-
1
-
-
0034927062
-
The developmental biology of braintumors
-
Wechsler-Reya R and Scott MP (2001). The developmental biology of braintumors. Annu Rev Neurosci 24, 385-428.
-
(2001)
Annu Rev Neurosci
, vol.24
, pp. 385-428
-
-
Wechsler-Reya, R.1
Scott, M.P.2
-
2
-
-
1642307767
-
Medulloblastoma: Signalling a change in treatment
-
Gilbertson RJ (2004). Medulloblastoma: signalling a change in treatment. Lancet Oncol 5, 209-218.
-
(2004)
Lancet Oncol
, vol.5
, pp. 209-218
-
-
Gilbertson, R.J.1
-
3
-
-
33746544343
-
New paradigms in anticancer therapy: Targeting multiple signaling pathways with kinase inhibitors
-
Faivre S, Djelloul S, and Raymond E (2006). New paradigms in anticancer therapy:targeting multiple signaling pathways with kinase inhibitors. Semin Oncol 33, 407-420.
-
(2006)
Semin Oncol
, vol.33
, pp. 407-420
-
-
Faivre, S.1
Djelloul, S.2
Raymond, E.3
-
4
-
-
18344390418
-
ERBB receptors and cancer: The complexity oftargeted inhibitors
-
Hynes NE and Lane HA (2005). ERBB receptors and cancer: the complexity oftargeted inhibitors. Nat Rev Cancer 5, 341-354.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 341-354
-
-
Hynes, N.E.1
Lane, H.A.2
-
5
-
-
34447632643
-
Angiogenesis in brain tumours
-
Jain RK, di Tomaso E, Duda DG, Loeffler JS, Sorensen AG, and Batchelor TT (2007). Angiogenesis in brain tumours. Nat Rev Neurosci 8, 610-622.
-
(2007)
Nat Rev Neurosci
, vol.8
, pp. 610-622
-
-
Jain, R.K.1
di Tomaso, E.2
Duda, D.G.3
Loeffler, J.S.4
Sorensen, A.G.5
Batchelor, T.T.6
-
6
-
-
0037699954
-
The biology of VEGF and itsreceptors
-
Ferrara N, Gerber HP, and LeCouter J (2003). The biology of VEGF and itsreceptors. Nat Med 9, 669-676.
-
(2003)
Nat Med
, vol.9
, pp. 669-676
-
-
Ferrara, N.1
Gerber, H.P.2
LeCouter, J.3
-
7
-
-
0027412319
-
Epidermal growth factor stimulates vascular endothelial growth factor productionby human malignant glioma cells: A model of glioblastoma multiforme pathophysiology
-
Goldman CK, Kim J, Wong WL, King V, Brock T, and Gillepsie GY (1993). Epidermal growth factor stimulates vascular endothelial growth factor productionby human malignant glioma cells: a model of glioblastoma multiforme pathophysiology. Mol Biol Cell 4, 121-133.
-
(1993)
Mol Biol Cell
, vol.4
, pp. 121-133
-
-
Goldman, C.K.1
Kim, J.2
Wong, W.L.3
King, V.4
Brock, T.5
Gillepsie, G.Y.6
-
8
-
-
33644529055
-
ErbB2 increases vascular endothelial growthfactor protein synthesis via activation of mammalian target of rapamycin/p70S6Kleading to increased angiogenesis and spontaneous metastasis of human breastcancer cells
-
Klos KS, Wyszomierski SL, Sun M, Tan M, Zhou X, Li P, Yang W, Yin G, Hittelman WN, and Yu D (2006). ErbB2 increases vascular endothelial growthfactor protein synthesis via activation of mammalian target of rapamycin/p70S6Kleading to increased angiogenesis and spontaneous metastasis of human breastcancer cells. Cancer Res 66, 2028-2037.
-
(2006)
Cancer Res
, vol.66
, pp. 2028-2037
-
-
Klos, K.S.1
Wyszomierski, S.L.2
Sun, M.3
Tan, M.4
Zhou, X.5
Li, P.6
Yang, W.7
Yin, G.8
Hittelman, W.N.9
Yu, D.10
-
9
-
-
0036604183
-
ErbB2 overexpressioncorrelates with increased expression of vascular endothelial growth factors A, C, and D in human breast carcinoma
-
Yang W, Klos K, Yang Y, Smith TL, Shi D, and Yu D (2002). ErbB2 overexpressioncorrelates with increased expression of vascular endothelial growth factors A, C, and D in human breast carcinoma. Cancer 94, 2855-2861.
-
(2002)
Cancer
, vol.94
, pp. 2855-2861
-
-
Yang, W.1
Klos, K.2
Yang, Y.3
Smith, T.L.4
Shi, D.5
Yu, D.6
-
10
-
-
51149086367
-
Combined targeting of EGFRdependentand VEGF-dependent pathways: Rationale, preclinical studies andclinical applications
-
Tortora G, Ciardiello F, and Gasparini G (2008). Combined targeting of EGFRdependentand VEGF-dependent pathways: rationale, preclinical studies andclinical applications. Nat Clin Pract Oncol 5, 521-530.
-
(2008)
Nat Clin Pract Oncol
, vol.5
, pp. 521-530
-
-
Tortora, G.1
Ciardiello, F.2
Gasparini, G.3
-
11
-
-
3142774878
-
AEE788: A dual family epidermalgrowth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosinekinase inhibitor with antitumor and antiangiogenic activity
-
Traxler P, Allegrini PR, Brandt R, Brueggen J, Cozens R, Fabbro D, Grosios K, Lane HA, McSheehy P, Mestan J, et al. (2004). AEE788: a dual family epidermalgrowth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosinekinase inhibitor with antitumor and antiangiogenic activity. Cancer Res 64,4931-4941.
-
(2004)
Cancer Res
, vol.64
, pp. 4931-4941
-
-
Traxler, P.1
Allegrini, P.R.2
Brandt, R.3
Brueggen, J.4
Cozens, R.5
Fabbro, D.6
Grosios, K.7
Lane, H.A.8
McSheehy, P.9
Mestan, J.10
-
12
-
-
33745216879
-
Dual epidermal growth factor receptor and vascular endothelial growth factorreceptor inhibition with NVP-AEE788 for the treatment of aggressive follicularthyroid cancer
-
Younes MN, Yazici YD, Kim S, Jasser SA, El-Naggar AK, and Myers JN (2006). Dual epidermal growth factor receptor and vascular endothelial growth factorreceptor inhibition with NVP-AEE788 for the treatment of aggressive follicularthyroid cancer. Clin Cancer Res 12, 3425-3434.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 3425-3434
-
-
Younes, M.N.1
Yazici, Y.D.2
Kim, S.3
Jasser, S.A.4
El-Naggar, A.K.5
Myers, J.N.6
-
13
-
-
20944433324
-
Dual inhibition of epidermalgrowth factor receptor and vascular endothelial growth factor receptor phosphorylationby AEE788 reduces growth and metastasis of human colon carcinoma in anorthotopic nude mouse model
-
Yokoi K, ThaKer PH, Yazici S, Rebhun RR, Nam DH, He J, Kim SJ, Abbruzzese JL, Hamilton SR, and Fidler IJ (2005). Dual inhibition of epidermalgrowth factor receptor and vascular endothelial growth factor receptor phosphorylationby AEE788 reduces growth and metastasis of human colon carcinoma in anorthotopic nude mouse model. Cancer Res 65, 3716-3725.
-
(2005)
Cancer Res
, vol.65
, pp. 3716-3725
-
-
Yokoi, K.1
Thaker, P.H.2
Yazici, S.3
Rebhun, R.R.4
Nam, D.H.5
He, J.6
Kim, S.J.7
Abbruzzese, J.L.8
Hamilton, S.R.9
Fidler, I.J.10
-
14
-
-
33846029123
-
A perivascular niche for braintumor stem cells
-
Calabrese C, Poppleton H, Kocak M, Hogg TL, Fuller C, Hamner B, Oh EY, Gaber MW, Finklestein D, Allen M, et al. (2007). A perivascular niche for braintumor stem cells. Cancer Cell 11, 69-82.
-
(2007)
Cancer Cell
, vol.11
, pp. 69-82
-
-
Calabrese, C.1
Poppleton, H.2
Kocak, M.3
Hogg, T.L.4
Fuller, C.5
Hamner, B.6
Oh, E.Y.7
Gaber, M.W.8
Finklestein, D.9
Allen, M.10
-
15
-
-
1842614251
-
Clinical, histopathologic, andmolecular markers of prognosis: Toward a new disease risk stratification systemfor medulloblastoma
-
Gajjar A, Hernan R, Kocak M, Fuller C, Lee Y, McKinnon PJ, Wallace D, Lau C, Chintagumpala M, Ashley DM, et al. (2004). Clinical, histopathologic, andmolecular markers of prognosis: toward a new disease risk stratification systemfor medulloblastoma. J Clin Oncol 22, 984-993.
-
(2004)
J Clin Oncol
, vol.22
, pp. 984-993
-
-
Gajjar, A.1
Hernan, R.2
Kocak, M.3
Fuller, C.4
Lee, Y.5
McKinnon, P.J.6
Wallace, D.7
Lau, C.8
Chintagumpala, M.9
Ashley, D.M.10
-
16
-
-
35648956157
-
Functional VEGF and VEGF receptors areexpressed in human medulloblastomas
-
Slongo ML, Molena B, Brunati AM, Frasson M, Gardiman M, Carli M, Perilongo G, Rosolen A, and Onisto M (2007). Functional VEGF and VEGF receptors areexpressed in human medulloblastomas. Neuro Oncol 9, 384-392.
-
(2007)
Neuro Oncol
, vol.9
, pp. 384-392
-
-
Slongo, M.L.1
Molena, B.2
Brunati, A.M.3
Frasson, M.4
Gardiman, M.5
Carli, M.6
Perilongo, G.7
Rosolen, A.8
Onisto, M.9
-
17
-
-
67649628171
-
Antitumor effect in medulloblastoma cells by gefitinib: Ectopic HER2 overexpression enhances gefitinib effects in vivo
-
Meco D, Servidei T, Riccardi A, Ferlini C, Cusano G, Zannoni GF, Giangaspero F, and Riccardi R (2009). Antitumor effect in medulloblastoma cells by gefitinib: ectopic HER2 overexpression enhances gefitinib effects in vivo. Neuro Oncol 11, 250-259.
-
(2009)
Neuro Oncol
, vol.11
, pp. 250-259
-
-
Meco, D.1
Servidei, T.2
Riccardi, A.3
Ferlini, C.4
Cusano, G.5
Zannoni, G.F.6
Giangaspero, F.7
Riccardi, R.8
-
18
-
-
49749122191
-
Autocrine regulation of glioblastoma cell cycle progression, viabilityand radioresistance through the VEGF-VEGFR2 (KDR) interplay
-
Knizetova P, Ehrmann J, Hlobilkova A, Vancova I, Kalita O, Kolar Z, and Bartek J (2008). Autocrine regulation of glioblastoma cell cycle progression, viabilityand radioresistance through the VEGF-VEGFR2 (KDR) interplay. Cell Cycle 7, 2553-2561.
-
(2008)
Cell Cycle
, vol.7
, pp. 2553-2561
-
-
Knizetova, P.1
Ehrmann, J.2
Hlobilkova, A.3
Vancova, I.4
Kalita, O.5
Kolar, Z.6
Bartek, J.7
-
19
-
-
0032170045
-
Expression of the ErbB-neuregulinsignaling network during human cerebellar development: Implications for thebiology of medulloblastoma
-
Gilbertson RJ, Clifford SC, MacMeekin W, Meekin W, Wright C, Perry RH, Kelly P, Pearson AD, and Lunec J (1998). Expression of the ErbB-neuregulinsignaling network during human cerebellar development: implications for thebiology of medulloblastoma. Cancer Res 58, 3932-3941.
-
(1998)
Cancer Res
, vol.58
, pp. 3932-3941
-
-
Gilbertson, R.J.1
Clifford, S.C.2
McMeekin, W.3
Meekin, W.4
Wright, C.5
Perry, R.H.6
Kelly, P.7
Pearson, A.D.8
Lunec, J.9
-
20
-
-
41349120284
-
Morphological effects ofradiochemotherapy on cervical carcinoma: A morphological study of 50 cases ofhysterectomy specimens after neoadjuvant treatment
-
Zannoni GF, Vellone VG, and Carbone A (2008). Morphological effects ofradiochemotherapy on cervical carcinoma: a morphological study of 50 cases ofhysterectomy specimens after neoadjuvant treatment. Int J Gynecol Pathol 27,274-281.
-
(2008)
Int J Gynecol Pathol
, vol.27
, pp. 274-281
-
-
Zannoni, G.F.1
Vellone, V.G.2
Carbone, A.3
-
21
-
-
33845219148
-
Concomitant inhibition of epidermalgrowth factor and vascular endothelial growth factor receptor tyrosine kinases reducesgrowth and metastasis of human salivary adenoid cystic carcinoma in anorthotopic nude mouse model
-
Younes MN, Park YW, Yazici YD, Gu M, Santillan AA, Nong X, Kim S, Jasser SA, El-Naggar AK, and Myers JN (2006). Concomitant inhibition of epidermalgrowth factor and vascular endothelial growth factor receptor tyrosine kinases reducesgrowth and metastasis of human salivary adenoid cystic carcinoma in anorthotopic nude mouse model. Mol Cancer Ther 5, 2696-2705.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 2696-2705
-
-
Younes, M.N.1
Park, Y.W.2
Yazici, Y.D.3
Gu, M.4
Santillan, A.A.5
Nong, X.6
Kim, S.7
Jasser, S.A.8
El-Naggar, A.K.9
Myers, J.N.10
-
22
-
-
13944269599
-
Combination therapyof inhibitors of epidermal growth factor receptor/vascular endothelial growth factorreceptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offersimproved glioblastoma tumor growth inhibition
-
Goudar RK, Shi Q, Hjelmeland MD, Keir ST, McLendon RE, Wikstrand CJ, Reese ED, Conrad CA, Traxler P, Lane HA, et al. (2005). Combination therapyof inhibitors of epidermal growth factor receptor/vascular endothelial growth factorreceptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offersimproved glioblastoma tumor growth inhibition. Mol Cancer Ther 4, 101-112.
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 101-112
-
-
Goudar, R.K.1
Shi, Q.2
Hjelmeland, M.D.3
Keir, S.T.4
McLendon, R.E.5
Wikstrand, C.J.6
Reese, E.D.7
Conrad, C.A.8
Traxler, P.9
Lane, H.A.10
-
23
-
-
0037945211
-
HER2/PI-3K/Akt activation leads to a multidrugresistance in human breast adenocarcinoma cells
-
Knuefermann C, Lu Y, Liu B, Jin W, Liang K, Wu L, Schmidt M, Mills GB, Mendelsohn J, and Fan Z (2003). HER2/PI-3K/Akt activation leads to a multidrugresistance in human breast adenocarcinoma cells. Oncogene 22, 3205-3212.
-
(2003)
Oncogene
, vol.22
, pp. 3205-3212
-
-
Knuefermann, C.1
Lu, Y.2
Liu, B.3
Jin, W.4
Liang, K.5
Wu, L.6
Schmidt, M.7
Mills, G.B.8
Mendelsohn, J.9
Fan, Z.10
-
24
-
-
57349172709
-
Chemoresistanttumor cell lines display altered epidermal growth factor receptor and HER3 signalingand enhanced sensitivity to gefitinib
-
Servidei T, Riccardi A, Ferlini C, Ferlini C, and Riccardi R (2008). Chemoresistanttumor cell lines display altered epidermal growth factor receptor and HER3 signalingand enhanced sensitivity to gefitinib. Int J Cancer 123, 2939-2949.
-
(2008)
Int J Cancer
, vol.123
, pp. 2939-2949
-
-
Servidei, T.1
Riccardi, A.2
Ferlini, C.3
Ferlini, C.4
Riccardi, R.5
-
25
-
-
0030944455
-
ErbB-2, the preferredheterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
-
Graus-Porta D, Beerli RR, Daly JM, and Hynes NE (1997). ErbB-2, the preferredheterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J 16, 1647-1655.
-
(1997)
EMBO J
, vol.16
, pp. 1647-1655
-
-
Graus-Porta, D.1
Beerli, R.R.2
Daly, J.M.3
Hynes, N.E.4
-
26
-
-
77649095719
-
HER3 comes of age: New insightsinto its functions and role in signaling, tumor biology, and cancer therapy
-
Campbell MR, Amin D, and Moasser MM (2010). HER3 comes of age: new insightsinto its functions and role in signaling, tumor biology, and cancer therapy. Clin Cancer Res 16, 1373-1383.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1373-1383
-
-
Campbell, M.R.1
Amin, D.2
Moasser, M.M.3
-
27
-
-
48649092620
-
A central role for HER3 in HER2-amplified breastcancer: Implications for targeted therapy
-
Lee-Hoeflich ST, Crocker L, Yao E, Pham T, Munroe X, Hoeflich KP, Sliwkowski MX, and Stern HM (2009). A central role for HER3 in HER2-amplified breastcancer: implications for targeted therapy. Cancer Res 68, 5878-5887.
-
(2009)
Cancer Res
, vol.68
, pp. 5878-5887
-
-
Lee-Hoeflich, S.T.1
Crocker, L.2
Yao, E.3
Pham, T.4
Munroe, X.5
Hoeflich, K.P.6
Sliwkowski, M.X.7
Stern, H.M.8
-
28
-
-
65349101151
-
Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941
-
Junttila TT, Akita RW, Parson K, Fields C, Lewis Phillips PC, Friedman LS, Sampath D, and Sliwkowski MX (2009). Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941. Cancer Cell 15, 429-440.
-
(2009)
Cancer Cell
, vol.15
, pp. 429-440
-
-
Junttila, T.T.1
Akita, R.W.2
Parson, K.3
Fields, C.4
Lewis Phillips, P.C.5
Friedman, L.S.6
Sampath, D.7
Sliwkowski, M.X.8
-
29
-
-
76749136371
-
AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2(HER2), and ERBB3: A unique agent for simultaneous ERBB receptor blockadein cancer
-
Hickinson DM, Klinowska T, Speake G, Vincent J, Trigwell C, Anderton J, Beck S, Marshall G, Davenport S, Callis R, et al. (2010). AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2(HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockadein cancer. Clin Cancer Res 16, 1159-1169.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1159-1169
-
-
Hickinson, D.M.1
Klinowska, T.2
Speake, G.3
Vincent, J.4
Trigwell, C.5
Anderton, J.6
Beck, S.7
Marshall, G.8
Davenport, S.9
Callis, R.10
-
30
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL (2003). Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3,721-732.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
31
-
-
76049125648
-
Targeting vascular endothelialgrowth factor receptor in thyroid cancer: The intracellular and extracellular implications
-
Keefe SM, Cohen MA, and Brose MS (2010). Targeting vascular endothelialgrowth factor receptor in thyroid cancer: the intracellular and extracellular implications. Clin Cancer Res 16, 778-783.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 778-783
-
-
Keefe, S.M.1
Cohen, M.A.2
Brose, M.S.3
-
32
-
-
14644440555
-
Role of the vascular endothelial growth factorpathway in tumor growth and angiogenesis
-
Hicklin DJ and Ellis LM (2005). Role of the vascular endothelial growth factorpathway in tumor growth and angiogenesis. J Clin Oncol 23, 1011-1027.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1011-1027
-
-
Hicklin, D.J.1
Ellis, L.M.2
-
33
-
-
67651006461
-
Kinome profilingin pediatric brain tumors as a new approach for target discovery
-
Sikkema AH, Dicks SH, den Dunnen WF, ter Elst A, Scherpen FJ, Hoving EW, Ruijtenbeek R, Boender PJ, de Wijn R, Kamps WA, et al. (2009). Kinome profilingin pediatric brain tumors as a new approach for target discovery. Cancer Res 69,5987-5995.
-
(2009)
Cancer Res
, vol.69
, pp. 5987-5995
-
-
Sikkema, A.H.1
Dicks, S.H.2
den Dunnen, W.F.3
ter Elst, A.4
Scherpen, F.J.5
Hoving, E.W.6
Ruijtenbeek, R.7
Boender, P.J.8
de Wijn, R.9
Kamps, W.A.10
|