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Volumn 20, Issue 4, 2008, Pages 412-418

Ewing sarcoma: Historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future

Author keywords

Biomarkers; Cancer; Ewing's sarcoma; IGF 1R; Molecular markers; Phase II trials; Prognosis; Sarcoma; Staging; Targeted therapy

Indexed keywords

BIOLOGICAL MARKER; CAMPTOTHECIN; CD99 ANTIGEN; CP 751871; CYCLOPHOSPHAMIDE; DACTINOMYCIN; DOCETAXEL; DOXORUBICIN; ETOPOSIDE; GEMCITABINE; IFOSFAMIDE; IMATINIB; IMC A12; IRINOTECAN; MITOGEN ACTIVATED PROTEIN KINASE; MONOCLONAL ANTIBODY; NVP AEW 541; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P53; R 1507; RNA BINDING PROTEIN EWS; SCH 717454; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; TEMOZOLOMIDE; TOPOTECAN; TRABECTEDIN; TRANSCRIPTION FACTOR FLI 1; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCRISTINE;

EID: 47249160783     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/CCO.0b013e328303ba1d     Document Type: Review
Times cited : (182)

References (55)
  • 2
    • 0016689146 scopus 로고
    • Extraskeletal neoplasm resembling Ewing's sarcoma
    • Angervall L, Enzinger FM. Extraskeletal neoplasm resembling Ewing's sarcoma. Cancer 1975; 36:240-251.
    • (1975) Cancer , vol.36 , pp. 240-251
    • Angervall, L.1    Enzinger, F.M.2
  • 3
    • 0018648499 scopus 로고
    • Malignant small cell tumor of the thoracopulmonary region in childhood: A distinctive clinicopathologic entity of uncertain histogenesis
    • Askin FB, Rosai J, Sibley RK, et al. Malignant small cell tumor of the thoracopulmonary region in childhood: a distinctive clinicopathologic entity of uncertain histogenesis. Cancer 1979; 43:2438-2451.
    • (1979) Cancer , vol.43 , pp. 2438-2451
    • Askin, F.B.1    Rosai, J.2    Sibley, R.K.3
  • 5
    • 0033989280 scopus 로고    scopus 로고
    • Molecular biology of the Ewing's sarcoma/primitive neuroectodermal tumor family
    • de Alava E, Gerald WL. Molecular biology of the Ewing's sarcoma/primitive neuroectodermal tumor family. J Clin Oncol 2000; 18:204-213.
    • (2000) J Clin Oncol , vol.18 , pp. 204-213
    • de Alava, E.1    Gerald, W.L.2
  • 6
    • 18044364798 scopus 로고    scopus 로고
    • Overview of sarcomas in the adolescent and young adult population
    • Herzog CE. Overview of sarcomas in the adolescent and young adult population. J Pediatr Hematol Oncol 2005; 27:215-218.
    • (2005) J Pediatr Hematol Oncol , vol.27 , pp. 215-218
    • Herzog, C.E.1
  • 7
    • 0027537308 scopus 로고
    • International variations in the incidence of childhood bone tumours
    • Parkin DM, Stiller CA, Nectoux J. International variations in the incidence of childhood bone tumours. Int J Cancer 1993; 53:371-376.
    • (1993) Int J Cancer , vol.53 , pp. 371-376
    • Parkin, D.M.1    Stiller, C.A.2    Nectoux, J.3
  • 8
    • 0026707515 scopus 로고
    • Unicolor and bicolor in situ hybridization in the diagnosis of peripheral neuroepithelioma and related tumors
    • Desmaze C, Zucman J, Delattre O, et al. Unicolor and bicolor in situ hybridization in the diagnosis of peripheral neuroepithelioma and related tumors. Genes Chromosomes Cancer 1992; 5:30-34.
    • (1992) Genes Chromosomes Cancer , vol.5 , pp. 30-34
    • Desmaze, C.1    Zucman, J.2    Delattre, O.3
  • 9
    • 0026746009 scopus 로고
    • Cloning and characterization of the Ewing's sarcoma and peripheral neuroepithelioma t(11;22) translocation breakpoints
    • Zucman J, Delattre O, Desmaze C, et al. Cloning and characterization of the Ewing's sarcoma and peripheral neuroepithelioma t(11;22) translocation breakpoints. Genes Chromosomes Cancer 1992; 5:271-277.
    • (1992) Genes Chromosomes Cancer , vol.5 , pp. 271-277
    • Zucman, J.1    Delattre, O.2    Desmaze, C.3
  • 10
    • 0026686674 scopus 로고
    • Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours
    • Delattre O, Zucman J, Plougastel B, et al. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature 1992; 359:162-165.
    • (1992) Nature , vol.359 , pp. 162-165
    • Delattre, O.1    Zucman, J.2    Plougastel, B.3
  • 11
    • 0027932782 scopus 로고
    • The Ewing family of tumors - a subgroup of small-round-cell tumors defined by specific chimeric transcripts
    • Delattre O, Zucman J, Melot T, et al. The Ewing family of tumors - a subgroup of small-round-cell tumors defined by specific chimeric transcripts. N Engl J Med 1994; 331:294-299.
    • (1994) N Engl J Med , vol.331 , pp. 294-299
    • Delattre, O.1    Zucman, J.2    Melot, T.3
  • 12
    • 41549137834 scopus 로고    scopus 로고
    • Ewing sarcoma protein ewsr1 maintains mitotic integrity and proneural cell survival in the zebrafish embryo
    • Azuma M, Embree LJ, Sabaawy H, Hickstein DD. Ewing sarcoma protein ewsr1 maintains mitotic integrity and proneural cell survival in the zebrafish embryo. PLoS ONE 2007; 2:e979.
    • (2007) PLoS ONE , vol.2
    • Azuma, M.1    Embree, L.J.2    Sabaawy, H.3    Hickstein, D.D.4
  • 13
    • 0027230568 scopus 로고
    • Ewing sarcoma 11; 22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation
    • May WA, Gishizky ML, Lessnick SL, et al. Ewing sarcoma 11; 22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation. Proc Natl Acad Sci U S A 1993; 90:5752-5756.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 5752-5756
    • May, W.A.1    Gishizky, M.L.2    Lessnick, S.L.3
  • 14
    • 34548749325 scopus 로고    scopus 로고
    • Honoki K, Stojanovski E, McEvoy M, et al. Prognostic significance of p16 INK4a alteration for Ewing sarcoma: a meta-analysis. Cancer 2007; 110: 1351-1360. A meta-analysis of the prognostic significance of p16 INK4a for Ewing's sarcoma.
    • Honoki K, Stojanovski E, McEvoy M, et al. Prognostic significance of p16 INK4a alteration for Ewing sarcoma: a meta-analysis. Cancer 2007; 110: 1351-1360. A meta-analysis of the prognostic significance of p16 INK4a for Ewing's sarcoma.
  • 15
    • 0344171979 scopus 로고    scopus 로고
    • Common musculoskeletal tumors of childhood and adolescence
    • Arndt CA, Crist WM. Common musculoskeletal tumors of childhood and adolescence. N Engl J Med 1999; 341:342-352.
    • (1999) N Engl J Med , vol.341 , pp. 342-352
    • Arndt, C.A.1    Crist, W.M.2
  • 16
    • 0033864605 scopus 로고    scopus 로고
    • Prognostic factors in Ewing's tumor of bone: Analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group
    • Cotterill SJ, Ahrens S, Paulussen M, et al. Prognostic factors in Ewing's tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group. J Clin Oncol 2000; 18:3108-3114.
    • (2000) J Clin Oncol , vol.18 , pp. 3108-3114
    • Cotterill, S.J.1    Ahrens, S.2    Paulussen, M.3
  • 17
    • 0037080272 scopus 로고    scopus 로고
    • Survival after recurrence of Ewing tumors: The St Jude Children's Research Hospital experience, 1979-1999
    • Rodriguez-Galindo C, Billups CA, Kun LE, et al. Survival after recurrence of Ewing tumors: the St Jude Children's Research Hospital experience, 1979-1999. Cancer 2002; 94:561-569.
    • (2002) Cancer , vol.94 , pp. 561-569
    • Rodriguez-Galindo, C.1    Billups, C.A.2    Kun, L.E.3
  • 18
    • 0031924824 scopus 로고    scopus 로고
    • EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma
    • de Alava E, Kawai A, Healey JH, et al. EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma. J Clin Oncol 1998; 16:1248-1255.
    • (1998) J Clin Oncol , vol.16 , pp. 1248-1255
    • de Alava, E.1    Kawai, A.2    Healey, J.H.3
  • 19
    • 0033119006 scopus 로고    scopus 로고
    • Differential transactivation by alternative EWS-FLI1 fusion proteins correlates with clinical heterogeneity in Ewing's sarcoma
    • Lin PP, Brody RI, Hamelin AC, et al. Differential transactivation by alternative EWS-FLI1 fusion proteins correlates with clinical heterogeneity in Ewing's sarcoma. Cancer Res 1999; 59:1428-1432.
    • (1999) Cancer Res , vol.59 , pp. 1428-1432
    • Lin, P.P.1    Brody, R.I.2    Hamelin, A.C.3
  • 20
    • 9244236526 scopus 로고    scopus 로고
    • Does expression of different EWS chimeric transcripts define clinically distinct risk groups of Ewing tumor patients?
    • Zoubek A, Dockhorn-Dworniczak B, Delattre O, et al. Does expression of different EWS chimeric transcripts define clinically distinct risk groups of Ewing tumor patients? J Clin Oncol 1996; 14:1245-1251.
    • (1996) J Clin Oncol , vol.14 , pp. 1245-1251
    • Zoubek, A.1    Dockhorn-Dworniczak, B.2    Delattre, O.3
  • 21
    • 0033969584 scopus 로고    scopus 로고
    • Cutaneous and subcutaneous Ewing's sarcoma: An indolent disease
    • Chow E, Merchant TE, Pappo A, et al. Cutaneous and subcutaneous Ewing's sarcoma: an indolent disease. Int J Radiat Oncol Biol Phys 2000; 46:433-438.
    • (2000) Int J Radiat Oncol Biol Phys , vol.46 , pp. 433-438
    • Chow, E.1    Merchant, T.E.2    Pappo, A.3
  • 22
    • 33646885901 scopus 로고
    • Cyclophosphamide therapy in children with Ewing's sarcoma
    • Sutow WW, Sullivan MP. Cyclophosphamide therapy in children with Ewing's sarcoma. Cancer Chemother Rep 1962; 23:55-60.
    • (1962) Cancer Chemother Rep , vol.23 , pp. 55-60
    • Sutow, W.W.1    Sullivan, M.P.2
  • 23
    • 0002084532 scopus 로고
    • Cyclophosphamide in children with cancer
    • Pinkel D. Cyclophosphamide in children with cancer. Cancer 1962; 15:42-49.
    • (1962) Cancer , vol.15 , pp. 42-49
    • Pinkel, D.1
  • 25
    • 0024497194 scopus 로고
    • Therapy for localized Ewing's sarcoma of bone
    • Hayes FA, Thompson EI, Meyer WH, et al. Therapy for localized Ewing's sarcoma of bone. J Clin Oncol 1989; 7:208-213.
    • (1989) J Clin Oncol , vol.7 , pp. 208-213
    • Hayes, F.A.1    Thompson, E.I.2    Meyer, W.H.3
  • 26
    • 0023833536 scopus 로고
    • Multidisciplinary treatment of primary Ewing's sarcoma of bone. A 6-year experience of a European Cooperative Trial
    • Jurgens H, Exner U, Gadner H, et al. Multidisciplinary treatment of primary Ewing's sarcoma of bone. A 6-year experience of a European Cooperative Trial. Cancer 1988; 61:23-32.
    • (1988) Cancer , vol.61 , pp. 23-32
    • Jurgens, H.1    Exner, U.2    Gadner, H.3
  • 27
    • 0018972088 scopus 로고
    • Intergroup Ewing's Sarcoma Study: Local control related to radiation dose, volume, and site of primary lesion in Ewing's sarcoma
    • Razek A, Perez CA, Tefft M, et al. Intergroup Ewing's Sarcoma Study: local control related to radiation dose, volume, and site of primary lesion in Ewing's sarcoma. Cancer 1980; 46:516-521.
    • (1980) Cancer , vol.46 , pp. 516-521
    • Razek, A.1    Perez, C.A.2    Tefft, M.3
  • 28
    • 0037456435 scopus 로고    scopus 로고
    • Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone
    • Grier HE, Krailo MD, Tarbell NJ, et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med 2003; 348:694-701.
    • (2003) N Engl J Med , vol.348 , pp. 694-701
    • Grier, H.E.1    Krailo, M.D.2    Tarbell, N.J.3
  • 29
    • 0033977253 scopus 로고    scopus 로고
    • Granulocyte colony stimulating factor permits dose intensification by interval compression in the treatment of Ewing's sarcomas and soft tissue sarcomas in children
    • Womer RB, Daller RT, Fenton JG, Miser JS. Granulocyte colony stimulating factor permits dose intensification by interval compression in the treatment of Ewing's sarcomas and soft tissue sarcomas in children. Eur J Cancer 2000; 36:87-94.
    • (2000) Eur J Cancer , vol.36 , pp. 87-94
    • Womer, R.B.1    Daller, R.T.2    Fenton, J.G.3    Miser, J.S.4
  • 30
    • 33846032244 scopus 로고    scopus 로고
    • Therapy-related myelodysplasia and acute myeloid leukemia after Ewing sarcoma and primitive neuroectodermal tumor of bone: A report from the Children's Oncology Group
    • Bhatia S, Krailo MD, Chen Z, et al. Therapy-related myelodysplasia and acute myeloid leukemia after Ewing sarcoma and primitive neuroectodermal tumor of bone: a report from the Children's Oncology Group. Blood 2007; 109:46-51.
    • (2007) Blood , vol.109 , pp. 46-51
    • Bhatia, S.1    Krailo, M.D.2    Chen, Z.3
  • 31
    • 4344571848 scopus 로고    scopus 로고
    • Treatment of metastatic Ewing's sarcoma or primitive neuroectodermal tumor of bone: Evaluation of combination ifosfamide and etoposide - a Children's Cancer Group and Pediatric Oncology Group study
    • Miser JS, Krailo MD, Tarbell NJ, et al. Treatment of metastatic Ewing's sarcoma or primitive neuroectodermal tumor of bone: evaluation of combination ifosfamide and etoposide - a Children's Cancer Group and Pediatric Oncology Group study. J Clin Oncol 2004; 22:2873-2876.
    • (2004) J Clin Oncol , vol.22 , pp. 2873-2876
    • Miser, J.S.1    Krailo, M.D.2    Tarbell, N.J.3
  • 32
    • 0035424844 scopus 로고    scopus 로고
    • Cyclophosphamide plus topotecan in children with recurrent or refractory solid tumors: A pediatric Oncology Group phase II study
    • Saylors RL 3rd, Stine KC, Sullivan J, et al. Cyclophosphamide plus topotecan in children with recurrent or refractory solid tumors: a pediatric Oncology Group phase II study. J Clin Oncol 2001; 19:3463-3469.
    • (2001) J Clin Oncol , vol.19 , pp. 3463-3469
    • Saylors 3rd, R.L.1    Stine, K.C.2    Sullivan, J.3
  • 33
    • 33749169684 scopus 로고    scopus 로고
    • Topotecan and cyclophosphamide in patients with refractory or relapsed Ewing tumors
    • Hunold A, Weddeling N, Paulussen M, et al. Topotecan and cyclophosphamide in patients with refractory or relapsed Ewing tumors. Pediatr Blood Cancer 2006; 47:795-800.
    • (2006) Pediatr Blood Cancer , vol.47 , pp. 795-800
    • Hunold, A.1    Weddeling, N.2    Paulussen, M.3
  • 34
    • 10744231592 scopus 로고    scopus 로고
    • Phase I trial of temozolomide and protracted irinotecan in pediatric patients with refractory solid tumors
    • Wagner LM, Crews KR, Iacono LC, et al. Phase I trial of temozolomide and protracted irinotecan in pediatric patients with refractory solid tumors. Clin Cancer Res 2004; 10:840-848.
    • (2004) Clin Cancer Res , vol.10 , pp. 840-848
    • Wagner, L.M.1    Crews, K.R.2    Iacono, L.C.3
  • 35
    • 33845618682 scopus 로고    scopus 로고
    • Temozolomide and intravenous irinotecan for treatment of advanced Ewing sarcoma
    • Wagner LM, McAllister N, Goldsby RE, et al. Temozolomide and intravenous irinotecan for treatment of advanced Ewing sarcoma. Pediatr Blood Cancer 2007; 48:132-139.
    • (2007) Pediatr Blood Cancer , vol.48 , pp. 132-139
    • Wagner, L.M.1    McAllister, N.2    Goldsby, R.E.3
  • 36
    • 37549041711 scopus 로고    scopus 로고
    • Bond M, Bernstein ML, Pappo A, et al. A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: a Children's Oncology Group study. Pediatr Blood Cancer 2008; 50:254-258. Despite the fact that c-kit is often expressed by Ewing's sarcoma cells, imatinib does not appear to be effective when used alone as only one patient responded out of 24 treated.
    • Bond M, Bernstein ML, Pappo A, et al. A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: a Children's Oncology Group study. Pediatr Blood Cancer 2008; 50:254-258. Despite the fact that c-kit is often expressed by Ewing's sarcoma cells, imatinib does not appear to be effective when used alone as only one patient responded out of 24 treated.
  • 37
    • 4444266113 scopus 로고    scopus 로고
    • Targeting the IGF-1 receptor: From rags to riches
    • Baserga R. Targeting the IGF-1 receptor: from rags to riches. Eur J Cancer 2004; 40:2013-2015.
    • (2004) Eur J Cancer , vol.40 , pp. 2013-2015
    • Baserga, R.1
  • 38
    • 0030695913 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts
    • Toretsky JA, Kalebic T, Blakesley V, et al. The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts. J Biol Chem 1997; 272:30822-30827.
    • (1997) J Biol Chem , vol.272 , pp. 30822-30827
    • Toretsky, J.A.1    Kalebic, T.2    Blakesley, V.3
  • 39
    • 0029838475 scopus 로고    scopus 로고
    • Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: A possible therapeutic target
    • Scotlandi K, Benini S, Sarti M, et al. Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: a possible therapeutic target. Cancer Res 1996; 56:4570-4574.
    • (1996) Cancer Res , vol.56 , pp. 4570-4574
    • Scotlandi, K.1    Benini, S.2    Sarti, M.3
  • 40
    • 3543026281 scopus 로고    scopus 로고
    • EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3
    • Prieur A, Tirode F, Cohen P, Delattre O. EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Mol Cell Biol 2004; 24:7275-7283.
    • (2004) Mol Cell Biol , vol.24 , pp. 7275-7283
    • Prieur, A.1    Tirode, F.2    Cohen, P.3    Delattre, O.4
  • 41
    • 0347626094 scopus 로고    scopus 로고
    • Contribution of MEK/MAPK and PI3-K signaling pathway to the malignant behavior of Ewing's sarcoma cells: Therapeutic prospects
    • Benini S, Manara MC, Cerisano V, et al. Contribution of MEK/MAPK and PI3-K signaling pathway to the malignant behavior of Ewing's sarcoma cells: therapeutic prospects. Int J Cancer 2004; 108:358-366.
    • (2004) Int J Cancer , vol.108 , pp. 358-366
    • Benini, S.1    Manara, M.C.2    Cerisano, V.3
  • 42
    • 35148837581 scopus 로고    scopus 로고
    • Mechanisms of disease: Signaling of the insulin-like growth factor 1 receptor pathway - therapeutic perspectives in cancer
    • Tao Y, Pinzi V, Bourhis J, Deutsch E. Mechanisms of disease: signaling of the insulin-like growth factor 1 receptor pathway - therapeutic perspectives in cancer. Nat Clin Pract Oncol 2007; 4:591-602.
    • (2007) Nat Clin Pract Oncol , vol.4 , pp. 591-602
    • Tao, Y.1    Pinzi, V.2    Bourhis, J.3    Deutsch, E.4
  • 43
    • 33947262154 scopus 로고    scopus 로고
    • Preclinical in vivo study of new insulin-like growth factor-I receptor - specific inhibitor in Ewing's sarcoma
    • The above article provides an excellent summary of the role of IGF-1R in Ewing's sarcoma pathogenesis and describes preclinical evaluation of a novel small-molecular IGF-1R inhibitor
    • Manara MC, Landuzzi L, Nanni P, et al. Preclinical in vivo study of new insulin-like growth factor-I receptor - specific inhibitor in Ewing's sarcoma. Clin Cancer Res 2007; 13:1322-1330. The above article provides an excellent summary of the role of IGF-1R in Ewing's sarcoma pathogenesis and describes preclinical evaluation of a novel small-molecular IGF-1R inhibitor.
    • (2007) Clin Cancer Res , vol.13 , pp. 1322-1330
    • Manara, M.C.1    Landuzzi, L.2    Nanni, P.3
  • 44
    • 0034665335 scopus 로고    scopus 로고
    • CD99 engagement: An effective therapeutic strategy for Ewing tumors
    • Scotlandi K, Baldini N, Cerisano V, et al. CD99 engagement: an effective therapeutic strategy for Ewing tumors. Cancer Res 2000; 60:5134-5142.
    • (2000) Cancer Res , vol.60 , pp. 5134-5142
    • Scotlandi, K.1    Baldini, N.2    Cerisano, V.3
  • 45
    • 3343024743 scopus 로고    scopus 로고
    • Molecular mechanisms of CD99-induced caspase-independent cell death and cell-cell adhesion in Ewing's sarcoma cells: Actin and zyxin as key intracellular mediators
    • Cerisano V, Aalto Y, Perdichizzi S, et al. Molecular mechanisms of CD99-induced caspase-independent cell death and cell-cell adhesion in Ewing's sarcoma cells: actin and zyxin as key intracellular mediators. Oncogene 2004; 23:5664-5674.
    • (2004) Oncogene , vol.23 , pp. 5664-5674
    • Cerisano, V.1    Aalto, Y.2    Perdichizzi, S.3
  • 46
    • 0027362619 scopus 로고
    • The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1
    • May WA, Lessnick SL, Braun BS, et al. The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1. Mol Cell Biol 1993; 13:7393-7398.
    • (1993) Mol Cell Biol , vol.13 , pp. 7393-7398
    • May, W.A.1    Lessnick, S.L.2    Braun, B.S.3
  • 47
    • 0031040025 scopus 로고    scopus 로고
    • Inhibition of EWS-FLI-1 fusion protein with antisense oligodeoxynucleotides
    • Toretsky JA, Connell Y, Neckers L, Bhat NK. Inhibition of EWS-FLI-1 fusion protein with antisense oligodeoxynucleotides. J Neurooncol 1997; 31:9-16.
    • (1997) J Neurooncol , vol.31 , pp. 9-16
    • Toretsky, J.A.1    Connell, Y.2    Neckers, L.3    Bhat, N.K.4
  • 48
    • 0031025207 scopus 로고    scopus 로고
    • EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells
    • Tanaka K, Iwakuma T, Harimaya K, et al. EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells. J Clin Invest 1997; 99:239-247.
    • (1997) J Clin Invest , vol.99 , pp. 239-247
    • Tanaka, K.1    Iwakuma, T.2    Harimaya, K.3
  • 49
    • 0034694834 scopus 로고    scopus 로고
    • EWS FLI-1 antisense nanocapsules inhibits ewing sarcoma-related tumor in mice
    • Lambert G, Bertrand JR, Fattal E, et al. EWS FLI-1 antisense nanocapsules inhibits ewing sarcoma-related tumor in mice. Biochem Biophys Res Commun 2000; 279:401-406.
    • (2000) Biochem Biophys Res Commun , vol.279 , pp. 401-406
    • Lambert, G.1    Bertrand, J.R.2    Fattal, E.3
  • 50
    • 41149109010 scopus 로고    scopus 로고
    • Treatment of Ewing's sarcoma using an antisense oligodeoxynucleotide to regulate the cell cycle
    • The authors report the successful use of antisense oligodeoxynucleotide against a chimeric gene product to induce regression of embyonic stem tumor growth. This type of therapy, or one similar to it, may eventually prove to be effective for treatment of embyonic stem patients
    • Asami S, Chin M, Shichino H, et al. Treatment of Ewing's sarcoma using an antisense oligodeoxynucleotide to regulate the cell cycle. Biol Pharm Bull 2008; 31:391-394. The authors report the successful use of antisense oligodeoxynucleotide against a chimeric gene product to induce regression of embyonic stem tumor growth. This type of therapy, or one similar to it, may eventually prove to be effective for treatment of embyonic stem patients.
    • (2008) Biol Pharm Bull , vol.31 , pp. 391-394
    • Asami, S.1    Chin, M.2    Shichino, H.3
  • 51
    • 0029829794 scopus 로고    scopus 로고
    • EWS/FLI-1 antagonists induce growth inhibition of Ewing tumor cells in vitro
    • Kovar H, Aryee DN, Jug G, et al. EWS/FLI-1 antagonists induce growth inhibition of Ewing tumor cells in vitro. Cell Growth Differ 1996; 7:429-437.
    • (1996) Cell Growth Differ , vol.7 , pp. 429-437
    • Kovar, H.1    Aryee, D.N.2    Jug, G.3
  • 52
    • 34548083036 scopus 로고    scopus 로고
    • Suppression of Ewing's sarcoma tumor growth, tumor vessel formation, and vasculogenesis following anti vascular endothelial growth factor receptor-2 therapy
    • Zhou Z, Bolontrade MF, Reddy K, et al. Suppression of Ewing's sarcoma tumor growth, tumor vessel formation, and vasculogenesis following anti vascular endothelial growth factor receptor-2 therapy. Clin Cancer Res 2007; 13:4867-4873.
    • (2007) Clin Cancer Res , vol.13 , pp. 4867-4873
    • Zhou, Z.1    Bolontrade, M.F.2    Reddy, K.3
  • 53
    • 40849114332 scopus 로고    scopus 로고
    • Schaefer KL, Eisenacher M, Braun Y, et al. Microarray analysis of Ewing's sarcoma family of tumours reveals characteristic gene expression signatures associated with metastasis and resistance to chemotherapy. Eur J Cancer 2008; 44:699-709. The above is one of the only studies to use DNA microarrays to characterize which genes or pathways are associated with good-chemotherapy or poor-chemotherapy response in Ewing's sarcoma patients treated on the ongoing EURO-EWING99 protocol. A number of those differentially expressed genes are currently in preclinical evaluation as potential targets of biological therapy.
    • Schaefer KL, Eisenacher M, Braun Y, et al. Microarray analysis of Ewing's sarcoma family of tumours reveals characteristic gene expression signatures associated with metastasis and resistance to chemotherapy. Eur J Cancer 2008; 44:699-709. The above is one of the only studies to use DNA microarrays to characterize which genes or pathways are associated with good-chemotherapy or poor-chemotherapy response in Ewing's sarcoma patients treated on the ongoing EURO-EWING99 protocol. A number of those differentially expressed genes are currently in preclinical evaluation as potential targets of biological therapy.
  • 54
    • 3543151418 scopus 로고    scopus 로고
    • Wnt/frizzled signaling in Ewing sarcoma
    • Uren A, Wolf V, Sun YF, et al. Wnt/frizzled signaling in Ewing sarcoma. Pediatr Blood Cancer 2004; 43:243-249.
    • (2004) Pediatr Blood Cancer , vol.43 , pp. 243-249
    • Uren, A.1    Wolf, V.2    Sun, Y.F.3
  • 55
    • 66749163829 scopus 로고    scopus 로고
    • Zwerner JP, Joo J, Warner KL, et al. The EWS/FLI1 oncogenic transcription factor deregulates GLI1. Oncogene 2007 [Epub ahead of print].
    • Zwerner JP, Joo J, Warner KL, et al. The EWS/FLI1 oncogenic transcription factor deregulates GLI1. Oncogene 2007 [Epub ahead of print].


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.