • Abraham J., et al. Preclinical testing of erlotinib in a transgenic alveolar rhabdomyosarcoma mouse model. Sarcoma 2011, 2011:130484.
    • (2011) Sarcoma , vol.2011 , pp. 130484
    • Abraham, J.1
  • 276
    • 44149091042 scopus 로고    scopus 로고
    • Stage 1 testing and pharmacodynamic evaluation of the HSP90 inhibitor alvespimycin (17-DMAG, KOS-1022) by the pediatric preclinical testing program
    • Smith M.A., et al. Stage 1 testing and pharmacodynamic evaluation of the HSP90 inhibitor alvespimycin (17-DMAG, KOS-1022) by the pediatric preclinical testing program. Pediatr. Blood Cancer 2008, 51(1):34-41.
    • (2008) Pediatr. Blood Cancer , vol.51 , Issue.1 , pp. 34-41
    • Smith, M.A.1
  • 277
    • 70350225462 scopus 로고    scopus 로고
    • High anti tumor activity against rhabdomyosarcoma cells and low normal cells cytotoxicity of heat shock protein 90 inhibitors, with special emphasis on 17-[2-(pyrrolidin-1-yl)ethyl]-aminno-17-demethoxygeldanamycin
    • Lukasiewicz E., et al. High anti tumor activity against rhabdomyosarcoma cells and low normal cells cytotoxicity of heat shock protein 90 inhibitors, with special emphasis on 17-[2-(pyrrolidin-1-yl)ethyl]-aminno-17-demethoxygeldanamycin. J. Physiol. Pharmacol. 2009, 60(3):161-166.
    • (2009) J. Physiol. Pharmacol. , vol.60 , Issue.3 , pp. 161-166
    • Lukasiewicz, E.1
  • 278
    • 14644406812 scopus 로고    scopus 로고
    • Ifosfamide, carboplatin, and etoposide (ICE) reinduction chemotherapy in a large cohort of children and adolescents with recurrent/refractory sarcoma: the Children's Cancer Group (CCG) experience
    • Van Winkle P., et al. Ifosfamide, carboplatin, and etoposide (ICE) reinduction chemotherapy in a large cohort of children and adolescents with recurrent/refractory sarcoma: the Children's Cancer Group (CCG) experience. Pediatr. Blood Cancer 2005, 44(4):338-347.
    • (2005) Pediatr. Blood Cancer , vol.44 , Issue.4 , pp. 338-347
    • Van Winkle, P.1
  • 279
    • 40449142495 scopus 로고    scopus 로고
    • Treatment of children with metastatic soft tissue sarcoma with oral maintenance compared to high dose chemotherapy: report of the HD CWS-96 trial
    • Klingebiel T., et al. Treatment of children with metastatic soft tissue sarcoma with oral maintenance compared to high dose chemotherapy: report of the HD CWS-96 trial. Pediatr. Blood Cancer 2008, 50(4):739-745.
    • (2008) Pediatr. Blood Cancer , vol.50 , Issue.4 , pp. 739-745
    • Klingebiel, T.1
  • 280
    • 33846990454 scopus 로고    scopus 로고
    • Phase II trial of irinotecan in children with relapsed or refractory rhabdomyosarcoma: a joint study of the French Society of Pediatric Oncology and the United Kingdom Children's Cancer Study Group
    • Vassal G., et al. Phase II trial of irinotecan in children with relapsed or refractory rhabdomyosarcoma: a joint study of the French Society of Pediatric Oncology and the United Kingdom Children's Cancer Study Group. J. Clin. Oncol. 2007, 25(4):356-361.
    • (2007) J. Clin. Oncol. , vol.25 , Issue.4 , pp. 356-361
    • Vassal, G.1
  • 281
    • 33846951814 scopus 로고    scopus 로고
    • Two consecutive phase II window trials of irinotecan alone or in combination with vincristine for the treatment of metastatic rhabdomyosarcoma: the Children's Oncology Group
    • Pappo A.S., et al. Two consecutive phase II window trials of irinotecan alone or in combination with vincristine for the treatment of metastatic rhabdomyosarcoma: the Children's Oncology Group. J. Clin. Oncol. 2007, 25(4):362-369.
    • (2007) J. Clin. Oncol. , vol.25 , Issue.4 , pp. 362-369
    • Pappo, A.S.1
  • 282
    • 65549144421 scopus 로고    scopus 로고
    • Efficacy of topotecan plus vincristine and doxorubicin in children with recurrent/refractory rhabdomyosarcoma
    • Meazza C., et al. Efficacy of topotecan plus vincristine and doxorubicin in children with recurrent/refractory rhabdomyosarcoma. Med. Oncol. 2009, 26(1):67-72.
    • (2009) Med. Oncol. , vol.26 , Issue.1 , pp. 67-72
    • Meazza, C.1
  • 283
    • 84876442851 scopus 로고    scopus 로고
    • Children's Oncology Group's 2013 blueprint for research: soft tissue sarcomas
    • Hawkins D.S., et al. Children's Oncology Group's 2013 blueprint for research: soft tissue sarcomas. Pediatr. Blood Cancer 2013, 60(6):1001-1008.
    • (2013) Pediatr. Blood Cancer , vol.60 , Issue.6 , pp. 1001-1008
    • Hawkins, D.S.1
  • 284
    • 77749261678 scopus 로고    scopus 로고
    • Downregulation of SS18-SSX1 expression in synovial sarcoma by small interfering RNA enhances the focal adhesion pathway and inhibits anchorage-independent growth in vitro and tumor growth in vivo
    • Takenaka S., et al. Downregulation of SS18-SSX1 expression in synovial sarcoma by small interfering RNA enhances the focal adhesion pathway and inhibits anchorage-independent growth in vitro and tumor growth in vivo. Int. J. Oncol. 2010, 36(4):823-831.
    • (2010) Int. J. Oncol. , vol.36 , Issue.4 , pp. 823-831
    • Takenaka, S.1
  • 285
    • 0036840271 scopus 로고    scopus 로고
    • Expression profiling of synovial sarcoma by cDNA microarrays: association of ERBB2, IGFBP2, and ELF3 with epithelial differentiation
    • Allander S.V., et al. Expression profiling of synovial sarcoma by cDNA microarrays: association of ERBB2, IGFBP2, and ELF3 with epithelial differentiation. Am. J. Pathol. 2002, 161(5):1587-1595.
    • (2002) Am. J. Pathol. , vol.161 , Issue.5 , pp. 1587-1595
    • Allander, S.V.1
  • 286
    • 0141648453 scopus 로고    scopus 로고
    • Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology
    • Nielsen T.O., et al. Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology. Am. J. Pathol. 2003, 163(4):1449-1456.
    • (2003) Am. J. Pathol. , vol.163 , Issue.4 , pp. 1449-1456
    • Nielsen, T.O.1
  • 287
    • 67651094040 scopus 로고    scopus 로고
    • Molecular and immunohistochemical analyses of BCL2, KI-67, and cyclin D1 expression in synovial sarcoma
    • Krskova L., et al. Molecular and immunohistochemical analyses of BCL2, KI-67, and cyclin D1 expression in synovial sarcoma. Cancer Genet. Cytogenet. 2009, 193(1):1-8.
    • (2009) Cancer Genet. Cytogenet. , vol.193 , Issue.1 , pp. 1-8
    • Krskova, L.1
  • 288
    • 57149093206 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 receptor acts as a growth regulator in synovial sarcoma
    • Friedrichs N., et al. Insulin-like growth factor-1 receptor acts as a growth regulator in synovial sarcoma. J. Pathol. 2008, 216(4):428-439.
    • (2008) J. Pathol. , vol.216 , Issue.4 , pp. 428-439
    • Friedrichs, N.1
  • 289
    • 43549083034 scopus 로고    scopus 로고
    • A phase II study of gefitinib for patients with advanced HER-1 expressing synovial sarcoma refractory to doxorubicin-containing regimens
    • Ray-Coquard I., et al. A phase II study of gefitinib for patients with advanced HER-1 expressing synovial sarcoma refractory to doxorubicin-containing regimens. Oncologist 2008, 13(4):467-473.
    • (2008) Oncologist , vol.13 , Issue.4 , pp. 467-473
    • Ray-Coquard, I.1
  • 290
    • 33645736984 scopus 로고    scopus 로고
    • G3139 antisense oligonucleotide directed against antiapoptotic Bcl-2 enhances doxorubicin cytotoxicity in the FU-SY-1 synovial sarcoma cell line
    • Joyner D.E., et al. G3139 antisense oligonucleotide directed against antiapoptotic Bcl-2 enhances doxorubicin cytotoxicity in the FU-SY-1 synovial sarcoma cell line. J. Orthop. Res. 2006, 24(3):474-480.
    • (2006) J. Orthop. Res. , vol.24 , Issue.3 , pp. 474-480
    • Joyner, D.E.1
  • 291
    • 34248157136 scopus 로고    scopus 로고
    • Phase I trial of G3139, a bcl-2 antisense oligonucleotide, combined with doxorubicin and cyclophosphamide in children with relapsed solid tumors: a Children's Oncology Group Study
    • Rheingold S.R., et al. Phase I trial of G3139, a bcl-2 antisense oligonucleotide, combined with doxorubicin and cyclophosphamide in children with relapsed solid tumors: a Children's Oncology Group Study. J. Clin. Oncol. 2007, 25(12):1512-1518.
    • (2007) J. Clin. Oncol. , vol.25 , Issue.12 , pp. 1512-1518
    • Rheingold, S.R.1
  • 292
    • 70350150140 scopus 로고    scopus 로고
    • Critical signaling pathways in bone sarcoma: candidates for therapeutic interventions
    • Geryk-Hall M., Hughes D.P. Critical signaling pathways in bone sarcoma: candidates for therapeutic interventions. Curr. Oncol. Rep. 2009, 11(6):446-453.
    • (2009) Curr. Oncol. Rep. , vol.11 , Issue.6 , pp. 446-453
    • Geryk-Hall, M.1    Hughes, D.P.2
  • 293
    • 50649122547 scopus 로고    scopus 로고
    • Specific tyrosine kinase inhibitors regulate human osteosarcoma cells in vitro
    • Messerschmitt P.J., et al. Specific tyrosine kinase inhibitors regulate human osteosarcoma cells in vitro. Clin. Orthop. Relat. Res. 2008, 466(9):2168-2175.
    • (2008) Clin. Orthop. Relat. Res. , vol.466 , Issue.9 , pp. 2168-2175
    • Messerschmitt, P.J.1
  • 294
    • 42349083307 scopus 로고    scopus 로고
    • Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program
    • Kolb E.A., et al. Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program. Pediatr. Blood Cancer 2008, 50(6):1190-1197.
    • (2008) Pediatr. Blood Cancer , vol.50 , Issue.6 , pp. 1190-1197
    • Kolb, E.A.1
  • 295
    • 76649095657 scopus 로고    scopus 로고
    • A fully human insulin-like growth factor-I receptor antibody SCH 717454 (robatumumab) has antitumor activity as a single agent and in combination with cytotoxics in pediatric tumor xenografts
    • Wang Y., et al. A fully human insulin-like growth factor-I receptor antibody SCH 717454 (robatumumab) has antitumor activity as a single agent and in combination with cytotoxics in pediatric tumor xenografts. Mol. Cancer Ther. 2010, 9(2):410-418.
    • (2010) Mol. Cancer Ther. , vol.9 , Issue.2 , pp. 410-418
    • Wang, Y.1
  • 296
    • 79551703145 scopus 로고    scopus 로고
    • Pharmacokinetically guided phase 1 trial of the IGF-1 receptor antagonist RG1507 in children with recurrent or refractory solid tumors
    • Bagatell R., et al. Pharmacokinetically guided phase 1 trial of the IGF-1 receptor antagonist RG1507 in children with recurrent or refractory solid tumors. Clin. Cancer Res. 2011, 17(3):611-619.
    • (2011) Clin. Cancer Res. , vol.17 , Issue.3 , pp. 611-619
    • Bagatell, R.1
  • 297
    • 84874007657 scopus 로고    scopus 로고
    • Epidermal growth factor receptor: is it a feasible target for the treatment of osteosarcoma?
    • Lee J.A., et al. Epidermal growth factor receptor: is it a feasible target for the treatment of osteosarcoma?. Cancer Res. Treat. 2012, 44(3):202-209.
    • (2012) Cancer Res. Treat. , vol.44 , Issue.3 , pp. 202-209
    • Lee, J.A.1
  • 298
    • 27844591419 scopus 로고    scopus 로고
    • HER2 amplification and overexpression is not present in pediatric osteosarcoma: a tissue microarray study
    • Somers G.R., et al. HER2 amplification and overexpression is not present in pediatric osteosarcoma: a tissue microarray study. Pediatr. Dev. Pathol. 2005, 8(5):525-532.
    • (2005) Pediatr. Dev. Pathol. , vol.8 , Issue.5 , pp. 525-532
    • Somers, G.R.1
  • 299
    • 45549091368 scopus 로고    scopus 로고
    • C-erbB-2 expression and prognostic significance in osteosarcoma
    • Yalçin B., et al. C-erbB-2 expression and prognostic significance in osteosarcoma. Pediatr. Blood Cancer 2008, 51(2):222-227.
    • (2008) Pediatr. Blood Cancer , vol.51 , Issue.2 , pp. 222-227
    • Yalçin, B.1
  • 300
    • 84864044404 scopus 로고    scopus 로고
    • Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the Children's Oncology Group
    • Ebb D., et al. Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the Children's Oncology Group. J. Clin. Oncol. 2012, 30(20):2545-2551.
    • (2012) J. Clin. Oncol. , vol.30 , Issue.20 , pp. 2545-2551
    • Ebb, D.1
  • 301
    • 43049095679 scopus 로고    scopus 로고
    • Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma
    • Kubo T., et al. Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma. Cancer 2008, 112(10):2119-2129.
    • (2008) Cancer , vol.112 , Issue.10 , pp. 2119-2129
    • Kubo, T.1
  • 302
    • 0036847703 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor-mediated proliferation of osteosarcoma cells by the novel tyrosine kinase inhibitor STI571
    • McGary E.C., et al. Inhibition of platelet-derived growth factor-mediated proliferation of osteosarcoma cells by the novel tyrosine kinase inhibitor STI571. Clin. Cancer Res. 2002, 8(11):3584-3591.
    • (2002) Clin. Cancer Res. , vol.8 , Issue.11 , pp. 3584-3591
    • McGary, E.C.1
  • 303
    • 33646390939 scopus 로고    scopus 로고
    • MET overexpression turns human primary osteoblasts into osteosarcomas
    • Patane S., et al. MET overexpression turns human primary osteoblasts into osteosarcomas. Cancer Res. 2006, 66(9):4750-4757.
    • (2006) Cancer Res. , vol.66 , Issue.9 , pp. 4750-4757
    • Patane, S.1
  • 304
    • 0038380439 scopus 로고    scopus 로고
    • Role of the MET/HGF receptor in proliferation and invasive behavior of osteosarcoma
    • Coltella N., et al. Role of the MET/HGF receptor in proliferation and invasive behavior of osteosarcoma. FASEB J. 2003, 17(9):1162-1164.
    • (2003) FASEB J. , vol.17 , Issue.9 , pp. 1162-1164
    • Coltella, N.1
  • 305
    • 70649112061 scopus 로고    scopus 로고
    • Functional genome screen for therapeutic targets of osteosarcoma
    • Yamaguchi U., et al. Functional genome screen for therapeutic targets of osteosarcoma. Cancer Sci. 2009, 100(12):2268-2274.
    • (2009) Cancer Sci. , vol.100 , Issue.12 , pp. 2268-2274
    • Yamaguchi, U.1
  • 306
    • 64549149292 scopus 로고    scopus 로고
    • Notch signalling contributes to the pathogenesis of human osteosarcomas
    • Engin F., et al. Notch signalling contributes to the pathogenesis of human osteosarcomas. Hum. Mol. Genet. 2009, 18(8):1464-1470.
    • (2009) Hum. Mol. Genet. , vol.18 , Issue.8 , pp. 1464-1470
    • Engin, F.1
  • 307
    • 84863241091 scopus 로고    scopus 로고
    • Initial testing (stage 1) by the pediatric preclinical testing program of RO4929097, a gamma-secretase inhibitor targeting notch signaling
    • Kolb E.A., et al. Initial testing (stage 1) by the pediatric preclinical testing program of RO4929097, a gamma-secretase inhibitor targeting notch signaling. Pediatr. Blood Cancer 2012, 58(5):815-818.
    • (2012) Pediatr. Blood Cancer , vol.58 , Issue.5 , pp. 815-818
    • Kolb, E.A.1
  • 308
    • 84901984072 scopus 로고    scopus 로고
    • Initial testing (stage 1) of the notch inhibitor PF-03084014, by the pediatric preclinical testing program
    • Carol H., et al. Initial testing (stage 1) of the notch inhibitor PF-03084014, by the pediatric preclinical testing program. Pediatr. Blood Cancer 2014, 61(8):1493-1496.
    • (2014) Pediatr. Blood Cancer , vol.61 , Issue.8 , pp. 1493-1496
    • Carol, H.1
  • 309
    • 84892923802 scopus 로고    scopus 로고
    • Wnt pathway in osteosarcoma, from oncogenic to therapeutic
    • Cai Y., et al. Wnt pathway in osteosarcoma, from oncogenic to therapeutic. J. Cell. Biochem. 2014, 115(4):625-631.
    • (2014) J. Cell. Biochem. , vol.115 , Issue.4 , pp. 625-631
    • Cai, Y.1
  • 310
    • 48249098887 scopus 로고    scopus 로고
    • Wnt10b induces chemotaxis of osteosarcoma and correlates with reduced survival
    • Chen K., et al. Wnt10b induces chemotaxis of osteosarcoma and correlates with reduced survival. Pediatr. Blood Cancer 2008, 51(3):349-355.
    • (2008) Pediatr. Blood Cancer , vol.51 , Issue.3 , pp. 349-355
    • Chen, K.1
  • 311
    • 84873430058 scopus 로고    scopus 로고
    • Inhibition of the Wnt-beta-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy
    • Ma Y., et al. Inhibition of the Wnt-beta-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy. Biochem. Biophys. Res. Commun. 2013, 431(2):274-279.
    • (2013) Biochem. Biophys. Res. Commun. , vol.431 , Issue.2 , pp. 274-279
    • Ma, Y.1
  • 312
    • 78049246448 scopus 로고    scopus 로고
    • Initial testing (stage 1) of the Akt inhibitor GSK690693 by the pediatric preclinical testing program
    • Carol H., et al. Initial testing (stage 1) of the Akt inhibitor GSK690693 by the pediatric preclinical testing program. Pediatr. Blood Cancer 2010, 55(7):1329-1337.
    • (2010) Pediatr. Blood Cancer , vol.55 , Issue.7 , pp. 1329-1337
    • Carol, H.1
  • 313
    • 84863870086 scopus 로고    scopus 로고
    • Testing of the Akt/PKB inhibitor MK-2206 by the Pediatric Preclinical Testing Program
    • Gorlick R., et al. Testing of the Akt/PKB inhibitor MK-2206 by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 2012, 59(3):518-524.
    • (2012) Pediatr. Blood Cancer , vol.59 , Issue.3 , pp. 518-524
    • Gorlick, R.1
  • 314
    • 40449091406 scopus 로고    scopus 로고
    • Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program
    • Houghton P.J., et al. Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program. Pediatr. Blood Cancer 2008, 50(4):799-805.
    • (2008) Pediatr. Blood Cancer , vol.50 , Issue.4 , pp. 799-805
    • Houghton, P.J.1
  • 315
    • 84877334055 scopus 로고    scopus 로고
    • The combination of sorafenib and everolimus abrogates mTORC1 and mTORC2 upregulation in osteosarcoma preclinical models
    • Pignochino Y., et al. The combination of sorafenib and everolimus abrogates mTORC1 and mTORC2 upregulation in osteosarcoma preclinical models. Clin. Cancer Res. 2013, 19(8):2117-2131.
    • (2013) Clin. Cancer Res. , vol.19 , Issue.8 , pp. 2117-2131
    • Pignochino, Y.1
  • 316
    • 9144228629 scopus 로고    scopus 로고
    • FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells
    • Imai T., et al. FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells. Oncogene 2003, 22(58):9231-9242.
    • (2003) Oncogene , vol.22 , Issue.58 , pp. 9231-9242
    • Imai, T.1
  • 317
    • 4344689912 scopus 로고    scopus 로고
    • Mechanism of histone deacetylase inhibitor Trichostatin A induced apoptosis in human osteosarcoma cells
    • Roh M.S., et al. Mechanism of histone deacetylase inhibitor Trichostatin A induced apoptosis in human osteosarcoma cells. Apoptosis 2004, 9(5):583-589.
    • (2004) Apoptosis , vol.9 , Issue.5 , pp. 583-589
    • Roh, M.S.1
  • 318
    • 84878645229 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor, MS-275 (entinostat), downregulates c-FLIP, sensitizes osteosarcoma cells to FasL, and induces the regression of osteosarcoma lung metastases
    • Rao-Bindal K., et al. The histone deacetylase inhibitor, MS-275 (entinostat), downregulates c-FLIP, sensitizes osteosarcoma cells to FasL, and induces the regression of osteosarcoma lung metastases. Curr. Cancer Drug Targets 2013, 13(4):411-422.
    • (2013) Curr. Cancer Drug Targets , vol.13 , Issue.4 , pp. 411-422
    • Rao-Bindal, K.1
  • 320
    • 84904865637 scopus 로고    scopus 로고
    • Towards a drug development path that targets metastatic progression in osteosarcoma
    • (Epub ahead of print)
    • Khanna C., et al. Towards a drug development path that targets metastatic progression in osteosarcoma. Clin. Cancer Res. 2014, (Epub ahead of print).
    • (2014) Clin. Cancer Res.
    • Khanna, C.1
  • 321
    • 79951906119 scopus 로고    scopus 로고
    • Pilot study using molecular profiling of patients' tumors to find potential targets and select treatments for their refractory cancers
    • Von Hoff D.D., et al. Pilot study using molecular profiling of patients' tumors to find potential targets and select treatments for their refractory cancers. J. Clin. Oncol. 2010, 28(33):4877-4883.
    • (2010) J. Clin. Oncol. , vol.28 , Issue.33 , pp. 4877-4883
    • Von Hoff, D.D.1
  • 322
    • 79957857433 scopus 로고    scopus 로고
    • The BATTLE trial: personalizing therapy for lung cancer
    • Kim E.S., et al. The BATTLE trial: personalizing therapy for lung cancer. Cancer Discov. 2011, 1(1):44-53.
    • (2011) Cancer Discov. , vol.1 , Issue.1 , pp. 44-53
    • Kim, E.S.1
  • 323
    • 0031896592 scopus 로고    scopus 로고
    • There are no bad anticancer agents, only bad clinical trial designs-twenty-first Richard and Hinda Rosenthal Foundation Award Lecture
    • Von Hoff D.D. There are no bad anticancer agents, only bad clinical trial designs-twenty-first Richard and Hinda Rosenthal Foundation Award Lecture. Clin. Cancer Res. 1998, 4(5):1079-1086.
    • (1998) Clin. Cancer Res. , vol.4 , Issue.5 , pp. 1079-1086
    • Von Hoff, D.D.1
  • 324
    • 67651216410 scopus 로고    scopus 로고
    • Next generation oncology drug development: opportunities and challenges
    • Gutierrez M.E., Kummar S., Giaccone G. Next generation oncology drug development: opportunities and challenges. Nat. Rev. Clin. Oncol. 2009, 6(5):259-265.
    • (2009) Nat. Rev. Clin. Oncol. , vol.6 , Issue.5 , pp. 259-265
    • Gutierrez, M.E.1    Kummar, S.2    Giaccone, G.3
  • 325
    • 15744374441 scopus 로고    scopus 로고
    • Clinical trial designs for predictive marker validation in cancer treatment trials
    • Sargent D.J., et al. Clinical trial designs for predictive marker validation in cancer treatment trials. J. Clin. Oncol. 2005, 23(9):2020-2027.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.9 , pp. 2020-2027
    • Sargent, D.J.1
  • 326
    • 73349116605 scopus 로고    scopus 로고
    • Genetic variations as cancer prognostic markers: review and update
    • Savas S., Liu G. Genetic variations as cancer prognostic markers: review and update. Hum. Mutat. 2009, 30(10):1369-1377.
    • (2009) Hum. Mutat. , vol.30 , Issue.10 , pp. 1369-1377
    • Savas, S.1    Liu, G.2
  • 327
    • 84857597802 scopus 로고    scopus 로고
    • The paradigm of personalized therapy in oncology
    • Gasparini G., Longo R. The paradigm of personalized therapy in oncology. Expert Opin. Ther. Targets 2012, 16(Suppl. 1):S7-S16.
    • (2012) Expert Opin. Ther. Targets , vol.16 , Issue.SUPPL. 1
    • Gasparini, G.1    Longo, R.2
  • 328
    • 84863651163 scopus 로고    scopus 로고
    • Combinatorial drug therapy for cancer in the post-genomic era
    • Al-Lazikani B., Banerji U., Workman P. Combinatorial drug therapy for cancer in the post-genomic era. Nat. Biotechnol. 2012, 30(7):679-692.
    • (2012) Nat. Biotechnol. , vol.30 , Issue.7 , pp. 679-692
    • Al-Lazikani, B.1    Banerji, U.2    Workman, P.3
  • 329
    • 84875490185 scopus 로고    scopus 로고
    • Cancer genome landscapes
    • Vogelstein B., et al. Cancer genome landscapes. Science 2013, 339(6127):1546-1558.
    • (2013) Science , vol.339 , Issue.6127 , pp. 1546-1558
    • Vogelstein, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.