메뉴 건너뛰기




Volumn 10, Issue 6, 2008, Pages 477-490

Pediatric developmental therapies: Interesting new drugs now in early-stage clinical trials

Author keywords

[No Author keywords available]

Indexed keywords

5 (4 BROMO 2 CHLOROANILINO) 4 FLUORO 1 METHYL 1H BENZIMIDAZOLE 6 CARBOHYDROXAMIC ACID 2 HYDROXYETHYL ESTER; ALEMTUZUMAB; BEVACIZUMAB; BORTEZOMIB; CLOFARABINE; CYCLOPHOSPHAMIDE; CYTARABINE; DASATINIB; DNA METHYLTRANSFERASE INHIBITOR; ETOPOSIDE; FORODESINE; HEAT SHOCK PROTEIN 90 INHIBITOR; HISTONE DEACETYLASE INHIBITOR; IDARUBICIN; IMATINIB; IRINOTECAN; LESTAURTINIB; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; NELARABINE; PROTEASOME INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; PURINE NUCLEOSIDE DERIVATIVE; RAPAMYCIN; TEMOZOLOMIDE; THALIDOMIDE; TIPIFARNIB; TOSITUMOMAB; UNINDEXED DRUG; VALPROIC ACID; VASCULOTROPIN INHIBITOR;

EID: 58649109966     PISSN: 15233790     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11912-008-0073-0     Document Type: Review
Times cited : (16)

References (140)
  • 1
    • 38449108084 scopus 로고    scopus 로고
    • Deaths: Leading causes for 2004
    • In Hyattsville, MD: National Center for Health Statistics
    • HeLon M: Deaths: leading causes for 2004. In National Vital Statistics Reports, vol 56, no 5. Hyattsville, MD: National Center for Health Statistics; 2007.
    • (2007) National Vital Statistics Reports , vol.56 , Issue.5
    • Heron, M.1
  • 2
    • 33745080964 scopus 로고    scopus 로고
    • Outcomes after HLA-matched sibling transplantation or chemotherapy in children with B-precursor acute lymphoblastic leukemia in a second remission: A collaborative study of the Children's Oncology Group and the Center for International Blood and Marrow Transplant Research
    • Eapen M, Raetz E, Zhang MJ, et al.: Outcomes after HLA-matched sibling transplantation or chemotherapy in children with B-precursor acute lymphoblastic leukemia in a second remission: A collaborative study of the Children's Oncology Group and the Center for International Blood and Marrow Transplant Research. Blood 2006, 107: 4961-4967.
    • (2006) Blood , vol.107 , pp. 4961-4967
    • Eapen, M.1    Raetz, E.2    Zhang, M.J.3
  • 3
    • 33746029948 scopus 로고    scopus 로고
    • Bone marrow transplantation versus prolonged intensive chemotherapy for children with acute lymphoblastic leukemia and an initial bone marrow relapse within 12 months of the completion of primary therapy: Children's Oncology Group study CCG-1941
    • Gaynon PS, Harris RE, Altman AJ, et al.: Bone marrow transplantation versus prolonged intensive chemotherapy for children with acute lymphoblastic leukemia and an initial bone marrow relapse within 12 months of the completion of primary therapy: Children's Oncology Group study CCG-1941. J Clin Oncol 2006, 24: 3150-3156.
    • (2006) J Clin Oncol , vol.24 , pp. 3150-3156
    • Gaynon, P.S.1    Harris, R.E.2    Altman, A.J.3
  • 4
    • 7944220987 scopus 로고    scopus 로고
    • Outcome of allogeneic bone marrow transplantation for children with advanced acute myeloid leukemia
    • Nemecek ER, Gooley TA, Woolfrey AE, et al.: Outcome of allogeneic bone marrow transplantation for children with advanced acute myeloid leukemia. Bone Marrow Transplant 2004, 34: 799-806.
    • (2004) Bone Marrow Transplant , vol.34 , pp. 799-806
    • Nemecek, E.R.1    Gooley, T.A.2    Woolfrey, A.E.3
  • 6
    • 33748502962 scopus 로고    scopus 로고
    • Survival after relapse in children with solid tumors: A follow-up study from the Italian off-therapy registry
    • Ceschel S, Casotto V, Valsecchi MG, et al.: Survival after relapse in children with solid tumors: A follow-up study from the Italian off-therapy registry. Pediatr Blood Cancer 2006, 47: 560-566.
    • (2006) Pediatr Blood Cancer , vol.47 , pp. 560-566
    • Ceschel, S.1    Casotto, V.2    Valsecchi, M.G.3
  • 7
    • 33746586965 scopus 로고    scopus 로고
    • Survival after recurrence of osteosarcoma: A 20-year experience at a single institution
    • Crompton BD, Goldsby RE, Weinberg VK, et al.: Survival after recurrence of osteosarcoma: A 20-year experience at a single institution. Pediatr Blood Cancer 2006, 47: 255-259.
    • (2006) Pediatr Blood Cancer , vol.47 , pp. 255-259
    • Crompton, B.D.1    Goldsby, R.E.2    Weinberg, V.K.3
  • 8
    • 8544230645 scopus 로고    scopus 로고
    • Expression of BCR-ABL, E2A-PBX1, and MLL-AF4 fusion transcripts in newly diagnosed children with acute lymphoblastic leukemia: A Children's Cancer Group initiative
    • Gaynon PS, Crotty ML, Sather HN, et al.: Expression of BCR-ABL, E2A-PBX1, and MLL-AF4 fusion transcripts in newly diagnosed children with acute lymphoblastic leukemia: A Children's Cancer Group initiative. Leuk Lymphoma 1997, 26: 57-65.
    • (1997) Leuk Lymphoma , vol.26 , pp. 57-65
    • Gaynon, P.S.1    Crotty, M.L.2    Sather, H.N.3
  • 9
    • 8944251627 scopus 로고    scopus 로고
    • Incidence and clinical outcome of children with BCR/ABL-positive acute lymphoblastic leukemia (ALL). A prospective RT-PCR study based on 673 patients enrolled in the German pediatric multicenter therapy trials ALL-BFM-90 and CoALL-05-92
    • Schlieben S, Borkhardt A, Reinisch I, et al.: Incidence and clinical outcome of children with BCR/ABL-positive acute lymphoblastic leukemia (ALL). A prospective RT-PCR study based on 673 patients enrolled in the German pediatric multicenter therapy trials ALL-BFM-90 and CoALL-05-92. Leukemia 1996, 10: 957-963.
    • (1996) Leukemia , vol.10 , pp. 957-963
    • Schlieben, S.1    Borkhardt, A.2    Reinisch, I.3
  • 10
    • 0032032270 scopus 로고    scopus 로고
    • Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3
    • Amarante-Mendes GP, Naekyung Kim C, Liu L, et al.: Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3. Blood 1998, 91: 1700-1705.
    • (1998) Blood , vol.91 , pp. 1700-1705
    • Amarante-Mendes, G.P.1    Naekyung Kim, C.2    Liu, L.3
  • 11
    • 0030725775 scopus 로고    scopus 로고
    • The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells
    • Cortez D, Reuther G, Pendergast AM: The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells. Oncogene 1997, 15: 2333-2342.
    • (1997) Oncogene , vol.15 , pp. 2333-2342
    • Cortez, D.1    Reuther, G.2    Pendergast, A.M.3
  • 12
    • 0034665713 scopus 로고    scopus 로고
    • Structural mechanism for STI-571 inhibition of abelson tyrosine kinase
    • Schindler T, Bornmann W, Pellicena P, et al.: Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. Science 2000, 289: 1938-1942.
    • (2000) Science , vol.289 , pp. 1938-1942
    • Schindler, T.1    Bornmann, W.2    Pellicena, P.3
  • 13
    • 52949099951 scopus 로고    scopus 로고
    • Improved Early Event Free Survival (EFS) in Children with Philadelphia Chromosome-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL) with Intensive Imatinib in Combination with High Dose Chemotherapy: Children's Oncology Group (COG) Study AALL0031
    • Schultz KR, Bowman WP, Slayton W, et al.: Improved Early Event Free Survival (EFS) in Children with Philadelphia Chromosome-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL) with Intensive Imatinib in Combination with High Dose Chemotherapy: Children's Oncology Group (COG) Study AALL0031. ASH Annual Meeting Abstracts 2007, 110: 9a.
    • (2007) ASH Annual Meeting Abstracts , vol.110
    • Schultz, K.R.1    Bowman, W.P.2    Slayton, W.3
  • 14
    • 2942618768 scopus 로고    scopus 로고
    • A renaissance for SRC
    • Yeatman TJ: A renaissance for SRC. Nat Rev Cancer 2004, 4: 470.
    • (2004) Nat Rev Cancer , vol.4 , pp. 470
    • Yeatman, T.J.1
  • 15
    • 0031439247 scopus 로고    scopus 로고
    • Cellular functions regulated by Src family kinases
    • Thomas SM, Brugge JS: Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 1997, 13: 513-609.
    • (1997) Annu Rev Cell Dev Biol , vol.13 , pp. 513-609
    • Thomas, S.M.1    Brugge, J.S.2
  • 16
    • 0027935349 scopus 로고
    • Expression of neuronal src mRNA as a favorable marker and inverse correlation to N-myc gene amplification in human neuroblastomas
    • Matsunaga T, Shirasawa H, Tanabe M, et al.: Expression of neuronal src mRNA as a favorable marker and inverse correlation to N-myc gene amplification in human neuroblastomas. Int J Cancer 1994, 58: 793-798.
    • (1994) Int J Cancer , vol.58 , pp. 793-798
    • Matsunaga, T.1    Shirasawa, H.2    Tanabe, M.3
  • 17
    • 33745182564 scopus 로고    scopus 로고
    • PI3-K/Aktmediated anoikis resistance of human osteosarcoma cells requires Src activation
    • Diaz-Montero CM, Wygant JN, McIntyre BW: PI3-K/Aktmediated anoikis resistance of human osteosarcoma cells requires Src activation. Eur J Cancer 2006, 42: 1491-1500.
    • (2006) Eur J Cancer , vol.42 , pp. 1491-1500
    • Diaz-Montero, C.M.1    Wygant, J.N.2    McIntyre, B.W.3
  • 18
    • 34447104040 scopus 로고    scopus 로고
    • Src kinase signaling in leukaemia
    • Li S: Src kinase signaling in leukaemia. Int J Biochem Cell Biol 2007, 39: 1483-1488.
    • (2007) Int J Biochem Cell Biol , vol.39 , pp. 1483-1488
    • Li, S.1
  • 19
    • 40849096092 scopus 로고    scopus 로고
    • Src family kinases promote AML cell survival through activation of signal transducers and activators of transcription (STAT)
    • Ozawa Y, Williams AH, Estes ML, et al.: Src family kinases promote AML cell survival through activation of signal transducers and activators of transcription (STAT). Leuk Res 2008, 32: 893-903.
    • (2008) Leuk Res , vol.32 , pp. 893-903
    • Ozawa, Y.1    Williams, A.H.2    Estes, M.L.3
  • 20
    • 43249100853 scopus 로고    scopus 로고
    • Antiproliferative and proapoptotic activities of new pyrazolo[3juvy4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells
    • Spreafico A, Schenone S, Serchi T, et al.: Antiproliferative and proapoptotic activities of new pyrazolo[3juvy4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells. FASEB J 2008, 22: 1560-1571.
    • (2008) FASEB J , vol.22 , pp. 1560-1571
    • Spreafico, A.1    Schenone, S.2    Serchi, T.3
  • 21
    • 34047265691 scopus 로고    scopus 로고
    • Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on Src kinase for survival
    • Shor AC, Keschman EA, Lee FY, et al.: Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on Src kinase for survival. Cancer Res 2007, 67: 2800-2808.
    • (2007) Cancer Res , vol.67 , pp. 2800-2808
    • Shor, A.C.1    Keschman, E.A.2    Lee, F.Y.3
  • 22
    • 42349094624 scopus 로고    scopus 로고
    • Initial testing of dasatinib by the pediatric preclinical testing program
    • Kolb EA, Gorlick R, Houghton PJ, et al.: Initial testing of dasatinib by the pediatric preclinical testing program. Pediatr Blood Cancer 2008, 50: 1198-1206.
    • (2008) Pediatr Blood Cancer , vol.50 , pp. 1198-1206
    • Kolb, E.A.1    Gorlick, R.2    Houghton, P.J.3
  • 23
    • 1542276560 scopus 로고    scopus 로고
    • FLT3 mutations in childhood acute lymphoblastic leukemia
    • Armstrong SA, Mabon ME, Silverman LB, et al.: FLT3 mutations in childhood acute lymphoblastic leukemia. Blood 2004, 103: 3544-3546.
    • (2004) Blood , vol.103 , pp. 3544-3546
    • Armstrong, S.A.1    Mabon, M.E.2    Silverman, L.B.3
  • 24
    • 0036720398 scopus 로고    scopus 로고
    • The roles of FLT3 in hematopoiesis and leukemia
    • Gilliland DG, Griffin JD: The roles of FLT3 in hematopoiesis and leukemia. Blood 2002, 100: 1532-1542.
    • (2002) Blood , vol.100 , pp. 1532-1542
    • Gilliland, D.G.1    Griffin, J.D.2
  • 25
    • 0041737454 scopus 로고    scopus 로고
    • Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia
    • Meshinchi S, Stirewalt DL, Alonzo TA, et al.: Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia. Blood 2003, 102: 1474-1479.
    • (2003) Blood , vol.102 , pp. 1474-1479
    • Meshinchi, S.1    Stirewalt, D.L.2    Alonzo, T.A.3
  • 26
    • 0141482006 scopus 로고    scopus 로고
    • FLT3 internal tandem duplication in 234 children with acute myeloid leukemia: Prognostic significance and relation to cellular drug resistance
    • Zwaan CM, Meshinchi S, Radich JP, et al.: FLT3 internal tandem duplication in 234 children with acute myeloid leukemia: Prognostic significance and relation to cellular drug resistance. Blood 2003, 102: 2387-2394.
    • (2003) Blood , vol.102 , pp. 2387-2394
    • Zwaan, C.M.1    Meshinchi, S.2    Radich, J.P.3
  • 27
    • 0036624916 scopus 로고    scopus 로고
    • A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo
    • Levis M, Allebach J, Tse KF, et al.: A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo. Blood 2002, 99: 3885-3891.
    • (2002) Blood , vol.99 , pp. 3885-3891
    • Levis, M.1    Allebach, J.2    Tse, K.F.3
  • 28
    • 0038204144 scopus 로고    scopus 로고
    • SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
    • O'Farrell AM, Abrams TJ, Yuen HA, et al.: SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood 2003, 101: 3597-3605.
    • (2003) Blood , vol.101 , pp. 3597-3605
    • O'Farrell, A.M.1    Abrams, T.J.2    Yuen, H.A.3
  • 29
    • 1842420032 scopus 로고    scopus 로고
    • Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia
    • Smith BD, Levis M, Beran M, et al.: Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia. Blood 2004, 103: 3669-3676.
    • (2004) Blood , vol.103 , pp. 3669-3676
    • Smith, B.D.1    Levis, M.2    Beran, M.3
  • 30
    • 0036595143 scopus 로고    scopus 로고
    • Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412
    • Weisberg E, Boulton C, Kelly LM, et al.: Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412. Cancer Cell 2002, 1: 433-443.
    • (2002) Cancer Cell , vol.1 , pp. 433-443
    • Weisberg, E.1    Boulton, C.2    Kelly, L.M.3
  • 31
    • 33746149660 scopus 로고    scopus 로고
    • Combinations of the FLT3 inhibitor CEP-701 and chemotherapy synergistically kill infant and childhood MLL-rearranged ALL cells in a sequence-dependent manner
    • Brown P, Levis M, McIntyre E, et al.: Combinations of the FLT3 inhibitor CEP-701 and chemotherapy synergistically kill infant and childhood MLL-rearranged ALL cells in a sequence-dependent manner. Leukemia 2006, 20: 1368-1376.
    • (2006) Leukemia , vol.20 , pp. 1368-1376
    • Brown, P.1    Levis, M.2    McIntyre, E.3
  • 32
    • 37549052922 scopus 로고    scopus 로고
    • Expression of KIT and PDGFR is associated with a good prognosis in neuroblastoma
    • Shimada A, Hirato J, Kuroiwa M, et al.: Expression of KIT and PDGFR is associated with a good prognosis in neuroblastoma. Pediatr Blood Cancer 2008, 50: 213-217.
    • (2008) Pediatr Blood Cancer , vol.50 , pp. 213-217
    • Shimada, A.1    Hirato, J.2    Kuroiwa, M.3
  • 33
    • 0034946929 scopus 로고    scopus 로고
    • Flt-3 and its ligand are expressed in neural crest-derived tumors and promote survival and proliferation of their cell lines
    • Timeus F, Ricotti E, Crescenzio N, et al.: Flt-3 and its ligand are expressed in neural crest-derived tumors and promote survival and proliferation of their cell lines. Lab Invest 2001, 81: 1025-1037.
    • (2001) Lab Invest , vol.81 , pp. 1025-1037
    • Timeus, F.1    Ricotti, E.2    Crescenzio, N.3
  • 34
    • 58649084721 scopus 로고    scopus 로고
    • Phase I Trial of the Orally Bioavailable TRK Tyrosine Kinase Inhibitor CEP-701 in Refractory Neuroblastoma: A New Approaches to Neuroblastoma Therapy (NANT) Study
    • In Vancouver, Canada
    • Maris J, Minturn J, Evans A, et al.: Phase I Trial of the Orally Bioavailable TRK Tyrosine Kinase Inhibitor CEP-701 in Refractory Neuroblastoma: A New Approaches to Neuroblastoma Therapy (NANT) Study. In SIOP XXXVII Annual Conference. Vancouver, Canada: 2005:416.
    • (2005) SIOP XXXVII Annual Conference , pp. 416
    • Maris, J.1    Minturn, J.2    Evans, A.3
  • 35
    • 26944447953 scopus 로고    scopus 로고
    • Mutations in KIT and RAS are frequent events in pediatric corebinding factor acute myeloid leukemia
    • Goemans BF, Zwaan CM, Miller M, et al.: Mutations in KIT and RAS are frequent events in pediatric corebinding factor acute myeloid leukemia. Leukemia 2005, 19: 1536-1542.
    • (2005) Leukemia , vol.19 , pp. 1536-1542
    • Goemans, B.F.1    Zwaan, C.M.2    Miller, M.3
  • 36
    • 19244367706 scopus 로고    scopus 로고
    • CD34/CD117 co-expression in childhood acute leukemia
    • Uckan D, Hicsonmez G, Yetgin S, et al.: CD34/CD117 co-expression in childhood acute leukemia. Leuk Res 2000, 24: 201-206.
    • (2000) Leuk Res , vol.24 , pp. 201-206
    • Uckan, D.1    Hicsonmez, G.2    Yetgin, S.3
  • 37
    • 34247333691 scopus 로고    scopus 로고
    • KIT gene in pediatric osteosarcomas: Could it be a new therapeutic target?
    • Entz-Werle N, Gaub MP, Lavaux T, et al.: KIT gene in pediatric osteosarcomas: Could it be a new therapeutic target? Int J Cancer 2007, 120: 2510-2516.
    • (2007) Int J Cancer , vol.120 , pp. 2510-2516
    • Entz-Werle, N.1    Gaub, M.P.2    Lavaux, T.3
  • 38
    • 33847348574 scopus 로고    scopus 로고
    • Protein expression of KIT and gene mutation of c-kit and PDGFRs in Ewing sarcomas
    • Do I, Araujo ES, Kalil RK, Bacchini P, et al.: Protein expression of KIT and gene mutation of c-kit and PDGFRs in Ewing sarcomas. Pathol Res Pract 2007, 203: 127-134.
    • (2007) Pathol Res Pract , vol.203 , pp. 127-134
    • Do, I.1    Araujo, E.S.2    Kalil, R.K.3    Bacchini, P.4
  • 39
    • 19944428974 scopus 로고    scopus 로고
    • Clinical and molecular evidence for c-kit receptor as a therapeutic target in neuroblastic tumors
    • Uccini S, Mannarino O, McDowell HP, et al.: Clinical and molecular evidence for c-kit receptor as a therapeutic target in neuroblastic tumors. Clin Cancer Res 2005, 11: 380-389.
    • (2005) Clin Cancer Res , vol.11 , pp. 380-389
    • Uccini, S.1    Mannarino, O.2    McDowell, H.P.3
  • 40
    • 0036209138 scopus 로고    scopus 로고
    • C-kit expression in pediatric solid tumors: A comparative immunohistochemical study
    • Smithey BE, Pappo AS, Hill DA: C-kit expression in pediatric solid tumors: A comparative immunohistochemical study. Am J Surg Pathol 2002, 26: 486-492.
    • (2002) Am J Surg Pathol , vol.26 , pp. 486-492
    • Smithey, B.E.1    Pappo, A.S.2    Hill, D.A.3
  • 41
    • 37549041711 scopus 로고    scopus 로고
    • A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: A Children's Oncology Group study
    • Bond M, Bernstein ML, Pappo A, et al.: A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: A Children's Oncology Group study. Pediatr Blood Cancer 2008, 50: 254-258.
    • (2008) Pediatr Blood Cancer , vol.50 , pp. 254-258
    • Bond, M.1    Bernstein, M.L.2    Pappo, A.3
  • 42
    • 22144455380 scopus 로고    scopus 로고
    • Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412
    • Growney JD, Clark JJ, Adelsperger J, et al.: Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412. Blood 2005, 106: 721-724.
    • (2005) Blood , vol.106 , pp. 721-724
    • Growney, J.D.1    Clark, J.J.2    Adelsperger, J.3
  • 43
    • 31544459272 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies
    • Schittenhelm MM, Shiraga S, Schroeder A, et al.: Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies. Cancer Res 2006, 66: 473-481.
    • (2006) Cancer Res , vol.66 , pp. 473-481
    • Schittenhelm, M.M.1    Shiraga, S.2    Schroeder, A.3
  • 44
    • 42949148257 scopus 로고    scopus 로고
    • Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
    • Burstein HJ, Elias AD, Rugo HS, et al.: Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. J Clin Oncol 2008, 26: 1810-1816.
    • (2008) J Clin Oncol , vol.26 , pp. 1810-1816
    • Burstein, H.J.1    Elias, A.D.2    Rugo, H.S.3
  • 45
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
    • Giantonio BJ, Catalano PJ, Meropol NJ, et al.: Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol 2007, 25: 1539-1544.
    • (2007) J Clin Oncol , vol.25 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 46
    • 20244381389 scopus 로고    scopus 로고
    • Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer
    • Herbst RS, Johnson DH, Mininberg E, et al.: Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer. J Clin Oncol 2005, 23: 2544-2555.
    • (2005) J Clin Oncol , vol.23 , pp. 2544-2555
    • Herbst, R.S.1    Johnson, D.H.2    Mininberg, E.3
  • 47
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • Yang JC, Haworth L, Sherry RM, et al.: A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003, 349: 427-434.
    • (2003) N Engl J Med , vol.349 , pp. 427-434
    • Yang, J.C.1    Haworth, L.2    Sherry, R.M.3
  • 48
    • 33746381463 scopus 로고    scopus 로고
    • Expression of the vascular endothelial growth factor receptors 1 and 2 in acute myeloid leukemia: Incidence and feasibility of immunohistochemical staining
    • Kharfan-Dabaja MA, Patel SA, Osunkoya AO, et al.: Expression of the vascular endothelial growth factor receptors 1 and 2 in acute myeloid leukemia: Incidence and feasibility of immunohistochemical staining. Clin Lab Haematol 2006, 28: 254-258.
    • (2006) Clin Lab Haematol , vol.28 , pp. 254-258
    • Kharfan-Dabaja, M.A.1    Patel, S.A.2    Osunkoya, A.O.3
  • 49
    • 2342614158 scopus 로고    scopus 로고
    • Bone marrow microvessel density (MVD) in adult acute myeloid leukemia (AML): Therapy induced changes and effects on survival
    • Kuzu I, Beksac M, Arat M, et al.: Bone marrow microvessel density (MVD) in adult acute myeloid leukemia (AML): Therapy induced changes and effects on survival. Leuk Lymphoma 2004, 45: 1185-1190.
    • (2004) Leuk Lymphoma , vol.45 , pp. 1185-1190
    • Kuzu, I.1    Beksac, M.2    Arat, M.3
  • 50
    • 0031059348 scopus 로고    scopus 로고
    • Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia
    • Perez-Atayde AR, Sallan SE, Tedrow U, et al.: Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia. Am J Pathol 1997, 150: 815-821.
    • (1997) Am J Pathol , vol.150 , pp. 815-821
    • Perez-Atayde, A.R.1    Sallan, S.E.2    Tedrow, U.3
  • 51
    • 19944431093 scopus 로고    scopus 로고
    • A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease
    • Fiedler W, Serve H, Dohner H, et al.: A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease. Blood 2005, 105: 986-993.
    • (2005) Blood , vol.105 , pp. 986-993
    • Fiedler, W.1    Serve, H.2    Dohner, H.3
  • 52
    • 21044438307 scopus 로고    scopus 로고
    • Anti-angiogenic effects and regression of localized murine AML produced by anti-VEGF and anti-Flk-1 antibodies
    • Reichert F, Barak V, Tarshis M, et al.: Anti-angiogenic effects and regression of localized murine AML produced by anti-VEGF and anti-Flk-1 antibodies. Eur J Haematol 2005, 75: 41-46.
    • (2005) Eur J Haematol , vol.75 , pp. 41-46
    • Reichert, F.1    Barak, V.2    Tarshis, M.3
  • 53
    • 33744482540 scopus 로고    scopus 로고
    • Phase 1 study of PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor, for the treatment of acute myeloid leukemia and myelodysplastic syndrome
    • Roboz GJ, Giles FJ, List AF, et al.: Phase 1 study of PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor, for the treatment of acute myeloid leukemia and myelodysplastic syndrome. Leukemia 2006, 20: 952-957.
    • (2006) Leukemia , vol.20 , pp. 952-957
    • Roboz, G.J.1    Giles, F.J.2    List, A.F.3
  • 54
    • 0242298170 scopus 로고    scopus 로고
    • Single agent thalidomide in patients with relapsed or refractory acute myeloid leukaemia
    • Thomas DA, Estey E, Giles FJ, et al.: Single agent thalidomide in patients with relapsed or refractory acute myeloid leukaemia. Br J Haematol 2003, 123: 436-441.
    • (2003) Br J Haematol , vol.123 , pp. 436-441
    • Thomas, D.A.1    Estey, E.2    Giles, F.J.3
  • 55
    • 39049101435 scopus 로고    scopus 로고
    • Proliferation of Ewing sarcoma cell lines is suppressed by the receptor tyrosine kinase inhibitors gefitinib and vandetanib
    • Andersson MK, Aman P: Proliferation of Ewing sarcoma cell lines is suppressed by the receptor tyrosine kinase inhibitors gefitinib and vandetanib. Cancer Cell Int 2008, 8: 1.
    • (2008) Cancer Cell Int , vol.8 , pp. 1
    • Andersson, M.K.1    Aman, P.2
  • 56
    • 0037143739 scopus 로고    scopus 로고
    • Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma
    • Kim ES, Serur A, Huang J, et al.: Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma. Proc Natl Acad Sci U S A 2002, 99: 11399-11404.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 11399-11404
    • Kim, E.S.1    Serur, A.2    Huang, J.3
  • 57
    • 45249097586 scopus 로고    scopus 로고
    • Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: Interim analysis of safety and tolerability
    • Lai A, Filka E, McGibbon B, et al.: Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: Interim analysis of safety and tolerability. Int J Radiat Oncol Biol Phys 2008, 71: 1372-1380.
    • (2008) Int J Radiat Oncol Biol Phys , vol.71 , pp. 1372-1380
    • Lai, A.1    Filka, E.2    McGibbon, B.3
  • 58
    • 0037370294 scopus 로고    scopus 로고
    • Anti-VEGF antibody in experimental hepatoblastoma: Suppression of tumor growth and altered angiogenesis
    • McCrudden KW, Hopkins B, Frischer J, et al.: Anti-VEGF antibody in experimental hepatoblastoma: Suppression of tumor growth and altered angiogenesis. J Pediatr Surg 2003, 38: 308-314.
    • (2003) J Pediatr Surg , vol.38 , pp. 308-314
    • McCrudden, K.W.1    Hopkins, B.2    Frischer, J.3
  • 59
    • 0033979730 scopus 로고    scopus 로고
    • Anti-VEGF antibody suppresses primary tumor growth and metastasis in an experimental model of Wilms' tumor
    • discussion 32-33
    • Rowe DH, Huang J, Kayton ML, et al.: Anti-VEGF antibody suppresses primary tumor growth and metastasis in an experimental model of Wilms' tumor. J Pediatr Surg 2000, 35: 30-32; discussion 32-33.
    • (2000) J Pediatr Surg , vol.35 , pp. 30-32
    • Rowe, D.H.1    Huang, J.2    Kayton, M.L.3
  • 60
    • 44149115014 scopus 로고    scopus 로고
    • Initial testing (stage 1) of sunitinib by the pediatric preclinical testing program
    • Maris JM, Courtright J, Houghton PJ, et al.: Initial testing (stage 1) of sunitinib by the pediatric preclinical testing program. Pediatr Blood Cancer 2008, 51: 42-48.
    • (2008) Pediatr Blood Cancer , vol.51 , pp. 42-48
    • Maris, J.M.1    Courtright, J.2    Houghton, P.J.3
  • 61
    • 38549164180 scopus 로고    scopus 로고
    • Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing program
    • Maris JM, Courtright J, Houghton PJ, et al.: Initial testing of the VEGFR inhibitor AZD2171 by the pediatric preclinical testing program. Pediatr Blood Cancer 2008, 50: 581-587.
    • (2008) Pediatr Blood Cancer , vol.50 , pp. 581-587
    • Maris, J.M.1    Courtright, J.2    Houghton, P.J.3
  • 62
    • 39749173077 scopus 로고    scopus 로고
    • Potent antitumor effects of ZD6474 on neuroblastoma via dual targeting of tumor cells and tumor endothelium
    • Beaudry P, Nilsson M, Rioth M, et al.: Potent antitumor effects of ZD6474 on neuroblastoma via dual targeting of tumor cells and tumor endothelium. Mol Cancer Ther 2008, 7: 418-424.
    • (2008) Mol Cancer Ther , vol.7 , pp. 418-424
    • Beaudry, P.1    Nilsson, M.2    Rioth, M.3
  • 63
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN: TOR signaling in growth and metabolism. Cell 2006, 124: 471.
    • (2006) Cell , vol.124 , pp. 471
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 64
    • 33847041527 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor signaling blockade combined with radiation
    • Allen GW, Saba C, Armstrong EA, et al.: Insulin-like growth factor-I receptor signaling blockade combined with radiation. Cancer Res 2007, 67: 1155-1162.
    • (2007) Cancer Res , vol.67 , pp. 1155-1162
    • Allen, G.W.1    Saba, C.2    Armstrong, E.A.3
  • 65
    • 0030738695 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 (IGF-1) alters drug sensitivity of HBL100 human breast cancer cells by inhibition of apoptosis induced by diverse anticancer drugs
    • Dunn SE, Hardman RA, Kari FW, Barrett JC: Insulin-like growth factor 1 (IGF-1) alters drug sensitivity of HBL100 human breast cancer cells by inhibition of apoptosis induced by diverse anticancer drugs. Cancer Res 1997, 57: 2687-2693.
    • (1997) Cancer Res , vol.57 , pp. 2687-2693
    • Dunn, S.E.1    Hardman, R.A.2    Kari, F.W.3    Barrett, J.C.4
  • 66
    • 5444242379 scopus 로고    scopus 로고
    • IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma
    • MacEwen EG, Pastor J, Kutzke J, et al.: IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma. J Cell Biochem 2004, 92: 77-91.
    • (2004) J Cell Biochem , vol.92 , pp. 77-91
    • MacEwen, E.G.1    Pastor, J.2    Kutzke, J.3
  • 67
    • 0029838475 scopus 로고    scopus 로고
    • Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: A possible therapeutic target
    • Scotlandi K, Benini S, Sarti M, et al.: Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: A possible therapeutic target. Cancer Res 1996, 56: 4570-4574.
    • (1996) Cancer Res , vol.56 , pp. 4570-4574
    • Scotlandi, K.1    Benini, S.2    Sarti, M.3
  • 68
    • 0032189704 scopus 로고    scopus 로고
    • Insulin-like growth factor II and PAX3-FKHR cooperate in the oncogenesis of rhabdomyosarcoma
    • Wang W, Kumar P, Wang W, et al.: Insulin-like growth factor II and PAX3-FKHR cooperate in the oncogenesis of rhabdomyosarcoma. Cancer Res 1998, 58: 4426-4433.
    • (1998) Cancer Res , vol.58 , pp. 4426-4433
    • Wang, W.1    Kumar, P.2    Wang, W.3
  • 69
    • 33845630749 scopus 로고    scopus 로고
    • A novel EWSWT1 gene fusion product in desmoplastic small round cell tumor is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene
    • Werner H, Idelman G, Rubinstein M, et al.: A novel EWSWT1 gene fusion product in desmoplastic small round cell tumor is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene. Cancer Lett 2007, 247: 84-90.
    • (2007) Cancer Lett , vol.247 , pp. 84-90
    • Werner, H.1    Idelman, G.2    Rubinstein, M.3
  • 70
    • 0029054127 scopus 로고
    • Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression
    • Werner H, Shen-Orr Z, Rauscher FJ 3rd, et al.: Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression. Mol Cell Biol 1995, 15: 3516-3522.
    • (1995) Mol Cell Biol , vol.15 , pp. 3516-3522
    • Werner, H.1    Shen-Orr, Z.2    Rauscher III, F.J.3
  • 71
    • 0034907769 scopus 로고    scopus 로고
    • The IGF/IGFBP system in CNS malignancy
    • Zumkeller W, Westphal M: The IGF/IGFBP system in CNS malignancy. Mol Pathol 2001, 54: 227-229.
    • (2001) Mol Pathol , vol.54 , pp. 227-229
    • Zumkeller, W.1    Westphal, M.2
  • 72
    • 20244364227 scopus 로고    scopus 로고
    • Inhibition of insulin-like growth factor I receptor increases the antitumor activity of doxorubicin and vincristine against Ewing's sarcoma cells
    • Benini S, Manara MC, Baldini N, et al.: Inhibition of insulin-like growth factor I receptor increases the antitumor activity of doxorubicin and vincristine against Ewing's sarcoma cells. Clin Cancer Res 2001, 7: 1790-1797.
    • (2001) Clin Cancer Res , vol.7 , pp. 1790-1797
    • Benini, S.1    Manara, M.C.2    Baldini, N.3
  • 73
    • 33745212417 scopus 로고    scopus 로고
    • Insulin-like growth factor I receptor pathway inhibition by ADW742, alone or in combination with imatinib, doxorubicin, or vincristine, is a novel therapeutic approach in Ewing tumor
    • Martins AS, Mackintosh C, Martin DH, et al.: Insulin-like growth factor I receptor pathway inhibition by ADW742, alone or in combination with imatinib, doxorubicin, or vincristine, is a novel therapeutic approach in Ewing tumor. Clin Cancer Res 2006, 12: 3532-3540.
    • (2006) Clin Cancer Res , vol.12 , pp. 3532-3540
    • Martins, A.S.1    Mackintosh, C.2    Martin, D.H.3
  • 74
    • 34548138930 scopus 로고    scopus 로고
    • Autocrine insulin-like growth factor-I signaling promotes growth and survival of human acute myeloid leukemia cells via the phosphoinositide 3-kinase/Akt pathway
    • Doepfner KT, Spertini O, Arcaro A: Autocrine insulin-like growth factor-I signaling promotes growth and survival of human acute myeloid leukemia cells via the phosphoinositide 3-kinase/Akt pathway. Leukemia 2007, 21: 1921-1930.
    • (2007) Leukemia , vol.21 , pp. 1921-1930
    • Doepfner, K.T.1    Spertini, O.2    Arcaro, A.3
  • 75
    • 0036164295 scopus 로고    scopus 로고
    • Expression of components of the IGF signalling system in childhood acute lymphoblastic leukaemia
    • Vorwerk P, Wex H, Hohmann B, et al.: Expression of components of the IGF signalling system in childhood acute lymphoblastic leukaemia. Mol Pathol 2002, 55: 40-45.
    • (2002) Mol Pathol , vol.55 , pp. 40-45
    • Vorwerk, P.1    Wex, H.2    Hohmann, B.3
  • 76
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L, et al.: BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004, 64: 7099-7109.
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 77
    • 18744405139 scopus 로고    scopus 로고
    • The ErbB receptors and their ligands in cancer: An overview
    • Normanno N, Bianco C, Strizzi L, et al.: The ErbB receptors and their ligands in cancer: An overview. Curr Drug Targets 2005, 6: 243-257.
    • (2005) Curr Drug Targets , vol.6 , pp. 243-257
    • Normanno, N.1    Bianco, C.2    Strizzi, L.3
  • 78
    • 33744487375 scopus 로고    scopus 로고
    • Incidence and prognostic impact of c-Kit, FLT3, and Ras gene mutations in core binding factor acute myeloid leukemia (CBF-AML)
    • Boissel N, Leroy H, Brethon B, et al.: Incidence and prognostic impact of c-Kit, FLT3, and Ras gene mutations in core binding factor acute myeloid leukemia (CBF-AML). Leukemia 2006, 20: 965-970.
    • (2006) Leukemia , vol.20 , pp. 965-970
    • Boissel, N.1    Leroy, H.2    Brethon, B.3
  • 79
    • 0037439437 scopus 로고    scopus 로고
    • The prognostic signifi-cance of bone marrow levels of neurofibromatosis-1 protein and ras oncogene mutations in patients with acute myeloid leukemia and myelodysplastic syndrome
    • Lu D, Nounou R, Beran M, et al.: The prognostic signifi-cance of bone marrow levels of neurofibromatosis-1 protein and ras oncogene mutations in patients with acute myeloid leukemia and myelodysplastic syndrome. Cancer 2003, 97: 441-449.
    • (2003) Cancer , vol.97 , pp. 441-449
    • Lu, D.1    Nounou, R.2    Beran, M.3
  • 80
    • 33646589708 scopus 로고    scopus 로고
    • Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignancies
    • Chen Y, Takita J, Hiwatari M, et al.: Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignancies. Genes Chromosomes Cancer 2006, 45: 583-591.
    • (2006) Genes Chromosomes Cancer , vol.45 , pp. 583-591
    • Chen, Y.1    Takita, J.2    Hiwatari, M.3
  • 81
    • 0033605482 scopus 로고    scopus 로고
    • Hyperactive Ras as a therapeutic target in neurofibromatosis type 1
    • Weiss B, Bollag G, Shannon K: Hyperactive Ras as a therapeutic target in neurofibromatosis type 1. Am J Med Genet 1999, 89: 14-22.
    • (1999) Am J Med Genet , vol.89 , pp. 14-22
    • Weiss, B.1    Bollag, G.2    Shannon, K.3
  • 82
    • 0034651043 scopus 로고    scopus 로고
    • Inhibition of juvenile myelomonocytic leukemia cell growth in vitro by farnesyltransferase inhibitors
    • Emanuel PD, Snyder RC, Wiley T, et al.: Inhibition of juvenile myelomonocytic leukemia cell growth in vitro by farnesyltransferase inhibitors. Blood 2000, 95: 639-645.
    • (2000) Blood , vol.95 , pp. 639-645
    • Emanuel, P.D.1    Snyder, R.C.2    Wiley, T.3
  • 83
    • 34248363673 scopus 로고    scopus 로고
    • A multicenter phase 2 study of the farnesyltransferase inhibitor tipifarnib in intermediate-to high-risk myelodysplastic syndrome
    • Fenaux P, Raza A, Mufti GJ, et al.: A multicenter phase 2 study of the farnesyltransferase inhibitor tipifarnib in intermediate-to high-risk myelodysplastic syndrome. Blood 2007, 109: 4158-4163.
    • (2007) Blood , vol.109 , pp. 4158-4163
    • Fenaux, P.1    Raza, A.2    Mufti, G.J.3
  • 84
    • 34250006852 scopus 로고    scopus 로고
    • A phase 2 study of the oral farnesyltransferase inhibitor tipifarnib in patients with refractory or relapsed acute myeloid leukemia
    • Harousseau JL, Lancet JE, Reiffers J, et al.: A phase 2 study of the oral farnesyltransferase inhibitor tipifarnib in patients with refractory or relapsed acute myeloid leukemia. Blood 2007, 109: 5151-5156.
    • (2007) Blood , vol.109 , pp. 5151-5156
    • Harousseau, J.L.1    Lancet, J.E.2    Reiffers, J.3
  • 85
    • 0035383789 scopus 로고    scopus 로고
    • Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: A phase 1 clinical-laboratory correlative trial
    • Karp JE, Lancet JE, Kaufmann SH, et al.: Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: A phase 1 clinical-laboratory correlative trial. Blood 2001, 97: 3361-3369.
    • (2001) Blood , vol.97 , pp. 3361-3369
    • Karp, J.E.1    Lancet, J.E.2    Kaufmann, S.H.3
  • 86
    • 9144222570 scopus 로고    scopus 로고
    • Clofarabine, a novel nucleoside analog, is active in pediatric patients with advanced leukemia
    • Jeha S, Gandhi V, Chan KW, et al.: Clofarabine, a novel nucleoside analog, is active in pediatric patients with advanced leukemia. Blood 2004, 103: 784-789.
    • (2004) Blood , vol.103 , pp. 784-789
    • Jeha, S.1    Gandhi, V.2    Chan, K.W.3
  • 87
    • 33750601477 scopus 로고    scopus 로고
    • Purine nucleoside analogs as immunosuppressive and antineoplastic agents: Mechanism of action and clinical activity
    • Robak T, Lech-Maranda E, Korycka A, Robak E: Purine nucleoside analogs as immunosuppressive and antineoplastic agents: Mechanism of action and clinical activity. Curr Med Chem 2006, 13: 3165-3189.
    • (2006) Curr Med Chem , vol.13 , pp. 3165-3189
    • Robak, T.1    Lech-Maranda, E.2    Korycka, A.3    Robak, E.4
  • 88
    • 0038730672 scopus 로고    scopus 로고
    • Mechanism of inhibition of T-acute lymphoblastic leukemia cells by PNP inhibitor-BCX-1777
    • Bantia S, Ananth SL, Parker CD, et al.: Mechanism of inhibition of T-acute lymphoblastic leukemia cells by PNP inhibitor-BCX-1777. Int Immunopharmacol 2003, 3: 879-887.
    • (2003) Int Immunopharmacol , vol.3 , pp. 879-887
    • Bantia, S.1    Ananth, S.L.2    Parker, C.D.3
  • 89
    • 33749329192 scopus 로고    scopus 로고
    • Approval summary: Nelarabine for the treatment of T-cell lymphoblastic leukemia/lymphoma
    • Cohen MH, JoNnson JR, Massie T, et al.: Approval summary: nelarabine for the treatment of T-cell lymphoblastic leukemia/lymphoma. Clin Cancer Res 2006, 12: 5329-5335.
    • (2006) Clin Cancer Res , vol.12 , pp. 5329-5335
    • Cohen, M.H.1    Johnson, J.R.2    Massie, T.3
  • 90
    • 37049003122 scopus 로고    scopus 로고
    • Forodesine IV (Bcx-1777) is clinically active in relapsed/refractory T-cell leukemia: Results of a phase II study (interim report)
    • Furman RR, Gore L, Ravandi F, Hoelzer D: Forodesine IV (Bcx-1777) is clinically active in relapsed/refractory T-cell leukemia: Results of a phase II study (interim report). ASH Annual Meeting Abstracts 2006, 108: 1851.
    • (2006) ASH Annual Meeting Abstracts , vol.108 , pp. 1851
    • Furman, R.R.1    Gore, L.2    Ravandi, F.3    Hoelzer, D.4
  • 91
    • 58649085157 scopus 로고    scopus 로고
    • Phase II study of forodesine, a PNP inhibitor, in patients with relapsed or refractory B-lineage acute lymphoblastic leukemia
    • In Orlando, Fl
    • Ritchie E, Gore L, Roboz G, et al.: Phase II study of forodesine, a PNP inhibitor, in patients with relapsed or refractory B-lineage acute lymphoblastic leukemia. In 48th Annual Meeting of the American Society of Hematology. Orlando, Fl: 2006.
    • (2006) 48th Annual Meeting of the American Society of Hematology
    • Ritchie, E.1    Gore, L.2    Roboz, G.3
  • 92
    • 2642551603 scopus 로고    scopus 로고
    • Development of the proteasome inhibitor Velcade (bortezomib)
    • Adams J, Kauffman M: Development of the proteasome inhibitor Velcade (bortezomib). Cancer Invest 2004, 22: 304-311.
    • (2004) Cancer Invest , vol.22 , pp. 304-311
    • Adams, J.1    Kauffman, M.2
  • 93
    • 0035328584 scopus 로고    scopus 로고
    • Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: Implications for systemic nuclear factor-kappaB inhibition
    • Cusack JC Jr, Liu R, Houston M, et al.: Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: Implications for systemic nuclear factor-kappaB inhibition. Cancer Res 2001, 61: 3535-3540.
    • (2001) Cancer Res , vol.61 , pp. 3535-3540
    • Cusack Jr., J.C.1    Liu, R.2    Houston, M.3
  • 94
    • 2542481724 scopus 로고    scopus 로고
    • Phase I study of bortezomib in refractory or relapsed acute leukemias
    • Cortes J, Thomas D, Koller C, et al.: Phase I study of bortezomib in refractory or relapsed acute leukemias. Clin Cancer Res 2004, 10: 3371-3376.
    • (2004) Clin Cancer Res , vol.10 , pp. 3371-3376
    • Cortes, J.1    Thomas, D.2    Koller, C.3
  • 95
    • 33747443493 scopus 로고    scopus 로고
    • Effect of bortezomib on human neuroblastoma cell growth, apoptosis, and angiogenesis
    • Brignole C, Marimpietri D, Pastorino F, et al.: Effect of bortezomib on human neuroblastoma cell growth, apoptosis, and angiogenesis. J Natl Cancer Inst 2006, 98: 1142-1157.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 1142-1157
    • Brignole, C.1    Marimpietri, D.2    Pastorino, F.3
  • 96
    • 33646472266 scopus 로고    scopus 로고
    • Proteasome inhibition to maximize the apoptotic potential of cytokine therapy for murine neuroblastoma tumors
    • Khan T, Stauffer JK, Williams R, et al.: Proteasome inhibition to maximize the apoptotic potential of cytokine therapy for murine neuroblastoma tumors. J Immunol 2006, 176: 6302-6312.
    • (2006) J Immunol , vol.176 , pp. 6302-6312
    • Khan, T.1    Stauffer, J.K.2    Williams, R.3
  • 97
    • 0030869925 scopus 로고    scopus 로고
    • Apoptosis of Ewing's sarcoma cells is accompanied by accumulation of ubiquitinated proteins
    • Soldatenkov VA, Dritschilo A: Apoptosis of Ewing's sarcoma cells is accompanied by accumulation of ubiquitinated proteins. Cancer Res 1997, 57: 3881-3885.
    • (1997) Cancer Res , vol.57 , pp. 3881-3885
    • Soldatenkov, V.A.1    Dritschilo, A.2
  • 98
    • 34447108737 scopus 로고    scopus 로고
    • Caspase-8 dependent osteosarcoma cell apoptosis induced by proteasome inhibitor MG132
    • Yan XB, Yang DS, Gao X, et al.: Caspase-8 dependent osteosarcoma cell apoptosis induced by proteasome inhibitor MG132. Cell Biol Int 2007, 31: 1136-1143.
    • (2007) Cell Biol Int , vol.31 , pp. 1136-1143
    • Yan, X.B.1    Yang, D.S.2    Gao, X.3
  • 99
    • 36849020943 scopus 로고    scopus 로고
    • Initial testing (stage 1) of the proteasome inhibitor bortezomib by the pediatric preclinical testing program
    • Houghton PJ, Morton CL, Kolb EA, et al.: Initial testing (stage 1) of the proteasome inhibitor bortezomib by the pediatric preclinical testing program. Pediatr Blood Cancer 2008, 50: 37-45.
    • (2008) Pediatr Blood Cancer , vol.50 , pp. 37-45
    • Houghton, P.J.1    Morton, C.L.2    Kolb, E.A.3
  • 100
    • 16544389047 scopus 로고    scopus 로고
    • Phase I study of the proteasome inhibitor bortezomib in pediatric patients with refractory solid tumors: A Children's Oncology Group study (ADVL0015)
    • Blaney SM, Bernstein M, Neville K, et al.: Phase I study of the proteasome inhibitor bortezomib in pediatric patients with refractory solid tumors: A Children's Oncology Group study (ADVL0015). J Clin Oncol 2004, 22: 4804-4809.
    • (2004) J Clin Oncol , vol.22 , pp. 4804-4809
    • Blaney, S.M.1    Bernstein, M.2    Neville, K.3
  • 101
    • 33947362982 scopus 로고    scopus 로고
    • A phase 1 study of the proteasome inhibitor bortezomib in pediatric patients with refractory leukemia: A Children's Oncology Group study
    • Horton TM, Pati D, Plon SE, et al.: A phase 1 study of the proteasome inhibitor bortezomib in pediatric patients with refractory leukemia: A Children's Oncology Group study. Clin Cancer Res 2007, 13: 1516-1522.
    • (2007) Clin Cancer Res , vol.13 , pp. 1516-1522
    • Horton, T.M.1    Pati, D.2    Plon, S.E.3
  • 102
    • 27644562277 scopus 로고    scopus 로고
    • A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from bortezomib
    • Chauhan D, Catley L, Li G, et al.: A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from bortezomib. Cancer Cell 2005, 8: 407-419.
    • (2005) Cancer Cell , vol.8 , pp. 407-419
    • Chauhan, D.1    Catley, L.2    Li, G.3
  • 103
    • 38949125853 scopus 로고    scopus 로고
    • Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma
    • Chauhan D, Singh A, Brahmandam M, et al.: Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma. Blood 2008, 111: 1654-1664.
    • (2008) Blood , vol.111 , pp. 1654-1664
    • Chauhan, D.1    Singh, A.2    Brahmandam, M.3
  • 104
    • 0034722888 scopus 로고    scopus 로고
    • The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
    • Hidalgo M, Rowinsky EK: The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene 2000, 19: 6680-6686.
    • (2000) Oncogene , vol.19 , pp. 6680-6686
    • Hidalgo, M.1    Rowinsky, E.K.2
  • 105
    • 2342559981 scopus 로고    scopus 로고
    • The TOR pathway: A target for cancer therapy
    • Bjornsti MAA Houghton PJ: The TOR pathway: a target for cancer therapy. Nat Rev Cancer 2004, 4: 335-348.
    • (2004) Nat Rev Cancer , vol.4 , pp. 335-348
    • Bjornsti, M.A.1    Houghton, P.J.2
  • 106
    • 0036174289 scopus 로고    scopus 로고
    • Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
    • Guba M, von Breitenbuch P, Steinbauer M, et al.: Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor. Nat Med 2002, 8: 128-135.
    • (2002) Nat Med , vol.8 , pp. 128-135
    • Guba, M.1    von Breitenbuch, P.2    Steinbauer, M.3
  • 107
    • 0345166113 scopus 로고    scopus 로고
    • Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling
    • Brown VI, Fang J, Alcorn K, et al.: Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling. Proc Natl Acad Sci U S A 2003, 100: 15113-15118.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 15113-15118
    • Brown, V.I.1    Fang, J.2    Alcorn, K.3
  • 108
    • 31544443832 scopus 로고    scopus 로고
    • The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL
    • Teachey DT, Obzut DA, Cooperman J, et al.: The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL. Blood 2006, 107: 1149-1155.
    • (2006) Blood , vol.107 , pp. 1149-1155
    • Teachey, D.T.1    Obzut, D.A.2    Cooperman, J.3
  • 109
    • 0035866358 scopus 로고    scopus 로고
    • Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy
    • Geoerger B, Kerr K, Tang CB, et al.: Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy. Cancer Res 2001, 61: 1527-1532.
    • (2001) Cancer Res , vol.61 , pp. 1527-1532
    • Geoerger, B.1    Kerr, K.2    Tang, C.B.3
  • 110
    • 42949133285 scopus 로고    scopus 로고
    • Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo
    • Johnsen JI, Segerstrom L, Orrego A, et al.: Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo. Oncogene 2008, 27: 2910-2922.
    • (2008) Oncogene , vol.27 , pp. 2910-2922
    • Johnsen, J.I.1    Segerstrom, L.2    Orrego, A.3
  • 111
    • 16844366544 scopus 로고    scopus 로고
    • Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma
    • Wan X, Mendoza A, Khanna C, Helman LJ: Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma. Cancer Res 2005, 65: 2406-2411.
    • (2005) Cancer Res , vol.65 , pp. 2406-2411
    • Wan, X.1    Mendoza, A.2    Khanna, C.3    Helman, L.J.4
  • 112
    • 33744829237 scopus 로고    scopus 로고
    • CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1alpha/VEGF signaling
    • Wan X, Shen N, Mendoza A, et al.: CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1alpha/VEGF signaling. Neoplasia 2006, 8: 394-401.
    • (2006) Neoplasia , vol.8 , pp. 394-401
    • Wan, X.1    Shen, N.2    Mendoza, A.3
  • 113
    • 40449091406 scopus 로고    scopus 로고
    • Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program
    • Houghton PJ, Morton CL, Kolb EA, et al.: Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program. Pediatr Blood Cancer 2008, 50: 799-805.
    • (2008) Pediatr Blood Cancer , vol.50 , pp. 799-805
    • Houghton, P.J.1    Morton, C.L.2    Kolb, E.A.3
  • 114
    • 34547864236 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Molecular mechanisms of action
    • Xu WS, Parmigiani RB, Marks PA: Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene 2007, 26: 5541-5552.
    • (2007) Oncogene , vol.26 , pp. 5541-5552
    • Xu, W.S.1    Parmigiani, R.B.2    Marks, P.A.3
  • 115
    • 23944450068 scopus 로고    scopus 로고
    • DNA methylation in neuroblastic tumors
    • Banelli B, Di Vinci A, Gelvi I, et al.: DNA methylation in neuroblastic tumors. Cancer Lett 2005, 228: 37-41.
    • (2005) Cancer Lett , vol.228 , pp. 37-41
    • Banelli, B.1    Di Vinci, A.2    Gelvi, I.3
  • 116
    • 2442471534 scopus 로고    scopus 로고
    • Aberrations of p16INK4A, p14ARF and p15INK4B genes in pediatric solid tumors
    • Obana K, Yang HW, Piao HY, et al.: Aberrations of p16INK4A, p14ARF and p15INK4B genes in pediatric solid tumors. Int J Oncol 2003, 23: 1151-1157.
    • (2003) Int J Oncol , vol.23 , pp. 1151-1157
    • Obana, K.1    Yang, H.W.2    Piao, H.Y.3
  • 117
    • 0036211680 scopus 로고    scopus 로고
    • Alterations in the INK4a/ARF locus and their effects on the growth of human osteosarcoma cell lines
    • Park YB, Park MJ, Kimura K, et al.: Alterations in the INK4a/ARF locus and their effects on the growth of human osteosarcoma cell lines. Cancer Genet Cytogenet 2002, 133: 105-111.
    • (2002) Cancer Genet Cytogenet , vol.133 , pp. 105-111
    • Park, Y.B.1    Park, M.J.2    Kimura, K.3
  • 118
    • 0036007596 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin, a potent and selective anti-CD33 antibody-calicheamicin conjugate for treatment of acute myeloid leukemia
    • Hamann PR, Hinman LM, Hollander I, et al.: Gemtuzumab ozogamicin, a potent and selective anti-CD33 antibody-calicheamicin conjugate for treatment of acute myeloid leukemia. Bioconjug Chem 2002, 13: 47-58.
    • (2002) Bioconjug Chem , vol.13 , pp. 47-58
    • Hamann, P.R.1    Hinman, L.M.2    Hollander, I.3
  • 119
    • 33845261567 scopus 로고    scopus 로고
    • Identification of candidate target antigens for antibody-based immunotherapy in childhood B-cell precursor ALL
    • Gudowius S, Recker K, Laws HJ, et al.: Identification of candidate target antigens for antibody-based immunotherapy in childhood B-cell precursor ALL. Klin Padiatr 2006, 218: 327-333.
    • (2006) Klin Padiatr , vol.218 , pp. 327-333
    • Gudowius, S.1    Recker, K.2    Laws, H.J.3
  • 120
    • 0030954684 scopus 로고    scopus 로고
    • Recombinant RFB4 immunotoxins exhibit potent cytotoxic activity for CD22-bearing cells and tumors
    • Mansfield E, Amlot P, Pastan I, FitzGerald DJ: Recombinant RFB4 immunotoxins exhibit potent cytotoxic activity for CD22-bearing cells and tumors. Blood 1997, 90: 2020-2026.
    • (1997) Blood , vol.90 , pp. 2020-2026
    • Mansfield, E.1    Amlot, P.2    Pastan, I.3    FitzGerald, D.J.4
  • 121
    • 33748778482 scopus 로고    scopus 로고
    • Epratuzumab, a CD22-targeting recombinant humanized antibody with a different mode of action from rituximab
    • Carnahan J, Stein R, Qu Z, et al.: Epratuzumab, a CD22-targeting recombinant humanized antibody with a different mode of action from rituximab. Mol Immunol 2007, 44: 1331-1341.
    • (2007) Mol Immunol , vol.44 , pp. 1331-1341
    • Carnahan, J.1    Stein, R.2    Qu, Z.3
  • 122
    • 12444270688 scopus 로고    scopus 로고
    • Epratuzumab, a humanized monoclonal antibody targeting CD22: Characterization of in vitro properties
    • Carnahan J, Wang P, Kendall R, et al.: Epratuzumab, a humanized monoclonal antibody targeting CD22: Characterization of in vitro properties. Clin Cancer Res 2003, 9: 3982S-3990S.
    • (2003) Clin Cancer Res , vol.9
    • Carnahan, J.1    Wang, P.2    Kendall, R.3
  • 123
    • 33947386313 scopus 로고    scopus 로고
    • Synergism between etoposide and 17-AAG in leukemia cells: Critical roles for Hsp90, FLT3, topoisomerase II, Chk1, and Rad51
    • Yao Q, Weigel B, Kersey J: Synergism between etoposide and 17-AAG in leukemia cells: Critical roles for Hsp90, FLT3, topoisomerase II, Chk1, and Rad51. Clin Cancer Res 2007, 13: 1591-1600.
    • (2007) Clin Cancer Res , vol.13 , pp. 1591-1600
    • Yao, Q.1    Weigel, B.2    Kersey, J.3
  • 124
    • 0029813620 scopus 로고    scopus 로고
    • Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway
    • Schulte TW, Blagosklonny MV, Romanova L, et al.: Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway. Mol Cell Biol 1996, 16: 5839-5845.
    • (1996) Mol Cell Biol , vol.16 , pp. 5839-5845
    • Schulte, T.W.1    Blagosklonny, M.V.2    Romanova, L.3
  • 125
    • 0028064940 scopus 로고
    • Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation
    • Whitesell L, Mimnaugh EG, De Costa B, et al.: Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation. Proc Natl Acad Sci U S A 1994, 91: 8324-8328.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 8324-8328
    • Whitesell, L.1    Mimnaugh, E.G.2    De Costa, B.3
  • 126
    • 2442695516 scopus 로고    scopus 로고
    • Cotreatment with 17-allylamino-demethoxygeldanamycin and FLT-3 kinase inhibitor PKC412 is highly effective against human acute myelogenous leukemia cells with mutant FLT-3
    • George P, Bali P, Cohen P, et al.: Cotreatment with 17-allylamino-demethoxygeldanamycin and FLT-3 kinase inhibitor PKC412 is highly effective against human acute myelogenous leukemia cells with mutant FLT-3. Cancer Res 2004, 64: 3645-3652.
    • (2004) Cancer Res , vol.64 , pp. 3645-3652
    • George, P.1    Bali, P.2    Cohen, P.3
  • 127
    • 22044437522 scopus 로고    scopus 로고
    • Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine
    • Mesa RA, Loegering D, Powell HL, et al.: Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine. Blood 2005, 106: 318-327.
    • (2005) Blood , vol.106 , pp. 318-327
    • Mesa, R.A.1    Loegering, D.2    Powell, H.L.3
  • 128
    • 10344225631 scopus 로고    scopus 로고
    • Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin
    • Bagatell R, Beliakoff J, David CL, et al.: Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin. Int J Cancer 2005, 113: 179-188.
    • (2005) Int J Cancer , vol.113 , pp. 179-188
    • Bagatell, R.1    Beliakoff, J.2    David, C.L.3
  • 129
    • 36048975114 scopus 로고    scopus 로고
    • Inhibition of Hsp90 function by ansamycins causes downregulation of cdc2 and cdc25c and G(2)/M arrest in glioblastoma cell lines
    • Garcia-Morales P, Carrasco-Garcia E, Ruiz-Rico P, et al.: Inhibition of Hsp90 function by ansamycins causes downregulation of cdc2 and cdc25c and G(2)/M arrest in glioblastoma cell lines. Oncogene 2007, 26: 7185-7193.
    • (2007) Oncogene , vol.26 , pp. 7185-7193
    • Garcia-Morales, P.1    Carrasco-Garcia, E.2    Ruiz-Rico, P.3
  • 130
    • 33745590865 scopus 로고    scopus 로고
    • Inhibition of neuroblastoma xenograft growth by Hsp90 inhibitors
    • Kang J, Kamal A, Burrows FJ, et al.: Inhibition of neuroblastoma xenograft growth by Hsp90 inhibitors. Anticancer Res 2006, 26: 1903-1908.
    • (2006) Anticancer Res , vol.26 , pp. 1903-1908
    • Kang, J.1    Kamal, A.2    Burrows, F.J.3
  • 131
    • 34250162501 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of 17-Nallylamino-17-demethoxygeldanamycin in pediatric patients with recurrent or refractory solid tumors: A pediatric oncology experimental therapeutics investigators consortium study
    • Bagatell R, Gore L, Egorin MJ, et al.: Phase I pharmacokinetic and pharmacodynamic study of 17-Nallylamino-17-demethoxygeldanamycin in pediatric patients with recurrent or refractory solid tumors: A pediatric oncology experimental therapeutics investigators consortium study. Clin Cancer Res 2007, 13: 1783-1788.
    • (2007) Clin Cancer Res , vol.13 , pp. 1783-1788
    • Bagatell, R.1    Gore, L.2    Egorin, M.J.3
  • 132
    • 34250182069 scopus 로고    scopus 로고
    • A phase I study of 17-allylaminogeldanamycin in relapsed/refractory pediatric patients with solid tumors: A Children's Oncology Group study
    • Weigel BJ, Blaney SM, Reid JM, et al.: A phase I study of 17-allylaminogeldanamycin in relapsed/refractory pediatric patients with solid tumors: A Children's Oncology Group study. Clin Cancer Res 2007, 13: 1789-1793.
    • (2007) Clin Cancer Res , vol.13 , pp. 1789-1793
    • Weigel, B.J.1    Blaney, S.M.2    Reid, J.M.3
  • 133
    • 33646366173 scopus 로고    scopus 로고
    • Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia
    • Grabher C, von Boehmer H, Look AT: Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. Nat Rev Cancer 2006, 6: 347-359.
    • (2006) Nat Rev Cancer , vol.6 , pp. 347-359
    • Grabher, C.1    von Boehmer, H.2    Look, A.T.3
  • 134
    • 0033617522 scopus 로고    scopus 로고
    • Notch signaling: Cell fate control and signal integration in development
    • Artavanis-TCakonas S, Rand MD, Lake RJ: Notch signaling: cell fate control and signal integration in development. Science 1999, 284: 770-776.
    • (1999) Science , vol.284 , pp. 770-776
    • Artavanis-Tsakonas, S.1    Rand, M.D.2    Lake, R.J.3
  • 136
    • 34250796873 scopus 로고    scopus 로고
    • Inhibition of notch signaling induces neural differentiation in Ewing sarcoma
    • Baliko F, Bright T, Poon R, et al.: Inhibition of notch signaling induces neural differentiation in Ewing sarcoma. Am J Pathol 2007, 170: 1686-1694.
    • (2007) Am J Pathol , vol.170 , pp. 1686-1694
    • Baliko, F.1    Bright, T.2    Poon, R.3
  • 137
    • 49649103793 scopus 로고    scopus 로고
    • Critical role of notch signaling in osteosarcoma invasion and metastasis
    • Zhang P, Yang Y, Zweidler-McKay PA, Hughes DP: Critical role of notch signaling in osteosarcoma invasion and metastasis. Clin Cancer Res 2008, 14: 2962-2969.
    • (2008) Clin Cancer Res , vol.14 , pp. 2962-2969
    • Zhang, P.1    Yang, Y.2    Zweidler-McKay, P.A.3    Hughes, D.P.4
  • 138
    • 5044225888 scopus 로고    scopus 로고
    • Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
    • Weng AP, Ferrando AA, Lee W, et al.: Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004, 306: 269-271.
    • (2004) Science , vol.306 , pp. 269-271
    • Weng, A.P.1    Ferrando, A.A.2    Lee, W.3
  • 139
    • 11144355129 scopus 로고    scopus 로고
    • Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation
    • Wong GT, Manfra D, Poulet FM, et al.: Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. J Biol Chem 2004, 279: 12876-12882.
    • (2004) J Biol Chem , vol.279 , pp. 12876-12882
    • Wong, G.T.1    Manfra, D.2    Poulet, F.M.3
  • 140
    • 38049177209 scopus 로고    scopus 로고
    • Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus
    • Breunig JJ, Silbereis J, Vaccarino FM, et al.: Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus. Proc Natl Acad Sci U S A 2007, 104: 20558-20563.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 20558-20563
    • Breunig, J.J.1    Silbereis, J.2    Vaccarino, F.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.