-
2
-
-
0037444803
-
Histone deacetylases (HDACs): Characterization of the classical HDAC family
-
DOI 10.1042/BJ20021321
-
de Ruijter AJ, van Gennip AH, Caron HN, Kemp S, van Kuilenburg AB. Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J 2003;370(Pt 3):737-49. (Pubitemid 36399066)
-
(2003)
Biochemical Journal
, vol.370
, Issue.3
, pp. 737-749
-
-
De, R.A.J.M.1
Van, G.A.H.2
Caron, H.N.3
Kemp, S.4
Van, K.A.B.P.5
-
3
-
-
0035755974
-
Histone deacetylases and cancer: Causes and therapies
-
Marks P, Rifkind RA, Richon VM, Breslow R, Miller T, Kelly WK. Histone deacetylases and cancer: causes and therapies. Nat Rev Cancer 2001;1:194-202. (Pubitemid 33741894)
-
(2001)
Nature Reviews Cancer
, vol.1
, Issue.3
, pp. 194-202
-
-
Marks, P.A.1
Rifkind, R.A.2
Richon, V.M.3
Breslow, R.4
Miller, T.5
Kelly, W.K.6
-
4
-
-
28644440158
-
Histone deacetylase inhibitors: Discovery and development as anticancer agents
-
DOI 10.1517/13543784.14.12.1497
-
Marks PA, Dokmanovic M. Histone deacetylase inhibitors: discovery and development as anticancer agents. Expert Opin Investig Drugs 2005;14:1497-511. (Pubitemid 41749195)
-
(2005)
Expert Opinion on Investigational Drugs
, vol.14
, Issue.12
, pp. 1497-1511
-
-
Marks, P.A.1
Dokmanovic, M.2
-
5
-
-
20144388146
-
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
-
Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G, et al. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet 2005;37:391-400.
-
(2005)
Nat Genet
, vol.37
, pp. 391-400
-
-
Fraga, M.F.1
Ballestar, E.2
Villar-Garea, A.3
Boix-Chornet, M.4
Espada, J.5
Schotta, G.6
-
6
-
-
33748451151
-
Anticancer activities of histone deacetylase inhibitors
-
DOI 10.1038/nrd2133, PII NRD2133
-
Bolden JE, Peart MJ, Johnstone RW. Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov 2006;5:769-84. (Pubitemid 44348499)
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, Issue.9
, pp. 769-784
-
-
Bolden, J.E.1
Peart, M.J.2
Johnstone, R.W.3
-
7
-
-
0036402177
-
Basic pharmacology of valproate: A review after 35 years of clinical use for the treatment of epilepsy
-
Loscher W. Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy. CNS Drugs 2002;16:669-94. (Pubitemid 35176853)
-
(2002)
CNS Drugs
, vol.16
, Issue.10
, pp. 669-694
-
-
Loscher, W.1
-
8
-
-
0035965343
-
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
-
Phiel CJ, Zhang F, Huang EY, Guenther MG, Lazar MA, Klein PS. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem 2001; 276:36734-41.
-
(2001)
J Biol Chem
, vol.276
, pp. 36734-36741
-
-
Phiel, C.J.1
Zhang, F.2
Huang, E.Y.3
Guenther, M.G.4
Lazar, M.A.5
Klein, P.S.6
-
9
-
-
18244383806
-
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
-
DOI 10.1093/emboj/20.24.6969
-
Gottlicher M, Minucci S, Zhu P, Krämer OH, Schimpf A, Giavara S, et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J 2001;20:6969-78. (Pubitemid 34062289)
-
(2001)
EMBO Journal
, vol.20
, Issue.24
, pp. 6969-6978
-
-
Gottlicher, M.1
Minucci, S.2
Zhu, P.3
Kramer, O.H.4
Schimpf, A.5
Giavara, S.6
Sleeman, J.P.7
Lo, C.F.8
Nervi, C.9
Pelicci, P.G.10
Heinzel, T.11
-
10
-
-
0035062167
-
Different effects of valproic acid on proliferation and migration of malignant glioma cells in vitro
-
Knupfer MM, Pulzer F, Schindler I, Hernaiz Driever P, Knupfer H, Keller E. Different effects of valproic acid on proliferation and migration of malignant glioma cells in vitro. Anticancer Res 2001;21:347-51.
-
(2001)
Anticancer Res
, vol.21
, pp. 347-351
-
-
Knupfer, M.M.1
Pulzer, F.2
Schindler, I.3
Hernaiz Driever, P.4
Knupfer, H.5
Keller, E.6
-
11
-
-
2342603414
-
Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis
-
DOI 10.1016/S1535-6108(04)00114-X, PII S153561080400114X
-
Zhu P, Martin E, Mengwasser J, Schlag P, Janssen KP, Gottlicher M. Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis. Cancer Cell 2004;5:455-63. (Pubitemid 38610247)
-
(2004)
Cancer Cell
, vol.5
, Issue.5
, pp. 455-463
-
-
Zhu, P.1
Martin, E.2
Mengwasser, J.3
Schlag, P.4
Janssen, K.-P.5
Gottlicher, M.6
-
12
-
-
58249129178
-
Valproic acid as a therapeutic agent for head and neck squamous cell carcinomas
-
Erlich RB, Rickwood D, Coman WB, Saunders NA, Guminski A. Valproic acid as a therapeutic agent for head and neck squamous cell carcinomas. Cancer Chemother Pharmacol 2008;63:381-9.
-
(2008)
Cancer Chemother Pharmacol
, vol.63
, pp. 381-389
-
-
Erlich, R.B.1
Rickwood, D.2
Coman, W.B.3
Saunders, N.A.4
Guminski, A.5
-
13
-
-
0029909687
-
Antitumor activity of sodium valproate in cultures of human neuroblastoma cells
-
Cinatl J, Jr., Cinatl J, Scholz M, Driever PH, Henrich D, Kabickova H, et al. Antitumor activity of sodium valproate in cultures of human neuroblastoma cells. Anticancer Drugs 1996;7:766-73. (Pubitemid 26388767)
-
(1996)
Anti-Cancer Drugs
, vol.7
, Issue.7
, pp. 766-773
-
-
Cinatl Jr., J.1
Cinatl, J.2
Scholz, M.3
Driever, P.H.4
Henrich, D.5
Kabickova, H.6
Vogel, J.-U.7
Doerr, H.W.8
Kornhuber, B.9
-
14
-
-
33748053974
-
Valproic acid prolongs survival time of severe combined immunodeficient mice bearing intracerebellar orthotopic medulloblastoma xenografts
-
DOI 10.1158/1078-0432.CCR-05-2849
-
Shu Q, Antalffy B, Su JM, Adesina A, Ou CN, Pietsch T, et al. Valproic Acid prolongs survival time of severe combined immunodeficient mice bearing intracerebellar orthotopic medulloblastoma xenografts. Clin Cancer Res 2006;12: 4687-94. (Pubitemid 44297822)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.15
, pp. 4687-4694
-
-
Shu, Q.1
Antalffy, B.2
Su, J.M.F.3
Adesina, A.4
Ou, C.-N.5
Pietsch, T.6
Blaney, S.M.7
Lau, C.C.8
Li, X.-N.9
-
15
-
-
33947153003
-
Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood
-
DOI 10.1002/ijc.22401
-
Furchert SE, Lanvers-Kaminsky C, Juurgens H, Jung M, Loidl A, Fruhwald MC. Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood. Int J Cancer 2007;120:1787-94. (Pubitemid 46399367)
-
(2007)
International Journal of Cancer
, vol.120
, Issue.8
, pp. 1787-1794
-
-
Furchert, S.E.1
Lanvers-Kaminsky, C.2
Jurgens, H.3
Jung, M.4
Loidl, A.5
Fruhwald, M.C.6
-
16
-
-
33744956666
-
Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer
-
DOI 10.1074/jbc.M510023200
-
Wilson AJ, Byun DS, Popova N, Murray LB, L'Italien K, Sowa Y, et al. Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer. J Biol Chem 2006;281:13548-58. (Pubitemid 43855268)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.19
, pp. 13548-13558
-
-
Wilson, A.J.1
Byun, D.-S.2
Popova, N.3
Murray, L.B.4
L'Italien, K.5
Sowa, Y.6
Arango, D.7
Velcich, A.8
Augenlicht, L.H.9
Mariadason, J.M.10
-
17
-
-
0842325787
-
Histone Deacetylase Is a Target of Valproic Acid-Mediated Cellular Differentiation
-
DOI 10.1158/0008-5472.CAN-03-0799
-
Gurvich N, Tsygankova OM, Meinkoth JL, Klein PS. Histone deacetylase is a target of valproic acid-mediated cellular differentiation. Cancer Res 2004;64:1079-86. (Pubitemid 38176913)
-
(2004)
Cancer Research
, vol.64
, Issue.3
, pp. 1079-1086
-
-
Gurvich, N.1
Tsygankova, O.M.2
Meinkoth, J.L.3
Klein, P.S.4
-
18
-
-
0141570564
-
Role of Class I and Class II histone deacetylases in carcinoma cells using siRNA
-
DOI 10.1016/j.bbrc.2003.09.043
-
Glaser KB, Li J, Staver MJ, Wei RQ, Albert DH, Davidsen SK. Role of class I and class II histone deacetylases in carcinoma cells using siRNA. Biochem Biophys Res Commun 2003;310:529-36. (Pubitemid 37163696)
-
(2003)
Biochemical and Biophysical Research Communications
, vol.310
, Issue.2
, pp. 529-536
-
-
Glaser, K.B.1
Li, J.2
Staver, M.J.3
Wei, R.-Q.4
Albert, D.H.5
Davidsen, S.K.6
-
19
-
-
33750530675
-
Phase 1/2 study of the combination of 5-aza-2′-deoxycytidine with valproic acid in patients with leukemia
-
Garcia-Manero G, Kantarjian HM, Sanchez-Gonzalez B, Yang H, Rosner G, Verstovsek S, et al. Phase 1/2 study of the combination of 5-aza-2′- deoxycytidine with valproic acid in patients with leukemia. Blood 2006;108:3271-9.
-
(2006)
Blood
, vol.108
, pp. 3271-3279
-
-
Garcia-Manero, G.1
Kantarjian, H.M.2
Sanchez-Gonzalez, B.3
Yang, H.4
Rosner, G.5
Verstovsek, S.6
-
20
-
-
34948845116
-
Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome
-
DOI 10.1182/blood-2007-03-078576
-
Soriano AO, Yang H, Faderl S, Estrov Z, Giles F, Ravandi F, et al. Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome. Blood 2007;110:2302-8. (Pubitemid 47523148)
-
(2007)
Blood
, vol.110
, Issue.7
, pp. 2302-2308
-
-
Soriano, A.O.1
Yang, H.2
Faderl, S.3
Estrov, Z.4
Giles, F.5
Ravandi, F.6
Cortes, J.7
Wierda, W.G.8
Ouzounian, S.9
Quezada, A.10
Pierce, S.11
Estey, E.H.12
Issa, J.-P.J.13
Kantarjian, H.M.14
Garcia-Manero, G.15
-
21
-
-
29744454120
-
The histone deacetylase (HDAC) inhibitor valproic acid as monotherapy or in combination with all-trans retinoic acid in patients with acute myeloid leukemia
-
DOI 10.1002/cncr.21552
-
Kuendgen A, Schmid M, Schlenk R, Knipp S, Hildebrandt B, Steidl C, et al. The histone deacetylase (HDAC) inhibitor valproic acid as monotherapy or in combination with all-trans retinoic acid in patients with acute myeloid leukemia. Cancer 2006;106:112-9. (Pubitemid 43032555)
-
(2006)
Cancer
, vol.106
, Issue.1
, pp. 112-119
-
-
Kuendgen, A.1
Schmid, M.2
Schlenk, R.3
Knipp, S.4
Hildebrandt, B.5
Steidl, C.6
Germing, U.7
Haas, R.8
Dohner, H.9
Gattermann, N.10
-
22
-
-
34548529948
-
Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia
-
DOI 10.1200/JCO.2006.09.4169
-
Blum W, Klisovic RB, Hackanson B, Liu Z, Liu S, Devine H, et al. Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia. J Clin Oncol 2007;25:3884-91. (Pubitemid 47477265)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.25
, pp. 3884-3891
-
-
Blum, W.1
Klisovic, R.B.2
Hackanson, B.3
Liu, Z.4
Liu, S.5
Devine, H.6
Vukosavljevic, T.7
Huynh, L.8
Lozanski, G.9
Kefauver, C.10
Plass, C.11
Devine, S.M.12
Heerema, N.A.13
Murgo, A.14
Chan, K.K.15
Grever, M.R.16
Byrd, J.C.17
Marcucci, G.18
-
23
-
-
65249131145
-
Potentiation of a topoisomerase I inhibitor, karenitecin, by the histone deacetylase inhibitor valproic acid in melanoma: Translational and phase I/II clinical trial
-
Daud AI, Dawson J, DeConti RC, Bicaku E, Marchion D, Bastien S, et al. Potentiation of a topoisomerase I inhibitor, karenitecin, by the histone deacetylase inhibitor valproic acid in melanoma: translational and phase I/II clinical trial. Clin Cancer Res 2009;15:2479-87.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2479-2487
-
-
Daud, A.I.1
Dawson, J.2
DeConti, R.C.3
Bicaku, E.4
Marchion, D.5
Bastien, S.6
-
24
-
-
34447304130
-
Valproic acid (VPA) in patients with refractory advanced cancer: A dose escalating phase I clinical trial
-
DOI 10.1038/sj.bjc.6603851, PII 6603851
-
Atmaca A, Al-Batran SE, Maurer A, Neumann A, Heinzel T, Hentsch B, et al. Valproic acid (VPA) in patients with refractory advanced cancer: a dose escalating phase I clinical trial. Br J Cancer 2007;97:177-82. (Pubitemid 47057472)
-
(2007)
British Journal of Cancer
, vol.97
, Issue.2
, pp. 177-182
-
-
Atmaca, A.1
Al-Batran, S.-E.2
Maurer, A.3
Neumann, A.4
Heinzel, T.5
Hentsch, B.6
Schwarz, S.E.7
Hovelmann, S.8
Gottlicher, M.9
Knuth, A.10
Jager, E.11
-
25
-
-
34548395116
-
A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors
-
DOI 10.1093/annonc/mdm204
-
Candelaria M, Gallardo-Rincon D, Arce C, Cetina L, Aguilar-Ponce JL, Arrieta O, et al. A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors. Ann Oncol 2007;18:1529-38. (Pubitemid 47365487)
-
(2007)
Annals of Oncology
, vol.18
, Issue.9
, pp. 1529-1538
-
-
Candelaria, M.1
Gallardo-Rincon, D.2
Arce, C.3
Cetina, L.4
Aguilar-Ponce, J.L.5
Arrieta, O.6
Gonzalez-Fierro, A.7
Chavez-Blanco, A.8
De, L.C.-H.E.9
Camargo, M.F.10
Trejo-Becerril, C.11
Perez-Cardenas, E.12
Perez-Plasencia, C.13
Taja-Chayeb, L.14
Wegman-Ostrosky, T.15
Revilla-Vazquez, A.16
Duenas-Gonzalez, A.17
-
26
-
-
58149174109
-
Phase I study of epigenetic modulation with 5-azacytidine and valproic acid in patients with advanced cancers
-
Braiteh F, Soriano AO, Garcia-Manero G, Hong D, Johnson MM, Silva Lde P, et al. Phase I study of epigenetic modulation with 5-azacytidine and valproic acid in patients with advanced cancers. Clin Cancer Res 2008;14:6296-301.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6296-6301
-
-
Braiteh, F.1
Soriano, A.O.2
Garcia-Manero, G.3
Hong, D.4
Johnson, M.M.5
Silva Lde, P.6
-
27
-
-
58149263278
-
A phase I-II study of the histone deacetylase inhibitor valproic acid plus chemoimmunotherapy in patients with advanced melanoma
-
Rocca A, Minucci S, Tosti G, Croci D, Contegno F, Ballarini M, et al. A phase I-II study of the histone deacetylase inhibitor valproic acid plus chemoimmunotherapy in patients with advanced melanoma. Br J Cancer 2009;100:28-36.
-
(2009)
Br J Cancer
, vol.100
, pp. 28-36
-
-
Rocca, A.1
Minucci, S.2
Tosti, G.3
Croci, D.4
Contegno, F.5
Ballarini, M.6
-
28
-
-
26844505068
-
Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer. A phase I study
-
Chavez-Blanco A, Segura-Pacheco B, Perez-Cardenas E, Taja-Chayeb L, Cetina L, Candelaria M, et al. Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer. A phase I study. Mol Cancer 2005;4:22.
-
(2005)
Mol Cancer
, vol.4
, pp. 22
-
-
Chavez-Blanco, A.1
Segura-Pacheco, B.2
Perez-Cardenas, E.3
Taja-Chayeb, L.4
Cetina, L.5
Candelaria, M.6
-
29
-
-
65249141665
-
Clinical and biological effects of valproic acid as a histone deacetylase inhibitor on tumor and surrogate tissues: Phase I/II trial of valproic acid and epirubicin/FEC
-
Munster P, Marchion D, Bicaku E, Lacevic M, Kim J, Centeno B, et al. Clinical and biological effects of valproic acid as a histone deacetylase inhibitor on tumor and surrogate tissues: phase I/II trial of valproic acid and epirubicin/FEC. Clin Cancer Res 2009;15:2488-96.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2488-2496
-
-
Munster, P.1
Marchion, D.2
Bicaku, E.3
Lacevic, M.4
Kim, J.5
Centeno, B.6
-
30
-
-
56249124221
-
Valproic acid was well tolerated in heavily pretreated pediatric patients with high-grade glioma
-
Wolff JE, Kramm C, Kortmann RD, Pietsch T, Rutkowski S, Jorch N, et al. Valproic acid was well tolerated in heavily pretreated pediatric patients with high-grade glioma. J Neurooncol 2008;90:309-14.
-
(2008)
J Neurooncol
, vol.90
, pp. 309-314
-
-
Wolff, J.E.1
Kramm, C.2
Kortmann, R.D.3
Pietsch, T.4
Rutkowski, S.5
Jorch, N.6
-
31
-
-
0019848515
-
Fluorescence polarization immunoassay for the determination of therapeutic drug levels in human plasma
-
Jolley ME. Fluorescence polarization immunoassay for the determination of therapeutic drug levels in human plasma. J Anal Toxicol 1981;5:236-40. (Pubitemid 12242810)
-
(1981)
Journal of Analytical Toxicology
, vol.5
, Issue.5
, pp. 236-240
-
-
Jolley, M.E.1
-
32
-
-
30344482565
-
Valproic acid induces growth arrest, apoptosis, and senescence in medulloblastomas by increasing histone hyperacetylation and regulating expression of p21Cip1, CDK4, and CMYC
-
DOI 10.1158/1535-7163.MCT-05-0184
-
Li XN, Shu Q, Su JM, Perlaky L, Blaney SM, Lau CC. Valproic acid induces growth arrest, apoptosis, and senescence in medulloblastomas by increasing histone hyperacetylation and regulating expression of p21Cip1, CDK4, and CMYC. Mol Cancer Ther 2005;4:1912-22. (Pubitemid 43056974)
-
(2005)
Molecular Cancer Therapeutics
, vol.4
, Issue.12
, pp. 1912-1922
-
-
Li, X.-N.1
Shu, Q.2
Su, J.M.-F.3
Perlaky, L.4
Blaney, S.M.5
Lau, C.C.6
-
33
-
-
0020513196
-
First-dose and steady-state pharmacokinetics of valproic acid in children with seizures
-
Hall K, Otten N, Irvine-Meek J, Leroux M, Budnick D, Verma M, et al. First-dose and steady-state pharmacokinetics of valproic acid in children with seizures. Clin Pharmacokinet 1983;8:447-55. (Pubitemid 13009123)
-
(1983)
Clinical Pharmacokinetics
, vol.8
, Issue.5
, pp. 447-455
-
-
Hall, K.1
Otten, N.2
Irvine, M.J.3
-
34
-
-
0022204962
-
Valproic acid pharmacokinetics in children. II. Discontinuation of concomitant antiepileptic drug therapy
-
Cloyd JC, Kriel RL, Fischer JH. Valproic acid pharmacokinetics in children. II. Discontinuation of concomitant antiepileptic drug therapy. Neurology 1985;35:1623-7.
-
(1985)
Neurology
, vol.35
, pp. 1623-1627
-
-
Cloyd, J.C.1
Kriel, R.L.2
Fischer, J.H.3
-
36
-
-
0025912584
-
Pharmacokinetics of total and free valproic acid during monotherapy in infants
-
Herngren L, Lundberg B, Nergardh A. Pharmacokinetics of total and free valproic acid during monotherapy in infants. J Neurol 1991; 238:315-9.
-
(1991)
J Neurol
, vol.238
, pp. 315-319
-
-
Herngren, L.1
Lundberg, B.2
Nergardh, A.3
-
37
-
-
0023685854
-
Pharmacokinetics of free and total sodium valproate in adolescents and young adults during maintenance therapy
-
DOI 10.1007/BF00314255
-
Herngren L, Nergardh A. Pharmacokinetics of free and total sodium valproate in adolescents and young adults during maintenance therapy. J Neurol 1988;235:491-5. (Pubitemid 18262986)
-
(1988)
Journal of Neurology
, vol.235
, Issue.8
, pp. 491-495
-
-
Herngren, L.1
Nergardh, A.2
-
38
-
-
3042831930
-
Valproic acid treatment of glioblastoma multiforme in a child [4]
-
DOI 10.1002/pbc.20083
-
Witt O, Schweigerer L, Driever PH, Wolff J, Pekrun A. Valproic acid treatment of glioblastoma multiforme in a child. Pediatr Blood Cancer 2004;43:181. (Pubitemid 38891170)
-
(2004)
Pediatric Blood and Cancer
, vol.43
, Issue.2
, pp. 181
-
-
Witt, O.1
Schweigerer, L.2
Hernaiz, D.P.3
Wolff, J.4
Pekrun, A.5
-
39
-
-
0031763892
-
Valproic acid inhibits proliferation and changes expression of CD44 and CD56 of malignant glioma cells in vitro
-
Knupfer MM, Hernaiz-Driever P, Poppenborg H, Wolff JE, Cinatl J. Valproic acid inhibits proliferation and changes expression of CD44 and CD56 of malignant glioma cells in vitro. Anticancer Res 1998;18: 3585-9. (Pubitemid 28546494)
-
(1998)
Anticancer Research
, vol.18
, Issue.5 A
, pp. 3585-3589
-
-
Knupfer, M.M.1
Hernaiz-Driever, P.2
Poppenborg, H.3
Wolff, J.E.A.4
Cinatl, J.5
-
40
-
-
33645071947
-
Antineoplastic effects of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in cancer cell lines
-
Chavez-Blanco A, Perez-Plasencia C, Perez-Cardenas E, Carrasco-Legleu C, Rangel-Lopez E, Segura-Pacheco B, et al. Antineoplastic effects of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in cancer cell lines. Cancer Cell Int 2006;6:181.
-
(2006)
Cancer Cell Int
, vol.6
, pp. 181
-
-
Chavez-Blanco, A.1
Perez-Plasencia, C.2
Perez-Cardenas, E.3
Carrasco-Legleu, C.4
Rangel-Lopez, E.5
Segura-Pacheco, B.6
-
41
-
-
34249937594
-
Phase I trial of histone deacetylase inhibition by valproic acid followed by the topoisomerase II inhibitor epirubicin in advanced solid tumors: A clinical and translational study
-
DOI 10.1200/JCO.2006.08.6165
-
Munster P, Marchion D, Bicaku E, Schmitt M, Lee JH, DeConti R, et al. Phase I trial of histone deacetylase inhibition by valproic acid followed by the topoisomerase II inhibitor epirubicin in advanced solid tumors: a clinical and translational study. J Clin Oncol 2007;25:1979-85. (Pubitemid 46972780)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.15
, pp. 1979-1985
-
-
Munster, P.1
Marchion, D.2
Bicaku, E.3
Schmitt, M.4
Ji, H.L.5
DeConti, R.6
Simon, G.7
Fishman, M.8
Minton, S.9
Garrett, C.10
Chiappori, A.11
Lush, R.12
Sullivan, D.13
Daud, A.14
-
42
-
-
0036443425
-
Valproic acid toxicity: Overview and management
-
DOI 10.1081/CLT-120014645
-
Sztajnkrycer MD. Valproic acid toxicity: overview and management. J Toxicol Clin Toxicol 2002;40:789-801. (Pubitemid 35423414)
-
(2002)
Journal of Toxicology - Clinical Toxicology
, vol.40
, Issue.6
, pp. 789-801
-
-
Sztajnkrycer, M.D.1
-
43
-
-
33747065289
-
Phase I study of depsipeptide in pediatric patients with refractory solid tumors: A children's oncology group report
-
DOI 10.1200/JCO.2006.06.4964
-
Fouladi M, Furman WL, Chin T, Freeman BB 3rd, Dudkin L, Stewart CF, et al. Phase I study of depsipeptide in pediatric patients with refractory solid tumors: a Children's Oncology Group report. J Clin Oncol 2006;24:3678-85. (Pubitemid 46630544)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.22
, pp. 3678-3685
-
-
Fouladi, M.1
Furman, W.L.2
Chin, T.3
Freeman III, B.B.4
Dudkin, L.5
Stewart, C.F.6
Krailo, M.D.7
Speights, R.8
Ingle, A.M.9
Houghton, P.J.10
Wright, J.11
Adamson, P.C.12
Blaney, S.M.13
-
44
-
-
35448999681
-
Valproic acid induces p21 and topoisomerase-II (alpha/beta) expression and synergistically enhances etoposide cytotoxicity in human glioblastoma cell lines
-
DOI 10.1007/s11060-007-9402-7
-
Das CM, Aguilera D, Vasquez H, Prasad P, Zhang M, Wolff JE, et al. Valproic acid induces p21 and topoisomerase-II (alpha/beta) expression and synergistically enhances etoposide cytotoxicity in human glioblastoma cell lines. J Neurooncol 2007;85:159-70. (Pubitemid 47629397)
-
(2007)
Journal of Neuro-Oncology
, vol.85
, Issue.2
, pp. 159-170
-
-
Das, C.M.1
Aguilera, D.2
Vasquez, H.3
Prasad, P.4
Zhang, M.5
Wolff, J.E.6
Gopalakrishnan, V.7
-
45
-
-
38149069545
-
Valproic acid increases the in vitro effects of nitrosureas on human glioma cell lines
-
Ciusani E, Balzarotti M, Calatozzolo C, de Grazia U, Boiardi A, Salmaggi A, et al. Valproic acid increases the in vitro effects of nitrosureas on human glioma cell lines. Oncol Res 2007;16: 453-63.
-
(2007)
Oncol Res
, vol.16
, pp. 453-463
-
-
Ciusani, E.1
Balzarotti, M.2
Calatozzolo, C.3
De Grazia, U.4
Boiardi, A.5
Salmaggi, A.6
-
46
-
-
28544432910
-
Synergistic interaction between histone deacetylase and topoisomerase II inhibitors is mediated through topoisomerase IIbeta
-
DOI 10.1158/1078-0432.CCR-05-1073
-
Marchion DC, Bicaku E, Turner JG, Daud AI, Sullivan DM, Munster PN. Synergistic interaction between histone deacetylase and topoisomerase II inhibitors is mediated through topoisomerase IIbeta. Clin Cancer Res 2005;11:8467-75. (Pubitemid 41746962)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.23
, pp. 8467-8475
-
-
Marchion, D.C.1
Bicaku, E.2
Turner, J.G.3
Daud, A.I.4
Sullivan, D.M.5
Munster, P.N.6
-
47
-
-
14044250159
-
Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid
-
DOI 10.1002/ijc.20774
-
Camphausen K, Cerna D, Scott T, Sproull M, Burgan WE, Cerra MA, et al. Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid. Int J Cancer 2005;114:380-6. (Pubitemid 40279957)
-
(2005)
International Journal of Cancer
, vol.114
, Issue.3
, pp. 380-386
-
-
Camphausen, K.1
Cerna, D.2
Scott, T.3
Sproull, M.4
Burgan, W.E.5
Cerra, M.A.6
Fine, H.7
Tofilon, P.J.8
-
48
-
-
53049089057
-
Postradiation sensitization of the histone deacetylase inhibitor valproic acid
-
Chinnaiyan P, Cerna D, Burgan WE, Beam K, Williams ES, Camphausen K, et al. Postradiation sensitization of the histone deacetylase inhibitor valproic acid. Clin Cancer Res 2008;14:5410-5.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 5410-5415
-
-
Chinnaiyan, P.1
Cerna, D.2
Burgan, W.E.3
Beam, K.4
Williams, E.S.5
Camphausen, K.6
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