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Volumn 42, Issue 5, 2006, Pages 646-649

Mutational analysis of PDGFR-RAS/MAPK pathway activation in childhood medulloblastoma

Author keywords

BRAF; Medulloblastoma; PDGFR; RAS

Indexed keywords

B RAF KINASE; H RAS PROTEIN; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR A; PLATELET DERIVED GROWTH FACTOR B; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN N RAS; RAS PROTEIN; UNCLASSIFIED DRUG;

EID: 33644785805     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2005.11.023     Document Type: Article
Times cited : (38)

References (24)
  • 1
    • 0037273964 scopus 로고    scopus 로고
    • What's new in neurooncology? Recent advances in medulloblastoma
    • D.W. Ellison, S.C. Clifford, and A. Gajjar What's new in neurooncology? Recent advances in medulloblastoma Eur J Paediatr Neurol 7 2003 53 66
    • (2003) Eur J Paediatr Neurol , vol.7 , pp. 53-66
    • Ellison, D.W.1    Clifford, S.C.2    Gajjar, A.3
  • 2
    • 1642307767 scopus 로고    scopus 로고
    • Medulloblastoma: Signalling a change in treatment
    • R.J. Gilbertson Medulloblastoma: signalling a change in treatment Lancet Oncol 5 2004 209 218
    • (2004) Lancet Oncol , vol.5 , pp. 209-218
    • Gilbertson, R.J.1
  • 3
    • 0242361321 scopus 로고    scopus 로고
    • PDGFRB is overexpressed in metastatic medulloblastoma
    • R.J. Gilbertson, and S.C. Clifford PDGFRB is overexpressed in metastatic medulloblastoma Nat Genet 35 2003 197 198
    • (2003) Nat Genet , vol.35 , pp. 197-198
    • Gilbertson, R.J.1    Clifford, S.C.2
  • 4
    • 0034794796 scopus 로고    scopus 로고
    • Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease
    • T.J. MacDonald, K.M. Brown, and B. LaFleur Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease Nat Genet 29 2001 143 152
    • (2001) Nat Genet , vol.29 , pp. 143-152
    • MacDonald, T.J.1    Brown, K.M.2    Lafleur, B.3
  • 5
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • J. Downward Targeting RAS signalling pathways in cancer therapy Nat Rev Cancer 3 2003 11 22
    • (2003) Nat Rev Cancer , vol.3 , pp. 11-22
    • Downward, J.1
  • 6
    • 0141486251 scopus 로고    scopus 로고
    • PDGF receptors as cancer drug targets
    • K. Pietras, T. Sjoblom, and K. Rubin PDGF receptors as cancer drug targets Cancer Cell 3 2003 439 443
    • (2003) Cancer Cell , vol.3 , pp. 439-443
    • Pietras, K.1    Sjoblom, T.2    Rubin, K.3
  • 7
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • H. Davies, G.R. Bignell, and C. Cox Mutations of the BRAF gene in human cancer Nature 417 2002 949 954
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 8
    • 0242670019 scopus 로고    scopus 로고
    • PDGFRA activating mutations in gastrointestinal stromal tumors
    • M.C. Heinrich, C.L. Corless, and A. Duensing PDGFRA activating mutations in gastrointestinal stromal tumors Science 299 2003 708 710
    • (2003) Science , vol.299 , pp. 708-710
    • Heinrich, M.C.1    Corless, C.L.2    Duensing, A.3
  • 9
    • 0037392444 scopus 로고    scopus 로고
    • Issues and progress with protein kinase inhibitors for cancer treatment
    • J. Dancey, and E.A. Sausville Issues and progress with protein kinase inhibitors for cancer treatment Nat Rev Drug Discov 2 2003 296 313
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 296-313
    • Dancey, J.1    Sausville, E.A.2
  • 10
    • 0036817874 scopus 로고    scopus 로고
    • Targeting the molecular pathophysiology of gastrointestinal stromal tumors with imatinib. Mechanisms, successes, and challenges to rational drug development
    • G.D. Demetri Targeting the molecular pathophysiology of gastrointestinal stromal tumors with imatinib. Mechanisms, successes, and challenges to rational drug development Hematol Oncol Clin North Am 16 2002 1115 1124
    • (2002) Hematol Oncol Clin North Am , vol.16 , pp. 1115-1124
    • Demetri, G.D.1
  • 11
    • 0014619880 scopus 로고
    • An operative staging system and a megavoltage radiotherapeutic technic for cerebellar medulloblastomas
    • C.H. Chang, E.M. Housepian, and C. Herbert Jr. An operative staging system and a megavoltage radiotherapeutic technic for cerebellar medulloblastomas Radiology 93 1969 1351 1359
    • (1969) Radiology , vol.93 , pp. 1351-1359
    • Chang, C.H.1    Housepian, E.M.2    Herbert Jr., C.3
  • 13
    • 1842614251 scopus 로고    scopus 로고
    • Clinical, histopathologic, and molecular markers of prognosis: Toward a new disease risk stratification system for medulloblastoma
    • A. Gajjar, R. Hernan, and M. Kocak Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma J Clin Oncol 22 2004 984 993
    • (2004) J Clin Oncol , vol.22 , pp. 984-993
    • Gajjar, A.1    Hernan, R.2    Kocak, M.3
  • 14
    • 1242351324 scopus 로고    scopus 로고
    • The TP53-ARF tumor suppressor pathway is frequently disrupted in large/cell anaplastic medulloblastoma
    • A.J. Frank, R. Hernan, and A. Hollander The TP53-ARF tumor suppressor pathway is frequently disrupted in large/cell anaplastic medulloblastoma Brain Res Mol Brain Res 121 2004 137 140
    • (2004) Brain Res Mol Brain Res , vol.121 , pp. 137-140
    • Frank, A.J.1    Hernan, R.2    Hollander, A.3
  • 15
    • 0036258111 scopus 로고    scopus 로고
    • The IARC TP53 database: New online mutation analysis and recommendations to users
    • M. Olivier, R. Eeles, and M. Hollstein The IARC TP53 database: new online mutation analysis and recommendations to users Hum Mutat 19 2002 607 614
    • (2002) Hum Mutat , vol.19 , pp. 607-614
    • Olivier, M.1    Eeles, R.2    Hollstein, M.3
  • 16
    • 0038670241 scopus 로고    scopus 로고
    • Mutational analysis of the tyrosine kinome in colorectal cancers
    • A. Bardelli, D.W. Parsons, and N. Silliman Mutational analysis of the tyrosine kinome in colorectal cancers Science 300 2003 949
    • (2003) Science , vol.300 , pp. 949
    • Bardelli, A.1    Parsons, D.W.2    Silliman, N.3
  • 17
    • 0037534075 scopus 로고    scopus 로고
    • Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma
    • R. Dammann, U. Schagdarsurengin, and L. Liu Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma Oncogene 22 2003 3806 3812
    • (2003) Oncogene , vol.22 , pp. 3806-3812
    • Dammann, R.1    Schagdarsurengin, U.2    Liu, L.3
  • 18
    • 0345392554 scopus 로고    scopus 로고
    • Alterations of RAS signalling in Chinese multiple myeloma patients: Absent BRAF and rare RAS mutations, but frequent inactivation of RASSF1A by transcriptional silencing or expression of a non-functional variant transcript
    • M.H. Ng, K.M. Lau, and W.S. Wong Alterations of RAS signalling in Chinese multiple myeloma patients: absent BRAF and rare RAS mutations, but frequent inactivation of RASSF1A by transcriptional silencing or expression of a non-functional variant transcript Brit J Haematol 123 2003 637 645
    • (2003) Brit J Haematol , vol.123 , pp. 637-645
    • Ng, M.H.1    Lau, K.M.2    Wong, W.S.3
  • 19
    • 18444408077 scopus 로고    scopus 로고
    • K-ras mutations and RASSF1A promoter methylation in colorectal cancer
    • M. van Engeland, G.M. Roemen, and M. Brink K-ras mutations and RASSF1A promoter methylation in colorectal cancer Oncogene 21 2002 3792 3795
    • (2002) Oncogene , vol.21 , pp. 3792-3795
    • Van Engeland, M.1    Roemen, G.M.2    Brink, M.3
  • 20
    • 1642272931 scopus 로고    scopus 로고
    • Early occurrence of RASSF1A hypermethylation and its mutual exclusion with BRAF mutation in thyroid tumorigenesis
    • M. Xing, Y. Cohen, and E. Mambo Early occurrence of RASSF1A hypermethylation and its mutual exclusion with BRAF mutation in thyroid tumorigenesis Cancer Res 64 2004 1664 1668
    • (2004) Cancer Res , vol.64 , pp. 1664-1668
    • Xing, M.1    Cohen, Y.2    Mambo, E.3
  • 21
    • 0141954012 scopus 로고    scopus 로고
    • Relationship of Ras association domain family 1 methylation and K-ras mutation in primary non-small cell lung cancer
    • D.H. Kim, J.S. Kim, and J.H. Park Relationship of Ras association domain family 1 methylation and K-ras mutation in primary non-small cell lung cancer Cancer Res 63 2003 6206 6211
    • (2003) Cancer Res , vol.63 , pp. 6206-6211
    • Kim, D.H.1    Kim, J.S.2    Park, J.H.3
  • 22
    • 1342330881 scopus 로고    scopus 로고
    • Frequent alterations of Ras signalling pathway genes in sporadic malignant melanomas
    • J. Reifenberger, C.B. Knobbe, and A.A. Sterzinger Frequent alterations of Ras signalling pathway genes in sporadic malignant melanomas Int J Cancer 109 2004 377 384
    • (2004) Int J Cancer , vol.109 , pp. 377-384
    • Reifenberger, J.1    Knobbe, C.B.2    Sterzinger, A.A.3
  • 23
    • 2442535041 scopus 로고    scopus 로고
    • Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling
    • J.C. Lindsey, M.E. Lusher, and J.A. Anderton Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling Carcinogenesis 25 2004 661 668
    • (2004) Carcinogenesis , vol.25 , pp. 661-668
    • Lindsey, J.C.1    Lusher, M.E.2    Anderton, J.A.3
  • 24
    • 0037108984 scopus 로고    scopus 로고
    • Biallelic epigenetic inactivation of the RASSF1A tumor suppressor gene in medulloblastoma development
    • M.E. Lusher, J.C. Lindsey, and F. Latif Biallelic epigenetic inactivation of the RASSF1A tumor suppressor gene in medulloblastoma development Cancer Res 62 2002 5906 5911
    • (2002) Cancer Res , vol.62 , pp. 5906-5911
    • Lusher, M.E.1    Lindsey, J.C.2    Latif, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.