The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosis via mitochondrial-lysosomal cross-talk

International Journal of Cancer

Volumn 132, Issue 11, 2013, Pages 2682-2693

  Seitz, Christian ^a   Hugle, Manuela ^a   Cristofanon, Silvia ^a   Tchoghandjian, Aurélie ^a   Fulda, Simone ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

apoptosis; BEZ235; lysosomes; neuroblastoma; PI3K

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; AUTOPHAGY PROTEIN 5; AUTOPHAGY PROTEIN 7; BAFILOMYCIN A1; BUPARLISIB; CASPASE; CELL PROTEIN; CHLOROQUINE; EVEROLIMUS; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER CELL CULTURE; CELL INTERACTION; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENTIATION; ENZYME ACTIVATION; LYSOSOME MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; NEUROBLASTOMA CELL; PRIORITY JOURNAL;

ANTIMALARIALS; APOPTOSIS; AUTOPHAGY; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CELL MEMBRANE PERMEABILITY; CHLOROQUINE; DRUG SYNERGISM; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; IMMUNOPRECIPITATION; LYSOSOMES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NEUROBLASTOMA; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; QUINOLINES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TUMOR CELLS, CULTURED;

EID: 84875615728     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.27935     Document Type: Article

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