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Volumn 3, Issue 5, 2010, Pages 326-335

Dual inhibitor AEE788 reduces tumor growth in preclinical models of medulloblastoma

Author keywords

[No Author keywords available]

Indexed keywords

6 [4 (4 ETHYL 1 PIPERAZINYLMETHYL)PHENYL] 4 (ALPHA METHYLBENZYLAMINO) 7H PYRROLO[2,3 D]PYRIMIDINE; CARBOPLATIN; CD31 ANTIGEN; CISPLATIN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; ETOPOSIDE; NEU DIFFERENTIATION FACTOR; PROTEIN KINASE B; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

EID: 78449260118     PISSN: None     EISSN: 19365233     Source Type: Journal    
DOI: 10.1593/tlo.10163     Document Type: Article
Times cited : (15)

References (33)
  • 1
    • 0034927062 scopus 로고    scopus 로고
    • The developmental biology of braintumors
    • Wechsler-Reya R and Scott MP (2001). The developmental biology of braintumors. Annu Rev Neurosci 24, 385-428.
    • (2001) Annu Rev Neurosci , vol.24 , pp. 385-428
    • Wechsler-Reya, R.1    Scott, M.P.2
  • 2
    • 1642307767 scopus 로고    scopus 로고
    • Medulloblastoma: Signalling a change in treatment
    • Gilbertson RJ (2004). Medulloblastoma: signalling a change in treatment. Lancet Oncol 5, 209-218.
    • (2004) Lancet Oncol , vol.5 , pp. 209-218
    • Gilbertson, R.J.1
  • 3
    • 33746544343 scopus 로고    scopus 로고
    • New paradigms in anticancer therapy: Targeting multiple signaling pathways with kinase inhibitors
    • Faivre S, Djelloul S, and Raymond E (2006). New paradigms in anticancer therapy:targeting multiple signaling pathways with kinase inhibitors. Semin Oncol 33, 407-420.
    • (2006) Semin Oncol , vol.33 , pp. 407-420
    • Faivre, S.1    Djelloul, S.2    Raymond, E.3
  • 4
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity oftargeted inhibitors
    • Hynes NE and Lane HA (2005). ERBB receptors and cancer: the complexity oftargeted inhibitors. Nat Rev Cancer 5, 341-354.
    • (2005) Nat Rev Cancer , vol.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 6
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and itsreceptors
    • Ferrara N, Gerber HP, and LeCouter J (2003). The biology of VEGF and itsreceptors. Nat Med 9, 669-676.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 7
    • 0027412319 scopus 로고
    • Epidermal growth factor stimulates vascular endothelial growth factor productionby human malignant glioma cells: A model of glioblastoma multiforme pathophysiology
    • Goldman CK, Kim J, Wong WL, King V, Brock T, and Gillepsie GY (1993). Epidermal growth factor stimulates vascular endothelial growth factor productionby human malignant glioma cells: a model of glioblastoma multiforme pathophysiology. Mol Biol Cell 4, 121-133.
    • (1993) Mol Biol Cell , vol.4 , pp. 121-133
    • Goldman, C.K.1    Kim, J.2    Wong, W.L.3    King, V.4    Brock, T.5    Gillepsie, G.Y.6
  • 8
    • 33644529055 scopus 로고    scopus 로고
    • ErbB2 increases vascular endothelial growthfactor protein synthesis via activation of mammalian target of rapamycin/p70S6Kleading to increased angiogenesis and spontaneous metastasis of human breastcancer cells
    • Klos KS, Wyszomierski SL, Sun M, Tan M, Zhou X, Li P, Yang W, Yin G, Hittelman WN, and Yu D (2006). ErbB2 increases vascular endothelial growthfactor protein synthesis via activation of mammalian target of rapamycin/p70S6Kleading to increased angiogenesis and spontaneous metastasis of human breastcancer cells. Cancer Res 66, 2028-2037.
    • (2006) Cancer Res , vol.66 , pp. 2028-2037
    • Klos, K.S.1    Wyszomierski, S.L.2    Sun, M.3    Tan, M.4    Zhou, X.5    Li, P.6    Yang, W.7    Yin, G.8    Hittelman, W.N.9    Yu, D.10
  • 9
    • 0036604183 scopus 로고    scopus 로고
    • ErbB2 overexpressioncorrelates with increased expression of vascular endothelial growth factors A, C, and D in human breast carcinoma
    • Yang W, Klos K, Yang Y, Smith TL, Shi D, and Yu D (2002). ErbB2 overexpressioncorrelates with increased expression of vascular endothelial growth factors A, C, and D in human breast carcinoma. Cancer 94, 2855-2861.
    • (2002) Cancer , vol.94 , pp. 2855-2861
    • Yang, W.1    Klos, K.2    Yang, Y.3    Smith, T.L.4    Shi, D.5    Yu, D.6
  • 10
    • 51149086367 scopus 로고    scopus 로고
    • Combined targeting of EGFRdependentand VEGF-dependent pathways: Rationale, preclinical studies andclinical applications
    • Tortora G, Ciardiello F, and Gasparini G (2008). Combined targeting of EGFRdependentand VEGF-dependent pathways: rationale, preclinical studies andclinical applications. Nat Clin Pract Oncol 5, 521-530.
    • (2008) Nat Clin Pract Oncol , vol.5 , pp. 521-530
    • Tortora, G.1    Ciardiello, F.2    Gasparini, G.3
  • 11
    • 3142774878 scopus 로고    scopus 로고
    • AEE788: A dual family epidermalgrowth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosinekinase inhibitor with antitumor and antiangiogenic activity
    • Traxler P, Allegrini PR, Brandt R, Brueggen J, Cozens R, Fabbro D, Grosios K, Lane HA, McSheehy P, Mestan J, et al. (2004). AEE788: a dual family epidermalgrowth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosinekinase inhibitor with antitumor and antiangiogenic activity. Cancer Res 64,4931-4941.
    • (2004) Cancer Res , vol.64 , pp. 4931-4941
    • Traxler, P.1    Allegrini, P.R.2    Brandt, R.3    Brueggen, J.4    Cozens, R.5    Fabbro, D.6    Grosios, K.7    Lane, H.A.8    McSheehy, P.9    Mestan, J.10
  • 12
    • 33745216879 scopus 로고    scopus 로고
    • Dual epidermal growth factor receptor and vascular endothelial growth factorreceptor inhibition with NVP-AEE788 for the treatment of aggressive follicularthyroid cancer
    • Younes MN, Yazici YD, Kim S, Jasser SA, El-Naggar AK, and Myers JN (2006). Dual epidermal growth factor receptor and vascular endothelial growth factorreceptor inhibition with NVP-AEE788 for the treatment of aggressive follicularthyroid cancer. Clin Cancer Res 12, 3425-3434.
    • (2006) Clin Cancer Res , vol.12 , pp. 3425-3434
    • Younes, M.N.1    Yazici, Y.D.2    Kim, S.3    Jasser, S.A.4    El-Naggar, A.K.5    Myers, J.N.6
  • 13
    • 20944433324 scopus 로고    scopus 로고
    • Dual inhibition of epidermalgrowth factor receptor and vascular endothelial growth factor receptor phosphorylationby AEE788 reduces growth and metastasis of human colon carcinoma in anorthotopic nude mouse model
    • Yokoi K, ThaKer PH, Yazici S, Rebhun RR, Nam DH, He J, Kim SJ, Abbruzzese JL, Hamilton SR, and Fidler IJ (2005). Dual inhibition of epidermalgrowth factor receptor and vascular endothelial growth factor receptor phosphorylationby AEE788 reduces growth and metastasis of human colon carcinoma in anorthotopic nude mouse model. Cancer Res 65, 3716-3725.
    • (2005) Cancer Res , vol.65 , pp. 3716-3725
    • Yokoi, K.1    Thaker, P.H.2    Yazici, S.3    Rebhun, R.R.4    Nam, D.H.5    He, J.6    Kim, S.J.7    Abbruzzese, J.L.8    Hamilton, S.R.9    Fidler, I.J.10
  • 17
    • 67649628171 scopus 로고    scopus 로고
    • Antitumor effect in medulloblastoma cells by gefitinib: Ectopic HER2 overexpression enhances gefitinib effects in vivo
    • Meco D, Servidei T, Riccardi A, Ferlini C, Cusano G, Zannoni GF, Giangaspero F, and Riccardi R (2009). Antitumor effect in medulloblastoma cells by gefitinib: ectopic HER2 overexpression enhances gefitinib effects in vivo. Neuro Oncol 11, 250-259.
    • (2009) Neuro Oncol , vol.11 , pp. 250-259
    • Meco, D.1    Servidei, T.2    Riccardi, A.3    Ferlini, C.4    Cusano, G.5    Zannoni, G.F.6    Giangaspero, F.7    Riccardi, R.8
  • 18
    • 49749122191 scopus 로고    scopus 로고
    • Autocrine regulation of glioblastoma cell cycle progression, viabilityand radioresistance through the VEGF-VEGFR2 (KDR) interplay
    • Knizetova P, Ehrmann J, Hlobilkova A, Vancova I, Kalita O, Kolar Z, and Bartek J (2008). Autocrine regulation of glioblastoma cell cycle progression, viabilityand radioresistance through the VEGF-VEGFR2 (KDR) interplay. Cell Cycle 7, 2553-2561.
    • (2008) Cell Cycle , vol.7 , pp. 2553-2561
    • Knizetova, P.1    Ehrmann, J.2    Hlobilkova, A.3    Vancova, I.4    Kalita, O.5    Kolar, Z.6    Bartek, J.7
  • 19
    • 0032170045 scopus 로고    scopus 로고
    • Expression of the ErbB-neuregulinsignaling network during human cerebellar development: Implications for thebiology of medulloblastoma
    • Gilbertson RJ, Clifford SC, MacMeekin W, Meekin W, Wright C, Perry RH, Kelly P, Pearson AD, and Lunec J (1998). Expression of the ErbB-neuregulinsignaling network during human cerebellar development: implications for thebiology of medulloblastoma. Cancer Res 58, 3932-3941.
    • (1998) Cancer Res , vol.58 , pp. 3932-3941
    • Gilbertson, R.J.1    Clifford, S.C.2    McMeekin, W.3    Meekin, W.4    Wright, C.5    Perry, R.H.6    Kelly, P.7    Pearson, A.D.8    Lunec, J.9
  • 20
    • 41349120284 scopus 로고    scopus 로고
    • Morphological effects ofradiochemotherapy on cervical carcinoma: A morphological study of 50 cases ofhysterectomy specimens after neoadjuvant treatment
    • Zannoni GF, Vellone VG, and Carbone A (2008). Morphological effects ofradiochemotherapy on cervical carcinoma: a morphological study of 50 cases ofhysterectomy specimens after neoadjuvant treatment. Int J Gynecol Pathol 27,274-281.
    • (2008) Int J Gynecol Pathol , vol.27 , pp. 274-281
    • Zannoni, G.F.1    Vellone, V.G.2    Carbone, A.3
  • 21
    • 33845219148 scopus 로고    scopus 로고
    • Concomitant inhibition of epidermalgrowth factor and vascular endothelial growth factor receptor tyrosine kinases reducesgrowth and metastasis of human salivary adenoid cystic carcinoma in anorthotopic nude mouse model
    • Younes MN, Park YW, Yazici YD, Gu M, Santillan AA, Nong X, Kim S, Jasser SA, El-Naggar AK, and Myers JN (2006). Concomitant inhibition of epidermalgrowth factor and vascular endothelial growth factor receptor tyrosine kinases reducesgrowth and metastasis of human salivary adenoid cystic carcinoma in anorthotopic nude mouse model. Mol Cancer Ther 5, 2696-2705.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2696-2705
    • Younes, M.N.1    Park, Y.W.2    Yazici, Y.D.3    Gu, M.4    Santillan, A.A.5    Nong, X.6    Kim, S.7    Jasser, S.A.8    El-Naggar, A.K.9    Myers, J.N.10
  • 22
    • 13944269599 scopus 로고    scopus 로고
    • Combination therapyof inhibitors of epidermal growth factor receptor/vascular endothelial growth factorreceptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offersimproved glioblastoma tumor growth inhibition
    • Goudar RK, Shi Q, Hjelmeland MD, Keir ST, McLendon RE, Wikstrand CJ, Reese ED, Conrad CA, Traxler P, Lane HA, et al. (2005). Combination therapyof inhibitors of epidermal growth factor receptor/vascular endothelial growth factorreceptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offersimproved glioblastoma tumor growth inhibition. Mol Cancer Ther 4, 101-112.
    • (2005) Mol Cancer Ther , vol.4 , pp. 101-112
    • Goudar, R.K.1    Shi, Q.2    Hjelmeland, M.D.3    Keir, S.T.4    McLendon, R.E.5    Wikstrand, C.J.6    Reese, E.D.7    Conrad, C.A.8    Traxler, P.9    Lane, H.A.10
  • 24
    • 57349172709 scopus 로고    scopus 로고
    • Chemoresistanttumor cell lines display altered epidermal growth factor receptor and HER3 signalingand enhanced sensitivity to gefitinib
    • Servidei T, Riccardi A, Ferlini C, Ferlini C, and Riccardi R (2008). Chemoresistanttumor cell lines display altered epidermal growth factor receptor and HER3 signalingand enhanced sensitivity to gefitinib. Int J Cancer 123, 2939-2949.
    • (2008) Int J Cancer , vol.123 , pp. 2939-2949
    • Servidei, T.1    Riccardi, A.2    Ferlini, C.3    Ferlini, C.4    Riccardi, R.5
  • 25
    • 0030944455 scopus 로고    scopus 로고
    • ErbB-2, the preferredheterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
    • Graus-Porta D, Beerli RR, Daly JM, and Hynes NE (1997). ErbB-2, the preferredheterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J 16, 1647-1655.
    • (1997) EMBO J , vol.16 , pp. 1647-1655
    • Graus-Porta, D.1    Beerli, R.R.2    Daly, J.M.3    Hynes, N.E.4
  • 26
    • 77649095719 scopus 로고    scopus 로고
    • HER3 comes of age: New insightsinto its functions and role in signaling, tumor biology, and cancer therapy
    • Campbell MR, Amin D, and Moasser MM (2010). HER3 comes of age: new insightsinto its functions and role in signaling, tumor biology, and cancer therapy. Clin Cancer Res 16, 1373-1383.
    • (2010) Clin Cancer Res , vol.16 , pp. 1373-1383
    • Campbell, M.R.1    Amin, D.2    Moasser, M.M.3
  • 29
    • 76749136371 scopus 로고    scopus 로고
    • AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2(HER2), and ERBB3: A unique agent for simultaneous ERBB receptor blockadein cancer
    • Hickinson DM, Klinowska T, Speake G, Vincent J, Trigwell C, Anderton J, Beck S, Marshall G, Davenport S, Callis R, et al. (2010). AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2(HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockadein cancer. Clin Cancer Res 16, 1159-1169.
    • (2010) Clin Cancer Res , vol.16 , pp. 1159-1169
    • Hickinson, D.M.1    Klinowska, T.2    Speake, G.3    Vincent, J.4    Trigwell, C.5    Anderton, J.6    Beck, S.7    Marshall, G.8    Davenport, S.9    Callis, R.10
  • 30
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL (2003). Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3,721-732.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 31
    • 76049125648 scopus 로고    scopus 로고
    • Targeting vascular endothelialgrowth factor receptor in thyroid cancer: The intracellular and extracellular implications
    • Keefe SM, Cohen MA, and Brose MS (2010). Targeting vascular endothelialgrowth factor receptor in thyroid cancer: the intracellular and extracellular implications. Clin Cancer Res 16, 778-783.
    • (2010) Clin Cancer Res , vol.16 , pp. 778-783
    • Keefe, S.M.1    Cohen, M.A.2    Brose, M.S.3
  • 32
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factorpathway in tumor growth and angiogenesis
    • Hicklin DJ and Ellis LM (2005). Role of the vascular endothelial growth factorpathway in tumor growth and angiogenesis. J Clin Oncol 23, 1011-1027.
    • (2005) J Clin Oncol , vol.23 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.