메뉴 건너뛰기




Volumn 4, Issue 5, 1998, Pages 1079-1086

There are no bad anticancer agents, only bad clinical trial designs- twenty-first Richard and Hinda Rosenthal foundation award lecture

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; CISPLATIN; DAUNORUBICIN; DOCETAXEL; DOXORUBICIN; FLUDARABINE PHOSPHATE; FLUOROURACIL; GEMCITABINE; IRINOTECAN; MITOGUAZONE; PACLITAXEL; VINCRISTINE;

EID: 0031896592     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (175)

References (62)
  • 1
    • 0028352593 scopus 로고
    • MGBG: Teaching an old drug new tricks
    • Von Hoff, D. D. MGBG: teaching an old drug new tricks. Ann. Oncol., 5: 487-493, 1994.
    • (1994) Ann. Oncol. , vol.5 , pp. 487-493
    • Von Hoff, D.D.1
  • 2
    • 84953996518 scopus 로고
    • Zur Kenntnis des amino gunidins. I. Condensations-produkte de amidoguanidins mit aldehyden and ketonen der fettreihe
    • Thiele, J., and Dralle, F. Zur Kenntnis des amino gunidins. I. Condensations-produkte de amidoguanidins mit aldehyden and ketonen der fettreihe. Justus Liebigs Ann. Chem., 302: 275-299, 1898.
    • (1898) Justus Liebigs Ann. Chem. , vol.302 , pp. 275-299
    • Thiele, J.1    Dralle, F.2
  • 3
    • 0016218908 scopus 로고
    • Specific inhibition of the enzymatic decarboxylation of S-adenosylmethionine by methylglyoxal bis(guanylhydrazone) and related substances
    • Corti, A., Dave, C., Williamson-Ashman, H. G., Mihich, E., and Schenone, A. Specific inhibition of the enzymatic decarboxylation of S-adenosylmethionine by methylglyoxal bis(guanylhydrazone) and related substances. Biochem. J., 139: 351-357, 1974.
    • (1974) Biochem. J. , vol.139 , pp. 351-357
    • Corti, A.1    Dave, C.2    Williamson-Ashman, H.G.3    Mihich, E.4    Schenone, A.5
  • 4
    • 0019128316 scopus 로고
    • Independence of drug action on mitochondria and polyamines in L1210 leukemia cells treated with methylglyoxal bis(guanylhydrazone)
    • Pleshkewych, A., Kramer, D. L., Kelly, E., and Porter, C. W. Independence of drug action on mitochondria and polyamines in L1210 leukemia cells treated with methylglyoxal bis(guanylhydrazone). Cancer Res., 40: 4533-4540, 1980.
    • (1980) Cancer Res. , vol.40 , pp. 4533-4540
    • Pleshkewych, A.1    Kramer, D.L.2    Kelly, E.3    Porter, C.W.4
  • 5
    • 0013871256 scopus 로고
    • The antimitochondrial actions of 2-chloro-4′,4″-bis(2-imidazolin 2-yl)-terephthalanilide and methylglyoxal bis(guanylhydrazone)
    • Pine, M. J., and DiPaolo, J. The antimitochondrial actions of 2-chloro-4′,4″-bis(2-imidazolin 2-yl)-terephthalanilide and methylglyoxal bis(guanylhydrazone). Cancer Res., 26: 18-25, 1966.
    • (1966) Cancer Res. , vol.26 , pp. 18-25
    • Pine, M.J.1    DiPaolo, J.2
  • 6
    • 0011869843 scopus 로고
    • Methylglyoxal bis(guanylhydrazone): A new agent active against acute myelocytic leukemia
    • Freireich, E., Frei, E., III, and Karon, M. Methylglyoxal bis(guanylhydrazone): a new agent active against acute myelocytic leukemia. Cancer Chemother. Rep., 16: 183-186, 1962.
    • (1962) Cancer Chemother. Rep. , vol.16 , pp. 183-186
    • Freireich, E.1    Frei III, E.2    Karon, M.3
  • 7
    • 9844227337 scopus 로고
    • Clinical experience with methylglyoxal bis(guanylhydrazone) dihydrochloride: A new agent with clinical activity in acute myelocytic leukemia and the lymphomas
    • Regelson, W., and Holland, J. F. Clinical experience with methylglyoxal bis(guanylhydrazone) dihydrochloride: a new agent with clinical activity in acute myelocytic leukemia and the lymphomas. Cancer Chemother. Rep., 27: 15-26, 1963.
    • (1963) Cancer Chemother. Rep. , vol.27 , pp. 15-26
    • Regelson, W.1    Holland, J.F.2
  • 8
    • 0141744574 scopus 로고
    • Treatment of acute leukemia with methylglyoxal bis(guanylhydrazone) (methyl-GAG)
    • Levin, R. H., Henderson, E., Karon, M., and Freireich, E. J. Treatment of acute leukemia with methylglyoxal bis(guanylhydrazone) (methyl-GAG). Clin. Pharmacol. Ther., 6: 31-42, 1964.
    • (1964) Clin. Pharmacol. Ther. , vol.6 , pp. 31-42
    • Levin, R.H.1    Henderson, E.2    Karon, M.3    Freireich, E.J.4
  • 9
    • 0019409820 scopus 로고
    • Plasma levels and urinary excretion of methyl-GAG following i.v. infusion in man
    • Marsh, K. C., Liesmann, J., Patton, T. F., Fabian, C. J., and Sternson, L. A. Plasma levels and urinary excretion of methyl-GAG following i.v. infusion in man. Cancer Treat. Rep., 65: 253-257, 1981.
    • (1981) Cancer Treat. Rep. , vol.65 , pp. 253-257
    • Marsh, K.C.1    Liesmann, J.2    Patton, T.F.3    Fabian, C.J.4    Sternson, L.A.5
  • 10
    • 0038316190 scopus 로고
    • Clinical and pharmacologic studies with weekly and biweekly methylglyoxal bis-guanylhydrazone (methyl-G)
    • Hart, R. D., Roboz, J., Wu, K., Bruckner, T., Ohnuma, T., and Holland, J. F. Clinical and pharmacologic studies with weekly and biweekly methylglyoxal bis-guanylhydrazone (methyl-G). Proc. Am. Assoc. Cancer Res., 21: 181, 1980.
    • (1980) Proc. Am. Assoc. Cancer Res. , vol.21 , pp. 181
    • Hart, R.D.1    Roboz, J.2    Wu, K.3    Bruckner, T.4    Ohnuma, T.5    Holland, J.F.6
  • 12
    • 0020958257 scopus 로고
    • Methylglyoxal bis-guanylhydrazone (methyl GAG, MGBG) in lymphoma and Hodgkin's disease
    • Knight, W. A., III, Fabian, C., Costanzi, J. J., Jones, S. E., and Coltman, C. A., Jr. Methylglyoxal bis-guanylhydrazone (methyl GAG, MGBG) in lymphoma and Hodgkin's disease. Invest. New Drugs, 1: 225-237, 1983.
    • (1983) Invest. New Drugs , vol.1 , pp. 225-237
    • Knight III, W.A.1    Fabian, C.2    Costanzi, J.J.3    Jones, S.E.4    Coltman Jr., C.A.5
  • 13
    • 0019449764 scopus 로고
    • Effectiveness of methyl-GAG (methylglyoxal-bis-[guanylhydrazone]) in patients with advanced malignant lymphoma
    • Warrell, R. P., Lee, B. J., Kempin, S. J., Lacher, M. J., Straus, D. J., and Young, C. W. Effectiveness of methyl-GAG (methylglyoxal-bis-[guanylhydrazone]) in patients with advanced malignant lymphoma. Blood, 57: 1011-1014, 1981.
    • (1981) Blood , vol.57 , pp. 1011-1014
    • Warrell, R.P.1    Lee, B.J.2    Kempin, S.J.3    Lacher, M.J.4    Straus, D.J.5    Young, C.W.6
  • 14
    • 0020623560 scopus 로고
    • Methylglyoxal- bis(guanylhydrazone) (methyl GAG): Current studies and future prospects
    • Warrell, R. P., and Burchenal, J. H. Methylglyoxal- bis(guanylhydrazone) (methyl GAG): current studies and future prospects. J. Clin. Oncol., 1: 52-65, 1983.
    • (1983) J. Clin. Oncol. , vol.1 , pp. 52-65
    • Warrell, R.P.1    Burchenal, J.H.2
  • 15
    • 0022647636 scopus 로고
    • Mitoguazone in advanced squamous cell carcinoma of head and neck origin: A Phase II trial of the Southeastern Cancer Study Group
    • Luedke, D. W., Maddox, W., Birch, R., Velez-Garcia, E., and Schleuter, J. Mitoguazone in advanced squamous cell carcinoma of head and neck origin: a Phase II trial of the Southeastern Cancer Study Group. Cancer Treat. Rep., 70: 529-530, 1986.
    • (1986) Cancer Treat. Rep. , vol.70 , pp. 529-530
    • Luedke, D.W.1    Maddox, W.2    Birch, R.3    Velez-Garcia, E.4    Schleuter, J.5
  • 16
    • 0021954259 scopus 로고
    • Methylglyoxal-bis(guanylhydrazone) in hormone-resistant adenocarcinoma of the prostate
    • Scher, H. I., Yagoda, A., Ahmed, T., and Watson, R. C. Methylglyoxal-bis(guanylhydrazone) in hormone-resistant adenocarcinoma of the prostate. J. Clin. Oncol., 3: 224-228, 1985.
    • (1985) J. Clin. Oncol. , vol.3 , pp. 224-228
    • Scher, H.I.1    Yagoda, A.2    Ahmed, T.3    Watson, R.C.4
  • 17
    • 0026425673 scopus 로고
    • Acquired immunodeficiency syndrome and non-Hodgkin's lymphoma
    • Karp, J. E., and Broders, S. Acquired immunodeficiency syndrome and non-Hodgkin's lymphoma. Cancer Res., 51: 4743-4756, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 4743-4756
    • Karp, J.E.1    Broders, S.2
  • 18
    • 0026762701 scopus 로고
    • Acquired immunodeficiency syndrome related lymphoma
    • Levine, A. Acquired immunodeficiency syndrome related lymphoma. Blood, 80: 8-20, 1992.
    • (1992) Blood , vol.80 , pp. 8-20
    • Levine, A.1
  • 21
    • 0015244583 scopus 로고
    • Increased polyamine concentrations in the urine of human cancer patients
    • Russell, D. H. Increased polyamine concentrations in the urine of human cancer patients. Nature (Lond.), 233: 144-145, 1971.
    • (1971) Nature (Lond.) , vol.233 , pp. 144-145
    • Russell, D.H.1
  • 22
    • 0019367634 scopus 로고
    • Penetration of methylglyoxal bis(guanylhydrazone) into intracerebral tumors in humans
    • Rosenblum, M. G., Stewart, D. J., Yap, B. S., Leavens, M., Benjamin, R. S., and Loo, T. L. Penetration of methylglyoxal bis(guanylhydrazone) into intracerebral tumors in humans. Cancer Res., 41: 459-462, 1981.
    • (1981) Cancer Res. , vol.41 , pp. 459-462
    • Rosenblum, M.G.1    Stewart, D.J.2    Yap, B.S.3    Leavens, M.4    Benjamin, R.S.5    Loo, T.L.6
  • 25
    • 0020543018 scopus 로고
    • Clinical productivity of transplantable tumor system in the selection of new drugs for solid tumors: Rationale for a three-stage strategy
    • Staquet, M. J., Byar, D. P., Green, S. P., and Rozenwey, M. Clinical productivity of transplantable tumor system in the selection of new drugs for solid tumors: rationale for a three-stage strategy. Cancer Treat. Rep., 67: 753-765, 1983.
    • (1983) Cancer Treat. Rep. , vol.67 , pp. 753-765
    • Staquet, M.J.1    Byar, D.P.2    Green, S.P.3    Rozenwey, M.4
  • 26
    • 0028307752 scopus 로고
    • Drug screening in xenografts: The European multi-center project
    • Twentyman, P. Drug screening in xenografts: the European multi-center project. Ann. Oncol., 5: 394-396, 1994.
    • (1994) Ann. Oncol. , vol.5 , pp. 394-396
    • Twentyman, P.1
  • 27
    • 0025325071 scopus 로고
    • Evaluation of the antitumor activity of gemcitabine (2′,2′-difluoro-2′-deoxycytidine)
    • Hertel, L. W., Boder, G. B., Kroin, J. S., Rinzel, S. M., Poore, G. A., Todd, G. C., and Grindey, G. B. Evaluation of the antitumor activity of gemcitabine (2′,2′-difluoro-2′-deoxycytidine). Cancer Res., 50: 4417-4422, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 4417-4422
    • Hertel, L.W.1    Boder, G.B.2    Kroin, J.S.3    Rinzel, S.M.4    Poore, G.A.5    Todd, G.C.6    Grindey, G.B.7
  • 28
    • 0023783698 scopus 로고
    • Comparison of the cellular pharmacokinetics and toxicity of 2′,2′-difluoro-deoxycytidine and 1-β-D-arabinofuranosyl cytosine
    • Heinemann, V., Hertel, L., Grindey, G. B., and Plunkett, W. Comparison of the cellular pharmacokinetics and toxicity of 2′,2′-difluoro-deoxycytidine and 1-β-D-arabinofuranosyl cytosine. Cancer Res., 48: 4024-4031, 1988.
    • (1988) Cancer Res. , vol.48 , pp. 4024-4031
    • Heinemann, V.1    Hertel, L.2    Grindey, G.B.3    Plunkett, W.4
  • 29
    • 0025295958 scopus 로고
    • Modulatory activity of 2′,2′-difluorodeoxycytidine on the phosphorylation and cytotoxicity of arabinosyl nucleosides
    • Ghandi, V., and Plunkett, W. Modulatory activity of 2′,2′-difluorodeoxycytidine on the phosphorylation and cytotoxicity of arabinosyl nucleosides. Cancer Res., 50: 3675-3680, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 3675-3680
    • Ghandi, V.1    Plunkett, W.2
  • 30
    • 0026324313 scopus 로고
    • Action of 2′,2′-difluorodeoxycytidine on DNA synthesis
    • Huang, P., Chubb, S., Hertel, L. W., Grindey, G. B., and Plunkett, W. Action of 2′,2′-difluorodeoxycytidine on DNA synthesis. Cancer Res., 51: 6110-6117, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 6110-6117
    • Huang, P.1    Chubb, S.2    Hertel, L.W.3    Grindey, G.B.4    Plunkett, W.5
  • 31
    • 0026640498 scopus 로고
    • Activity of 2′,2′-difluorodeoxycytidine (gemcitabine) against human tumor colony forming units
    • Hanauske, A., Degen, D., Marshall, M. H., Hilsenbeck, S. G., Grindey, G. B., and Von Hoff, D. D. Activity of 2′,2′-difluorodeoxycytidine (gemcitabine) against human tumor colony forming units. Anticancer Drugs, 3: 143-146, 1992.
    • (1992) Anticancer Drugs , vol.3 , pp. 143-146
    • Hanauske, A.1    Degen, D.2    Marshall, M.H.3    Hilsenbeck, S.G.4    Grindey, G.B.5    Von Hoff, D.D.6
  • 38
    • 0023271255 scopus 로고
    • The Memorial Pain Assessment Card: A valid instrument for the evaluation of cancer pain
    • Phila.
    • Fishman, B., Pasternak, S., and Wallenstein, S. L. The Memorial Pain Assessment Card: a valid instrument for the evaluation of cancer pain. Cancer (Phila.), 60: 1151-1158, 1987.
    • (1987) Cancer , vol.60 , pp. 1151-1158
    • Fishman, B.1    Pasternak, S.2    Wallenstein, S.L.3
  • 40
    • 0027076295 scopus 로고
    • Southwest Oncology Group standard response criteria, endpoint definitions, and toxicity criteria
    • Green, S., and Weiss, G. R. Southwest Oncology Group standard response criteria, endpoint definitions, and toxicity criteria. Invest. New Drugs, 10: 239-253, 1992.
    • (1992) Invest. New Drugs , vol.10 , pp. 239-253
    • Green, S.1    Weiss, G.R.2
  • 45
    • 0017917570 scopus 로고
    • Analogues of ornithine as inhibitors of ornithine decarboxylase: New deductions concerning the topography of the enzyme's active site
    • Bey, P., Danzin, C., Von Dorsselaer, V., Mamont, P., Jung, M., and Tardif, C. Analogues of ornithine as inhibitors of ornithine decarboxylase: new deductions concerning the topography of the enzyme's active site. J. Med. Chem., 21: 50-55, 1978.
    • (1978) J. Med. Chem. , vol.21 , pp. 50-55
    • Bey, P.1    Danzin, C.2    Von Dorsselaer, V.3    Mamont, P.4    Jung, M.5    Tardif, C.6
  • 46
    • 0023881236 scopus 로고
    • Polyamine metabolism and its importance in neoplastic growth and as a target for chemotherapy
    • Pegg, A. E. Polyamine metabolism and its importance in neoplastic growth and as a target for chemotherapy. Cancer Res., 48: 759-784, 1988.
    • (1988) Cancer Res. , vol.48 , pp. 759-784
    • Pegg, A.E.1
  • 48
    • 0023625905 scopus 로고
    • Polyamine biosynthetic activity in normal and neoplastic human colorectal tissue
    • Phila.
    • Porter, C., Herrera-Ornelas, L., Pera, P., Retrelli, N. F., and Mittelman, A. Polyamine biosynthetic activity in normal and neoplastic human colorectal tissue. Cancer (Phila.), 60: 1275-1281, 1987.
    • (1987) Cancer , vol.60 , pp. 1275-1281
    • Porter, C.1    Herrera-Ornelas, L.2    Pera, P.3    Retrelli, N.F.4    Mittelman, A.5
  • 49
  • 50
    • 0029832374 scopus 로고    scopus 로고
    • Prognostic influence on survival of increased ornithine decarboxylase activity in human breast cancer
    • Manni, A., Mauger, D., Gimotty, P., and Badges, B. Prognostic influence on survival of increased ornithine decarboxylase activity in human breast cancer. Clin. Cancer Res., 2: 1401-1406, 1996.
    • (1996) Clin. Cancer Res. , vol.2 , pp. 1401-1406
    • Manni, A.1    Mauger, D.2    Gimotty, P.3    Badges, B.4
  • 51
    • 0026683752 scopus 로고
    • Ornithine decarboxylase activity is critical for cell transformation
    • Auvinen, M., Paasinen, A., Anderson, L. C., and Holtta, E. Ornithine decarboxylase activity is critical for cell transformation. Nature (Lond.), 360: 355-358, 1992.
    • (1992) Nature (Lond.) , vol.360 , pp. 355-358
    • Auvinen, M.1    Paasinen, A.2    Anderson, L.C.3    Holtta, E.4
  • 52
    • 0021951646 scopus 로고
    • Effect of concentration of DL-α-difluoromethylornithine on murine mammary carcinogenesis
    • Thompson, H. J., Meeker, L. D., Herbst, E. J., Ronan, A. M., and Minocha, R. Effect of concentration of DL-α-difluoromethylornithine on murine mammary carcinogenesis. Cancer Res., 45: 1170-1173, 1985.
    • (1985) Cancer Res. , vol.45 , pp. 1170-1173
    • Thompson, H.J.1    Meeker, L.D.2    Herbst, E.J.3    Ronan, A.M.4    Minocha, R.5
  • 53
    • 0025270332 scopus 로고
    • Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal anti-inflammatory drug with DL-α-difluoromethylornithine on ornithine decarboxylase inhibitor
    • Reddy, B. S., Nayini, J., Tokumo, K., Rigotty, J., Zang, E., and Kelloff, G. Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal anti-inflammatory drug with DL-α-difluoromethylornithine on ornithine decarboxylase inhibitor. Cancer Res., 50: 2562-2568, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 2562-2568
    • Reddy, B.S.1    Nayini, J.2    Tokumo, K.3    Rigotty, J.4    Zang, E.5    Kelloff, G.6
  • 54
    • 0023485265 scopus 로고
    • Inhibition of N-butyl-N (hydroxybutyl) nitrosamine-induced rat urinary bladder carcinogenesis by α-difluoromethylornithine
    • Homma, Y., Kakizoe, T., Samma, S., and Oyasu, R. Inhibition of N-butyl-N (hydroxybutyl) nitrosamine-induced rat urinary bladder carcinogenesis by α-difluoromethylornithine. Cancer Res., 47: 6176-6179, 1987.
    • (1987) Cancer Res. , vol.47 , pp. 6176-6179
    • Homma, Y.1    Kakizoe, T.2    Samma, S.3    Oyasu, R.4
  • 55
    • 0000382583 scopus 로고
    • Difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits tumor promoter-induced polyamine accumulation and carcinogenesis in the mouse skin
    • Weeks, C. E., Herrimann, A. L., Nelson, F. R., and Sloga, T. J. Difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits tumor promoter-induced polyamine accumulation and carcinogenesis in the mouse skin. Proc. Natl. Acad. Sci. USA, 74: 6028-6032, 1982.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.74 , pp. 6028-6032
    • Weeks, C.E.1    Herrimann, A.L.2    Nelson, F.R.3    Sloga, T.J.4
  • 62
    • 0028913573 scopus 로고
    • Shifting the cancer paradigm: Must we kill to cure?
    • Schipper, H., Goh, C. R., and Wang, T. L. Shifting the cancer paradigm: must we kill to cure? J. Clin. Oncol., 13: 801-807, 1994.
    • (1994) J. Clin. Oncol. , vol.13 , pp. 801-807
    • Schipper, H.1    Goh, C.R.2    Wang, T.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.