메뉴 건너뛰기




Volumn 3 FEB, Issue , 2013, Pages

Type 1 insulin-like growth factor receptor targeted therapies in pediatric cancer

Author keywords

IGF 1R; Insulin like growth factor pathway; Pediatric cancer; Resistance mechanisms; Sarcoma

Indexed keywords

AEW 541; ANTINEOPLASTIC AGENT; BMS 536924; CIXUTUMUMAB; DOXORUBICIN; EM 164; FIGITUMUMAB; GANITUMAB; IMATINIB; LAPATINIB; MAB 391; MAMMALIAN TARGET OF RAPAMYCIN; NVP AEW 541; PEGVISOMANT; PROTEIN KINASE B; R 1507; RAPAMYCIN; ROBATUMUMAB; SOMATOMEDIN B RECEPTOR; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN C RECEPTOR; SOMATOMEDIN C RECEPTOR INHIBITOR; SUNITINIB; TEMSIROLIMUS; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR PAX3; TRANSCRIPTION FACTOR PAX7; UNCLASSIFIED DRUG; VINCRISTINE;

EID: 84879591354     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2013.00009     Document Type: Short Survey
Times cited : (12)

References (71)
  • 2
  • 3
    • 0035728324 scopus 로고    scopus 로고
    • Transcriptional regulation of IGF-I receptor gene expression by the PAX3-FKHR oncoprotein
    • Ayalon, D., Glaser, T., and Werner, H. (2001). Transcriptional regulation of IGF-I receptor gene expression by the PAX3-FKHR oncoprotein. Growth Horm. IGF Res. 11, 289-297.
    • (2001) Growth Horm. IGF Res. , vol.11 , pp. 289-297
    • Ayalon, D.1    Glaser, T.2    Werner, H.3
  • 5
    • 84861218734 scopus 로고    scopus 로고
    • Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition
    • Bielen, A., Box, G., Perryman, L., Bjerke, L., Popov, S., Jamin, Y., et al. (2012). Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition. Proc. Natl. Acad. Sci. U.S.A. E1267-E1276.
    • (2012) Proc. Natl. Acad. Sci. U.S.A.
    • Bielen, A.1    Box, G.2    Perryman, L.3    Bjerke, L.4    Popov, S.5    Jamin, Y.6
  • 6
    • 80051597880 scopus 로고    scopus 로고
    • Enhanced efficacy of IGF1R inhibition in pediatric glioblastoma by combinatorial targeting of PDGFRa/ß
    • Bielen, A., Perryman, L., Box, G. M., Valenti, M., de Haven Brandon, A., Martins, V., et al. (2011). Enhanced efficacy of IGF1R inhibition in pediatric glioblastoma by combinatorial targeting of PDGFRa/ß. Mol. Cancer Ther. 10, 1407-1418.
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 1407-1418
    • Bielen, A.1    Perryman, L.2    Box, G.M.3    Valenti, M.4    de Haven Brandon, A.5    Martins, V.6
  • 7
    • 54249157471 scopus 로고    scopus 로고
    • Addiction to elevated insulin-like growth factor 1 receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody
    • Cao, L., Yu, Y., Darko, I., Currier, D., Mayeenuddin, L. H., Wan, X., et al. (2008). Addiction to elevated insulin-like growth factor 1 receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody. Cancer Res. 68, 8039-8048.
    • (2008) Cancer Res. , vol.68 , pp. 8039-8048
    • Cao, L.1    Yu, Y.2    Darko, I.3    Currier, D.4    Mayeenuddin, L.H.5    Wan, X.6
  • 8
    • 0036782071 scopus 로고    scopus 로고
    • Structural biology of insulin and IGF1 receptors: Implications for drug design
    • De Meyts, P., and Whittaker, J. (2002). Structural biology of insulin and IGF1 receptors: Implications for drug design. Nat. Rev. Drug Discov. 1, 769-783.
    • (2002) Nat. Rev. Drug Discov. , vol.1 , pp. 769-783
    • De Meyts, P.1    Whittaker, J.2
  • 9
    • 0036278440 scopus 로고    scopus 로고
    • Insulin-like growth factor I receptor activity in human medulloblastomas
    • Del Valle, L., Enam, S., Lassak, A., Wang, J. Y., Croul, S., Khalili, K., et al. (2002). Insulin-like growth factor I receptor activity in human medulloblastomas. Clin. Cancer Res. 8, 1822-1830.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 1822-1830
    • Del Valle, L.1    Enam, S.2    Lassak, A.3    Wang, J.Y.4    Croul, S.5    Khalili, K.6
  • 10
    • 33749505836 scopus 로고    scopus 로고
    • Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial
    • Demetri, G. D., van Oosterom, A. T., Garrett, C. R., Blackstein, M. E., Shah, M. H., Verweij, J., et al. (2006). Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet 368, 1329-1338.
    • (2006) Lancet , vol.368 , pp. 1329-1338
    • Demetri, G.D.1    van Oosterom, A.T.2    Garrett, C.R.3    Blackstein, M.E.4    Shah, M.H.5    Verweij, J.6
  • 12
    • 0024465983 scopus 로고
    • Autonomous growth of a human neuroblastoma cell line is mediated by insulin-like growth factor II
    • El-Badry, O. M., Romanus, J. A., Helman, L. J., Cooper, M. J., Rechler, M. M., and Israel, M. A. (1989). Autonomous growth of a human neuroblastoma cell line is mediated by insulin-like growth factor II. J. Clin. Invest. 84, 829-839.
    • (1989) J. Clin. Invest. , vol.84 , pp. 829-839
    • El-Badry, O.M.1    Romanus, J.A.2    Helman, L.J.3    Cooper, M.J.4    Rechler, M.M.5    Israel, M.A.6
  • 13
    • 57149093206 scopus 로고    scopus 로고
    • Insulin-likegrowthfactor-1receptoracts as a growth regulator in synovial sarcoma
    • Friedrichs, N., Küchler, J., Endl, E., Koch, A., Czerwitzki, J., Wurst, P., et al. (2008). Insulin-likegrowthfactor-1receptoracts as a growth regulator in synovial sarcoma. J. Pathol. 216, 428-439.
    • (2008) J. Pathol. , vol.216 , pp. 428-439
    • Friedrichs, N.1    Küchler, J.2    Endl, E.3    Koch, A.4    Czerwitzki, J.5    Wurst, P.6
  • 14
    • 0024804371 scopus 로고
    • Antibody to type I insulin like growth factor receptor inhibits growth of Wilms tumor in culture and in athymic mice
    • Gansler, T., Furlaneto, R., Gramling, T. S., Robinson, K. A., Blocker, N., Buse, M. G., et al. (1989). Antibody to type I insulin like growth factor receptor inhibits growth of Wilms tumor in culture and in athymic mice. Am. J. Pathol. 135, 961-966.
    • (1989) Am. J. Pathol. , vol.135 , pp. 961-966
    • Gansler, T.1    Furlaneto, R.2    Gramling, T.S.3    Robinson, K.A.4    Blocker, N.5    Buse, M.G.6
  • 15
    • 84865585349 scopus 로고    scopus 로고
    • Identification of common and distinctive mechanisms of resistance to different anti-IGF-1R agents in Ewing's sarcoma
    • Garofalo, C., Mancarella, C., Grilli, A., Manara, M. C., Astolfi, A., Marino, M. T., et al. (2012). Identification of common and distinctive mechanisms of resistance to different anti-IGF-1R agents in Ewing's sarcoma. Mol. Endocrinol. 26, 1603-1616.
    • (2012) Mol. Endocrinol. , vol.26 , pp. 1603-1616
    • Garofalo, C.1    Mancarella, C.2    Grilli, A.3    Manara, M.C.4    Astolfi, A.5    Marino, M.T.6
  • 16
    • 78649636617 scopus 로고    scopus 로고
    • Anti-insulin-like growth factor 1 receptor antibody EM164 (murine AVE1642) exhibits anti-tumour activity alone and in combination with temozolomide against neuroblastoma
    • Geoerger, B., Brasme, J. F., Daudigeos-Dubus, E., Opolon, P., Venot, C., Debussche, L., et al. (2010). Anti-insulin-like growth factor 1 receptor antibody EM164 (murine AVE1642) exhibits anti-tumour activity alone and in combination with temozolomide against neuroblastoma. Eur. J. Cancer 46, 3251-3262.
    • (2010) Eur. J. Cancer , vol.46 , pp. 3251-3262
    • Geoerger, B.1    Brasme, J.F.2    Daudigeos-Dubus, E.3    Opolon, P.4    Venot, C.5    Debussche, L.6
  • 17
    • 0037336348 scopus 로고    scopus 로고
    • Mannose 6-phosphate receptors: new twists in the tale
    • Ghosh, P., Dahms, N. M., and Kornfeld, S. (2003). Mannose 6-phosphate receptors: new twists in the tale. Nat. Rev. Mol. Cell Biol. 4, 202-212.
    • (2003) Nat. Rev. Mol. Cell Biol. , vol.4 , pp. 202-212
    • Ghosh, P.1    Dahms, N.M.2    Kornfeld, S.3
  • 18
    • 0034097566 scopus 로고    scopus 로고
    • Role of Insulin-like growth factors and their binding proteins in growth control and carcinogenesis
    • Grimberg, A., and Cohen, P. (2000). Role of Insulin-like growth factors and their binding proteins in growth control and carcinogenesis. J. Cell. Physiol. 183, 1-9.
    • (2000) J. Cell. Physiol. , vol.183 , pp. 1-9
    • Grimberg, A.1    Cohen, P.2
  • 19
    • 77951747892 scopus 로고    scopus 로고
    • Initial testing of a monoclonal antibody (IMC-A12) against IGF-1R by the Pediatric Preclinical Testing Program
    • Houghton, P. J., Morton, C. L., Gorlick, R., Kolb, E. A., Keir, S. T., Reynolds, C. P., et al. (2010). Initial testing of a monoclonal antibody (IMC-A12) against IGF-1R by the Pediatric Preclinical Testing Program. Pediatr. Blood Cancer 54, 921-926.
    • (2010) Pediatr. Blood Cancer , vol.54 , pp. 921-926
    • Houghton, P.J.1    Morton, C.L.2    Gorlick, R.3    Kolb, E.A.4    Keir, S.T.5    Reynolds, C.P.6
  • 20
    • 58249101005 scopus 로고    scopus 로고
    • The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors
    • Huang, F., Greer, A., Hurlburt, W., Han, X., Hafezi, X., Wittenberg, G. M., et al. (2009). The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors. Cancer Res. 69, 169-170.
    • (2009) Cancer Res. , vol.69 , pp. 169-170
    • Huang, F.1    Greer, A.2    Hurlburt, W.3    Han, X.4    Hafezi, X.5    Wittenberg, G.M.6
  • 21
    • 77956922669 scopus 로고    scopus 로고
    • Differential mechanisms of acquired resistance to insulin-like growth factor-I receptor antibody therapy or to a small-molecule inhibitor, BMS-754807, in a human rhabdomyosarcoma model
    • Huang, F., Hurlburt, W., Greer, A., Reeves, K. A., Hillerman, S., Chang, H., et al. (2010). Differential mechanisms of acquired resistance to insulin-like growth factor-I receptor antibody therapy or to a small-molecule inhibitor, BMS-754807, in a human rhabdomyosarcoma model. Cancer Res. 70, 7221-7231.
    • (2010) Cancer Res. , vol.70 , pp. 7221-7231
    • Huang, F.1    Hurlburt, W.2    Greer, A.3    Reeves, K.A.4    Hillerman, S.5    Chang, H.6
  • 22
    • 80053994190 scopus 로고    scopus 로고
    • R1507, an anti-insulin-like growth factor-1 receptor (IGF-1R) antibody, and EWS/FLI-1 siRNA in Ewing's sarcoma: convergence at the IGF/IGFR/Akt axis
    • doi: 10.1371/journal.pone.0026060
    • Huang, H. J., Angelo, L. S., Rodon, J., Sun, M., Kuenkele, K. P., Parsons, H. A., et al. (2011). R1507, an anti-insulin-like growth factor-1 receptor (IGF-1R) antibody, and EWS/FLI-1 siRNA in Ewing's sarcoma: convergence at the IGF/IGFR/Akt axis. PLoS ONE 6:e26060. doi: 10.1371/journal.pone.0026060
    • (2011) PLoS ONE , vol.6
    • Huang, H.J.1    Angelo, L.S.2    Rodon, J.3    Sun, M.4    Kuenkele, K.P.5    Parsons, H.A.6
  • 23
    • 84868200205 scopus 로고    scopus 로고
    • Patterns of deregulation of insulin growth factor signaling pathway in paediatric and adult gastrointestinal stromal tumours
    • Italiano, A., Chen, J., Zhang, L., Hajdu, M., Singer, S., DeMatteo, R. P., et al. (2012). Patterns of deregulation of insulin growth factor signaling pathway in paediatric and adult gastrointestinal stromal tumours. Eur. J. Cancer 48, 3215-3222.
    • (2012) Eur. J. Cancer , vol.48 , pp. 3215-3222
    • Italiano, A.1    Chen, J.2    Zhang, L.3    Hajdu, M.4    Singer, S.5    DeMatteo, R.P.6
  • 25
    • 35148813515 scopus 로고    scopus 로고
    • Pediatric KIT wild-type and platelet-derived growth factor receptor alpha-wild-type gastrointestinal stromal tumors share KIT activation but not mechanisms of genetic progression with adult gastrointestinal stromal tumors
    • Janeway, K. A., Liegl, B., Harlow, A., Le, C., Perez-Atayde, A., Kozakewich, H., et al. (2007). Pediatric KIT wild-type and platelet-derived growth factor receptor alpha-wild-type gastrointestinal stromal tumors share KIT activation but not mechanisms of genetic progression with adult gastrointestinal stromal tumors. Cancer Res. 67, 9084-8.
    • (2007) Cancer Res. , vol.67 , pp. 9084-8
    • Janeway, K.A.1    Liegl, B.2    Harlow, A.3    Le, C.4    Perez-Atayde, A.5    Kozakewich, H.6
  • 26
    • 84860290527 scopus 로고    scopus 로고
    • Treatment guidelines for gastrointestinal stromal tumors in children and young adults
    • Janeway, K. A., and Pappo, A. (2012). Treatment guidelines for gastrointestinal stromal tumors in children and young adults. J. Pediatr. Hematol. Oncol. 34(Suppl. 2), S69-S72.
    • (2012) J. Pediatr. Hematol. Oncol. , vol.34 , Issue.SUPPL. 2
    • Janeway, K.A.1    Pappo, A.2
  • 27
    • 78049495856 scopus 로고    scopus 로고
    • Strong expression of IGF1R in pediatric gastrointestinal stromal tumors without IGF1R genomic amplification
    • Janeway, K. A., Zhu, M. J., Barretina, J., Perez-Atayde, A., Demetri, G. D., and Fletcher, J. A. (2010). Strong expression of IGF1R in pediatric gastrointestinal stromal tumors without IGF1R genomic amplification. Int. J. Cancer 127, 2718-2722.
    • (2010) Int. J. Cancer , vol.127 , pp. 2718-2722
    • Janeway, K.A.1    Zhu, M.J.2    Barretina, J.3    Perez-Atayde, A.4    Demetri, G.D.5    Fletcher, J.A.6
  • 28
    • 80053062871 scopus 로고    scopus 로고
    • Preliminary efficacy of the anti-insulin-like growth factor type 1 receptor antibody figitumumab in patients with refractory Ewing sarcoma
    • Juergens, H., Daw, N. C., Geoerger, B., Ferrari, S., Villarroel, M., Aerts, I., et al. (2011). Preliminary efficacy of the anti-insulin-like growth factor type 1 receptor antibody figitumumab in patients with refractory Ewing sarcoma. J. Clin. Oncol. 29, 4534-4540.
    • (2011) J. Clin. Oncol. , vol.29 , pp. 4534-4540
    • Juergens, H.1    Daw, N.C.2    Geoerger, B.3    Ferrari, S.4    Villarroel, M.5    Aerts, I.6
  • 30
    • 0028332784 scopus 로고
    • Human osteosarcoma cell lines are dependent on insulin-like growth factor I for in vitro growth
    • Kappel, C. C., VelezYanguas, M. C., Hirschfeld, S., and Helman, L. J. (1994). Human osteosarcoma cell lines are dependent on insulin-like growth factor I for in vitro growth. Cancer Res. 54, 2803-2807.
    • (1994) Cancer Res. , vol.54 , pp. 2803-2807
    • Kappel, C.C.1    VelezYanguas, M.C.2    Hirschfeld, S.3    Helman, L.J.4
  • 31
    • 69149097240 scopus 로고    scopus 로고
    • Targeting IGF-1R in the treatment of sarcomas: past, present and future
    • Kim, S. Y., Wan, X., and Helman, L. J. (2009). Targeting IGF-1R in the treatment of sarcomas: past, present and future. Bull. Cancer 96, E52-E60.
    • (2009) Bull. Cancer , vol.96
    • Kim, S.Y.1    Wan, X.2    Helman, L.J.3
  • 32
    • 42349083307 scopus 로고    scopus 로고
    • Initial testing (stage1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program
    • Kolb, E. A., Gorlick, R., Houghton, P. J., Morton, C. L., Lock, R., Carol, H., et al. (2008). Initial testing (stage1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program. Pediatr. Blood Cancer 50, 1190-1197.
    • (2008) Pediatr. Blood Cancer , vol.50 , pp. 1190-1197
    • Kolb, E.A.1    Gorlick, R.2    Houghton, P.J.3    Morton, C.L.4    Lock, R.5    Carol, H.6
  • 33
    • 79551630554 scopus 로고    scopus 로고
    • Initial testing (Stage I) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program
    • Kolb, E. A., Gorlick, R., Lock, R., Carol, H., Morton, C. L., Keir, S. T., et al. (2011). Initial testing (Stage I) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program. Pediatr. Blood Cancer 56, 595-603.
    • (2011) Pediatr. Blood Cancer , vol.56 , pp. 595-603
    • Kolb, E.A.1    Gorlick, R.2    Lock, R.3    Carol, H.4    Morton, C.L.5    Keir, S.T.6
  • 34
    • 84863278693 scopus 로고    scopus 로고
    • Combination testing (Stage2) of the Anti-IGF-1receptorantibodyIMC-A12 with rapamycin by the pediatric preclinical testing program
    • Kolb, E. A., Gorlick, R., Maris, J. M., Keir, S. T., Morton, C. L., Wu, J., et al. (2012). Combination testing (Stage2) of the Anti-IGF-1receptorantibodyIMC-A12 with rapamycin by the pediatric preclinical testing program. Pediatr. Blood Cancer 58, 729-735.
    • (2012) Pediatr. Blood Cancer , vol.58 , pp. 729-735
    • Kolb, E.A.1    Gorlick, R.2    Maris, J.M.3    Keir, S.T.4    Morton, C.L.5    Wu, J.6
  • 35
    • 77953256426 scopus 로고    scopus 로고
    • R1507, a fully human monoclonal antibody targeting IGF-1R, is effective alone and in combination with rapamycin in inhibiting growth of osteosarcoma xenografts
    • Kolb, E. A., Kamara, D., Zhang, W., Lin, J., Hingorani, P., Baker, L., et al. (2010). R1507, a fully human monoclonal antibody targeting IGF-1R, is effective alone and in combination with rapamycin in inhibiting growth of osteosarcoma xenografts. Pediatr. Blood Cancer 55, 67-75.
    • (2010) Pediatr. Blood Cancer , vol.55 , pp. 67-75
    • Kolb, E.A.1    Kamara, D.2    Zhang, W.3    Lin, J.4    Hingorani, P.5    Baker, L.6
  • 36
    • 0029996244 scopus 로고    scopus 로고
    • Proteolysis of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in 150-kilodalton IGFBP complexes by a cation-dependent protease activity in adult rat serum promotes the release of bound IGF-I
    • Lee, G. Y., and Rechler, M. M. (1996). Proteolysis of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in 150-kilodalton IGFBP complexes by a cation-dependent protease activity in adult rat serum promotes the release of bound IGF-I. Endocrinology 137, 2051-2058.
    • (1996) Endocrinology , vol.137 , pp. 2051-2058
    • Lee, G.Y.1    Rechler, M.M.2
  • 37
    • 79951860072 scopus 로고    scopus 로고
    • Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer
    • Maki, R. G. (2010). Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer. J. Clin. Oncol. 28, 4985-4995.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 4985-4995
    • Maki, R.G.1
  • 39
    • 84862907964 scopus 로고    scopus 로고
    • Phase I/II trial and pharmacokinetic study of cixutumumab in pediatric patients with refractory solid tumors and Ewing sarcoma: a report from the Children's Oncology Group
    • Malempati, S., Weigel, B., Ingle, A. M., Ahern, C. H., Carroll, J. M., Roberts, C. T., et al. (2012). Phase I/II trial and pharmacokinetic study of cixutumumab in pediatric patients with refractory solid tumors and Ewing sarcoma: a report from the Children's Oncology Group. J. Clin. Oncol. 30, 256-262.
    • (2012) J. Clin. Oncol. , vol.30 , pp. 256-262
    • Malempati, S.1    Weigel, B.2    Ingle, A.M.3    Ahern, C.H.4    Carroll, J.M.5    Roberts, C.T.6
  • 40
    • 77953523121 scopus 로고    scopus 로고
    • Recent advances in neuroblastoma
    • Maris, J. (2010). Recent advances in neuroblastoma. N. Engl. J. Med. 362, 2202-2211.
    • (2010) N. Engl. J. Med. , vol.362 , pp. 2202-2211
    • Maris, J.1
  • 41
    • 33745212417 scopus 로고    scopus 로고
    • Insulin like growth factor I receptor pathway inhibition by ADW742, alone or in combination with imatinib, doxorubicin, or vincristine, is a novel therapeutic approach in Ewing tumor
    • Martins, A. S., Mackintosh, C., Martín, D. H., Campos, M., Hernández, T., Ordóñez, J. L., et al. (2006). Insulin like growth factor I receptor pathway inhibition by ADW742, alone or in combination with imatinib, doxorubicin, or vincristine, is a novel therapeutic approach in Ewing tumor. Clin. Cancer Res. 12, 3532-3540.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 3532-3540
    • Martins, A.S.1    Mackintosh, C.2    Martín, D.H.3    Campos, M.4    Hernández, T.5    Ordóñez, J.L.6
  • 42
    • 63449118087 scopus 로고    scopus 로고
    • Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results Program
    • Mirabello, L., Troisi, R. J., and Savage, S. A. (2009). Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results Program. Cancer 115, 1531-1543.
    • (2009) Cancer , vol.115 , pp. 1531-1543
    • Mirabello, L.1    Troisi, R.J.2    Savage, S.A.3
  • 43
    • 84860506226 scopus 로고    scopus 로고
    • Insulin growth factor-receptor (IGF-1R) antibody cixutumumab combined with the mTOR inhibitor temsirolimus in patients with refractory Ewing's sarcoma family tumors
    • Naing, A., LoRusso, P., Fu, S., Hong, D. S., Anderson, P., Benjamin, R. S., et al. (2012). Insulin growth factor-receptor (IGF-1R) antibody cixutumumab combined with the mTOR inhibitor temsirolimus in patients with refractory Ewing's sarcoma family tumors. Clin. Cancer Res. 18, 2625-2631.
    • (2012) Clin. Cancer Res. , vol.18 , pp. 2625-2631
    • Naing, A.1    LoRusso, P.2    Fu, S.3    Hong, D.S.4    Anderson, P.5    Benjamin, R.S.6
  • 44
    • 33845754407 scopus 로고    scopus 로고
    • Blastemal expression of type I inslin-like growth factor receptor in Wilms tumors is driven by increased copy number and correlates with relapse
    • Natrajan, R., Reis-Filho, J. S., Little, S. E., Messahel, B., Brundler, M. A., Dome, J. S., et al. (2006). Blastemal expression of type I inslin-like growth factor receptor in Wilms tumors is driven by increased copy number and correlates with relapse. Cancer Res. 66, 11148-11155.
    • (2006) Cancer Res. , vol.66 , pp. 11148-11155
    • Natrajan, R.1    Reis-Filho, J.S.2    Little, S.E.3    Messahel, B.4    Brundler, M.A.5    Dome, J.S.6
  • 46
    • 75249097799 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study
    • Olmos, D., Postel-Vinay, S., Molife, L. R., Okuno, S. H., Schuetze, S. M., Paccagnella, M. L., et al. (2010). Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study. Lancet Oncol. 11, 129-135.
    • (2010) Lancet Oncol. , vol.11 , pp. 129-135
    • Olmos, D.1    Postel-Vinay, S.2    Molife, L.R.3    Okuno, S.H.4    Schuetze, S.M.5    Paccagnella, M.L.6
  • 47
    • 83255163333 scopus 로고    scopus 로고
    • R1507, a monoclonal antibody to the insulin-like growth factor-1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research Through Collaboration study
    • Pappo, A. S., Patel, S. R., Crowley, J., Reinke, D. K., Kuenkele, K. P., Chawla, S. P., et al. (2011). R1507, a monoclonal antibody to the insulin-like growth factor-1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research Through Collaboration study. J. Clin. Oncol. 29, 4541-4547.
    • (2011) J. Clin. Oncol. , vol.29 , pp. 4541-4547
    • Pappo, A.S.1    Patel, S.R.2    Crowley, J.3    Reinke, D.K.4    Kuenkele, K.P.5    Chawla, S.P.6
  • 48
    • 77954596239 scopus 로고    scopus 로고
    • Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease
    • Paugh, B. S., Qu, C., Jones, C., Liu, Z., Adamowicz-Brice, M., Zhang, J., et al. (2010). Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease. J. Clin. Oncol. 28, 3061-3068.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 3061-3068
    • Paugh, B.S.1    Qu, C.2    Jones, C.3    Liu, Z.4    Adamowicz-Brice, M.5    Zhang, J.6
  • 49
    • 34248216623 scopus 로고    scopus 로고
    • Phosphoprotein pathway mapping: Akt/mammalian target of rapamycin activation is negatively associated with childhood rhabdomyosarcoma survival
    • Petricoin, E. F. III, Espina, V., Araujo, R. P., Midura, B., Yeung, C., Wan, X., et al. (2007). Phosphoprotein pathway mapping: Akt/mammalian target of rapamycin activation is negatively associated with childhood rhabdomyosarcoma survival. Cancer Res. 67, 3431-3440.
    • (2007) Cancer Res. , vol.67 , pp. 3431-3440
    • Petricoin III, E.F.1    Espina, V.2    Araujo, R.P.3    Midura, B.4    Yeung, C.5    Wan, X.6
  • 50
    • 56749184290 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor signalling in neoplasia
    • Pollack, M. (2008). Insulin and insulin-like growth factor signalling in neoplasia. Nat. Rev. Cancer 8, 915-928.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 915-928
    • Pollack, M.1
  • 51
    • 78449309033 scopus 로고    scopus 로고
    • Synthetic lethality screens reveal RPS6 and MST1R as modifiers of insulin-like growth factor-1 receptor inhibitor activity in childhood sarcomas
    • Potratz, J. C., Saunders, D. N., Wai, D. H., Ng, T. L., McKinney, S. E., Carboni, J. M., et al. (2010). Synthetic lethality screens reveal RPS6 and MST1R as modifiers of insulin-like growth factor-1 receptor inhibitor activity in childhood sarcomas. Cancer Res. 70, 8770-8781.
    • (2010) Cancer Res. , vol.70 , pp. 8770-8781
    • Potratz, J.C.1    Saunders, D.N.2    Wai, D.H.3    Ng, T.L.4    McKinney, S.E.5    Carboni, J.M.6
  • 52
    • 20944442418 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors in children and young adults: a clinicopathologic, molecular, and genomic study of 15 cases and review of the literature
    • Prakash, S., Sarran, L., Socci, N., DeMatteo, R.P., Eisenstat, J., Greco, A. M., et al. (2005). Gastrointestinal stromal tumors in children and young adults: a clinicopathologic, molecular, and genomic study of 15 cases and review of the literature. J. Pediatr. Hematol. Oncol. 27, 179-187.
    • (2005) J. Pediatr. Hematol. Oncol. , vol.27 , pp. 179-187
    • Prakash, S.1    Sarran, L.2    Socci, N.3    DeMatteo, R.P.4    Eisenstat, J.5    Greco, A.M.6
  • 53
    • 3543026281 scopus 로고    scopus 로고
    • EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3
    • Prieur, A., Tirode, F., Cohen, P., and Delattre, O. (2004). EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Mol. Cell. Biol. 24, 7274-7283.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 7274-7283
    • Prieur, A.1    Tirode, F.2    Cohen, P.3    Delattre, O.4
  • 54
    • 79951816312 scopus 로고    scopus 로고
    • Combination mTOR and IGF-1R inhibition: phase I trial of everolimus and figitumumab in patients with advanced sarcomas and other solid tumors
    • Quek, R., Wang, Q., Morgan, J. A., Shapiro, G. I., Butrynski, J. B., Ramaiya, N., et al. (2011). Combination mTOR and IGF-1R inhibition: phase I trial of everolimus and figitumumab in patients with advanced sarcomas and other solid tumors. Clin. Cancer Res. 17, 871-879.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 871-879
    • Quek, R.1    Wang, Q.2    Morgan, J.A.3    Shapiro, G.I.4    Butrynski, J.B.5    Ramaiya, N.6
  • 55
    • 0035115056 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF) binding protein-3 inhibits type 1 IGF receptor activation independently of its IGF binding affinity
    • Ricort, J. M., and Binoux, M. (2001). Insulin-like growth factor (IGF) binding protein-3 inhibits type 1 IGF receptor activation independently of its IGF binding affinity. Endocrinology 142, 108-113.
    • (2001) Endocrinology , vol.142 , pp. 108-113
    • Ricort, J.M.1    Binoux, M.2
  • 57
    • 76549137130 scopus 로고    scopus 로고
    • Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas
    • Schiffman, J. D., Hodgson, J. G., VandenBerg, S. R., Flaherty, P., Polley, M. Y., Yu, M., et al. (2010). Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas. Cancer Res. 70, 512-519.
    • (2010) Cancer Res. , vol.70 , pp. 512-519
    • Schiffman, J.D.1    Hodgson, J.G.2    VandenBerg, S.R.3    Flaherty, P.4    Polley, M.Y.5    Yu, M.6
  • 58
    • 84890673797 scopus 로고    scopus 로고
    • The phase II Trial of the mTOR inhibitor temsirolimus and the IGF-1R inhibitor cixutumumab (IMC-A12) in patients with IGF-1R (+) and IGF-1R (-) bone and soft tissue sarcoma (STS)
    • Chicago. Abstract 10003.
    • Schwartz, G. K., Tap, W. D., Qin, L. X., Livingston, M. B., Undevia, S. D., Chmielowski, B., et al. (2012). "The phase II Trial of the mTOR inhibitor temsirolimus and the IGF-1R inhibitor cixutumumab (IMC-A12) in patients with IGF-1R (+) and IGF-1R (-) bone and soft tissue sarcoma (STS)," in Annual Meeting of the American Society of Clinical Oncology, Chicago. Abstract 10003.
    • (2012) Annual Meeting of the American Society of Clinical Oncology
    • Schwartz, G.K.1    Tap, W.D.2    Qin, L.X.3    Livingston, M.B.4    Undevia, S.D.5    Chmielowski, B.6
  • 59
    • 17744417798 scopus 로고    scopus 로고
    • Blockage of insulin-like growth factor-I receptor inhibits the growth of Ewing's sarcoma in athymic mice
    • Scotlandi, K., Benini, S., Nanni, P., Lollini, P, L., Nicoletti, G., Landuzzi, L., et al. (1998). Blockage of insulin-like growth factor-I receptor inhibits the growth of Ewing's sarcoma in athymic mice. Cancer Res. 58, 4127-4131.
    • (1998) Cancer Res. , vol.58 , pp. 4127-4131
    • Scotlandi, K.1    Benini, S.2    Nanni, P.3    Lollini, P.L.4    Nicoletti, G.5    Landuzzi, L.6
  • 60
    • 0034669290 scopus 로고    scopus 로고
    • Synovial sarcoma: a clinicopathologic, staging, and prognostic assessment
    • Spillane, A. J., A'Hern, R., Judson, I. R., Fisher, C., and Thomas, J. M. (2000). Synovial sarcoma: a clinicopathologic, staging, and prognostic assessment. J. Clin. Oncol. 18, 3794-3803.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 3794-3803
    • Spillane, A.J.1    A'Hern, R.2    Judson, I.R.3    Fisher, C.4    Thomas, J.M.5
  • 61
    • 33244494390 scopus 로고    scopus 로고
    • IGF-2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1
    • Sun, Y., Gao, D., Liu, Y., Huang, J., Lessnick, S., and Tanaka, S. (2006). IGF-2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1. Oncogene 25, 1042-1052.
    • (2006) Oncogene , vol.25 , pp. 1042-1052
    • Sun, Y.1    Gao, D.2    Liu, Y.3    Huang, J.4    Lessnick, S.5    Tanaka, S.6
  • 62
    • 84863908472 scopus 로고    scopus 로고
    • Phase II study of ganitumab, a fully human anti-type-1 insulin-like growth factor receptor antibody, in patients with metastatic Ewing family tumors or desmoplastic small round cell tumors
    • Tap, W. D., Demetri, G., Barnette, P., Desai, J, Kavan, P., Tozer, R., et al. (2012). Phase II study of ganitumab, a fully human anti-type-1 insulin-like growth factor receptor antibody, in patients with metastatic Ewing family tumors or desmoplastic small round cell tumors. J. Clin. Oncol. 30, 1849-1856.
    • (2012) J. Clin. Oncol. , vol.30 , pp. 1849-1856
    • Tap, W.D.1    Demetri, G.2    Barnette, P.3    Desai, J.4    Kavan, P.5    Tozer, R.6
  • 63
    • 73349099049 scopus 로고    scopus 로고
    • Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1
    • Tolcher, A. W., Sarantopoulos, J., Patnaik, A., Papadopoulos, K., Lin, C. C., Rodon, J., et al. (2009). Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1. J. Clin. Oncol. 27, 5800-5807.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 5800-5807
    • Tolcher, A.W.1    Sarantopoulos, J.2    Patnaik, A.3    Papadopoulos, K.4    Lin, C.C.5    Rodon, J.6
  • 64
    • 33746143756 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor expression regulates neuroblastoma metastasis to bone
    • van Golen, C. M., Schwab, T. S., Kim, B., Soules, M. E., Su Oh, S., Fung, K., et al. (2006). Insulin-like growth factor-I receptor expression regulates neuroblastoma metastasis to bone. Cancer Res. 66, 6570-6578.
    • (2006) Cancer Res. , vol.66 , pp. 6570-6578
    • van Golen, C.M.1    Schwab, T.S.2    Kim, B.3    Soules, M.E.4    Su Oh, S.5    Fung, K.6
  • 65
    • 33947538050 scopus 로고    scopus 로고
    • Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism
    • Wan, X., Harkavy, B., Shen, N., Grohar, P., and Helman, L. J. (2007). Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene 26, 1932-1940.
    • (2007) Oncogene , vol.26 , pp. 1932-1940
    • Wan, X.1    Harkavy, B.2    Shen, N.3    Grohar, P.4    Helman, L.J.5
  • 66
    • 84860389568 scopus 로고    scopus 로고
    • Increased expression of insulin-like growth factor-1 receptor is correlated with tumor metastasis and prognosis in patients with osteosarcoma
    • Wang, Y. H., Han, X. D., Qiu, Y., Xiong, J., Yu, Y., Wang, B., et al. (2012). Increased expression of insulin-like growth factor-1 receptor is correlated with tumor metastasis and prognosis in patients with osteosarcoma. J. Surg. Oncol. 105, 235-243.
    • (2012) J. Surg. Oncol. , vol.105 , pp. 235-243
    • Wang, Y.H.1    Han, X.D.2    Qiu, Y.3    Xiong, J.4    Yu, Y.5    Wang, B.6
  • 68
    • 84867300753 scopus 로고    scopus 로고
    • Novel agents targeting the IGF-1R/PI3K pathway impair cell proliferation and survival in subsets of medulloblastoma and neuroblastoma
    • doi: 10.1371/journal.pone.0047109
    • Wojtalla, A., Salm, F., Christiansen, D. G., Cremona, T., Cwiek, P., Shalaby, T., et al. (2012). Novel agents targeting the IGF-1R/PI3K pathway impair cell proliferation and survival in subsets of medulloblastoma and neuroblastoma. PLoS ONE 7:e47109. doi: 10.1371/journal.pone.0047109
    • (2012) PLoS ONE , vol.7
    • Wojtalla, A.1    Salm, F.2    Christiansen, D.G.3    Cremona, T.4    Cwiek, P.5    Shalaby, T.6
  • 69
    • 0036491040 scopus 로고    scopus 로고
    • Molecular pathogenesis of rhabdomyosarcoma
    • Xiao, S. J., Pressey, J. G., and Barr, F. G. (2002). Molecular pathogenesis of rhabdomyosarcoma. Cancer Biol. Ther. 1, 97-104.
    • (2002) Cancer Biol. Ther. , vol.1 , pp. 97-104
    • Xiao, S.J.1    Pressey, J.G.2    Barr, F.G.3
  • 70
    • 0033179378 scopus 로고    scopus 로고
    • Expression of insulin-like growth factor-1 receptor in synovial sarcoma: association with an aggressive phenotype
    • Xie, Y., Skytting, B., Nilsson, G., Brodin, B., and Larsson, O. (1999). Expression of insulin-like growth factor-1 receptor in synovial sarcoma: association with an aggressive phenotype. Cancer Res. 59, 3588-3591.
    • (1999) Cancer Res. , vol.59 , pp. 3588-3591
    • Xie, Y.1    Skytting, B.2    Nilsson, G.3    Brodin, B.4    Larsson, O.5
  • 71
    • 0025632981 scopus 로고
    • Insulin-like growth factor I expression by tumors of neuroectodermal origin with the t(11;22) chromosomal translocation. A potential autocrine growth factor
    • Yee, D., Favoni, R. E., Lebovic, G. S., Lombana, F., Powell, D. R., Reynolds, C. P., et al. (1990). Insulin-like growth factor I expression by tumors of neuroectodermal origin with the t(11;22) chromosomal translocation. A potential autocrine growth factor. J. Clin. Invest. 86, 1806-1814.
    • (1990) J. Clin. Invest. , vol.86 , pp. 1806-1814
    • Yee, D.1    Favoni, R.E.2    Lebovic, G.S.3    Lombana, F.4    Powell, D.R.5    Reynolds, C.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.